Pyridoxal phosphate phosphatase PHOSPHO2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative Phosphatase/Protein of unknown function DUF89, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H5R3_LEIDO

TriTrypDb:

LdBPK_060640.1 , LdCL_060011500 , LDHU3_06.0750

Length:

1010

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H5R3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5R3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016791	phosphatase activity	5	12
GO:0042578	phosphoric ester hydrolase activity	4	12
GO:0005488	binding	1	4
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4
GO:0016829	lyase activity	2	1
GO:0016830	carbon-carbon lyase activity	3	1
GO:0016832	aldehyde-lyase activity	4	1
GO:0097023	fructose 6-phosphate aldolase activity	5	1
GO:0103026	fructose-1-phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.578
CLV_C14_Caspase3-7	840	844	PF00656	0.749
CLV_MEL_PAP_1	419	425	PF00089	0.716
CLV_MEL_PAP_1	995	1001	PF00089	0.484
CLV_NRD_NRD_1	200	202	PF00675	0.410
CLV_NRD_NRD_1	272	274	PF00675	0.415
CLV_NRD_NRD_1	34	36	PF00675	0.450
CLV_NRD_NRD_1	356	358	PF00675	0.653
CLV_NRD_NRD_1	39	41	PF00675	0.399
CLV_NRD_NRD_1	421	423	PF00675	0.649
CLV_NRD_NRD_1	539	541	PF00675	0.757
CLV_NRD_NRD_1	66	68	PF00675	0.402
CLV_NRD_NRD_1	780	782	PF00675	0.423
CLV_NRD_NRD_1	894	896	PF00675	0.339
CLV_NRD_NRD_1	919	921	PF00675	0.806
CLV_PCSK_KEX2_1	272	274	PF00082	0.414
CLV_PCSK_KEX2_1	34	36	PF00082	0.450
CLV_PCSK_KEX2_1	349	351	PF00082	0.596
CLV_PCSK_KEX2_1	356	358	PF00082	0.556
CLV_PCSK_KEX2_1	39	41	PF00082	0.399
CLV_PCSK_KEX2_1	421	423	PF00082	0.716
CLV_PCSK_KEX2_1	539	541	PF00082	0.754
CLV_PCSK_KEX2_1	780	782	PF00082	0.420
CLV_PCSK_KEX2_1	894	896	PF00082	0.339
CLV_PCSK_PC1ET2_1	349	351	PF00082	0.596
CLV_PCSK_PC7_1	35	41	PF00082	0.402
CLV_PCSK_SKI1_1	108	112	PF00082	0.526
CLV_PCSK_SKI1_1	314	318	PF00082	0.588
CLV_PCSK_SKI1_1	343	347	PF00082	0.490
CLV_PCSK_SKI1_1	40	44	PF00082	0.520
CLV_PCSK_SKI1_1	577	581	PF00082	0.535
CLV_PCSK_SKI1_1	617	621	PF00082	0.348
CLV_PCSK_SKI1_1	738	742	PF00082	0.418
CLV_PCSK_SKI1_1	780	784	PF00082	0.439
CLV_PCSK_SKI1_1	785	789	PF00082	0.425
CLV_PCSK_SKI1_1	801	805	PF00082	0.367
CLV_PCSK_SKI1_1	971	975	PF00082	0.420
CLV_Separin_Metazoa	378	382	PF03568	0.558
CLV_Separin_Metazoa	556	560	PF03568	0.704
DEG_APCC_DBOX_1	355	363	PF00400	0.656
DEG_APCC_DBOX_1	780	788	PF00400	0.639
DEG_Nend_UBRbox_1	1	4	PF02207	0.730
DOC_CKS1_1	939	944	PF01111	0.773
DOC_CYCLIN_yCln2_LP_2	993	999	PF00134	0.482
DOC_MAPK_gen_1	371	379	PF00069	0.639
DOC_MAPK_gen_1	429	436	PF00069	0.577
DOC_MAPK_gen_1	971	981	PF00069	0.444
DOC_MAPK_gen_1	986	995	PF00069	0.493
DOC_MAPK_RevD_3	524	540	PF00069	0.736
DOC_PP1_RVXF_1	202	208	PF00149	0.389
DOC_PP1_RVXF_1	736	742	PF00149	0.540
DOC_PP2B_LxvP_1	159	162	PF13499	0.565
DOC_PP2B_LxvP_1	434	437	PF13499	0.567
DOC_PP2B_LxvP_1	993	996	PF13499	0.449
DOC_PP4_MxPP_1	388	391	PF00568	0.517
DOC_USP7_MATH_1	125	129	PF00917	0.482
DOC_USP7_MATH_1	162	166	PF00917	0.709
DOC_USP7_MATH_1	179	183	PF00917	0.735
DOC_USP7_MATH_1	287	291	PF00917	0.527
DOC_USP7_MATH_1	406	410	PF00917	0.686
DOC_USP7_MATH_1	515	519	PF00917	0.713
DOC_USP7_MATH_1	70	74	PF00917	0.500
DOC_USP7_MATH_1	863	867	PF00917	0.796
DOC_USP7_MATH_1	966	970	PF00917	0.604
DOC_WW_Pin1_4	421	426	PF00397	0.752
DOC_WW_Pin1_4	502	507	PF00397	0.764
DOC_WW_Pin1_4	751	756	PF00397	0.573
DOC_WW_Pin1_4	938	943	PF00397	0.783
LIG_14-3-3_CanoR_1	108	113	PF00244	0.724
LIG_14-3-3_CanoR_1	234	244	PF00244	0.460
LIG_14-3-3_CanoR_1	343	348	PF00244	0.460
LIG_14-3-3_CanoR_1	356	360	PF00244	0.475
LIG_14-3-3_CanoR_1	501	506	PF00244	0.811
LIG_14-3-3_CanoR_1	6	10	PF00244	0.475
LIG_14-3-3_CanoR_1	780	785	PF00244	0.596
LIG_14-3-3_CanoR_1	971	981	PF00244	0.498
LIG_Actin_WH2_1	904	922	PF00022	0.678
LIG_Actin_WH2_2	341	358	PF00022	0.466
LIG_Actin_WH2_2	51	69	PF00022	0.450
LIG_BRCT_BRCA1_1	770	774	PF00533	0.522
LIG_Clathr_ClatBox_1	10	14	PF01394	0.374
LIG_Clathr_ClatBox_1	130	134	PF01394	0.527
LIG_deltaCOP1_diTrp_1	899	907	PF00928	0.537
LIG_EH1_1	274	282	PF00400	0.434
LIG_FHA_1	22	28	PF00498	0.434
LIG_FHA_1	236	242	PF00498	0.435
LIG_FHA_1	480	486	PF00498	0.685
LIG_FHA_1	503	509	PF00498	0.710
LIG_FHA_1	695	701	PF00498	0.581
LIG_FHA_1	830	836	PF00498	0.459
LIG_FHA_1	845	851	PF00498	0.815
LIG_FHA_1	903	909	PF00498	0.646
LIG_FHA_1	960	966	PF00498	0.516
LIG_FHA_2	109	115	PF00498	0.602
LIG_FHA_2	16	22	PF00498	0.394
LIG_FHA_2	356	362	PF00498	0.509
LIG_FHA_2	752	758	PF00498	0.537
LIG_FHA_2	949	955	PF00498	0.624
LIG_IBAR_NPY_1	154	156	PF08397	0.556
LIG_LIR_Apic_2	809	815	PF02991	0.537
LIG_LIR_Gen_1	409	419	PF02991	0.700
LIG_LIR_Gen_1	482	491	PF02991	0.640
LIG_LIR_Gen_1	590	599	PF02991	0.465
LIG_LIR_Gen_1	8	15	PF02991	0.389
LIG_LIR_Gen_1	82	90	PF02991	0.531
LIG_LIR_Gen_1	924	934	PF02991	0.696
LIG_LIR_Gen_1	951	959	PF02991	0.474
LIG_LIR_LC3C_4	8	12	PF02991	0.347
LIG_LIR_Nem_3	1000	1006	PF02991	0.435
LIG_LIR_Nem_3	153	159	PF02991	0.454
LIG_LIR_Nem_3	255	259	PF02991	0.437
LIG_LIR_Nem_3	341	345	PF02991	0.480
LIG_LIR_Nem_3	409	414	PF02991	0.683
LIG_LIR_Nem_3	448	454	PF02991	0.457
LIG_LIR_Nem_3	482	486	PF02991	0.651
LIG_LIR_Nem_3	571	576	PF02991	0.663
LIG_LIR_Nem_3	590	594	PF02991	0.522
LIG_LIR_Nem_3	608	614	PF02991	0.357
LIG_LIR_Nem_3	8	12	PF02991	0.389
LIG_LIR_Nem_3	816	821	PF02991	0.584
LIG_LIR_Nem_3	82	87	PF02991	0.444
LIG_LIR_Nem_3	890	896	PF02991	0.543
LIG_LIR_Nem_3	924	929	PF02991	0.705
LIG_LIR_Nem_3	951	955	PF02991	0.482
LIG_NRBOX	683	689	PF00104	0.639
LIG_PCNA_PIPBox_1	80	89	PF02747	0.389
LIG_PDZ_Class_2	1005	1010	PF00595	0.432
LIG_Pex14_1	401	405	PF04695	0.457
LIG_Pex14_2	9	13	PF04695	0.415
LIG_PTB_Apo_2	151	158	PF02174	0.602
LIG_PTB_Apo_2	401	408	PF02174	0.602
LIG_PTB_Apo_2	490	497	PF02174	0.722
LIG_PTB_Apo_2	824	831	PF02174	0.590
LIG_PTB_Phospho_1	151	157	PF10480	0.602
LIG_PTB_Phospho_1	401	407	PF10480	0.601
LIG_SH2_CRK	256	260	PF00017	0.461
LIG_SH2_CRK	405	409	PF00017	0.526
LIG_SH2_CRK	411	415	PF00017	0.628
LIG_SH2_CRK	611	615	PF00017	0.540
LIG_SH2_CRK	893	897	PF00017	0.639
LIG_SH2_GRB2like	411	414	PF00017	0.699
LIG_SH2_GRB2like	721	724	PF00017	0.591
LIG_SH2_NCK_1	411	415	PF00017	0.731
LIG_SH2_SRC	208	211	PF00017	0.439
LIG_SH2_SRC	405	408	PF00017	0.601
LIG_SH2_SRC	411	414	PF00017	0.707
LIG_SH2_STAP1	157	161	PF00017	0.541
LIG_SH2_STAP1	554	558	PF00017	0.656
LIG_SH2_STAP1	769	773	PF00017	0.574
LIG_SH2_STAT3	721	724	PF00017	0.639
LIG_SH2_STAT5	256	259	PF00017	0.413
LIG_SH2_STAT5	407	410	PF00017	0.624
LIG_SH2_STAT5	450	453	PF00017	0.434
LIG_SH2_STAT5	683	686	PF00017	0.627
LIG_SH2_STAT5	721	724	PF00017	0.639
LIG_SH2_STAT5	749	752	PF00017	0.537
LIG_SH2_STAT5	769	772	PF00017	0.445
LIG_SH2_STAT5	829	832	PF00017	0.493
LIG_SH2_STAT5	86	89	PF00017	0.517
LIG_SH2_STAT5	94	97	PF00017	0.719
LIG_SH3_3	259	265	PF00018	0.468
LIG_SH3_3	387	393	PF00018	0.537
LIG_SH3_3	420	426	PF00018	0.666
LIG_SH3_3	506	512	PF00018	0.724
LIG_SH3_3	523	529	PF00018	0.632
LIG_SH3_3	555	561	PF00018	0.797
LIG_SH3_3	562	568	PF00018	0.726
LIG_SH3_3	75	81	PF00018	0.542
LIG_SH3_3	784	790	PF00018	0.606
LIG_SH3_3	832	838	PF00018	0.506
LIG_SH3_3	93	99	PF00018	0.748
LIG_SH3_3	976	982	PF00018	0.452
LIG_TRAF2_1	358	361	PF00917	0.609
LIG_TRAF2_1	468	471	PF00917	0.619
LIG_TRAF2_1	912	915	PF00917	0.685
LIG_TYR_ITIM	891	896	PF00017	0.639
LIG_UBA3_1	588	593	PF00899	0.520
LIG_WW_2	390	393	PF00397	0.579
LIG_WW_3	821	825	PF00397	0.629
MOD_CDK_SPK_2	751	756	PF00069	0.641
MOD_CK1_1	366	372	PF00069	0.592
MOD_CK1_1	628	634	PF00069	0.548
MOD_CK1_1	751	757	PF00069	0.565
MOD_CK1_1	768	774	PF00069	0.565
MOD_CK1_1	836	842	PF00069	0.706
MOD_CK1_1	969	975	PF00069	0.499
MOD_CK2_1	355	361	PF00069	0.570
MOD_CK2_1	528	534	PF00069	0.602
MOD_CK2_1	924	930	PF00069	0.674
MOD_CK2_1	948	954	PF00069	0.638
MOD_CMANNOS	618	621	PF00535	0.348
MOD_Cter_Amidation	32	35	PF01082	0.450
MOD_GlcNHglycan	166	169	PF01048	0.472
MOD_GlcNHglycan	365	368	PF01048	0.716
MOD_GlcNHglycan	517	520	PF01048	0.745
MOD_GlcNHglycan	561	564	PF01048	0.797
MOD_GlcNHglycan	835	838	PF01048	0.647
MOD_GlcNHglycan	839	842	PF01048	0.749
MOD_GlcNHglycan	850	853	PF01048	0.726
MOD_GlcNHglycan	865	868	PF01048	0.600
MOD_GlcNHglycan	881	884	PF01048	0.314
MOD_GlcNHglycan	926	929	PF01048	0.665
MOD_GlcNHglycan	956	959	PF01048	0.550
MOD_GlcNHglycan	999	1002	PF01048	0.499
MOD_GSK3_1	146	153	PF00069	0.483
MOD_GSK3_1	528	535	PF00069	0.667
MOD_GSK3_1	829	836	PF00069	0.505
MOD_GSK3_1	844	851	PF00069	0.728
MOD_N-GLC_1	363	368	PF02516	0.653
MOD_N-GLC_1	414	419	PF02516	0.760
MOD_N-GLC_1	694	699	PF02516	0.408
MOD_N-GLC_2	225	227	PF02516	0.389
MOD_NEK2_1	15	20	PF00069	0.425
MOD_NEK2_1	226	231	PF00069	0.380
MOD_NEK2_1	235	240	PF00069	0.388
MOD_NEK2_1	48	53	PF00069	0.461
MOD_NEK2_1	635	640	PF00069	0.572
MOD_NEK2_1	758	763	PF00069	0.648
MOD_NEK2_1	765	770	PF00069	0.656
MOD_NEK2_1	848	853	PF00069	0.786
MOD_NEK2_1	857	862	PF00069	0.715
MOD_NEK2_1	907	912	PF00069	0.524
MOD_NEK2_1	929	934	PF00069	0.686
MOD_NEK2_2	568	573	PF00069	0.689
MOD_NEK2_2	966	971	PF00069	0.407
MOD_PIKK_1	146	152	PF00454	0.507
MOD_PIKK_1	162	168	PF00454	0.574
MOD_PIKK_1	484	490	PF00454	0.729
MOD_PIKK_1	494	500	PF00454	0.712
MOD_PIKK_1	571	577	PF00454	0.738
MOD_PIKK_1	810	816	PF00454	0.548
MOD_PIKK_1	829	835	PF00454	0.452
MOD_PIKK_1	935	941	PF00454	0.702
MOD_PIKK_1	959	965	PF00454	0.506
MOD_PK_1	350	356	PF00069	0.626
MOD_PK_1	528	534	PF00069	0.674
MOD_PKA_1	780	786	PF00069	0.591
MOD_PKA_2	200	206	PF00069	0.475
MOD_PKA_2	355	361	PF00069	0.500
MOD_PKA_2	5	11	PF00069	0.483
MOD_PKA_2	500	506	PF00069	0.847
MOD_PKA_2	780	786	PF00069	0.692
MOD_PKA_2	997	1003	PF00069	0.472
MOD_Plk_1	15	21	PF00069	0.374
MOD_Plk_1	625	631	PF00069	0.547
MOD_Plk_1	758	764	PF00069	0.584
MOD_Plk_1	765	771	PF00069	0.575
MOD_Plk_1	929	935	PF00069	0.689
MOD_Plk_2-3	21	27	PF00069	0.386
MOD_Plk_2-3	72	78	PF00069	0.450
MOD_Plk_2-3	948	954	PF00069	0.607
MOD_Plk_4	15	21	PF00069	0.380
MOD_Plk_4	226	232	PF00069	0.463
MOD_Plk_4	237	243	PF00069	0.401
MOD_Plk_4	327	333	PF00069	0.568
MOD_Plk_4	343	349	PF00069	0.502
MOD_Plk_4	350	356	PF00069	0.618
MOD_Plk_4	5	11	PF00069	0.463
MOD_Plk_4	53	59	PF00069	0.420
MOD_Plk_4	532	538	PF00069	0.662
MOD_Plk_4	568	574	PF00069	0.768
MOD_Plk_4	625	631	PF00069	0.559
MOD_Plk_4	807	813	PF00069	0.601
MOD_Plk_4	929	935	PF00069	0.677
MOD_ProDKin_1	421	427	PF00069	0.754
MOD_ProDKin_1	502	508	PF00069	0.763
MOD_ProDKin_1	751	757	PF00069	0.573
MOD_ProDKin_1	938	944	PF00069	0.783
MOD_SUMO_for_1	678	681	PF00179	0.531
MOD_SUMO_for_1	912	915	PF00179	0.632
MOD_SUMO_for_1	973	976	PF00179	0.426
MOD_SUMO_rev_2	72	81	PF00179	0.511
TRG_DiLeu_BaEn_4	914	920	PF01217	0.659
TRG_DiLeu_BaLyEn_6	231	236	PF01217	0.389
TRG_DiLeu_BaLyEn_6	683	688	PF01217	0.639
TRG_ENDOCYTIC_2	1003	1006	PF00928	0.426
TRG_ENDOCYTIC_2	156	159	PF00928	0.548
TRG_ENDOCYTIC_2	256	259	PF00928	0.461
TRG_ENDOCYTIC_2	405	408	PF00928	0.517
TRG_ENDOCYTIC_2	411	414	PF00928	0.623
TRG_ENDOCYTIC_2	452	455	PF00928	0.424
TRG_ENDOCYTIC_2	554	557	PF00928	0.642
TRG_ENDOCYTIC_2	576	579	PF00928	0.504
TRG_ENDOCYTIC_2	611	614	PF00928	0.542
TRG_ENDOCYTIC_2	818	821	PF00928	0.537
TRG_ENDOCYTIC_2	893	896	PF00928	0.639
TRG_ENDOCYTIC_2	926	929	PF00928	0.540
TRG_ER_diArg_1	263	266	PF00400	0.388
TRG_ER_diArg_1	355	357	PF00400	0.625
TRG_ER_diArg_1	39	41	PF00400	0.402
TRG_ER_diArg_1	421	423	PF00400	0.649
TRG_ER_diArg_1	538	540	PF00400	0.738
TRG_ER_diArg_1	780	782	PF00400	0.496
TRG_ER_diArg_1	893	895	PF00400	0.537
TRG_NES_CRM1_1	114	127	PF08389	0.495
TRG_NES_CRM1_1	312	322	PF08389	0.598
TRG_Pf-PMV_PEXEL_1	314	318	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	357	361	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	894	899	PF00026	0.337

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDC9	Leptomonas seymouri	67%	100%
A0A0S4J9G5	Bodo saltans	35%	100%
A0A1X0NKN4	Trypanosomatidae	41%	100%
A0A3R7MAF3	Trypanosoma rangeli	39%	100%
A4H4M8	Leishmania braziliensis	83%	100%
A4HSV3	Leishmania infantum	100%	100%
C9ZTG3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AKU1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QJ16	Leishmania major	96%	100%
V5BT19	Trypanosoma cruzi	41%	100%