U-box domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U-box domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H5Q9_LEIDO

TriTrypDb:

LdBPK_060530.1 , LdCL_060010400 , LDHU3_06.0630

Length:

661

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A0A3S5H5Q9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5Q9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004842	ubiquitin-protein transferase activity	4	7
GO:0016740	transferase activity	2	7
GO:0019787	ubiquitin-like protein transferase activity	3	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.760
CLV_C14_Caspase3-7	166	170	PF00656	0.631
CLV_C14_Caspase3-7	552	556	PF00656	0.747
CLV_NRD_NRD_1	238	240	PF00675	0.608
CLV_NRD_NRD_1	487	489	PF00675	0.512
CLV_NRD_NRD_1	495	497	PF00675	0.450
CLV_NRD_NRD_1	501	503	PF00675	0.515
CLV_NRD_NRD_1	66	68	PF00675	0.484
CLV_PCSK_FUR_1	64	68	PF00082	0.596
CLV_PCSK_KEX2_1	238	240	PF00082	0.608
CLV_PCSK_KEX2_1	486	488	PF00082	0.531
CLV_PCSK_KEX2_1	495	497	PF00082	0.427
CLV_PCSK_KEX2_1	501	503	PF00082	0.492
CLV_PCSK_KEX2_1	592	594	PF00082	0.346
CLV_PCSK_KEX2_1	64	66	PF00082	0.486
CLV_PCSK_PC1ET2_1	592	594	PF00082	0.346
CLV_PCSK_SKI1_1	190	194	PF00082	0.487
CLV_PCSK_SKI1_1	244	248	PF00082	0.510
CLV_PCSK_SKI1_1	284	288	PF00082	0.473
CLV_PCSK_SKI1_1	308	312	PF00082	0.509
CLV_PCSK_SKI1_1	316	320	PF00082	0.476
CLV_PCSK_SKI1_1	488	492	PF00082	0.459
CLV_PCSK_SKI1_1	502	506	PF00082	0.477
CLV_PCSK_SKI1_1	59	63	PF00082	0.579
DEG_Nend_UBRbox_3	1	3	PF02207	0.552
DEG_ODPH_VHL_1	39	51	PF01847	0.699
DEG_ODPH_VHL_1	459	472	PF01847	0.509
DEG_SCF_FBW7_1	98	105	PF00400	0.729
DEG_SPOP_SBC_1	103	107	PF00917	0.806
DEG_SPOP_SBC_1	446	450	PF00917	0.543
DEG_SPOP_SBC_1	558	562	PF00917	0.763
DOC_CKS1_1	565	570	PF01111	0.706
DOC_CYCLIN_yCln2_LP_2	360	366	PF00134	0.778
DOC_CYCLIN_yCln2_LP_2	506	512	PF00134	0.761
DOC_MAPK_gen_1	501	508	PF00069	0.682
DOC_MAPK_MEF2A_6	284	291	PF00069	0.637
DOC_MAPK_MEF2A_6	38	47	PF00069	0.695
DOC_MAPK_MEF2A_6	501	508	PF00069	0.709
DOC_MAPK_NFAT4_5	284	292	PF00069	0.636
DOC_MAPK_RevD_3	49	65	PF00069	0.775
DOC_PP1_RVXF_1	503	509	PF00149	0.712
DOC_PP1_RVXF_1	57	64	PF00149	0.781
DOC_PP1_RVXF_1	634	640	PF00149	0.530
DOC_PP2B_LxvP_1	510	513	PF13499	0.664
DOC_PP2B_LxvP_1	515	518	PF13499	0.634
DOC_PP4_FxxP_1	508	511	PF00568	0.763
DOC_USP7_MATH_1	103	107	PF00917	0.737
DOC_USP7_MATH_1	202	206	PF00917	0.705
DOC_USP7_MATH_1	267	271	PF00917	0.691
DOC_USP7_MATH_1	354	358	PF00917	0.715
DOC_USP7_MATH_1	446	450	PF00917	0.557
DOC_USP7_MATH_1	461	465	PF00917	0.366
DOC_USP7_MATH_1	74	78	PF00917	0.791
DOC_WW_Pin1_4	325	330	PF00397	0.805
DOC_WW_Pin1_4	335	340	PF00397	0.730
DOC_WW_Pin1_4	359	364	PF00397	0.778
DOC_WW_Pin1_4	522	527	PF00397	0.700
DOC_WW_Pin1_4	564	569	PF00397	0.786
DOC_WW_Pin1_4	570	575	PF00397	0.708
DOC_WW_Pin1_4	98	103	PF00397	0.727
LIG_14-3-3_CanoR_1	129	133	PF00244	0.727
LIG_14-3-3_CanoR_1	152	157	PF00244	0.735
LIG_14-3-3_CanoR_1	164	168	PF00244	0.676
LIG_14-3-3_CanoR_1	190	196	PF00244	0.677
LIG_14-3-3_CanoR_1	369	374	PF00244	0.750
LIG_14-3-3_CanoR_1	393	397	PF00244	0.381
LIG_14-3-3_CanoR_1	432	438	PF00244	0.509
LIG_14-3-3_CanoR_1	444	453	PF00244	0.552
LIG_APCC_ABBA_1	531	536	PF00400	0.702
LIG_BIR_III_2	571	575	PF00653	0.757
LIG_BRCT_BRCA1_1	204	208	PF00533	0.636
LIG_BRCT_BRCA1_1	287	291	PF00533	0.785
LIG_EVH1_1	508	512	PF00568	0.685
LIG_FHA_1	153	159	PF00498	0.679
LIG_FHA_1	260	266	PF00498	0.690
LIG_FHA_1	343	349	PF00498	0.777
LIG_FHA_1	410	416	PF00498	0.488
LIG_FHA_1	432	438	PF00498	0.529
LIG_FHA_1	577	583	PF00498	0.646
LIG_FHA_1	620	626	PF00498	0.523
LIG_FHA_1	632	638	PF00498	0.526
LIG_FHA_2	280	286	PF00498	0.772
LIG_GBD_Chelix_1	43	51	PF00786	0.493
LIG_Integrin_isoDGR_2	179	181	PF01839	0.489
LIG_Integrin_isoDGR_2	430	432	PF01839	0.717
LIG_LIR_Apic_2	333	339	PF02991	0.785
LIG_LIR_Apic_2	395	400	PF02991	0.390
LIG_LIR_Gen_1	131	140	PF02991	0.761
LIG_LIR_Gen_1	151	159	PF02991	0.679
LIG_LIR_Gen_1	205	215	PF02991	0.680
LIG_LIR_Nem_3	131	135	PF02991	0.762
LIG_LIR_Nem_3	151	157	PF02991	0.693
LIG_LIR_Nem_3	205	211	PF02991	0.681
LIG_LIR_Nem_3	22	28	PF02991	0.383
LIG_LIR_Nem_3	241	246	PF02991	0.709
LIG_LIR_Nem_3	586	591	PF02991	0.549
LIG_PDZ_Class_1	656	661	PF00595	0.690
LIG_Pex14_1	132	136	PF04695	0.765
LIG_Pex14_1	30	34	PF04695	0.411
LIG_Pex14_2	195	199	PF04695	0.678
LIG_SH2_CRK	336	340	PF00017	0.833
LIG_SH2_NCK_1	652	656	PF00017	0.622
LIG_SH2_STAP1	124	128	PF00017	0.771
LIG_SH2_STAP1	453	457	PF00017	0.448
LIG_SH2_STAP1	652	656	PF00017	0.677
LIG_SH2_STAT5	156	159	PF00017	0.676
LIG_SH2_STAT5	214	217	PF00017	0.691
LIG_SH2_STAT5	378	381	PF00017	0.492
LIG_SH2_STAT5	471	474	PF00017	0.397
LIG_SH2_STAT5	652	655	PF00017	0.605
LIG_SH2_STAT5	78	81	PF00017	0.743
LIG_SH3_1	336	342	PF00018	0.829
LIG_SH3_2	511	516	PF14604	0.654
LIG_SH3_3	144	150	PF00018	0.705
LIG_SH3_3	336	342	PF00018	0.819
LIG_SH3_3	439	445	PF00018	0.510
LIG_SH3_3	455	461	PF00018	0.340
LIG_SH3_3	506	512	PF00018	0.697
LIG_SH3_3	562	568	PF00018	0.736
LIG_SUMO_SIM_anti_2	139	145	PF11976	0.734
LIG_SUMO_SIM_anti_2	412	419	PF11976	0.547
LIG_SUMO_SIM_par_1	141	148	PF11976	0.763
LIG_TRAF2_1	520	523	PF00917	0.634
LIG_TRAF2_1	612	615	PF00917	0.563
LIG_TRAF2_2	599	604	PF00917	0.546
LIG_TRFH_1	508	512	PF08558	0.752
LIG_UBA3_1	587	592	PF00899	0.546
LIG_WRC_WIRS_1	192	197	PF05994	0.677
MOD_CDK_SPK_2	364	369	PF00069	0.749
MOD_CDK_SPK_2	572	577	PF00069	0.739
MOD_CDK_SPxxK_3	570	577	PF00069	0.747
MOD_CK1_1	116	122	PF00069	0.763
MOD_CK1_1	145	151	PF00069	0.687
MOD_CK1_1	194	200	PF00069	0.679
MOD_CK1_1	221	227	PF00069	0.720
MOD_CK1_1	250	256	PF00069	0.728
MOD_CK1_1	300	306	PF00069	0.694
MOD_CK1_1	338	344	PF00069	0.776
MOD_CK1_1	358	364	PF00069	0.597
MOD_CK1_1	448	454	PF00069	0.596
MOD_CK1_1	81	87	PF00069	0.722
MOD_CK2_1	267	273	PF00069	0.730
MOD_CK2_1	279	285	PF00069	0.674
MOD_CK2_1	287	293	PF00069	0.599
MOD_CK2_1	325	331	PF00069	0.847
MOD_CK2_1	609	615	PF00069	0.602
MOD_Cter_Amidation	236	239	PF01082	0.611
MOD_GlcNHglycan	120	123	PF01048	0.585
MOD_GlcNHglycan	202	205	PF01048	0.560
MOD_GlcNHglycan	223	226	PF01048	0.523
MOD_GlcNHglycan	235	238	PF01048	0.542
MOD_GlcNHglycan	240	243	PF01048	0.461
MOD_GlcNHglycan	299	302	PF01048	0.569
MOD_GlcNHglycan	364	367	PF01048	0.562
MOD_GlcNHglycan	389	392	PF01048	0.411
MOD_GlcNHglycan	540	544	PF01048	0.480
MOD_GlcNHglycan	568	571	PF01048	0.595
MOD_GlcNHglycan	645	648	PF01048	0.449
MOD_GlcNHglycan	83	86	PF01048	0.548
MOD_GSK3_1	113	120	PF00069	0.729
MOD_GSK3_1	148	155	PF00069	0.702
MOD_GSK3_1	159	166	PF00069	0.591
MOD_GSK3_1	190	197	PF00069	0.677
MOD_GSK3_1	210	217	PF00069	0.524
MOD_GSK3_1	247	254	PF00069	0.746
MOD_GSK3_1	285	292	PF00069	0.785
MOD_GSK3_1	3	10	PF00069	0.510
MOD_GSK3_1	338	345	PF00069	0.764
MOD_GSK3_1	354	361	PF00069	0.630
MOD_GSK3_1	401	408	PF00069	0.551
MOD_GSK3_1	445	452	PF00069	0.583
MOD_GSK3_1	566	573	PF00069	0.721
MOD_GSK3_1	619	626	PF00069	0.483
MOD_GSK3_1	74	81	PF00069	0.759
MOD_GSK3_1	98	105	PF00069	0.729
MOD_N-GLC_1	631	636	PF02516	0.266
MOD_N-GLC_1	74	79	PF02516	0.523
MOD_NEK2_1	128	133	PF00069	0.738
MOD_NEK2_1	159	164	PF00069	0.654
MOD_NEK2_1	191	196	PF00069	0.677
MOD_NEK2_1	207	212	PF00069	0.686
MOD_NEK2_1	247	252	PF00069	0.768
MOD_NEK2_1	279	284	PF00069	0.805
MOD_NEK2_1	287	292	PF00069	0.689
MOD_NEK2_1	297	302	PF00069	0.555
MOD_NEK2_1	34	39	PF00069	0.400
MOD_NEK2_1	387	392	PF00069	0.372
MOD_NEK2_1	45	50	PF00069	0.718
MOD_NEK2_1	630	635	PF00069	0.530
MOD_NEK2_1	650	655	PF00069	0.685
MOD_NEK2_1	7	12	PF00069	0.482
MOD_NEK2_1	79	84	PF00069	0.785
MOD_PIKK_1	159	165	PF00454	0.678
MOD_PIKK_1	369	375	PF00454	0.815
MOD_PKA_1	238	244	PF00069	0.769
MOD_PKA_2	128	134	PF00069	0.718
MOD_PKA_2	163	169	PF00069	0.696
MOD_PKA_2	238	244	PF00069	0.732
MOD_PKA_2	392	398	PF00069	0.381
MOD_PKA_2	431	437	PF00069	0.501
MOD_PKA_2	576	582	PF00069	0.664
MOD_PKA_2	609	615	PF00069	0.537
MOD_Plk_1	355	361	PF00069	0.747
MOD_Plk_1	630	636	PF00069	0.530
MOD_Plk_1	74	80	PF00069	0.743
MOD_Plk_2-3	604	610	PF00069	0.546
MOD_Plk_4	142	148	PF00069	0.724
MOD_Plk_4	195	201	PF00069	0.688
MOD_Plk_4	202	208	PF00069	0.692
MOD_Plk_4	210	216	PF00069	0.699
MOD_Plk_4	259	265	PF00069	0.687
MOD_Plk_4	29	35	PF00069	0.389
MOD_Plk_4	3	9	PF00069	0.442
MOD_Plk_4	355	361	PF00069	0.773
MOD_Plk_4	39	45	PF00069	0.676
MOD_Plk_4	559	565	PF00069	0.680
MOD_Plk_4	74	80	PF00069	0.796
MOD_ProDKin_1	325	331	PF00069	0.807
MOD_ProDKin_1	335	341	PF00069	0.729
MOD_ProDKin_1	359	365	PF00069	0.778
MOD_ProDKin_1	522	528	PF00069	0.700
MOD_ProDKin_1	564	570	PF00069	0.783
MOD_ProDKin_1	572	578	PF00069	0.661
MOD_ProDKin_1	98	104	PF00069	0.728
TRG_DiLeu_BaEn_1	527	532	PF01217	0.619
TRG_DiLeu_BaLyEn_6	495	500	PF01217	0.757
TRG_DiLeu_BaLyEn_6	56	61	PF01217	0.778
TRG_ENDOCYTIC_2	156	159	PF00928	0.676
TRG_ER_diArg_1	350	353	PF00400	0.678
TRG_ER_diArg_1	485	488	PF00400	0.723
TRG_ER_diArg_1	495	497	PF00400	0.587
TRG_ER_diArg_1	500	502	PF00400	0.685
TRG_ER_diArg_1	63	66	PF00400	0.685
TRG_ER_diArg_1	639	642	PF00400	0.563
TRG_ER_FFAT_2	399	408	PF00635	0.454
TRG_NES_CRM1_1	309	322	PF08389	0.706
TRG_Pf-PMV_PEXEL_1	593	598	PF00026	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIV8	Leptomonas seymouri	50%	100%
A4H4L7	Leishmania braziliensis	78%	100%
A4HSU3	Leishmania infantum	99%	100%
E9AKT0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QJ27	Leishmania major	93%	100%