DUF3849 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5Q7_LEIDO

TriTrypDb:

LdBPK_060500.1 , LdCL_060010100 , LDHU3_06.0600

Length:

325

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H5Q7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5Q7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	300	304	PF00656	0.593
CLV_NRD_NRD_1	16	18	PF00675	0.368
CLV_NRD_NRD_1	79	81	PF00675	0.489
CLV_NRD_NRD_1	95	97	PF00675	0.345
CLV_PCSK_KEX2_1	115	117	PF00082	0.295
CLV_PCSK_KEX2_1	79	81	PF00082	0.478
CLV_PCSK_KEX2_1	95	97	PF00082	0.348
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.452
CLV_PCSK_SKI1_1	168	172	PF00082	0.379
CLV_PCSK_SKI1_1	17	21	PF00082	0.365
CLV_Separin_Metazoa	51	55	PF03568	0.371
DOC_CYCLIN_RxL_1	13	23	PF00134	0.457
DOC_MAPK_gen_1	102	111	PF00069	0.351
DOC_MAPK_gen_1	135	144	PF00069	0.400
DOC_MAPK_gen_1	79	87	PF00069	0.417
DOC_MAPK_gen_1	95	101	PF00069	0.293
DOC_MAPK_HePTP_8	99	111	PF00069	0.467
DOC_MAPK_MEF2A_6	102	111	PF00069	0.390
DOC_MAPK_MEF2A_6	135	144	PF00069	0.390
DOC_MAPK_NFAT4_5	104	112	PF00069	0.356
DOC_USP7_MATH_1	170	174	PF00917	0.393
DOC_USP7_MATH_1	178	182	PF00917	0.415
DOC_USP7_MATH_1	270	274	PF00917	0.498
DOC_USP7_MATH_1	282	286	PF00917	0.490
DOC_USP7_MATH_1	57	61	PF00917	0.561
DOC_WW_Pin1_4	278	283	PF00397	0.571
LIG_14-3-3_CanoR_1	139	145	PF00244	0.358
LIG_DLG_GKlike_1	102	109	PF00625	0.470
LIG_FHA_1	253	259	PF00498	0.475
LIG_FHA_1	92	98	PF00498	0.485
LIG_FHA_2	122	128	PF00498	0.637
LIG_FHA_2	282	288	PF00498	0.586
LIG_FHA_2	45	51	PF00498	0.384
LIG_HCF-1_HBM_1	231	234	PF13415	0.376
LIG_IBAR_NPY_1	245	247	PF08397	0.503
LIG_IRF3_LxIS_1	136	143	PF10401	0.420
LIG_LIR_Gen_1	173	184	PF02991	0.479
LIG_LIR_Gen_1	285	296	PF02991	0.583
LIG_LIR_Nem_3	173	179	PF02991	0.509
LIG_LIR_Nem_3	231	237	PF02991	0.424
LIG_LIR_Nem_3	285	291	PF02991	0.583
LIG_PCNA_yPIPBox_3	183	196	PF02747	0.407
LIG_SH2_CRK	176	180	PF00017	0.418
LIG_SH2_CRK	223	227	PF00017	0.552
LIG_SH2_STAP1	146	150	PF00017	0.454
LIG_SH2_STAP1	176	180	PF00017	0.418
LIG_SH2_STAP1	234	238	PF00017	0.388
LIG_SH2_STAT5	247	250	PF00017	0.532
LIG_SH2_STAT5	9	12	PF00017	0.371
LIG_SH3_3	197	203	PF00018	0.484
LIG_TRAF2_1	319	322	PF00917	0.591
MOD_CK1_1	273	279	PF00069	0.719
MOD_CK1_1	281	287	PF00069	0.643
MOD_CK2_1	281	287	PF00069	0.701
MOD_CK2_1	316	322	PF00069	0.592
MOD_CK2_1	44	50	PF00069	0.431
MOD_GlcNHglycan	172	175	PF01048	0.536
MOD_GlcNHglycan	176	179	PF01048	0.521
MOD_GlcNHglycan	191	195	PF01048	0.499
MOD_GlcNHglycan	276	279	PF01048	0.710
MOD_GlcNHglycan	59	62	PF01048	0.648
MOD_GSK3_1	170	177	PF00069	0.511
MOD_GSK3_1	270	277	PF00069	0.676
MOD_GSK3_1	278	285	PF00069	0.617
MOD_GSK3_1	287	294	PF00069	0.489
MOD_GSK3_1	312	319	PF00069	0.587
MOD_N-GLC_1	312	317	PF02516	0.664
MOD_NEK2_1	140	145	PF00069	0.354
MOD_NEK2_1	179	184	PF00069	0.571
MOD_PIKK_1	270	276	PF00454	0.589
MOD_PIKK_1	317	323	PF00454	0.593
MOD_PKA_2	140	146	PF00069	0.353
MOD_PKA_2	174	180	PF00069	0.410
MOD_PKA_2	317	323	PF00069	0.671
MOD_PKA_2	57	63	PF00069	0.645
MOD_Plk_1	102	108	PF00069	0.482
MOD_Plk_1	291	297	PF00069	0.685
MOD_Plk_2-3	287	293	PF00069	0.739
MOD_Plk_2-3	44	50	PF00069	0.403
MOD_Plk_4	202	208	PF00069	0.378
MOD_Plk_4	210	216	PF00069	0.381
MOD_ProDKin_1	278	284	PF00069	0.573
TRG_ENDOCYTIC_2	176	179	PF00928	0.530
TRG_ENDOCYTIC_2	212	215	PF00928	0.462
TRG_ENDOCYTIC_2	223	226	PF00928	0.401
TRG_ENDOCYTIC_2	238	241	PF00928	0.357
TRG_ENDOCYTIC_2	9	12	PF00928	0.353
TRG_ER_diArg_1	134	137	PF00400	0.540
TRG_ER_diArg_1	139	142	PF00400	0.367
TRG_ER_diArg_1	79	81	PF00400	0.467
TRG_ER_diArg_1	95	97	PF00400	0.350
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.393
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVD6	Leptomonas seymouri	58%	99%
A0A0S4KF96	Bodo saltans	30%	100%
A0A1X0NKJ3	Trypanosomatidae	44%	100%
A4H4L4	Leishmania braziliensis	84%	98%
A4HSU0	Leishmania infantum	100%	100%
C9ZTF2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AKS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QJ30	Leishmania major	97%	100%
V5B7V1	Trypanosoma cruzi	48%	100%