Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S5H5Q5_LEIDO

TriTrypDb:

LdBPK_060470.1 , LdCL_060009800 , LDHU3_06.0570

Length:

457

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H5Q5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5Q5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	156	160	PF00656	0.697
CLV_C14_Caspase3-7	209	213	PF00656	0.755
CLV_C14_Caspase3-7	28	32	PF00656	0.783
CLV_C14_Caspase3-7	69	73	PF00656	0.742
CLV_NRD_NRD_1	213	215	PF00675	0.735
CLV_NRD_NRD_1	248	250	PF00675	0.638
CLV_NRD_NRD_1	304	306	PF00675	0.765
CLV_NRD_NRD_1	331	333	PF00675	0.809
CLV_NRD_NRD_1	5	7	PF00675	0.674
CLV_NRD_NRD_1	97	99	PF00675	0.761
CLV_PCSK_FUR_1	186	190	PF00082	0.604
CLV_PCSK_FUR_1	331	335	PF00082	0.807
CLV_PCSK_KEX2_1	188	190	PF00082	0.601
CLV_PCSK_KEX2_1	247	249	PF00082	0.630
CLV_PCSK_KEX2_1	331	333	PF00082	0.812
CLV_PCSK_KEX2_1	5	7	PF00082	0.673
CLV_PCSK_KEX2_1	97	99	PF00082	0.761
CLV_PCSK_PC1ET2_1	188	190	PF00082	0.601
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.812
CLV_PCSK_SKI1_1	139	143	PF00082	0.664
CLV_Separin_Metazoa	196	200	PF03568	0.613
DEG_APCC_DBOX_1	258	266	PF00400	0.580
DEG_Nend_Nbox_1	1	3	PF02207	0.592
DEG_SPOP_SBC_1	10	14	PF00917	0.726
DEG_SPOP_SBC_1	265	269	PF00917	0.710
DEG_SPOP_SBC_1	49	53	PF00917	0.706
DEG_SPOP_SBC_1	64	68	PF00917	0.702
DEG_SPOP_SBC_1	71	75	PF00917	0.766
DEG_SPOP_SBC_1	82	86	PF00917	0.553
DOC_ANK_TNKS_1	449	456	PF00023	0.675
DOC_MAPK_DCC_7	339	348	PF00069	0.686
DOC_MAPK_gen_1	114	124	PF00069	0.707
DOC_MAPK_HePTP_8	211	227	PF00069	0.592
DOC_MAPK_MEF2A_6	220	227	PF00069	0.799
DOC_MAPK_MEF2A_6	339	348	PF00069	0.644
DOC_MAPK_NFAT4_5	220	228	PF00069	0.798
DOC_PP4_FxxP_1	18	21	PF00568	0.733
DOC_USP7_MATH_1	105	109	PF00917	0.710
DOC_USP7_MATH_1	160	164	PF00917	0.731
DOC_USP7_MATH_1	337	341	PF00917	0.713
DOC_USP7_MATH_1	424	428	PF00917	0.716
DOC_USP7_MATH_1	64	68	PF00917	0.696
DOC_USP7_MATH_1	70	74	PF00917	0.601
DOC_USP7_UBL2_3	319	323	PF12436	0.613
DOC_USP7_UBL2_3	389	393	PF12436	0.785
DOC_WW_Pin1_4	164	169	PF00397	0.703
DOC_WW_Pin1_4	266	271	PF00397	0.699
LIG_14-3-3_CanoR_1	139	145	PF00244	0.801
LIG_14-3-3_CanoR_1	189	198	PF00244	0.646
LIG_14-3-3_CanoR_1	259	263	PF00244	0.643
LIG_14-3-3_CanoR_1	266	270	PF00244	0.653
LIG_14-3-3_CanoR_1	303	309	PF00244	0.662
LIG_14-3-3_CanoR_1	44	50	PF00244	0.706
LIG_14-3-3_CanoR_1	445	450	PF00244	0.640
LIG_14-3-3_CanoR_1	5	11	PF00244	0.621
LIG_14-3-3_CanoR_1	89	95	PF00244	0.821
LIG_BRCT_BRCA1_1	14	18	PF00533	0.766
LIG_BRCT_BRCA1_1	409	413	PF00533	0.681
LIG_FHA_1	156	162	PF00498	0.719
LIG_FHA_1	179	185	PF00498	0.735
LIG_FHA_1	382	388	PF00498	0.591
LIG_FHA_1	66	72	PF00498	0.739
LIG_FHA_2	141	147	PF00498	0.664
LIG_FHA_2	152	158	PF00498	0.809
LIG_FHA_2	207	213	PF00498	0.730
LIG_FHA_2	348	354	PF00498	0.679
LIG_FHA_2	76	82	PF00498	0.732
LIG_LIR_Apic_2	15	21	PF02991	0.729
LIG_LIR_Gen_1	76	83	PF02991	0.690
LIG_LIR_Nem_3	40	46	PF02991	0.758
LIG_LIR_Nem_3	76	82	PF02991	0.689
LIG_SH2_CRK	374	378	PF00017	0.659
LIG_SH2_CRK	43	47	PF00017	0.720
LIG_SH2_CRK	7	11	PF00017	0.717
LIG_SH2_GRB2like	374	377	PF00017	0.658
LIG_SH2_NCK_1	7	11	PF00017	0.717
LIG_SH2_STAT5	327	330	PF00017	0.779
LIG_SH3_3	159	165	PF00018	0.705
LIG_SH3_3	195	201	PF00018	0.775
LIG_SH3_3	235	241	PF00018	0.685
LIG_TRAF2_1	193	196	PF00917	0.658
LIG_TRAF2_1	241	244	PF00917	0.669
LIG_TRAF2_1	367	370	PF00917	0.669
LIG_WRC_WIRS_1	141	146	PF05994	0.642
LIG_WW_3	94	98	PF00397	0.705
MOD_CDC14_SPxK_1	269	272	PF00782	0.784
MOD_CDK_SPxK_1	266	272	PF00069	0.787
MOD_CK1_1	103	109	PF00069	0.569
MOD_CK1_1	151	157	PF00069	0.774
MOD_CK1_1	178	184	PF00069	0.710
MOD_CK1_1	19	25	PF00069	0.646
MOD_CK1_1	258	264	PF00069	0.635
MOD_CK1_1	34	40	PF00069	0.608
MOD_CK1_1	42	48	PF00069	0.739
MOD_CK1_1	52	58	PF00069	0.592
MOD_CK1_1	66	72	PF00069	0.807
MOD_CK1_1	73	79	PF00069	0.759
MOD_CK1_1	8	14	PF00069	0.722
MOD_CK1_1	87	93	PF00069	0.625
MOD_CK2_1	103	109	PF00069	0.718
MOD_CK2_1	140	146	PF00069	0.651
MOD_CK2_1	190	196	PF00069	0.689
MOD_CK2_1	347	353	PF00069	0.777
MOD_CK2_1	364	370	PF00069	0.525
MOD_DYRK1A_RPxSP_1	266	270	PF00069	0.571
MOD_GlcNHglycan	102	105	PF01048	0.722
MOD_GlcNHglycan	119	122	PF01048	0.779
MOD_GlcNHglycan	14	17	PF01048	0.591
MOD_GlcNHglycan	151	154	PF01048	0.735
MOD_GlcNHglycan	162	165	PF01048	0.715
MOD_GlcNHglycan	27	30	PF01048	0.706
MOD_GlcNHglycan	275	278	PF01048	0.663
MOD_GlcNHglycan	316	319	PF01048	0.532
MOD_GlcNHglycan	38	42	PF01048	0.651
MOD_GlcNHglycan	402	405	PF01048	0.584
MOD_GlcNHglycan	426	429	PF01048	0.705
MOD_GlcNHglycan	54	57	PF01048	0.770
MOD_GlcNHglycan	68	71	PF01048	0.644
MOD_GlcNHglycan	86	89	PF01048	0.565
MOD_GlcNHglycan	92	95	PF01048	0.660
MOD_GSK3_1	113	120	PF00069	0.800
MOD_GSK3_1	140	147	PF00069	0.689
MOD_GSK3_1	151	158	PF00069	0.635
MOD_GSK3_1	160	167	PF00069	0.692
MOD_GSK3_1	19	26	PF00069	0.552
MOD_GSK3_1	223	230	PF00069	0.772
MOD_GSK3_1	44	51	PF00069	0.780
MOD_GSK3_1	5	12	PF00069	0.679
MOD_GSK3_1	52	59	PF00069	0.646
MOD_GSK3_1	60	67	PF00069	0.784
MOD_GSK3_1	71	78	PF00069	0.608
MOD_GSK3_1	83	90	PF00069	0.613
MOD_LATS_1	4	10	PF00433	0.672
MOD_N-GLC_1	178	183	PF02516	0.739
MOD_N-GLC_1	29	34	PF02516	0.755
MOD_N-GLC_2	347	349	PF02516	0.578
MOD_NEK2_1	144	149	PF00069	0.707
MOD_NEK2_1	223	228	PF00069	0.699
MOD_NEK2_1	264	269	PF00069	0.641
MOD_NEK2_1	407	412	PF00069	0.795
MOD_NEK2_1	50	55	PF00069	0.674
MOD_NEK2_1	83	88	PF00069	0.800
MOD_NEK2_2	137	142	PF00069	0.592
MOD_PK_1	445	451	PF00069	0.607
MOD_PK_1	6	12	PF00069	0.716
MOD_PKA_1	5	11	PF00069	0.716
MOD_PKA_2	258	264	PF00069	0.653
MOD_PKA_2	265	271	PF00069	0.681
MOD_PKA_2	304	310	PF00069	0.765
MOD_PKA_2	5	11	PF00069	0.716
MOD_Plk_1	207	213	PF00069	0.742
MOD_Plk_1	407	413	PF00069	0.717
MOD_Plk_4	223	229	PF00069	0.700
MOD_Plk_4	304	310	PF00069	0.637
MOD_Plk_4	31	37	PF00069	0.704
MOD_Plk_4	45	51	PF00069	0.696
MOD_ProDKin_1	164	170	PF00069	0.699
MOD_ProDKin_1	266	272	PF00069	0.701
TRG_ENDOCYTIC_2	327	330	PF00928	0.583
TRG_ENDOCYTIC_2	374	377	PF00928	0.663
TRG_ENDOCYTIC_2	43	46	PF00928	0.719
TRG_ENDOCYTIC_2	7	10	PF00928	0.668
TRG_ER_diArg_1	247	249	PF00400	0.671
TRG_ER_diArg_1	330	332	PF00400	0.817
TRG_ER_diArg_1	5	7	PF00400	0.669
TRG_ER_diArg_1	96	98	PF00400	0.714
TRG_NLS_MonoExtN_4	331	336	PF00514	0.595

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3T5	Leptomonas seymouri	37%	93%
A4H4L1	Leishmania braziliensis	53%	100%
A4HST7	Leishmania infantum	100%	100%
E9AKS4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%
Q4QJ33	Leishmania major	82%	100%