Kinesin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Kinesin

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5Q4_LEIDO

TriTrypDb:

LdBPK_060450.1 , LdCL_060009600 , LDHU3_06.0550

Length:

691

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005819	spindle	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H5Q4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5Q4

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	2
GO:0007018	microtubule-based movement	3	2
GO:0009987	cellular process	1	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003774	cytoskeletal motor activity	1	2
GO:0003777	microtubule motor activity	2	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0005524	ATP binding	5	2
GO:0008017	microtubule binding	5	2
GO:0008092	cytoskeletal protein binding	3	2
GO:0015631	tubulin binding	4	2
GO:0017076	purine nucleotide binding	4	2
GO:0030554	adenyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032559	adenyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:0140657	ATP-dependent activity	1	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.759
CLV_NRD_NRD_1	281	283	PF00675	0.612
CLV_NRD_NRD_1	304	306	PF00675	0.455
CLV_NRD_NRD_1	424	426	PF00675	0.623
CLV_NRD_NRD_1	469	471	PF00675	0.565
CLV_NRD_NRD_1	517	519	PF00675	0.566
CLV_NRD_NRD_1	607	609	PF00675	0.539
CLV_NRD_NRD_1	637	639	PF00675	0.593
CLV_PCSK_FUR_1	422	426	PF00082	0.623
CLV_PCSK_FUR_1	635	639	PF00082	0.591
CLV_PCSK_KEX2_1	304	306	PF00082	0.455
CLV_PCSK_KEX2_1	424	426	PF00082	0.623
CLV_PCSK_KEX2_1	517	519	PF00082	0.462
CLV_PCSK_KEX2_1	609	611	PF00082	0.541
CLV_PCSK_KEX2_1	637	639	PF00082	0.608
CLV_PCSK_PC1ET2_1	609	611	PF00082	0.548
CLV_PCSK_SKI1_1	275	279	PF00082	0.550
CLV_PCSK_SKI1_1	409	413	PF00082	0.502
CLV_PCSK_SKI1_1	42	46	PF00082	0.591
CLV_PCSK_SKI1_1	60	64	PF00082	0.483
DEG_APCC_KENBOX_2	196	200	PF00400	0.782
DEG_Nend_UBRbox_2	1	3	PF02207	0.641
DEG_SCF_FBW7_1	16	22	PF00400	0.626
DEG_SCF_TRCP1_1	82	88	PF00400	0.591
DEG_SPOP_SBC_1	62	66	PF00917	0.682
DEG_SPOP_SBC_1	86	90	PF00917	0.628
DOC_CKS1_1	16	21	PF01111	0.469
DOC_CYCLIN_yCln2_LP_2	356	362	PF00134	0.437
DOC_MAPK_DCC_7	352	362	PF00069	0.529
DOC_MAPK_gen_1	304	312	PF00069	0.411
DOC_MAPK_gen_1	608	619	PF00069	0.575
DOC_MAPK_MEF2A_6	540	548	PF00069	0.480
DOC_PP4_FxxP_1	255	258	PF00568	0.517
DOC_USP7_MATH_1	127	131	PF00917	0.444
DOC_USP7_MATH_1	158	162	PF00917	0.618
DOC_USP7_MATH_1	21	25	PF00917	0.764
DOC_USP7_MATH_1	273	277	PF00917	0.546
DOC_USP7_MATH_1	337	341	PF00917	0.580
DOC_USP7_MATH_1	450	454	PF00917	0.624
DOC_USP7_MATH_1	593	597	PF00917	0.462
DOC_USP7_MATH_1	62	66	PF00917	0.680
DOC_USP7_MATH_1	80	84	PF00917	0.771
DOC_USP7_MATH_1	86	90	PF00917	0.773
DOC_USP7_MATH_1	93	97	PF00917	0.770
DOC_USP7_UBL2_3	42	46	PF12436	0.617
DOC_WW_Pin1_4	15	20	PF00397	0.740
DOC_WW_Pin1_4	154	159	PF00397	0.506
LIG_14-3-3_CanoR_1	113	121	PF00244	0.554
LIG_14-3-3_CanoR_1	150	155	PF00244	0.463
LIG_14-3-3_CanoR_1	304	308	PF00244	0.439
LIG_14-3-3_CanoR_1	352	357	PF00244	0.446
LIG_14-3-3_CanoR_1	388	396	PF00244	0.461
LIG_14-3-3_CanoR_1	540	548	PF00244	0.584
LIG_14-3-3_CanoR_1	6	11	PF00244	0.721
LIG_14-3-3_CanoR_1	60	70	PF00244	0.568
LIG_14-3-3_CanoR_1	626	633	PF00244	0.600
LIG_14-3-3_CanoR_1	643	651	PF00244	0.469
LIG_14-3-3_CterR_2	686	691	PF00244	0.694
LIG_Actin_WH2_2	562	577	PF00022	0.603
LIG_BIR_III_4	193	197	PF00653	0.798
LIG_BRCT_BRCA1_1	102	106	PF00533	0.503
LIG_BRCT_BRCA1_1	136	140	PF00533	0.423
LIG_BRCT_BRCA1_1	509	513	PF00533	0.575
LIG_EH1_1	396	404	PF00400	0.461
LIG_FHA_1	222	228	PF00498	0.626
LIG_FHA_1	285	291	PF00498	0.405
LIG_FHA_1	352	358	PF00498	0.382
LIG_FHA_1	464	470	PF00498	0.481
LIG_FHA_1	507	513	PF00498	0.545
LIG_FHA_1	628	634	PF00498	0.610
LIG_FHA_2	193	199	PF00498	0.791
LIG_FHA_2	309	315	PF00498	0.383
LIG_FHA_2	353	359	PF00498	0.410
LIG_FHA_2	502	508	PF00498	0.600
LIG_LIR_Apic_2	153	158	PF02991	0.473
LIG_LIR_Apic_2	254	258	PF02991	0.516
LIG_LIR_Gen_1	137	146	PF02991	0.467
LIG_LIR_Gen_1	309	318	PF02991	0.385
LIG_LIR_Gen_1	510	519	PF02991	0.570
LIG_LIR_Gen_1	64	75	PF02991	0.533
LIG_LIR_Nem_3	137	141	PF02991	0.498
LIG_LIR_Nem_3	228	234	PF02991	0.516
LIG_LIR_Nem_3	309	315	PF02991	0.387
LIG_LIR_Nem_3	510	516	PF02991	0.571
LIG_LIR_Nem_3	64	70	PF02991	0.542
LIG_NRBOX	352	358	PF00104	0.382
LIG_Pex14_1	102	106	PF04695	0.502
LIG_SH2_CRK	155	159	PF00017	0.499
LIG_SH2_CRK	67	71	PF00017	0.521
LIG_SH2_NCK_1	10	14	PF00017	0.757
LIG_SH2_NCK_1	296	300	PF00017	0.490
LIG_SH2_PTP2	138	141	PF00017	0.523
LIG_SH2_PTP2	364	367	PF00017	0.413
LIG_SH2_SRC	121	124	PF00017	0.503
LIG_SH2_SRC	296	299	PF00017	0.484
LIG_SH2_STAP1	10	14	PF00017	0.718
LIG_SH2_STAP1	121	125	PF00017	0.556
LIG_SH2_STAT5	138	141	PF00017	0.418
LIG_SH2_STAT5	364	367	PF00017	0.413
LIG_SH2_STAT5	572	575	PF00017	0.539
LIG_SH2_STAT5	67	70	PF00017	0.558
LIG_SH3_3	121	127	PF00018	0.449
LIG_SH3_3	139	145	PF00018	0.328
LIG_SH3_3	250	256	PF00018	0.492
LIG_SH3_3	259	265	PF00018	0.462
LIG_SH3_3	274	280	PF00018	0.359
LIG_SH3_3	292	298	PF00018	0.406
LIG_SH3_3	670	676	PF00018	0.773
LIG_SH3_3	69	75	PF00018	0.630
LIG_SUMO_SIM_par_1	366	372	PF11976	0.482
LIG_TYR_ITIM	362	367	PF00017	0.437
LIG_UBA3_1	173	182	PF00899	0.596
LIG_UBA3_1	603	611	PF00899	0.622
MOD_CK1_1	130	136	PF00069	0.499
MOD_CK1_1	148	154	PF00069	0.325
MOD_CK1_1	15	21	PF00069	0.740
MOD_CK1_1	207	213	PF00069	0.790
MOD_CK1_1	306	312	PF00069	0.410
MOD_CK1_1	369	375	PF00069	0.390
MOD_CK1_1	382	388	PF00069	0.391
MOD_CK1_1	391	397	PF00069	0.533
MOD_CK1_1	47	53	PF00069	0.603
MOD_CK1_1	639	645	PF00069	0.548
MOD_CK1_1	65	71	PF00069	0.396
MOD_CK1_1	663	669	PF00069	0.698
MOD_CK1_1	682	688	PF00069	0.489
MOD_CK1_1	87	93	PF00069	0.805
MOD_CK1_1	95	101	PF00069	0.748
MOD_CK2_1	192	198	PF00069	0.796
MOD_CK2_1	210	216	PF00069	0.491
MOD_CK2_1	352	358	PF00069	0.398
MOD_CK2_1	501	507	PF00069	0.550
MOD_CK2_1	53	59	PF00069	0.534
MOD_CK2_1	546	552	PF00069	0.477
MOD_Cter_Amidation	302	305	PF01082	0.497
MOD_Cter_Amidation	606	609	PF01082	0.591
MOD_GlcNHglycan	133	136	PF01048	0.468
MOD_GlcNHglycan	147	150	PF01048	0.409
MOD_GlcNHglycan	212	215	PF01048	0.794
MOD_GlcNHglycan	23	26	PF01048	0.803
MOD_GlcNHglycan	341	344	PF01048	0.612
MOD_GlcNHglycan	373	376	PF01048	0.433
MOD_GlcNHglycan	547	551	PF01048	0.547
MOD_GlcNHglycan	55	58	PF01048	0.602
MOD_GlcNHglycan	575	578	PF01048	0.584
MOD_GlcNHglycan	644	647	PF01048	0.658
MOD_GlcNHglycan	681	684	PF01048	0.712
MOD_GlcNHglycan	686	689	PF01048	0.670
MOD_GlcNHglycan	82	85	PF01048	0.794
MOD_GlcNHglycan	97	100	PF01048	0.645
MOD_GSK3_1	127	134	PF00069	0.484
MOD_GSK3_1	15	22	PF00069	0.676
MOD_GSK3_1	150	157	PF00069	0.479
MOD_GSK3_1	2	9	PF00069	0.658
MOD_GSK3_1	202	209	PF00069	0.816
MOD_GSK3_1	216	223	PF00069	0.562
MOD_GSK3_1	299	306	PF00069	0.537
MOD_GSK3_1	348	355	PF00069	0.444
MOD_GSK3_1	530	537	PF00069	0.534
MOD_GSK3_1	58	65	PF00069	0.542
MOD_GSK3_1	593	600	PF00069	0.614
MOD_GSK3_1	650	657	PF00069	0.613
MOD_GSK3_1	659	666	PF00069	0.620
MOD_GSK3_1	80	87	PF00069	0.688
MOD_LATS_1	51	57	PF00433	0.536
MOD_N-GLC_1	106	111	PF02516	0.477
MOD_N-GLC_1	130	135	PF02516	0.541
MOD_N-GLC_1	450	455	PF02516	0.633
MOD_NEK2_1	106	111	PF00069	0.493
MOD_NEK2_1	348	353	PF00069	0.523
MOD_NEK2_1	379	384	PF00069	0.449
MOD_NEK2_1	4	9	PF00069	0.688
MOD_NEK2_1	463	468	PF00069	0.567
MOD_NEK2_1	535	540	PF00069	0.550
MOD_NEK2_1	546	551	PF00069	0.487
MOD_NEK2_1	654	659	PF00069	0.681
MOD_PIKK_1	100	106	PF00454	0.656
MOD_PIKK_1	148	154	PF00454	0.478
MOD_PIKK_1	202	208	PF00454	0.800
MOD_PIKK_1	507	513	PF00454	0.511
MOD_PIKK_1	528	534	PF00454	0.556
MOD_PIKK_1	535	541	PF00454	0.500
MOD_PIKK_1	587	593	PF00454	0.612
MOD_PIKK_1	667	673	PF00454	0.728
MOD_PIKK_1	674	680	PF00454	0.680
MOD_PIKK_1	8	14	PF00454	0.764
MOD_PIKK_1	87	93	PF00454	0.773
MOD_PKA_2	303	309	PF00069	0.441
MOD_PKA_2	351	357	PF00069	0.472
MOD_PKA_2	442	448	PF00069	0.608
MOD_PKA_2	539	545	PF00069	0.583
MOD_PKA_2	625	631	PF00069	0.578
MOD_PKA_2	636	642	PF00069	0.543
MOD_PKA_2	654	660	PF00069	0.546
MOD_Plk_1	106	112	PF00069	0.475
MOD_Plk_1	285	291	PF00069	0.405
MOD_Plk_1	324	330	PF00069	0.533
MOD_Plk_1	546	552	PF00069	0.477
MOD_Plk_1	587	593	PF00069	0.633
MOD_Plk_4	134	140	PF00069	0.474
MOD_Plk_4	150	156	PF00069	0.418
MOD_Plk_4	273	279	PF00069	0.524
MOD_Plk_4	308	314	PF00069	0.430
MOD_Plk_4	352	358	PF00069	0.386
MOD_ProDKin_1	15	21	PF00069	0.733
MOD_ProDKin_1	154	160	PF00069	0.510
MOD_SUMO_rev_2	276	285	PF00179	0.564
MOD_SUMO_rev_2	547	555	PF00179	0.505
TRG_DiLeu_BaEn_1	325	330	PF01217	0.392
TRG_DiLeu_BaEn_4	514	520	PF01217	0.501
TRG_DiLeu_BaLyEn_6	265	270	PF01217	0.488
TRG_ENDOCYTIC_2	121	124	PF00928	0.462
TRG_ENDOCYTIC_2	138	141	PF00928	0.418
TRG_ENDOCYTIC_2	231	234	PF00928	0.507
TRG_ENDOCYTIC_2	296	299	PF00928	0.442
TRG_ENDOCYTIC_2	364	367	PF00928	0.413
TRG_ENDOCYTIC_2	67	70	PF00928	0.506
TRG_ER_diArg_1	265	268	PF00400	0.585
TRG_ER_diArg_1	421	424	PF00400	0.628
TRG_ER_diArg_1	516	518	PF00400	0.569
TRG_ER_diArg_1	610	613	PF00400	0.579
TRG_ER_diArg_1	637	640	PF00400	0.638
TRG_ER_diArg_1	70	73	PF00400	0.630
TRG_NLS_MonoCore_2	607	612	PF00514	0.611
TRG_NLS_MonoExtC_3	607	612	PF00514	0.575
TRG_NLS_MonoExtN_4	608	613	PF00514	0.525
TRG_Pf-PMV_PEXEL_1	268	272	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	409	413	PF00026	0.562
TRG_Pf-PMV_PEXEL_1	517	521	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC06	Leptomonas seymouri	72%	99%
A0A0S4KIG4	Bodo saltans	28%	94%
A0A1X0NKL3	Trypanosomatidae	54%	100%
A0A3R7LWH4	Trypanosoma rangeli	52%	100%
A4H4K9	Leishmania braziliensis	88%	99%
A4HST5	Leishmania infantum	100%	100%
C9ZTE1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AKS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QJ35	Leishmania major	97%	100%
V5DPG4	Trypanosoma cruzi	52%	100%