Ribosomal protein L19e family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L19, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H5Q3_LEIDO

TriTrypDb:

LdBPK_060410.1 , LdCL_060009200 , LdCL_060009400 , LDHU3_06.0510

Length:

245

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 28

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0015934	large ribosomal subunit	4	13
GO:0022625	cytosolic large ribosomal subunit	5	13
GO:0032991	protein-containing complex	1	13
GO:0044391	ribosomal subunit	3	13
GO:1990904	ribonucleoprotein complex	2	13
GO:0005730	nucleolus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3S5H5Q3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5Q3

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	13
GO:0006518	peptide metabolic process	4	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009058	biosynthetic process	2	13
GO:0009059	macromolecule biosynthetic process	4	13
GO:0009987	cellular process	1	13
GO:0019538	protein metabolic process	3	13
GO:0034641	cellular nitrogen compound metabolic process	3	13
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	13
GO:0043043	peptide biosynthetic process	5	13
GO:0043170	macromolecule metabolic process	3	13
GO:0043603	amide metabolic process	3	13
GO:0043604	amide biosynthetic process	4	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044249	cellular biosynthetic process	3	13
GO:0044260	obsolete cellular macromolecule metabolic process	3	13
GO:0044271	cellular nitrogen compound biosynthetic process	4	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13
GO:1901566	organonitrogen compound biosynthetic process	4	13
GO:1901576	organic substance biosynthetic process	3	13

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	13
GO:0003723	RNA binding	4	13
GO:0003735	structural constituent of ribosome	2	13
GO:0005198	structural molecule activity	1	13
GO:0005488	binding	1	13
GO:0097159	organic cyclic compound binding	2	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.357
CLV_NRD_NRD_1	106	108	PF00675	0.357
CLV_NRD_NRD_1	173	175	PF00675	0.563
CLV_NRD_NRD_1	178	180	PF00675	0.572
CLV_NRD_NRD_1	189	191	PF00675	0.611
CLV_NRD_NRD_1	37	39	PF00675	0.357
CLV_NRD_NRD_1	41	43	PF00675	0.357
CLV_NRD_NRD_1	51	53	PF00675	0.357
CLV_NRD_NRD_1	63	65	PF00675	0.333
CLV_NRD_NRD_1	80	82	PF00675	0.267
CLV_NRD_NRD_1	97	99	PF00675	0.357
CLV_PCSK_FUR_1	133	137	PF00082	0.357
CLV_PCSK_FUR_1	187	191	PF00082	0.555
CLV_PCSK_KEX2_1	103	105	PF00082	0.357
CLV_PCSK_KEX2_1	135	137	PF00082	0.381
CLV_PCSK_KEX2_1	180	182	PF00082	0.711
CLV_PCSK_KEX2_1	189	191	PF00082	0.587
CLV_PCSK_KEX2_1	80	82	PF00082	0.376
CLV_PCSK_KEX2_1	97	99	PF00082	0.357
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.366
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.711
CLV_PCSK_PC7_1	185	191	PF00082	0.554
CLV_PCSK_SKI1_1	103	107	PF00082	0.357
CLV_PCSK_SKI1_1	43	47	PF00082	0.357
CLV_PCSK_SKI1_1	53	57	PF00082	0.357
CLV_PCSK_SKI1_1	64	68	PF00082	0.357
DOC_USP7_MATH_1	205	209	PF00917	0.718
DOC_USP7_MATH_1	212	216	PF00917	0.761
DOC_USP7_MATH_1	219	223	PF00917	0.653
DOC_USP7_UBL2_3	146	150	PF12436	0.512
DOC_USP7_UBL2_3	241	245	PF12436	0.693
DOC_USP7_UBL2_3	39	43	PF12436	0.357
LIG_14-3-3_CanoR_1	38	42	PF00244	0.357
LIG_NRBOX	101	107	PF00104	0.357
LIG_SH2_STAT5	124	127	PF00017	0.352
LIG_SH3_3	226	232	PF00018	0.689
LIG_UBA3_1	101	108	PF00899	0.357
MOD_CK1_1	37	43	PF00069	0.365
MOD_Cter_Amidation	78	81	PF01082	0.357
MOD_GlcNHglycan	207	210	PF01048	0.742
MOD_GlcNHglycan	214	217	PF01048	0.764
MOD_GlcNHglycan	221	224	PF01048	0.681
MOD_NEK2_1	10	15	PF00069	0.471
MOD_PKA_2	37	43	PF00069	0.357
MOD_Plk_4	10	16	PF00069	0.449
MOD_SUMO_for_1	145	148	PF00179	0.500
TRG_DiLeu_BaLyEn_6	101	106	PF01217	0.357
TRG_ENDOCYTIC_2	120	123	PF00928	0.357
TRG_ER_diArg_1	102	104	PF00400	0.357
TRG_ER_diArg_1	178	181	PF00400	0.585
TRG_ER_diArg_1	187	190	PF00400	0.569
TRG_ER_diArg_1	19	22	PF00400	0.357
TRG_ER_diArg_1	60	63	PF00400	0.357
TRG_ER_diArg_1	96	98	PF00400	0.357
TRG_ER_diLys_1	241	245	PF00400	0.767
TRG_NLS_Bipartite_1	97	111	PF00514	0.471
TRG_NLS_MonoExtC_3	106	112	PF00514	0.471
TRG_NLS_MonoExtC_3	240	245	PF00514	0.766
TRG_NLS_MonoExtN_4	104	111	PF00514	0.471
TRG_NLS_MonoExtN_4	239	245	PF00514	0.759
TRG_Pf-PMV_PEXEL_1	136	140	PF00026	0.357
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	42	47	PF00026	0.357

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTS2	Leptomonas seymouri	94%	94%
A0A1X0NL07	Trypanosomatidae	83%	92%
A0A3R7MF58	Trypanosoma rangeli	87%	82%
A4H4K5	Leishmania braziliensis	97%	100%
A4H4K7	Leishmania braziliensis	97%	90%
A4HST1	Leishmania infantum	100%	100%
A4HST3	Leishmania infantum	100%	100%
C9ZTD7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	85%	94%
D0VWQ5	Canis lupus familiaris	56%	100%
E9AKR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
O02639	Caenorhabditis elegans	56%	100%
O42699	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	54%	100%
P05734	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	55%	100%
P0CX82	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	52%	100%
P0CX83	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	52%	100%
P0DJ60	Tetrahymena thermophila (strain SB210)	55%	100%
P14329	Dictyostelium discoideum	59%	100%
P49693	Arabidopsis thaliana	60%	100%
P84098	Homo sapiens	56%	100%
P84099	Mus musculus	56%	100%
P84100	Rattus norvegicus	56%	100%
Q3T0W9	Bos taurus	56%	100%
Q4QJ37	Leishmania major	99%	100%
Q4QJ39	Leishmania major	99%	92%
Q5RB99	Pongo abelii	56%	100%
Q7ZYS1	Xenopus laevis	54%	100%
Q8HXN9	Macaca fascicularis	56%	100%
Q9LUQ6	Arabidopsis thaliana	51%	100%
Q9SRX2	Arabidopsis thaliana	61%	100%