Fructose-bisphosphate aldolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Download

Quick info

Protein:

Gene product:

Fructose-bisphosphate aldolase class-I, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H5Q1_LEIDO

TriTrypDb:

LdCL_060009100 , LDHU3_06.0500

Length:

100

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3S5H5Q1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5Q1

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	2
GO:0006082	organic acid metabolic process	3	2
GO:0006090	pyruvate metabolic process	7	2
GO:0006091	generation of precursor metabolites and energy	3	2
GO:0006096	glycolytic process	5	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006163	purine nucleotide metabolic process	5	2
GO:0006165	obsolete nucleoside diphosphate phosphorylation	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006753	nucleoside phosphate metabolic process	4	2
GO:0006757	obsolete ATP generation from ADP	4	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009117	nucleotide metabolic process	5	2
GO:0009132	nucleoside diphosphate metabolic process	5	2
GO:0009135	purine nucleoside diphosphate metabolic process	6	2
GO:0009141	nucleoside triphosphate metabolic process	5	2
GO:0009144	purine nucleoside triphosphate metabolic process	6	2
GO:0009150	purine ribonucleotide metabolic process	6	2
GO:0009179	purine ribonucleoside diphosphate metabolic process	7	2
GO:0009185	ribonucleoside diphosphate metabolic process	6	2
GO:0009199	ribonucleoside triphosphate metabolic process	6	2
GO:0009205	purine ribonucleoside triphosphate metabolic process	7	2
GO:0009259	ribonucleotide metabolic process	5	2
GO:0009987	cellular process	1	2
GO:0016052	carbohydrate catabolic process	4	2
GO:0016310	phosphorylation	5	2
GO:0019637	organophosphate metabolic process	3	2
GO:0019693	ribose phosphate metabolic process	4	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0032787	monocarboxylic acid metabolic process	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044281	small molecule metabolic process	2	2
GO:0046031	ADP metabolic process	7	2
GO:0046034	ATP metabolic process	7	2
GO:0046483	heterocycle metabolic process	3	2
GO:0046939	obsolete nucleotide phosphorylation	6	2
GO:0055086	nucleobase-containing small molecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0072521	purine-containing compound metabolic process	4	2
GO:1901135	carbohydrate derivative metabolic process	3	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004332	fructose-bisphosphate aldolase activity	5	2
GO:0016829	lyase activity	2	2
GO:0016830	carbon-carbon lyase activity	3	2
GO:0016832	aldehyde-lyase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.199
CLV_PCSK_SKI1_1	14	18	PF00082	0.199
CLV_PCSK_SKI1_1	89	93	PF00082	0.366
DOC_MAPK_gen_1	9	18	PF00069	0.400
LIG_CSL_BTD_1	95	98	PF09270	0.387
LIG_FHA_1	18	24	PF00498	0.400
LIG_FHA_1	46	52	PF00498	0.400
LIG_LIR_Gen_1	45	52	PF02991	0.400
LIG_SUMO_SIM_par_1	14	22	PF11976	0.400
LIG_TRAF2_1	74	77	PF00917	0.400
LIG_WRC_WIRS_1	66	71	PF05994	0.400
MOD_CK1_1	33	39	PF00069	0.400
MOD_CK2_1	65	71	PF00069	0.400
MOD_GlcNHglycan	35	38	PF01048	0.199
MOD_GlcNHglycan	42	45	PF01048	0.199
MOD_GlcNHglycan	57	60	PF01048	0.199
MOD_GSK3_1	17	24	PF00069	0.400
MOD_NEK2_1	42	47	PF00069	0.400
MOD_Plk_1	3	9	PF00069	0.400
MOD_Plk_4	42	48	PF00069	0.400
MOD_Plk_4	65	71	PF00069	0.400
MOD_SUMO_rev_2	58	66	PF00179	0.400
TRG_NES_CRM1_1	21	35	PF08389	0.400
TRG_NLS_MonoExtN_4	9	15	PF00514	0.400