FSA_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5Q0_LEIDO

TriTrypDb:

LdBPK_060390.1 , LdCL_060009000 , LDHU3_06.0490

Length:

907

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H5Q0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5Q0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.447
CLV_C14_Caspase3-7	611	615	PF00656	0.580
CLV_C14_Caspase3-7	775	779	PF00656	0.495
CLV_NRD_NRD_1	11	13	PF00675	0.479
CLV_NRD_NRD_1	400	402	PF00675	0.633
CLV_NRD_NRD_1	642	644	PF00675	0.614
CLV_NRD_NRD_1	838	840	PF00675	0.496
CLV_PCSK_KEX2_1	11	13	PF00082	0.567
CLV_PCSK_KEX2_1	221	223	PF00082	0.423
CLV_PCSK_KEX2_1	402	404	PF00082	0.641
CLV_PCSK_KEX2_1	838	840	PF00082	0.496
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.482
CLV_PCSK_PC1ET2_1	402	404	PF00082	0.652
CLV_PCSK_PC7_1	834	840	PF00082	0.483
CLV_PCSK_SKI1_1	142	146	PF00082	0.455
CLV_PCSK_SKI1_1	308	312	PF00082	0.425
CLV_PCSK_SKI1_1	356	360	PF00082	0.454
CLV_PCSK_SKI1_1	383	387	PF00082	0.622
CLV_PCSK_SKI1_1	441	445	PF00082	0.474
CLV_PCSK_SKI1_1	839	843	PF00082	0.516
CLV_PCSK_SKI1_1	860	864	PF00082	0.629
CLV_PCSK_SKI1_1	93	97	PF00082	0.432
DEG_APCC_DBOX_1	355	363	PF00400	0.393
DEG_APCC_DBOX_1	520	528	PF00400	0.471
DEG_SCF_TRCP1_1	481	487	PF00400	0.558
DEG_SPOP_SBC_1	699	703	PF00917	0.616
DOC_CKS1_1	227	232	PF01111	0.470
DOC_CKS1_1	690	695	PF01111	0.599
DOC_CYCLIN_RxL_1	139	148	PF00134	0.461
DOC_CYCLIN_RxL_1	353	360	PF00134	0.516
DOC_CYCLIN_RxL_1	62	74	PF00134	0.371
DOC_CYCLIN_yCln2_LP_2	210	216	PF00134	0.600
DOC_CYCLIN_yCln2_LP_2	633	639	PF00134	0.612
DOC_CYCLIN_yCln2_LP_2	69	75	PF00134	0.446
DOC_MAPK_gen_1	221	227	PF00069	0.377
DOC_MAPK_JIP1_4	747	753	PF00069	0.537
DOC_MAPK_MEF2A_6	116	125	PF00069	0.397
DOC_MAPK_MEF2A_6	547	555	PF00069	0.500
DOC_MAPK_MEF2A_6	896	904	PF00069	0.544
DOC_PP1_RVXF_1	365	371	PF00149	0.446
DOC_PP2B_LxvP_1	133	136	PF13499	0.488
DOC_PP2B_LxvP_1	311	314	PF13499	0.497
DOC_PP2B_LxvP_1	69	72	PF13499	0.417
DOC_SPAK_OSR1_1	347	351	PF12202	0.587
DOC_USP7_MATH_1	134	138	PF00917	0.554
DOC_USP7_MATH_1	36	40	PF00917	0.459
DOC_USP7_MATH_1	512	516	PF00917	0.535
DOC_USP7_MATH_1	642	646	PF00917	0.606
DOC_USP7_MATH_1	699	703	PF00917	0.658
DOC_USP7_MATH_1	75	79	PF00917	0.520
DOC_USP7_MATH_1	786	790	PF00917	0.727
DOC_WW_Pin1_4	226	231	PF00397	0.446
DOC_WW_Pin1_4	378	383	PF00397	0.502
DOC_WW_Pin1_4	484	489	PF00397	0.748
DOC_WW_Pin1_4	490	495	PF00397	0.786
DOC_WW_Pin1_4	558	563	PF00397	0.528
DOC_WW_Pin1_4	603	608	PF00397	0.519
DOC_WW_Pin1_4	677	682	PF00397	0.722
DOC_WW_Pin1_4	689	694	PF00397	0.602
LIG_14-3-3_CanoR_1	403	410	PF00244	0.744
LIG_14-3-3_CanoR_1	441	450	PF00244	0.549
LIG_14-3-3_CanoR_1	506	516	PF00244	0.469
LIG_14-3-3_CanoR_1	568	572	PF00244	0.523
LIG_14-3-3_CanoR_1	600	606	PF00244	0.566
LIG_14-3-3_CanoR_1	704	709	PF00244	0.636
LIG_14-3-3_CanoR_1	734	743	PF00244	0.657
LIG_14-3-3_CanoR_1	762	767	PF00244	0.515
LIG_14-3-3_CanoR_1	773	777	PF00244	0.642
LIG_14-3-3_CanoR_1	896	904	PF00244	0.500
LIG_APCC_ABBA_1	61	66	PF00400	0.518
LIG_APCC_ABBAyCdc20_2	93	99	PF00400	0.435
LIG_BRCT_BRCA1_1	15	19	PF00533	0.547
LIG_BRCT_BRCA1_1	512	516	PF00533	0.491
LIG_BRCT_BRCA1_1	57	61	PF00533	0.368
LIG_BRCT_BRCA1_1	836	840	PF00533	0.539
LIG_Clathr_ClatBox_1	261	265	PF01394	0.626
LIG_Clathr_ClatBox_1	290	294	PF01394	0.302
LIG_deltaCOP1_diTrp_1	15	23	PF00928	0.523
LIG_FHA_1	130	136	PF00498	0.540
LIG_FHA_1	139	145	PF00498	0.581
LIG_FHA_1	19	25	PF00498	0.549
LIG_FHA_1	227	233	PF00498	0.360
LIG_FHA_1	26	32	PF00498	0.688
LIG_FHA_1	271	277	PF00498	0.611
LIG_FHA_1	315	321	PF00498	0.597
LIG_FHA_1	372	378	PF00498	0.597
LIG_FHA_1	455	461	PF00498	0.515
LIG_FHA_1	661	667	PF00498	0.634
LIG_FHA_1	713	719	PF00498	0.629
LIG_FHA_1	772	778	PF00498	0.531
LIG_FHA_1	814	820	PF00498	0.480
LIG_FHA_2	431	437	PF00498	0.630
LIG_FHA_2	467	473	PF00498	0.579
LIG_FHA_2	611	617	PF00498	0.734
LIG_FHA_2	773	779	PF00498	0.602
LIG_FHA_2	798	804	PF00498	0.655
LIG_FHA_2	864	870	PF00498	0.659
LIG_Integrin_isoDGR_2	365	367	PF01839	0.420
LIG_IRF3_LxIS_1	897	903	PF10401	0.538
LIG_LIR_Apic_2	2	6	PF02991	0.481
LIG_LIR_Gen_1	452	460	PF02991	0.461
LIG_LIR_Gen_1	468	478	PF02991	0.388
LIG_LIR_Gen_1	570	580	PF02991	0.533
LIG_LIR_Gen_1	818	826	PF02991	0.460
LIG_LIR_Gen_1	894	905	PF02991	0.522
LIG_LIR_LC3C_4	714	719	PF02991	0.590
LIG_LIR_Nem_3	277	282	PF02991	0.484
LIG_LIR_Nem_3	433	438	PF02991	0.501
LIG_LIR_Nem_3	452	456	PF02991	0.393
LIG_LIR_Nem_3	468	474	PF02991	0.367
LIG_LIR_Nem_3	570	576	PF02991	0.530
LIG_LIR_Nem_3	58	64	PF02991	0.377
LIG_LIR_Nem_3	765	769	PF02991	0.403
LIG_LIR_Nem_3	818	823	PF02991	0.445
LIG_LIR_Nem_3	866	871	PF02991	0.462
LIG_LIR_Nem_3	894	900	PF02991	0.548
LIG_LYPXL_yS_3	214	217	PF13949	0.435
LIG_NRBOX	256	262	PF00104	0.592
LIG_NRBOX	306	312	PF00104	0.402
LIG_PCNA_yPIPBox_3	247	261	PF02747	0.513
LIG_Pex14_2	19	23	PF04695	0.478
LIG_Pex14_2	470	474	PF04695	0.417
LIG_PTB_Apo_2	861	868	PF02174	0.437
LIG_PTB_Phospho_1	861	867	PF10480	0.436
LIG_SH2_CRK	3	7	PF00017	0.533
LIG_SH2_CRK	760	764	PF00017	0.402
LIG_SH2_NCK_1	340	344	PF00017	0.396
LIG_SH2_STAP1	155	159	PF00017	0.415
LIG_SH2_STAP1	767	771	PF00017	0.417
LIG_SH2_STAT3	546	549	PF00017	0.535
LIG_SH2_STAT5	3	6	PF00017	0.577
LIG_SH2_STAT5	752	755	PF00017	0.435
LIG_SH3_3	210	216	PF00018	0.480
LIG_SH3_3	224	230	PF00018	0.376
LIG_SH3_3	556	562	PF00018	0.545
LIG_SUMO_SIM_anti_2	34	40	PF11976	0.391
LIG_SUMO_SIM_anti_2	376	381	PF11976	0.438
LIG_SUMO_SIM_anti_2	523	529	PF11976	0.528
LIG_SUMO_SIM_anti_2	566	573	PF11976	0.606
LIG_SUMO_SIM_anti_2	662	669	PF11976	0.521
LIG_SUMO_SIM_anti_2	714	720	PF11976	0.650
LIG_SUMO_SIM_par_1	130	137	PF11976	0.434
LIG_SUMO_SIM_par_1	662	669	PF11976	0.521
LIG_TRAF2_1	414	417	PF00917	0.601
LIG_TRFH_1	603	607	PF08558	0.563
LIG_TYR_ITSM	864	871	PF00017	0.564
LIG_WRPW_2	279	282	PF00400	0.425
LIG_WRPW_2	61	64	PF00400	0.415
LIG_WW_1	271	274	PF00397	0.645
LIG_WW_3	5	9	PF00397	0.532
MOD_CDK_SPK_2	378	383	PF00069	0.425
MOD_CK1_1	108	114	PF00069	0.525
MOD_CK1_1	378	384	PF00069	0.514
MOD_CK1_1	442	448	PF00069	0.547
MOD_CK1_1	473	479	PF00069	0.512
MOD_CK1_1	484	490	PF00069	0.663
MOD_CK1_1	493	499	PF00069	0.657
MOD_CK1_1	510	516	PF00069	0.338
MOD_CK1_1	557	563	PF00069	0.560
MOD_CK1_1	564	570	PF00069	0.477
MOD_CK1_1	606	612	PF00069	0.560
MOD_CK1_1	703	709	PF00069	0.653
MOD_CK1_1	711	717	PF00069	0.552
MOD_CK1_1	737	743	PF00069	0.718
MOD_CK1_1	825	831	PF00069	0.517
MOD_CK1_1	895	901	PF00069	0.658
MOD_CK2_1	108	114	PF00069	0.419
MOD_CK2_1	249	255	PF00069	0.690
MOD_CK2_1	354	360	PF00069	0.455
MOD_CK2_1	411	417	PF00069	0.707
MOD_CK2_1	430	436	PF00069	0.608
MOD_CK2_1	46	52	PF00069	0.467
MOD_CK2_1	466	472	PF00069	0.436
MOD_CK2_1	610	616	PF00069	0.732
MOD_CK2_1	642	648	PF00069	0.602
MOD_CK2_1	662	668	PF00069	0.537
MOD_CK2_1	797	803	PF00069	0.583
MOD_CK2_1	825	831	PF00069	0.517
MOD_CK2_1	863	869	PF00069	0.519
MOD_GlcNHglycan	107	110	PF01048	0.596
MOD_GlcNHglycan	147	150	PF01048	0.505
MOD_GlcNHglycan	327	330	PF01048	0.574
MOD_GlcNHglycan	412	416	PF01048	0.803
MOD_GlcNHglycan	441	444	PF01048	0.492
MOD_GlcNHglycan	475	478	PF01048	0.558
MOD_GlcNHglycan	480	484	PF01048	0.574
MOD_GlcNHglycan	509	512	PF01048	0.609
MOD_GlcNHglycan	530	533	PF01048	0.572
MOD_GlcNHglycan	556	559	PF01048	0.535
MOD_GlcNHglycan	610	613	PF01048	0.578
MOD_GlcNHglycan	644	647	PF01048	0.718
MOD_GlcNHglycan	73	76	PF01048	0.628
MOD_GlcNHglycan	824	827	PF01048	0.556
MOD_GSK3_1	134	141	PF00069	0.599
MOD_GSK3_1	270	277	PF00069	0.583
MOD_GSK3_1	37	44	PF00069	0.597
MOD_GSK3_1	371	378	PF00069	0.594
MOD_GSK3_1	454	461	PF00069	0.505
MOD_GSK3_1	466	473	PF00069	0.436
MOD_GSK3_1	486	493	PF00069	0.553
MOD_GSK3_1	506	513	PF00069	0.606
MOD_GSK3_1	554	561	PF00069	0.555
MOD_GSK3_1	563	570	PF00069	0.485
MOD_GSK3_1	606	613	PF00069	0.580
MOD_GSK3_1	699	706	PF00069	0.692
MOD_GSK3_1	708	715	PF00069	0.713
MOD_GSK3_1	71	78	PF00069	0.607
MOD_GSK3_1	733	740	PF00069	0.580
MOD_GSK3_1	888	895	PF00069	0.573
MOD_LATS_1	245	251	PF00433	0.601
MOD_N-GLC_1	282	287	PF02516	0.435
MOD_N-GLC_1	422	427	PF02516	0.686
MOD_N-GLC_1	430	435	PF02516	0.639
MOD_N-GLC_1	863	868	PF02516	0.670
MOD_NEK2_1	105	110	PF00069	0.405
MOD_NEK2_1	127	132	PF00069	0.581
MOD_NEK2_1	145	150	PF00069	0.449
MOD_NEK2_1	157	162	PF00069	0.256
MOD_NEK2_1	199	204	PF00069	0.449
MOD_NEK2_1	232	237	PF00069	0.383
MOD_NEK2_1	324	329	PF00069	0.624
MOD_NEK2_1	439	444	PF00069	0.436
MOD_NEK2_1	526	531	PF00069	0.477
MOD_NEK2_1	56	61	PF00069	0.425
MOD_NEK2_1	585	590	PF00069	0.471
MOD_NEK2_1	88	93	PF00069	0.394
MOD_NEK2_1	900	905	PF00069	0.564
MOD_NEK2_2	535	540	PF00069	0.488
MOD_PIKK_1	134	140	PF00454	0.465
MOD_PIKK_1	249	255	PF00454	0.667
MOD_PIKK_1	37	43	PF00454	0.406
MOD_PIKK_1	735	741	PF00454	0.622
MOD_PIKK_1	844	850	PF00454	0.561
MOD_PKA_2	567	573	PF00069	0.524
MOD_PKA_2	642	648	PF00069	0.658
MOD_PKA_2	703	709	PF00069	0.643
MOD_PKA_2	733	739	PF00069	0.574
MOD_PKA_2	772	778	PF00069	0.541
MOD_PKA_2	895	901	PF00069	0.716
MOD_PKB_1	401	409	PF00069	0.693
MOD_PKB_1	858	866	PF00069	0.499
MOD_Plk_1	274	280	PF00069	0.597
MOD_Plk_1	282	288	PF00069	0.474
MOD_Plk_1	375	381	PF00069	0.536
MOD_Plk_1	422	428	PF00069	0.623
MOD_Plk_1	451	457	PF00069	0.474
MOD_Plk_1	465	471	PF00069	0.427
MOD_Plk_1	711	717	PF00069	0.680
MOD_Plk_1	863	869	PF00069	0.571
MOD_Plk_1	892	898	PF00069	0.671
MOD_Plk_2-3	466	472	PF00069	0.423
MOD_Plk_2-3	662	668	PF00069	0.537
MOD_Plk_2-3	888	894	PF00069	0.576
MOD_Plk_4	302	308	PF00069	0.300
MOD_Plk_4	375	381	PF00069	0.428
MOD_Plk_4	466	472	PF00069	0.404
MOD_Plk_4	512	518	PF00069	0.505
MOD_Plk_4	567	573	PF00069	0.504
MOD_Plk_4	585	591	PF00069	0.368
MOD_Plk_4	662	668	PF00069	0.652
MOD_Plk_4	712	718	PF00069	0.590
MOD_Plk_4	762	768	PF00069	0.455
MOD_Plk_4	772	778	PF00069	0.580
MOD_Plk_4	815	821	PF00069	0.532
MOD_ProDKin_1	226	232	PF00069	0.451
MOD_ProDKin_1	378	384	PF00069	0.514
MOD_ProDKin_1	484	490	PF00069	0.742
MOD_ProDKin_1	558	564	PF00069	0.530
MOD_ProDKin_1	603	609	PF00069	0.525
MOD_ProDKin_1	677	683	PF00069	0.718
MOD_ProDKin_1	689	695	PF00069	0.609
MOD_SUMO_for_1	149	152	PF00179	0.365
MOD_SUMO_for_1	19	22	PF00179	0.505
MOD_SUMO_for_1	262	265	PF00179	0.577
TRG_DiLeu_BaEn_1	52	57	PF01217	0.470
TRG_DiLeu_BaEn_1	616	621	PF01217	0.550
TRG_DiLeu_BaEn_1	831	836	PF01217	0.417
TRG_DiLeu_BaLyEn_6	166	171	PF01217	0.472
TRG_DiLeu_BaLyEn_6	445	450	PF01217	0.482
TRG_DiLeu_LyEn_5	831	836	PF01217	0.417
TRG_ENDOCYTIC_2	214	217	PF00928	0.435
TRG_ENDOCYTIC_2	760	763	PF00928	0.398
TRG_ENDOCYTIC_2	868	871	PF00928	0.462
TRG_ER_diArg_1	10	12	PF00400	0.614
TRG_ER_diArg_1	123	126	PF00400	0.486
TRG_ER_diArg_1	367	370	PF00400	0.589
TRG_ER_diArg_1	400	403	PF00400	0.672
TRG_ER_diArg_1	838	840	PF00400	0.496
TRG_ER_diArg_1	857	860	PF00400	0.534
TRG_NLS_MonoExtC_3	400	405	PF00514	0.671
TRG_NLS_MonoExtN_4	401	406	PF00514	0.719
TRG_Pf-PMV_PEXEL_1	11	15	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	356	360	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	448	452	PF00026	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G5	Leptomonas seymouri	43%	100%
A0A1X0NMA5	Trypanosomatidae	31%	100%
A0A422NGV5	Trypanosoma rangeli	32%	100%
A4H4K4	Leishmania braziliensis	80%	100%
A4HST0	Leishmania infantum	99%	100%
C9ZTD6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AKR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QJ40	Leishmania major	93%	100%