LeishMANIAdb
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Zinc_finger_C-x8-C-x5-C-x3-H_type_(And_similar)_p utative/Pfam:PF00642

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Zinc_finger_C-x8-C-x5-C-x3-H_type_(And_similar)_p utative/Pfam:PF00642
Gene product:
Present in the outer mitochondrial membrane proteome 35
Species:
Leishmania donovani
UniProt:
A0A3S5H5P9_LEIDO
TriTrypDb:
LdBPK_060380.1 , LdCL_060008900 , LDHU3_06.0470
Length:
401

Annotations

LeishMANIAdb annotations

A Zn-finger protein with a TM segment on the C-terminus (2 paralogous lineages in Kinetoplastids: A4HSS9_LEIINvs. A4I356_LEIIN). Unlikely to be GPI-anchored due to reverse topology. Weakly similar to NLRC3/NOD3 intracellular immune receptor.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 12
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0005929 cilium 4 14
GO:0042995 cell projection 2 14
GO:0043226 organelle 2 14
GO:0043227 membrane-bounded organelle 3 14
GO:0110165 cellular anatomical entity 1 14
GO:0120025 plasma membrane bounded cell projection 3 14
GO:0005737 cytoplasm 2 1
GO:0005741 mitochondrial outer membrane 5 1
GO:0016020 membrane 2 6
GO:0019867 outer membrane 3 1
GO:0031090 organelle membrane 3 1
GO:0031966 mitochondrial membrane 4 1
GO:0031968 organelle outer membrane 4 1
GO:0098588 bounding membrane of organelle 4 1

Expansion

Sequence features

A0A3S5H5P9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5P9

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 10
GO:0003723 RNA binding 4 10
GO:0003729 mRNA binding 5 10
GO:0005488 binding 1 14
GO:0043167 ion binding 2 14
GO:0043169 cation binding 3 14
GO:0046872 metal ion binding 4 14
GO:0097159 organic cyclic compound binding 2 10
GO:1901363 heterocyclic compound binding 2 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 102 106 PF00656 0.432
CLV_C14_Caspase3-7 56 60 PF00656 0.530
CLV_NRD_NRD_1 227 229 PF00675 0.612
CLV_PCSK_FUR_1 38 42 PF00082 0.664
CLV_PCSK_KEX2_1 227 229 PF00082 0.727
CLV_PCSK_KEX2_1 257 259 PF00082 0.750
CLV_PCSK_KEX2_1 40 42 PF00082 0.687
CLV_PCSK_PC1ET2_1 257 259 PF00082 0.731
CLV_PCSK_PC1ET2_1 40 42 PF00082 0.667
CLV_PCSK_SKI1_1 257 261 PF00082 0.702
DEG_SPOP_SBC_1 326 330 PF00917 0.489
DOC_CYCLIN_yCln2_LP_2 341 347 PF00134 0.488
DOC_PP2B_LxvP_1 341 344 PF13499 0.487
DOC_USP7_MATH_1 267 271 PF00917 0.559
DOC_USP7_MATH_1 286 290 PF00917 0.346
DOC_USP7_MATH_1 305 309 PF00917 0.375
DOC_USP7_MATH_1 314 318 PF00917 0.408
DOC_USP7_MATH_1 379 383 PF00917 0.510
DOC_USP7_UBL2_3 257 261 PF12436 0.490
DOC_WW_Pin1_4 12 17 PF00397 0.369
DOC_WW_Pin1_4 364 369 PF00397 0.581
LIG_14-3-3_CanoR_1 207 212 PF00244 0.489
LIG_14-3-3_CanoR_1 258 264 PF00244 0.505
LIG_APCC_ABBA_1 107 112 PF00400 0.443
LIG_APCC_ABBAyCdc20_2 46 52 PF00400 0.392
LIG_BIR_II_1 1 5 PF00653 0.585
LIG_BRCT_BRCA1_1 323 327 PF00533 0.492
LIG_EH_1 218 222 PF12763 0.384
LIG_FHA_1 15 21 PF00498 0.239
LIG_FHA_1 297 303 PF00498 0.401
LIG_FHA_1 327 333 PF00498 0.444
LIG_FHA_2 61 67 PF00498 0.475
LIG_LIR_Gen_1 105 115 PF02991 0.365
LIG_LIR_Gen_1 206 216 PF02991 0.365
LIG_LIR_Nem_3 105 110 PF02991 0.416
LIG_LIR_Nem_3 48 53 PF02991 0.405
LIG_MYND_1 6 10 PF01753 0.209
LIG_SH2_NCK_1 311 315 PF00017 0.427
LIG_SH2_PTP2 293 296 PF00017 0.263
LIG_SH2_SRC 135 138 PF00017 0.311
LIG_SH2_SRC 293 296 PF00017 0.276
LIG_SH2_SRC 361 364 PF00017 0.460
LIG_SH2_STAP1 361 365 PF00017 0.461
LIG_SH2_STAP1 50 54 PF00017 0.368
LIG_SH2_STAT5 135 138 PF00017 0.311
LIG_SH2_STAT5 293 296 PF00017 0.271
LIG_SH2_STAT5 53 56 PF00017 0.381
LIG_SH2_STAT5 78 81 PF00017 0.436
LIG_SH3_3 18 24 PF00018 0.477
LIG_SUMO_SIM_anti_2 139 145 PF11976 0.342
LIG_SUMO_SIM_anti_2 387 392 PF11976 0.377
LIG_TRAF2_1 65 68 PF00917 0.497
LIG_TRFH_1 12 16 PF08558 0.218
LIG_TYR_ITIM 133 138 PF00017 0.361
LIG_UBA3_1 143 148 PF00899 0.349
MOD_CK1_1 127 133 PF00069 0.347
MOD_CK1_1 139 145 PF00069 0.352
MOD_CK1_1 22 28 PF00069 0.611
MOD_CK1_1 328 334 PF00069 0.611
MOD_CK1_1 364 370 PF00069 0.675
MOD_CK1_1 57 63 PF00069 0.614
MOD_CK2_1 197 203 PF00069 0.405
MOD_GlcNHglycan 160 164 PF01048 0.367
MOD_GlcNHglycan 229 232 PF01048 0.643
MOD_GlcNHglycan 24 27 PF01048 0.603
MOD_GlcNHglycan 315 319 PF01048 0.637
MOD_GlcNHglycan 56 59 PF01048 0.561
MOD_GSK3_1 12 19 PF00069 0.451
MOD_GSK3_1 123 130 PF00069 0.389
MOD_GSK3_1 203 210 PF00069 0.564
MOD_GSK3_1 259 266 PF00069 0.716
MOD_GSK3_1 321 328 PF00069 0.577
MOD_N-GLC_1 124 129 PF02516 0.424
MOD_NEK2_1 159 164 PF00069 0.413
MOD_NEK2_1 177 182 PF00069 0.360
MOD_NEK2_1 189 194 PF00069 0.404
MOD_NEK2_1 259 264 PF00069 0.728
MOD_NEK2_1 327 332 PF00069 0.580
MOD_NEK2_1 386 391 PF00069 0.296
MOD_PIKK_1 373 379 PF00454 0.570
MOD_PK_1 197 203 PF00069 0.405
MOD_PKA_1 227 233 PF00069 0.615
MOD_PKA_1 45 51 PF00069 0.544
MOD_PKA_2 227 233 PF00069 0.514
MOD_PKB_1 334 342 PF00069 0.636
MOD_Plk_1 124 130 PF00069 0.421
MOD_Plk_1 139 145 PF00069 0.365
MOD_Plk_1 189 195 PF00069 0.452
MOD_Plk_1 197 203 PF00069 0.464
MOD_Plk_1 296 302 PF00069 0.662
MOD_Plk_1 361 367 PF00069 0.800
MOD_Plk_1 69 75 PF00069 0.722
MOD_Plk_4 124 130 PF00069 0.363
MOD_Plk_4 139 145 PF00069 0.334
MOD_Plk_4 16 22 PF00069 0.502
MOD_Plk_4 189 195 PF00069 0.468
MOD_Plk_4 197 203 PF00069 0.482
MOD_Plk_4 259 265 PF00069 0.627
MOD_Plk_4 306 312 PF00069 0.549
MOD_Plk_4 379 385 PF00069 0.565
MOD_Plk_4 386 392 PF00069 0.264
MOD_Plk_4 45 51 PF00069 0.657
MOD_ProDKin_1 12 18 PF00069 0.369
MOD_ProDKin_1 364 370 PF00069 0.746
MOD_SUMO_rev_2 230 238 PF00179 0.557
TRG_ENDOCYTIC_2 135 138 PF00928 0.369
TRG_ENDOCYTIC_2 208 211 PF00928 0.424
TRG_ER_diArg_1 226 228 PF00400 0.683
TRG_ER_diArg_1 334 337 PF00400 0.638
TRG_ER_diArg_1 340 343 PF00400 0.577
TRG_NLS_MonoExtC_3 256 261 PF00514 0.640

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0NM91 Trypanosomatidae 53% 97%
A0A3R7KZS1 Trypanosoma rangeli 54% 99%
A0A3S7X0C2 Leishmania donovani 22% 100%
A4H4K3 Leishmania braziliensis 86% 100%
A4HFD8 Leishmania braziliensis 21% 100%
A4HSS9 Leishmania infantum 100% 100%
A4I356 Leishmania infantum 22% 100%
C9ZTD5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 54% 100%
E9AKR6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
E9AYS2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 21% 100%
Q4QJ41 Leishmania major 96% 100%
V5BXP3 Trypanosoma cruzi 58% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS