Zinc_finger_C-x8-C-x5-C-x3-H_type_(And_similar)_p utative/Pfam:PF00642

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 35

Species:

Leishmania donovani

UniProt:

A0A3S5H5P9_LEIDO

TriTrypDb:

LdBPK_060380.1 , LdCL_060008900 , LDHU3_06.0470

Length:

401

Annotations

LeishMANIAdb annotations

A Zn-finger protein with a TM segment on the C-terminus (2 paralogous lineages in Kinetoplastids: A4HSS9_LEIINvs. A4I356_LEIIN). Unlikely to be GPI-anchored due to reverse topology. Weakly similar to NLRC3/NOD3 intracellular immune receptor.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 12
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	14
GO:0042995	cell projection	2	14
GO:0043226	organelle	2	14
GO:0043227	membrane-bounded organelle	3	14
GO:0110165	cellular anatomical entity	1	14
GO:0120025	plasma membrane bounded cell projection	3	14
GO:0005737	cytoplasm	2	1
GO:0005741	mitochondrial outer membrane	5	1
GO:0016020	membrane	2	6
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

A0A3S5H5P9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5P9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0003729	mRNA binding	5	10
GO:0005488	binding	1	14
GO:0043167	ion binding	2	14
GO:0043169	cation binding	3	14
GO:0046872	metal ion binding	4	14
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.432
CLV_C14_Caspase3-7	56	60	PF00656	0.530
CLV_NRD_NRD_1	227	229	PF00675	0.612
CLV_PCSK_FUR_1	38	42	PF00082	0.664
CLV_PCSK_KEX2_1	227	229	PF00082	0.727
CLV_PCSK_KEX2_1	257	259	PF00082	0.750
CLV_PCSK_KEX2_1	40	42	PF00082	0.687
CLV_PCSK_PC1ET2_1	257	259	PF00082	0.731
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.667
CLV_PCSK_SKI1_1	257	261	PF00082	0.702
DEG_SPOP_SBC_1	326	330	PF00917	0.489
DOC_CYCLIN_yCln2_LP_2	341	347	PF00134	0.488
DOC_PP2B_LxvP_1	341	344	PF13499	0.487
DOC_USP7_MATH_1	267	271	PF00917	0.559
DOC_USP7_MATH_1	286	290	PF00917	0.346
DOC_USP7_MATH_1	305	309	PF00917	0.375
DOC_USP7_MATH_1	314	318	PF00917	0.408
DOC_USP7_MATH_1	379	383	PF00917	0.510
DOC_USP7_UBL2_3	257	261	PF12436	0.490
DOC_WW_Pin1_4	12	17	PF00397	0.369
DOC_WW_Pin1_4	364	369	PF00397	0.581
LIG_14-3-3_CanoR_1	207	212	PF00244	0.489
LIG_14-3-3_CanoR_1	258	264	PF00244	0.505
LIG_APCC_ABBA_1	107	112	PF00400	0.443
LIG_APCC_ABBAyCdc20_2	46	52	PF00400	0.392
LIG_BIR_II_1	1	5	PF00653	0.585
LIG_BRCT_BRCA1_1	323	327	PF00533	0.492
LIG_EH_1	218	222	PF12763	0.384
LIG_FHA_1	15	21	PF00498	0.239
LIG_FHA_1	297	303	PF00498	0.401
LIG_FHA_1	327	333	PF00498	0.444
LIG_FHA_2	61	67	PF00498	0.475
LIG_LIR_Gen_1	105	115	PF02991	0.365
LIG_LIR_Gen_1	206	216	PF02991	0.365
LIG_LIR_Nem_3	105	110	PF02991	0.416
LIG_LIR_Nem_3	48	53	PF02991	0.405
LIG_MYND_1	6	10	PF01753	0.209
LIG_SH2_NCK_1	311	315	PF00017	0.427
LIG_SH2_PTP2	293	296	PF00017	0.263
LIG_SH2_SRC	135	138	PF00017	0.311
LIG_SH2_SRC	293	296	PF00017	0.276
LIG_SH2_SRC	361	364	PF00017	0.460
LIG_SH2_STAP1	361	365	PF00017	0.461
LIG_SH2_STAP1	50	54	PF00017	0.368
LIG_SH2_STAT5	135	138	PF00017	0.311
LIG_SH2_STAT5	293	296	PF00017	0.271
LIG_SH2_STAT5	53	56	PF00017	0.381
LIG_SH2_STAT5	78	81	PF00017	0.436
LIG_SH3_3	18	24	PF00018	0.477
LIG_SUMO_SIM_anti_2	139	145	PF11976	0.342
LIG_SUMO_SIM_anti_2	387	392	PF11976	0.377
LIG_TRAF2_1	65	68	PF00917	0.497
LIG_TRFH_1	12	16	PF08558	0.218
LIG_TYR_ITIM	133	138	PF00017	0.361
LIG_UBA3_1	143	148	PF00899	0.349
MOD_CK1_1	127	133	PF00069	0.347
MOD_CK1_1	139	145	PF00069	0.352
MOD_CK1_1	22	28	PF00069	0.611
MOD_CK1_1	328	334	PF00069	0.611
MOD_CK1_1	364	370	PF00069	0.675
MOD_CK1_1	57	63	PF00069	0.614
MOD_CK2_1	197	203	PF00069	0.405
MOD_GlcNHglycan	160	164	PF01048	0.367
MOD_GlcNHglycan	229	232	PF01048	0.643
MOD_GlcNHglycan	24	27	PF01048	0.603
MOD_GlcNHglycan	315	319	PF01048	0.637
MOD_GlcNHglycan	56	59	PF01048	0.561
MOD_GSK3_1	12	19	PF00069	0.451
MOD_GSK3_1	123	130	PF00069	0.389
MOD_GSK3_1	203	210	PF00069	0.564
MOD_GSK3_1	259	266	PF00069	0.716
MOD_GSK3_1	321	328	PF00069	0.577
MOD_N-GLC_1	124	129	PF02516	0.424
MOD_NEK2_1	159	164	PF00069	0.413
MOD_NEK2_1	177	182	PF00069	0.360
MOD_NEK2_1	189	194	PF00069	0.404
MOD_NEK2_1	259	264	PF00069	0.728
MOD_NEK2_1	327	332	PF00069	0.580
MOD_NEK2_1	386	391	PF00069	0.296
MOD_PIKK_1	373	379	PF00454	0.570
MOD_PK_1	197	203	PF00069	0.405
MOD_PKA_1	227	233	PF00069	0.615
MOD_PKA_1	45	51	PF00069	0.544
MOD_PKA_2	227	233	PF00069	0.514
MOD_PKB_1	334	342	PF00069	0.636
MOD_Plk_1	124	130	PF00069	0.421
MOD_Plk_1	139	145	PF00069	0.365
MOD_Plk_1	189	195	PF00069	0.452
MOD_Plk_1	197	203	PF00069	0.464
MOD_Plk_1	296	302	PF00069	0.662
MOD_Plk_1	361	367	PF00069	0.800
MOD_Plk_1	69	75	PF00069	0.722
MOD_Plk_4	124	130	PF00069	0.363
MOD_Plk_4	139	145	PF00069	0.334
MOD_Plk_4	16	22	PF00069	0.502
MOD_Plk_4	189	195	PF00069	0.468
MOD_Plk_4	197	203	PF00069	0.482
MOD_Plk_4	259	265	PF00069	0.627
MOD_Plk_4	306	312	PF00069	0.549
MOD_Plk_4	379	385	PF00069	0.565
MOD_Plk_4	386	392	PF00069	0.264
MOD_Plk_4	45	51	PF00069	0.657
MOD_ProDKin_1	12	18	PF00069	0.369
MOD_ProDKin_1	364	370	PF00069	0.746
MOD_SUMO_rev_2	230	238	PF00179	0.557
TRG_ENDOCYTIC_2	135	138	PF00928	0.369
TRG_ENDOCYTIC_2	208	211	PF00928	0.424
TRG_ER_diArg_1	226	228	PF00400	0.683
TRG_ER_diArg_1	334	337	PF00400	0.638
TRG_ER_diArg_1	340	343	PF00400	0.577
TRG_NLS_MonoExtC_3	256	261	PF00514	0.640

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NM91	Trypanosomatidae	53%	97%
A0A3R7KZS1	Trypanosoma rangeli	54%	99%
A0A3S7X0C2	Leishmania donovani	22%	100%
A4H4K3	Leishmania braziliensis	86%	100%
A4HFD8	Leishmania braziliensis	21%	100%
A4HSS9	Leishmania infantum	100%	100%
A4I356	Leishmania infantum	22%	100%
C9ZTD5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AKR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9AYS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	100%
Q4QJ41	Leishmania major	96%	100%
V5BXP3	Trypanosoma cruzi	58%	99%