Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5P7_LEIDO

TriTrypDb:

LdBPK_060360.1 , LdCL_060008700 , LDHU3_06.0430

Length:

451

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H5P7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5P7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	410	414	PF00656	0.657
CLV_C14_Caspase3-7	431	435	PF00656	0.648
CLV_NRD_NRD_1	103	105	PF00675	0.572
CLV_NRD_NRD_1	259	261	PF00675	0.564
CLV_NRD_NRD_1	339	341	PF00675	0.587
CLV_NRD_NRD_1	396	398	PF00675	0.577
CLV_NRD_NRD_1	402	404	PF00675	0.561
CLV_PCSK_KEX2_1	103	105	PF00082	0.572
CLV_PCSK_KEX2_1	339	341	PF00082	0.584
CLV_PCSK_KEX2_1	395	397	PF00082	0.605
CLV_PCSK_KEX2_1	404	406	PF00082	0.571
CLV_PCSK_PC1ET2_1	404	406	PF00082	0.613
CLV_PCSK_SKI1_1	104	108	PF00082	0.663
CLV_PCSK_SKI1_1	154	158	PF00082	0.588
CLV_PCSK_SKI1_1	217	221	PF00082	0.569
CLV_PCSK_SKI1_1	327	331	PF00082	0.718
CLV_PCSK_SKI1_1	334	338	PF00082	0.636
CLV_PCSK_SKI1_1	397	401	PF00082	0.575
DEG_APCC_DBOX_1	216	224	PF00400	0.480
DOC_CYCLIN_yClb5_NLxxxL_5	239	245	PF00134	0.561
DOC_MAPK_gen_1	196	204	PF00069	0.630
DOC_MAPK_gen_1	331	338	PF00069	0.559
DOC_MAPK_gen_1	395	401	PF00069	0.715
DOC_PP2B_LxvP_1	233	236	PF13499	0.579
DOC_PP2B_LxvP_1	379	382	PF13499	0.693
DOC_PP4_FxxP_1	107	110	PF00568	0.549
DOC_USP7_MATH_1	134	138	PF00917	0.700
DOC_USP7_MATH_1	164	168	PF00917	0.537
DOC_USP7_MATH_1	419	423	PF00917	0.568
DOC_USP7_MATH_1	50	54	PF00917	0.600
DOC_USP7_MATH_1	60	64	PF00917	0.547
DOC_USP7_UBL2_3	327	331	PF12436	0.686
DOC_WW_Pin1_4	205	210	PF00397	0.540
DOC_WW_Pin1_4	266	271	PF00397	0.562
LIG_14-3-3_CanoR_1	154	159	PF00244	0.600
LIG_14-3-3_CanoR_1	184	188	PF00244	0.526
LIG_14-3-3_CanoR_1	239	244	PF00244	0.477
LIG_14-3-3_CanoR_1	249	257	PF00244	0.447
LIG_14-3-3_CanoR_1	260	265	PF00244	0.428
LIG_14-3-3_CanoR_1	284	293	PF00244	0.703
LIG_14-3-3_CanoR_1	33	39	PF00244	0.621
LIG_14-3-3_CanoR_1	407	417	PF00244	0.734
LIG_Actin_WH2_2	139	156	PF00022	0.563
LIG_BIR_II_1	1	5	PF00653	0.603
LIG_Clathr_ClatBox_1	254	258	PF01394	0.594
LIG_Clathr_ClatBox_1	436	440	PF01394	0.669
LIG_deltaCOP1_diTrp_1	212	219	PF00928	0.558
LIG_DLG_GKlike_1	260	267	PF00625	0.511
LIG_FHA_1	250	256	PF00498	0.492
LIG_FHA_1	290	296	PF00498	0.648
LIG_FHA_1	382	388	PF00498	0.583
LIG_FHA_1	404	410	PF00498	0.764
LIG_FHA_1	423	429	PF00498	0.707
LIG_FHA_1	431	437	PF00498	0.698
LIG_FHA_2	196	202	PF00498	0.575
LIG_FHA_2	429	435	PF00498	0.690
LIG_FHA_2	8	14	PF00498	0.595
LIG_GBD_Chelix_1	88	96	PF00786	0.691
LIG_LIR_Gen_1	222	232	PF02991	0.470
LIG_LIR_Gen_1	263	272	PF02991	0.429
LIG_LIR_Gen_1	35	45	PF02991	0.595
LIG_LIR_Gen_1	367	374	PF02991	0.626
LIG_LIR_Nem_3	222	227	PF02991	0.442
LIG_LIR_Nem_3	231	235	PF02991	0.505
LIG_LIR_Nem_3	263	267	PF02991	0.422
LIG_LIR_Nem_3	35	41	PF02991	0.483
LIG_LIR_Nem_3	367	371	PF02991	0.636
LIG_NRBOX	222	228	PF00104	0.509
LIG_PDZ_Class_3	446	451	PF00595	0.682
LIG_SH2_SRC	314	317	PF00017	0.611
LIG_SH2_STAP1	264	268	PF00017	0.426
LIG_SH2_STAT5	145	148	PF00017	0.424
LIG_SH2_STAT5	161	164	PF00017	0.498
LIG_SH2_STAT5	232	235	PF00017	0.445
LIG_SH2_STAT5	373	376	PF00017	0.597
LIG_SH3_4	327	334	PF00018	0.541
LIG_Sin3_1	223	233	PF02671	0.473
LIG_SUMO_SIM_par_1	251	258	PF11976	0.573
LIG_SUMO_SIM_par_1	269	276	PF11976	0.615
LIG_SUMO_SIM_par_1	431	440	PF11976	0.694
LIG_TYR_ITIM	262	267	PF00017	0.448
LIG_UBA3_1	92	101	PF00899	0.576
LIG_WRC_WIRS_1	174	179	PF05994	0.516
MOD_CK1_1	169	175	PF00069	0.421
MOD_CK1_1	21	27	PF00069	0.606
MOD_CK1_1	248	254	PF00069	0.467
MOD_CK1_1	289	295	PF00069	0.591
MOD_CK1_1	319	325	PF00069	0.694
MOD_CK1_1	386	392	PF00069	0.660
MOD_CK1_1	408	414	PF00069	0.691
MOD_CK1_1	422	428	PF00069	0.594
MOD_CK2_1	134	140	PF00069	0.686
MOD_CK2_1	195	201	PF00069	0.587
MOD_CK2_1	231	237	PF00069	0.525
MOD_CK2_1	260	266	PF00069	0.591
MOD_Cter_Amidation	258	261	PF01082	0.568
MOD_Cter_Amidation	331	334	PF01082	0.754
MOD_GlcNHglycan	137	140	PF01048	0.608
MOD_GlcNHglycan	166	169	PF01048	0.515
MOD_GlcNHglycan	171	174	PF01048	0.470
MOD_GlcNHglycan	214	217	PF01048	0.563
MOD_GlcNHglycan	286	289	PF01048	0.694
MOD_GlcNHglycan	306	309	PF01048	0.511
MOD_GlcNHglycan	323	327	PF01048	0.438
MOD_GlcNHglycan	34	37	PF01048	0.609
MOD_GlcNHglycan	388	391	PF01048	0.663
MOD_GlcNHglycan	421	424	PF01048	0.685
MOD_GlcNHglycan	52	55	PF01048	0.484
MOD_GlcNHglycan	56	59	PF01048	0.603
MOD_GlcNHglycan	75	78	PF01048	0.411
MOD_GlcNHglycan	80	83	PF01048	0.634
MOD_GSK3_1	108	115	PF00069	0.632
MOD_GSK3_1	169	176	PF00069	0.491
MOD_GSK3_1	207	214	PF00069	0.513
MOD_GSK3_1	244	251	PF00069	0.434
MOD_GSK3_1	262	269	PF00069	0.514
MOD_GSK3_1	273	280	PF00069	0.463
MOD_GSK3_1	282	289	PF00069	0.348
MOD_GSK3_1	3	10	PF00069	0.528
MOD_GSK3_1	403	410	PF00069	0.688
MOD_GSK3_1	50	57	PF00069	0.626
MOD_N-GLC_1	135	140	PF02516	0.584
MOD_N-GLC_1	159	164	PF02516	0.648
MOD_N-GLC_1	239	244	PF02516	0.545
MOD_NEK2_1	177	182	PF00069	0.463
MOD_NEK2_1	219	224	PF00069	0.467
MOD_NEK2_1	244	249	PF00069	0.458
MOD_NEK2_1	277	282	PF00069	0.539
MOD_NEK2_1	304	309	PF00069	0.668
MOD_NEK2_1	34	39	PF00069	0.623
MOD_NEK2_1	348	353	PF00069	0.535
MOD_NEK2_1	358	363	PF00069	0.571
MOD_NEK2_1	92	97	PF00069	0.564
MOD_OFUCOSY	105	112	PF10250	0.719
MOD_PIKK_1	114	120	PF00454	0.742
MOD_PIKK_1	3	9	PF00454	0.441
MOD_PK_1	405	411	PF00069	0.491
MOD_PKA_1	260	266	PF00069	0.514
MOD_PKA_1	403	409	PF00069	0.674
MOD_PKA_2	183	189	PF00069	0.473
MOD_PKA_2	248	254	PF00069	0.467
MOD_PKA_2	32	38	PF00069	0.639
MOD_PKB_1	403	411	PF00069	0.711
MOD_Plk_1	239	245	PF00069	0.496
MOD_Plk_2-3	231	237	PF00069	0.494
MOD_Plk_4	177	183	PF00069	0.481
MOD_Plk_4	21	27	PF00069	0.553
MOD_Plk_4	219	225	PF00069	0.445
MOD_Plk_4	239	245	PF00069	0.231
MOD_Plk_4	92	98	PF00069	0.562
MOD_ProDKin_1	205	211	PF00069	0.540
MOD_ProDKin_1	266	272	PF00069	0.559
MOD_SUMO_for_1	309	312	PF00179	0.606
TRG_DiLeu_BaLyEn_6	267	272	PF01217	0.586
TRG_DiLeu_BaLyEn_6	291	296	PF01217	0.595
TRG_ENDOCYTIC_2	232	235	PF00928	0.476
TRG_ENDOCYTIC_2	264	267	PF00928	0.424
TRG_ENDOCYTIC_2	38	41	PF00928	0.483
TRG_ER_diArg_1	338	340	PF00400	0.610
TRG_ER_diArg_1	395	397	PF00400	0.632
TRG_NLS_MonoExtC_3	402	407	PF00514	0.651
TRG_NLS_MonoExtN_4	403	408	PF00514	0.722

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZQ7	Leptomonas seymouri	46%	100%
A0A1X0NL47	Trypanosomatidae	33%	98%
A0A3S5IR10	Trypanosoma rangeli	30%	97%
A4H4K1	Leishmania braziliensis	78%	100%
A4HSS7	Leishmania infantum	99%	100%
C9ZTC6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	98%
E9AKR4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QJ43	Leishmania major	95%	100%
V5BA95	Trypanosoma cruzi	32%	98%