NAD(P)-dependent steroid dehydrogenase protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NAD(P)-dependent steroid dehydrogenase protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H5P6_LEIDO

TriTrypDb:

LdBPK_060350.1 , LdCL_060008600 , LDHU3_06.0420

Length:

407

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3S5H5P6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5P6

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0006694	steroid biosynthetic process	5	12
GO:0008152	metabolic process	1	12
GO:0008202	steroid metabolic process	4	12
GO:0008610	lipid biosynthetic process	4	12
GO:0009058	biosynthetic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901362	organic cyclic compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0000252	C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity	5	2
GO:0003824	catalytic activity	1	12
GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity	5	12
GO:0016229	steroid dehydrogenase activity	3	12
GO:0016491	oxidoreductase activity	2	12
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	12
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	12
GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	12
GO:0047012	sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity	5	2
GO:0103066	4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity	5	2
GO:0103067	4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity	5	2
GO:0102294	cholesterol dehydrogenase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	239	243	PF00656	0.455
CLV_NRD_NRD_1	114	116	PF00675	0.294
CLV_NRD_NRD_1	403	405	PF00675	0.738
CLV_PCSK_KEX2_1	114	116	PF00082	0.330
CLV_PCSK_KEX2_1	15	17	PF00082	0.377
CLV_PCSK_KEX2_1	350	352	PF00082	0.600
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.351
CLV_PCSK_PC1ET2_1	350	352	PF00082	0.461
CLV_PCSK_SKI1_1	135	139	PF00082	0.306
DEG_MDM2_SWIB_1	361	369	PF02201	0.278
DOC_ANK_TNKS_1	152	159	PF00023	0.515
DOC_PP1_RVXF_1	233	239	PF00149	0.445
DOC_PP1_RVXF_1	349	356	PF00149	0.258
DOC_PP1_RVXF_1	51	58	PF00149	0.455
DOC_PP2B_LxvP_1	212	215	PF13499	0.455
DOC_PP4_FxxP_1	151	154	PF00568	0.455
DOC_SPAK_OSR1_1	264	268	PF12202	0.541
DOC_USP7_MATH_1	18	22	PF00917	0.599
DOC_USP7_UBL2_3	253	257	PF12436	0.541
DOC_USP7_UBL2_3	285	289	PF12436	0.491
DOC_WW_Pin1_4	138	143	PF00397	0.455
DOC_WW_Pin1_4	256	261	PF00397	0.455
DOC_WW_Pin1_4	8	13	PF00397	0.522
LIG_14-3-3_CanoR_1	16	25	PF00244	0.578
LIG_14-3-3_CanoR_1	235	244	PF00244	0.455
LIG_APCC_ABBA_1	358	363	PF00400	0.312
LIG_BRCT_BRCA1_1	142	146	PF00533	0.466
LIG_deltaCOP1_diTrp_1	363	372	PF00928	0.280
LIG_EH1_1	130	138	PF00400	0.515
LIG_EVH1_1	22	26	PF00568	0.535
LIG_FHA_1	119	125	PF00498	0.455
LIG_FHA_1	221	227	PF00498	0.455
LIG_FHA_1	325	331	PF00498	0.373
LIG_FHA_1	33	39	PF00498	0.428
LIG_FHA_2	158	164	PF00498	0.455
LIG_FHA_2	177	183	PF00498	0.324
LIG_FHA_2	237	243	PF00498	0.455
LIG_FHA_2	267	273	PF00498	0.466
LIG_LIR_Apic_2	149	154	PF02991	0.479
LIG_LIR_Gen_1	170	177	PF02991	0.455
LIG_LIR_Gen_1	82	91	PF02991	0.480
LIG_LIR_Nem_3	111	116	PF02991	0.463
LIG_LIR_Nem_3	19	25	PF02991	0.539
LIG_LIR_Nem_3	192	198	PF02991	0.496
LIG_LIR_Nem_3	352	358	PF02991	0.290
LIG_LIR_Nem_3	368	374	PF02991	0.371
LIG_LIR_Nem_3	82	87	PF02991	0.469
LIG_LYPXL_yS_3	22	25	PF13949	0.531
LIG_MAD2	53	61	PF02301	0.455
LIG_MYND_1	8	12	PF01753	0.536
LIG_Pex14_1	376	380	PF04695	0.298
LIG_Pex14_2	361	365	PF04695	0.279
LIG_Pex14_2	372	376	PF04695	0.298
LIG_PTB_Apo_2	255	262	PF02174	0.504
LIG_PTB_Phospho_1	255	261	PF10480	0.504
LIG_SH2_CRK	113	117	PF00017	0.515
LIG_SH2_NCK_1	84	88	PF00017	0.479
LIG_SH2_STAT5	244	247	PF00017	0.541
LIG_SH2_STAT5	261	264	PF00017	0.469
LIG_SH2_STAT5	266	269	PF00017	0.439
LIG_SH2_STAT5	280	283	PF00017	0.410
LIG_SH2_STAT5	311	314	PF00017	0.323
LIG_SH2_STAT5	76	79	PF00017	0.455
LIG_SH3_2	23	28	PF14604	0.540
LIG_SH3_3	103	109	PF00018	0.446
LIG_SH3_3	162	168	PF00018	0.455
LIG_SH3_3	20	26	PF00018	0.518
LIG_SH3_3	202	208	PF00018	0.455
LIG_SH3_3	300	306	PF00018	0.585
LIG_SH3_3	354	360	PF00018	0.320
LIG_TYR_ITSM	80	87	PF00017	0.515
MOD_CDK_SPxxK_3	138	145	PF00069	0.455
MOD_CDK_SPxxK_3	8	15	PF00069	0.516
MOD_CK1_1	140	146	PF00069	0.446
MOD_CK1_1	392	398	PF00069	0.448
MOD_CK1_1	85	91	PF00069	0.560
MOD_CK2_1	157	163	PF00069	0.451
MOD_CK2_1	176	182	PF00069	0.324
MOD_CK2_1	270	276	PF00069	0.455
MOD_GlcNHglycan	392	395	PF01048	0.675
MOD_GlcNHglycan	86	90	PF01048	0.364
MOD_GSK3_1	136	143	PF00069	0.445
MOD_GSK3_1	266	273	PF00069	0.454
MOD_N-GLC_1	146	151	PF02516	0.304
MOD_N-GLC_1	365	370	PF02516	0.585
MOD_N-GLC_2	243	245	PF02516	0.341
MOD_NEK2_1	136	141	PF00069	0.455
MOD_NEK2_1	146	151	PF00069	0.455
MOD_NEK2_1	324	329	PF00069	0.376
MOD_NEK2_1	336	341	PF00069	0.216
MOD_NEK2_1	37	42	PF00069	0.459
MOD_PIKK_1	16	22	PF00454	0.543
MOD_PIKK_1	392	398	PF00454	0.390
MOD_PKA_2	187	193	PF00069	0.567
MOD_Plk_1	365	371	PF00069	0.367
MOD_Plk_1	383	389	PF00069	0.402
MOD_Plk_1	79	85	PF00069	0.536
MOD_Plk_2-3	157	163	PF00069	0.455
MOD_Plk_2-3	80	86	PF00069	0.532
MOD_Plk_4	146	152	PF00069	0.479
MOD_Plk_4	295	301	PF00069	0.535
MOD_ProDKin_1	138	144	PF00069	0.455
MOD_ProDKin_1	256	262	PF00069	0.455
MOD_ProDKin_1	8	14	PF00069	0.517
MOD_SUMO_rev_2	11	17	PF00179	0.607
TRG_DiLeu_LyEn_5	5	10	PF01217	0.572
TRG_ENDOCYTIC_2	113	116	PF00928	0.455
TRG_ENDOCYTIC_2	172	175	PF00928	0.455
TRG_ENDOCYTIC_2	22	25	PF00928	0.517
TRG_ENDOCYTIC_2	280	283	PF00928	0.498
TRG_ENDOCYTIC_2	84	87	PF00928	0.466
TRG_ER_diArg_1	113	115	PF00400	0.521
TRG_Pf-PMV_PEXEL_1	351	356	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6H3	Leptomonas seymouri	89%	100%
A0A0S4J083	Bodo saltans	67%	99%
A0A1X0NKS1	Trypanosomatidae	73%	100%
A0A3R7NBA3	Trypanosoma rangeli	72%	100%
A4H4K0	Leishmania braziliensis	93%	100%
A4HSS6	Leishmania infantum	100%	100%
A6NKP2	Homo sapiens	26%	96%
A8DZE7	Danio rerio	27%	100%
A9X4U2	Arabidopsis thaliana	27%	73%
B2FI29	Stenotrophomonas maltophilia (strain K279a)	29%	100%
C9ZTC5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
E9AKR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O35296	Mesocricetus auratus	23%	100%
O35469	Mus musculus	24%	100%
O43050	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
O46516	Equus caballus	23%	100%
O57245	Vaccinia virus (strain Ankara)	23%	100%
P14893	Bos taurus	21%	100%
P21097	Vaccinia virus (strain Copenhagen)	23%	100%
P22071	Rattus norvegicus	25%	100%
P22072	Rattus norvegicus	24%	100%
P24815	Mus musculus	25%	100%
P26149	Mus musculus	25%	100%
P26150	Mus musculus	25%	100%
P26670	Vaccinia virus (strain Western Reserve)	23%	100%
P27364	Rattus norvegicus	24%	100%
P27365	Macaca mulatta	22%	100%
P53199	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
P75821	Escherichia coli (strain K12)	23%	100%
P9WQP6	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	27%	100%
P9WQP7	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	27%	100%
Q0IH73	Xenopus laevis	27%	100%
Q15738	Homo sapiens	32%	100%
Q32L94	Bos taurus	26%	100%
Q3ZBE9	Bos taurus	31%	100%
Q4QJ44	Leishmania major	98%	100%
Q4R7R1	Macaca fascicularis	25%	100%
Q5A1B0	Candida albicans (strain SC5314 / ATCC MYA-2876)	26%	100%
Q5IFP1	Canis lupus familiaris	22%	100%
Q5PPL3	Rattus norvegicus	29%	100%
Q60555	Mesocricetus auratus	24%	100%
Q62878	Rattus norvegicus	25%	100%
Q64421	Mesocricetus auratus	24%	100%
Q67ZE1	Arabidopsis thaliana	32%	72%
Q8EG63	Shewanella oneidensis (strain MR-1)	26%	100%
Q8PDW5	Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)	29%	100%
Q8WUS8	Homo sapiens	25%	100%
Q9D665	Mus musculus	27%	100%
Q9FX01	Arabidopsis thaliana	31%	93%
Q9H2F3	Homo sapiens	25%	100%
Q9N119	Sus scrofa	23%	100%
Q9R1J0	Mus musculus	29%	100%
Q9RR28	Streptomyces antibioticus	24%	100%
Q9XWF0	Caenorhabditis elegans	24%	88%
V5BEU6	Trypanosoma cruzi	71%	100%