Serine peptidase, clan SC, family S9A-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oligopeptidase B-like protein

Species:

Leishmania donovani

UniProt:

A0A3S5H5P5_LEIDO

TriTrypDb:

LdBPK_060340.1 , LdCL_060008500 , LDHU3_06.0410

Length:

905

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H5P5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5P5

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0019538	protein metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004175	endopeptidase activity	4	12
GO:0004252	serine-type endopeptidase activity	5	12
GO:0008233	peptidase activity	3	12
GO:0008236	serine-type peptidase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0017171	serine hydrolase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	145	147	PF00675	0.225
CLV_NRD_NRD_1	19	21	PF00675	0.545
CLV_NRD_NRD_1	274	276	PF00675	0.257
CLV_NRD_NRD_1	523	525	PF00675	0.401
CLV_NRD_NRD_1	571	573	PF00675	0.265
CLV_NRD_NRD_1	737	739	PF00675	0.272
CLV_NRD_NRD_1	845	847	PF00675	0.524
CLV_PCSK_KEX2_1	147	149	PF00082	0.239
CLV_PCSK_KEX2_1	19	21	PF00082	0.524
CLV_PCSK_KEX2_1	523	525	PF00082	0.401
CLV_PCSK_KEX2_1	570	572	PF00082	0.307
CLV_PCSK_KEX2_1	685	687	PF00082	0.407
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.239
CLV_PCSK_PC1ET2_1	685	687	PF00082	0.407
CLV_PCSK_SKI1_1	281	285	PF00082	0.317
CLV_PCSK_SKI1_1	310	314	PF00082	0.257
CLV_PCSK_SKI1_1	388	392	PF00082	0.266
CLV_PCSK_SKI1_1	405	409	PF00082	0.286
CLV_PCSK_SKI1_1	524	528	PF00082	0.443
CLV_PCSK_SKI1_1	812	816	PF00082	0.508
CLV_PCSK_SKI1_1	841	845	PF00082	0.484
DEG_SCF_FBW7_1	304	311	PF00400	0.516
DOC_AGCK_PIF_2	492	497	PF00069	0.448
DOC_CKS1_1	305	310	PF01111	0.517
DOC_CKS1_1	538	543	PF01111	0.422
DOC_CYCLIN_yClb5_NLxxxL_5	8	17	PF00134	0.541
DOC_CYCLIN_yCln2_LP_2	159	165	PF00134	0.517
DOC_CYCLIN_yCln2_LP_2	256	262	PF00134	0.470
DOC_CYCLIN_yCln2_LP_2	296	302	PF00134	0.439
DOC_MAPK_gen_1	146	154	PF00069	0.425
DOC_MAPK_gen_1	275	285	PF00069	0.442
DOC_MAPK_gen_1	441	450	PF00069	0.432
DOC_MAPK_gen_1	570	577	PF00069	0.307
DOC_MAPK_gen_1	822	831	PF00069	0.485
DOC_MAPK_JIP1_4	46	52	PF00069	0.476
DOC_MAPK_JIP1_4	746	752	PF00069	0.310
DOC_MAPK_MEF2A_6	217	226	PF00069	0.425
DOC_MAPK_MEF2A_6	421	429	PF00069	0.425
DOC_PP2B_LxvP_1	256	259	PF13499	0.439
DOC_PP2B_LxvP_1	296	299	PF13499	0.439
DOC_PP4_FxxP_1	851	854	PF00568	0.491
DOC_USP7_MATH_1	308	312	PF00917	0.489
DOC_USP7_MATH_1	322	326	PF00917	0.527
DOC_USP7_MATH_1	626	630	PF00917	0.276
DOC_USP7_MATH_1	854	858	PF00917	0.540
DOC_USP7_MATH_1	875	879	PF00917	0.624
DOC_USP7_UBL2_3	310	314	PF12436	0.517
DOC_USP7_UBL2_3	594	598	PF12436	0.286
DOC_USP7_UBL2_3	727	731	PF12436	0.250
DOC_USP7_UBL2_3	812	816	PF12436	0.508
DOC_WW_Pin1_4	304	309	PF00397	0.517
DOC_WW_Pin1_4	416	421	PF00397	0.517
DOC_WW_Pin1_4	433	438	PF00397	0.427
DOC_WW_Pin1_4	468	473	PF00397	0.491
DOC_WW_Pin1_4	490	495	PF00397	0.473
DOC_WW_Pin1_4	537	542	PF00397	0.439
DOC_WW_Pin1_4	651	656	PF00397	0.279
LIG_14-3-3_CanoR_1	180	188	PF00244	0.425
LIG_14-3-3_CanoR_1	30	34	PF00244	0.560
LIG_14-3-3_CanoR_1	476	484	PF00244	0.494
LIG_14-3-3_CanoR_1	487	495	PF00244	0.419
LIG_14-3-3_CanoR_1	570	576	PF00244	0.274
LIG_14-3-3_CanoR_1	703	707	PF00244	0.278
LIG_Actin_WH2_2	14	32	PF00022	0.547
LIG_AP2alpha_2	60	62	PF02296	0.425
LIG_APCC_ABBA_1	260	265	PF00400	0.414
LIG_APCC_ABBA_1	370	375	PF00400	0.412
LIG_APCC_ABBA_1	50	55	PF00400	0.344
LIG_BIR_II_1	1	5	PF00653	0.658
LIG_BRCT_BRCA1_1	222	226	PF00533	0.436
LIG_BRCT_BRCA1_1	488	492	PF00533	0.506
LIG_BRCT_BRCA1_1	556	560	PF00533	0.324
LIG_BRCT_BRCA1_1	87	91	PF00533	0.465
LIG_CSL_BTD_1	6	9	PF09270	0.532
LIG_CSL_BTD_1	851	854	PF09270	0.491
LIG_CtBP_PxDLS_1	669	673	PF00389	0.237
LIG_eIF4E_1	617	623	PF01652	0.284
LIG_FHA_1	129	135	PF00498	0.414
LIG_FHA_1	189	195	PF00498	0.442
LIG_FHA_1	217	223	PF00498	0.465
LIG_FHA_1	434	440	PF00498	0.423
LIG_FHA_1	762	768	PF00498	0.265
LIG_FHA_1	8	14	PF00498	0.639
LIG_FHA_2	491	497	PF00498	0.437
LIG_FHA_2	530	536	PF00498	0.512
LIG_FHA_2	616	622	PF00498	0.278
LIG_FHA_2	660	666	PF00498	0.250
LIG_FHA_2	735	741	PF00498	0.337
LIG_FHA_2	75	81	PF00498	0.490
LIG_FHA_2	853	859	PF00498	0.475
LIG_LIR_Apic_2	31	36	PF02991	0.616
LIG_LIR_Apic_2	496	500	PF02991	0.391
LIG_LIR_Apic_2	614	620	PF02991	0.394
LIG_LIR_Apic_2	676	681	PF02991	0.251
LIG_LIR_Apic_2	848	854	PF02991	0.559
LIG_LIR_Gen_1	126	135	PF02991	0.425
LIG_LIR_Gen_1	211	221	PF02991	0.425
LIG_LIR_Gen_1	279	288	PF02991	0.422
LIG_LIR_Gen_1	325	333	PF02991	0.426
LIG_LIR_Gen_1	336	343	PF02991	0.424
LIG_LIR_Gen_1	449	459	PF02991	0.434
LIG_LIR_Gen_1	493	503	PF02991	0.397
LIG_LIR_Gen_1	654	664	PF02991	0.263
LIG_LIR_Nem_3	126	130	PF02991	0.415
LIG_LIR_Nem_3	184	190	PF02991	0.421
LIG_LIR_Nem_3	211	216	PF02991	0.425
LIG_LIR_Nem_3	268	274	PF02991	0.421
LIG_LIR_Nem_3	279	285	PF02991	0.420
LIG_LIR_Nem_3	301	305	PF02991	0.425
LIG_LIR_Nem_3	325	330	PF02991	0.426
LIG_LIR_Nem_3	336	340	PF02991	0.436
LIG_LIR_Nem_3	364	370	PF02991	0.441
LIG_LIR_Nem_3	449	455	PF02991	0.421
LIG_LIR_Nem_3	502	507	PF02991	0.346
LIG_LIR_Nem_3	551	555	PF02991	0.345
LIG_LIR_Nem_3	574	580	PF02991	0.270
LIG_LIR_Nem_3	654	659	PF02991	0.266
LIG_LIR_Nem_3	695	700	PF02991	0.273
LIG_LIR_Nem_3	837	843	PF02991	0.492
LIG_LIR_Nem_3	848	853	PF02991	0.469
LIG_LYPXL_yS_3	706	709	PF13949	0.250
LIG_PCNA_yPIPBox_3	205	216	PF02747	0.425
LIG_Pex14_1	329	333	PF04695	0.456
LIG_Pex14_1	573	577	PF04695	0.265
LIG_Pex14_1	836	840	PF04695	0.501
LIG_PTB_Apo_2	158	165	PF02174	0.415
LIG_Rb_LxCxE_1	601	621	PF01857	0.270
LIG_Rb_pABgroove_1	63	71	PF01858	0.425
LIG_REV1ctd_RIR_1	310	317	PF16727	0.457
LIG_SH2_CRK	348	352	PF00017	0.517
LIG_SH2_CRK	452	456	PF00017	0.456
LIG_SH2_GRB2like	697	700	PF00017	0.255
LIG_SH2_NCK_1	617	621	PF00017	0.265
LIG_SH2_PTP2	282	285	PF00017	0.440
LIG_SH2_SRC	547	550	PF00017	0.293
LIG_SH2_STAP1	190	194	PF00017	0.414
LIG_SH2_STAP1	452	456	PF00017	0.536
LIG_SH2_STAT5	127	130	PF00017	0.421
LIG_SH2_STAT5	187	190	PF00017	0.452
LIG_SH2_STAT5	200	203	PF00017	0.465
LIG_SH2_STAT5	234	237	PF00017	0.426
LIG_SH2_STAT5	282	285	PF00017	0.422
LIG_SH2_STAT5	352	355	PF00017	0.508
LIG_SH2_STAT5	547	550	PF00017	0.296
LIG_SH2_STAT5	617	620	PF00017	0.254
LIG_SH2_STAT5	728	731	PF00017	0.265
LIG_SH2_STAT5	759	762	PF00017	0.284
LIG_SH2_STAT5	76	79	PF00017	0.404
LIG_SH3_3	3	9	PF00018	0.537
LIG_SH3_3	300	306	PF00018	0.439
LIG_SH3_3	535	541	PF00018	0.490
LIG_SH3_3	663	669	PF00018	0.224
LIG_SH3_3	701	707	PF00018	0.265
LIG_SH3_3	741	747	PF00018	0.269
LIG_SUMO_SIM_anti_2	151	158	PF11976	0.439
LIG_SUMO_SIM_anti_2	687	692	PF11976	0.394
LIG_SUMO_SIM_par_1	190	195	PF11976	0.439
LIG_SUMO_SIM_par_1	219	225	PF11976	0.442
LIG_SUMO_SIM_par_1	667	674	PF11976	0.264
LIG_TRFH_1	560	564	PF08558	0.339
LIG_WRC_WIRS_1	309	314	PF05994	0.517
LIG_WRC_WIRS_1	831	836	PF05994	0.556
LIG_WRC_WIRS_1	885	890	PF05994	0.478
LIG_WW_3	457	461	PF00397	0.517
MOD_CDK_SPK_2	416	421	PF00069	0.517
MOD_CDK_SPK_2	537	542	PF00069	0.450
MOD_CDK_SPxK_1	304	310	PF00069	0.517
MOD_CK1_1	433	439	PF00069	0.465
MOD_CK1_1	468	474	PF00069	0.436
MOD_CK1_1	85	91	PF00069	0.465
MOD_CK1_1	878	884	PF00069	0.652
MOD_CK2_1	108	114	PF00069	0.425
MOD_CK2_1	529	535	PF00069	0.516
MOD_CK2_1	548	554	PF00069	0.307
MOD_CK2_1	615	621	PF00069	0.275
MOD_CK2_1	668	674	PF00069	0.250
MOD_CK2_1	74	80	PF00069	0.512
MOD_CK2_1	852	858	PF00069	0.463
MOD_CMANNOS	817	820	PF00535	0.466
MOD_GlcNHglycan	227	230	PF01048	0.281
MOD_GlcNHglycan	324	327	PF01048	0.319
MOD_GlcNHglycan	628	631	PF01048	0.269
MOD_GlcNHglycan	711	714	PF01048	0.307
MOD_GlcNHglycan	754	757	PF01048	0.266
MOD_GlcNHglycan	880	883	PF01048	0.633
MOD_GSK3_1	216	223	PF00069	0.498
MOD_GSK3_1	304	311	PF00069	0.517
MOD_GSK3_1	446	453	PF00069	0.420
MOD_GSK3_1	482	489	PF00069	0.461
MOD_GSK3_1	507	514	PF00069	0.377
MOD_GSK3_1	70	77	PF00069	0.440
MOD_GSK3_1	82	89	PF00069	0.412
MOD_LATS_1	828	834	PF00433	0.616
MOD_N-GLC_1	208	213	PF02516	0.247
MOD_N-GLC_1	333	338	PF02516	0.174
MOD_N-GLC_1	797	802	PF02516	0.511
MOD_N-GLC_2	766	768	PF02516	0.310
MOD_NEK2_1	13	18	PF00069	0.656
MOD_NEK2_1	188	193	PF00069	0.444
MOD_NEK2_1	29	34	PF00069	0.482
MOD_NEK2_1	391	396	PF00069	0.450
MOD_NEK2_1	450	455	PF00069	0.442
MOD_NEK2_1	615	620	PF00069	0.321
MOD_NEK2_1	709	714	PF00069	0.265
MOD_NEK2_1	773	778	PF00069	0.364
MOD_NEK2_1	799	804	PF00069	0.514
MOD_NEK2_1	86	91	PF00069	0.424
MOD_NEK2_1	93	98	PF00069	0.407
MOD_NEK2_2	308	313	PF00069	0.517
MOD_NEK2_2	875	880	PF00069	0.521
MOD_PIKK_1	470	476	PF00454	0.500
MOD_PIKK_1	482	488	PF00454	0.390
MOD_PIKK_1	53	59	PF00454	0.524
MOD_PIKK_1	70	76	PF00454	0.425
MOD_PIKK_1	773	779	PF00454	0.372
MOD_PK_1	172	178	PF00069	0.517
MOD_PK_1	598	604	PF00069	0.377
MOD_PKA_1	571	577	PF00069	0.265
MOD_PKA_2	179	185	PF00069	0.425
MOD_PKA_2	216	222	PF00069	0.465
MOD_PKA_2	274	280	PF00069	0.457
MOD_PKA_2	29	35	PF00069	0.561
MOD_PKA_2	486	492	PF00069	0.504
MOD_PKA_2	571	577	PF00069	0.265
MOD_PKA_2	70	76	PF00069	0.434
MOD_PKA_2	702	708	PF00069	0.277
MOD_PKA_2	752	758	PF00069	0.267
MOD_PKA_2	875	881	PF00069	0.595
MOD_PKA_2	93	99	PF00069	0.465
MOD_Plk_1	172	178	PF00069	0.503
MOD_Plk_1	208	214	PF00069	0.425
MOD_Plk_4	208	214	PF00069	0.429
MOD_Plk_4	308	314	PF00069	0.511
MOD_Plk_4	333	339	PF00069	0.524
MOD_Plk_4	446	452	PF00069	0.449
MOD_Plk_4	499	505	PF00069	0.386
MOD_Plk_4	659	665	PF00069	0.265
MOD_ProDKin_1	304	310	PF00069	0.517
MOD_ProDKin_1	416	422	PF00069	0.517
MOD_ProDKin_1	433	439	PF00069	0.427
MOD_ProDKin_1	468	474	PF00069	0.493
MOD_ProDKin_1	490	496	PF00069	0.468
MOD_ProDKin_1	537	543	PF00069	0.423
MOD_ProDKin_1	651	657	PF00069	0.279
MOD_SUMO_rev_2	103	109	PF00179	0.461
MOD_SUMO_rev_2	273	283	PF00179	0.465
MOD_SUMO_rev_2	287	291	PF00179	0.391
MOD_SUMO_rev_2	311	319	PF00179	0.517
MOD_SUMO_rev_2	364	370	PF00179	0.485
MOD_SUMO_rev_2	856	864	PF00179	0.558
TRG_DiLeu_BaEn_1	366	371	PF01217	0.425
TRG_DiLeu_BaEn_2	768	774	PF01217	0.324
TRG_DiLeu_BaEn_4	769	775	PF01217	0.329
TRG_ENDOCYTIC_2	127	130	PF00928	0.443
TRG_ENDOCYTIC_2	282	285	PF00928	0.434
TRG_ENDOCYTIC_2	348	351	PF00928	0.533
TRG_ENDOCYTIC_2	452	455	PF00928	0.444
TRG_ENDOCYTIC_2	504	507	PF00928	0.346
TRG_ENDOCYTIC_2	552	555	PF00928	0.360
TRG_ENDOCYTIC_2	565	568	PF00928	0.338
TRG_ENDOCYTIC_2	697	700	PF00928	0.275
TRG_ENDOCYTIC_2	706	709	PF00928	0.282
TRG_ER_diArg_1	145	148	PF00400	0.439
TRG_ER_diArg_1	19	21	PF00400	0.484
TRG_ER_diArg_1	569	572	PF00400	0.265
TRG_ER_diArg_1	750	753	PF00400	0.321
TRG_NES_CRM1_1	769	781	PF08389	0.342
TRG_NLS_MonoExtC_3	145	151	PF00514	0.439
TRG_Pf-PMV_PEXEL_1	894	899	PF00026	0.704

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7J4	Leptomonas seymouri	25%	100%
A0A0N0P803	Leptomonas seymouri	23%	100%
A0A0N1PDP3	Leptomonas seymouri	88%	100%
A0A0S4J065	Bodo saltans	65%	97%
A0A0S4JND1	Bodo saltans	25%	100%
A0A1X0NKN5	Trypanosomatidae	77%	99%
A0A1X0NMH6	Trypanosomatidae	25%	100%
A0A3Q8IGZ3	Leishmania donovani	24%	95%
A0A3Q8IJI4	Leishmania donovani	21%	93%
A0A422N761	Trypanosoma rangeli	27%	100%
A4H4J9	Leishmania braziliensis	94%	100%
A4H5Q8	Leishmania braziliensis	24%	95%
A4HQJ7	Leishmania braziliensis	21%	100%
A4HSS5	Leishmania infantum	100%	100%
A4HTZ8	Leishmania infantum	24%	95%
A4ICB5	Leishmania infantum	22%	93%
A5LFV8	Macaca fascicularis	25%	100%
C9ZTC4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	100%
D0A3P6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9AKR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9AMS8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	95%
E9AUB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	91%
P55627	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	25%	100%
P55656	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	26%	100%
Q06903	Aeromonas hydrophila	24%	100%
Q32N48	Xenopus laevis	26%	100%
Q4J6C6	Homo sapiens	25%	100%
Q4Q080	Leishmania major	21%	93%
Q4QHU7	Leishmania major	24%	95%
Q4QJ45	Leishmania major	98%	100%
Q59536	Moraxella lacunata	24%	100%
Q5HZA6	Rattus norvegicus	25%	100%
Q5RAK4	Pongo abelii	25%	100%
Q5ZKL5	Gallus gallus	26%	100%
Q8C167	Mus musculus	25%	100%
Q9QUR6	Mus musculus	21%	100%
Q9XTA2	Bos taurus	22%	100%
V5B5S3	Trypanosoma cruzi	76%	100%
V5B860	Trypanosoma cruzi	25%	100%