FHA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5P2_LEIDO

TriTrypDb:

LdBPK_060280.1 , LdCL_060007900 , LDHU3_06.0340

Length:

855

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0030870	Mre11 complex	3	7
GO:0032991	protein-containing complex	1	7
GO:0140513	nuclear protein-containing complex	2	7
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H5P2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5P2

Function

Biological processes
Term	Name	Level	Count
GO:0000075	cell cycle checkpoint signaling	4	7
GO:0000077	DNA damage checkpoint signaling	5	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006281	DNA repair	5	7
GO:0006302	double-strand break repair	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006950	response to stress	2	7
GO:0006974	DNA damage response	4	7
GO:0007093	mitotic cell cycle checkpoint signaling	4	7
GO:0007095	mitotic G2 DNA damage checkpoint signaling	6	7
GO:0007165	signal transduction	2	7
GO:0007346	regulation of mitotic cell cycle	5	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0010389	regulation of G2/M transition of mitotic cell cycle	7	7
GO:0010564	regulation of cell cycle process	5	7
GO:0010948	negative regulation of cell cycle process	6	7
GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	8	7
GO:0022402	cell cycle process	2	7
GO:0031570	DNA integrity checkpoint signaling	5	7
GO:0033554	cellular response to stress	3	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0035556	intracellular signal transduction	3	7
GO:0042770	signal transduction in response to DNA damage	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0044773	mitotic DNA damage checkpoint signaling	6	7
GO:0044774	mitotic DNA integrity checkpoint signaling	5	7
GO:0044818	mitotic G2/M transition checkpoint	5	7
GO:0045786	negative regulation of cell cycle	5	7
GO:0045930	negative regulation of mitotic cell cycle	6	7
GO:0046483	heterocycle metabolic process	3	7
GO:0048519	negative regulation of biological process	3	7
GO:0048523	negative regulation of cellular process	4	7
GO:0050789	regulation of biological process	2	7
GO:0050794	regulation of cellular process	3	7
GO:0050896	response to stimulus	1	7
GO:0051716	cellular response to stimulus	2	7
GO:0051726	regulation of cell cycle	4	7
GO:0065007	biological regulation	1	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:1901987	regulation of cell cycle phase transition	6	7
GO:1901988	negative regulation of cell cycle phase transition	7	7
GO:1901990	regulation of mitotic cell cycle phase transition	6	7
GO:1901991	negative regulation of mitotic cell cycle phase transition	7	7
GO:1902749	regulation of cell cycle G2/M phase transition	7	7
GO:1902750	negative regulation of cell cycle G2/M phase transition	8	7
GO:1903047	mitotic cell cycle process	3	7
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0006310	DNA recombination	5	1
GO:0006996	organelle organization	4	1
GO:0016043	cellular component organization	3	1
GO:0032392	DNA geometric change	7	1
GO:0032508	DNA duplex unwinding	8	1
GO:0051276	chromosome organization	5	1
GO:0071103	DNA conformation change	6	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003684	damaged DNA binding	5	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.335
CLV_C14_Caspase3-7	239	243	PF00656	0.584
CLV_C14_Caspase3-7	430	434	PF00656	0.461
CLV_C14_Caspase3-7	610	614	PF00656	0.653
CLV_C14_Caspase3-7	66	70	PF00656	0.366
CLV_C14_Caspase3-7	839	843	PF00656	0.520
CLV_NRD_NRD_1	133	135	PF00675	0.653
CLV_NRD_NRD_1	408	410	PF00675	0.449
CLV_NRD_NRD_1	574	576	PF00675	0.617
CLV_NRD_NRD_1	605	607	PF00675	0.679
CLV_NRD_NRD_1	708	710	PF00675	0.612
CLV_NRD_NRD_1	766	768	PF00675	0.614
CLV_NRD_NRD_1	772	774	PF00675	0.624
CLV_NRD_NRD_1	803	805	PF00675	0.559
CLV_PCSK_FUR_1	706	710	PF00082	0.630
CLV_PCSK_KEX2_1	135	137	PF00082	0.666
CLV_PCSK_KEX2_1	408	410	PF00082	0.446
CLV_PCSK_KEX2_1	574	576	PF00082	0.617
CLV_PCSK_KEX2_1	605	607	PF00082	0.665
CLV_PCSK_KEX2_1	708	710	PF00082	0.612
CLV_PCSK_KEX2_1	765	767	PF00082	0.618
CLV_PCSK_KEX2_1	772	774	PF00082	0.624
CLV_PCSK_KEX2_1	803	805	PF00082	0.559
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.666
CLV_PCSK_PC7_1	799	805	PF00082	0.567
CLV_PCSK_SKI1_1	348	352	PF00082	0.441
CLV_PCSK_SKI1_1	409	413	PF00082	0.445
CLV_PCSK_SKI1_1	461	465	PF00082	0.436
CLV_PCSK_SKI1_1	476	480	PF00082	0.369
CLV_PCSK_SKI1_1	55	59	PF00082	0.508
CLV_PCSK_SKI1_1	620	624	PF00082	0.661
CLV_PCSK_SKI1_1	683	687	PF00082	0.571
CLV_PCSK_SKI1_1	690	694	PF00082	0.550
DEG_APCC_DBOX_1	347	355	PF00400	0.432
DEG_APCC_DBOX_1	408	416	PF00400	0.317
DEG_APCC_DBOX_1	460	468	PF00400	0.475
DEG_COP1_1	714	723	PF00400	0.667
DEG_Nend_Nbox_1	1	3	PF02207	0.328
DEG_SCF_FBW7_1	254	261	PF00400	0.657
DEG_SPOP_SBC_1	455	459	PF00917	0.518
DOC_CKS1_1	314	319	PF01111	0.399
DOC_CKS1_1	550	555	PF01111	0.485
DOC_CYCLIN_RxL_1	405	416	PF00134	0.443
DOC_CYCLIN_yCln2_LP_2	449	455	PF00134	0.490
DOC_CYCLIN_yCln2_LP_2	649	655	PF00134	0.590
DOC_MAPK_DCC_7	58	67	PF00069	0.372
DOC_MAPK_gen_1	21	31	PF00069	0.445
DOC_MAPK_gen_1	282	292	PF00069	0.415
DOC_MAPK_gen_1	473	481	PF00069	0.436
DOC_MAPK_gen_1	803	811	PF00069	0.541
DOC_MAPK_MEF2A_6	145	154	PF00069	0.498
DOC_MAPK_MEF2A_6	326	333	PF00069	0.424
DOC_MAPK_MEF2A_6	39	48	PF00069	0.390
DOC_PP1_RVXF_1	182	188	PF00149	0.345
DOC_PP1_RVXF_1	436	442	PF00149	0.530
DOC_PP2B_LxvP_1	449	452	PF13499	0.468
DOC_PP2B_LxvP_1	521	524	PF13499	0.458
DOC_PP2B_LxvP_1	693	696	PF13499	0.565
DOC_PP4_FxxP_1	618	621	PF00568	0.667
DOC_USP7_MATH_1	278	282	PF00917	0.466
DOC_USP7_MATH_1	334	338	PF00917	0.433
DOC_USP7_MATH_1	342	346	PF00917	0.348
DOC_USP7_MATH_1	358	362	PF00917	0.536
DOC_USP7_MATH_1	386	390	PF00917	0.570
DOC_USP7_MATH_1	394	398	PF00917	0.415
DOC_USP7_MATH_1	455	459	PF00917	0.509
DOC_USP7_MATH_1	466	470	PF00917	0.401
DOC_USP7_MATH_1	548	552	PF00917	0.493
DOC_USP7_MATH_1	637	641	PF00917	0.622
DOC_USP7_MATH_1	669	673	PF00917	0.649
DOC_USP7_MATH_1	840	844	PF00917	0.554
DOC_USP7_UBL2_3	686	690	PF12436	0.564
DOC_WW_Pin1_4	107	112	PF00397	0.501
DOC_WW_Pin1_4	254	259	PF00397	0.592
DOC_WW_Pin1_4	260	265	PF00397	0.590
DOC_WW_Pin1_4	313	318	PF00397	0.334
DOC_WW_Pin1_4	325	330	PF00397	0.412
DOC_WW_Pin1_4	549	554	PF00397	0.467
DOC_WW_Pin1_4	6	11	PF00397	0.459
DOC_WW_Pin1_4	784	789	PF00397	0.593
DOC_WW_Pin1_4	90	95	PF00397	0.660
LIG_14-3-3_CanoR_1	138	148	PF00244	0.621
LIG_14-3-3_CanoR_1	166	170	PF00244	0.415
LIG_14-3-3_CanoR_1	285	291	PF00244	0.402
LIG_14-3-3_CanoR_1	498	504	PF00244	0.449
LIG_14-3-3_CanoR_1	574	582	PF00244	0.607
LIG_Actin_WH2_2	169	186	PF00022	0.367
LIG_APCC_ABBA_1	3	8	PF00400	0.384
LIG_APCC_ABBA_1	478	483	PF00400	0.363
LIG_BIR_III_2	577	581	PF00653	0.668
LIG_BRCT_BRCA1_1	842	846	PF00533	0.585
LIG_Clathr_ClatBox_1	185	189	PF01394	0.352
LIG_Clathr_ClatBox_1	699	703	PF01394	0.627
LIG_CtBP_PxDLS_1	245	251	PF00389	0.521
LIG_deltaCOP1_diTrp_1	613	618	PF00928	0.670
LIG_EVH1_1	521	525	PF00568	0.474
LIG_EVH1_1	655	659	PF00568	0.568
LIG_FHA_1	153	159	PF00498	0.427
LIG_FHA_1	171	177	PF00498	0.473
LIG_FHA_1	221	227	PF00498	0.621
LIG_FHA_1	293	299	PF00498	0.348
LIG_FHA_1	300	306	PF00498	0.346
LIG_FHA_1	41	47	PF00498	0.374
LIG_FHA_1	414	420	PF00498	0.415
LIG_FHA_1	482	488	PF00498	0.461
LIG_FHA_1	545	551	PF00498	0.537
LIG_FHA_1	643	649	PF00498	0.599
LIG_FHA_1	715	721	PF00498	0.663
LIG_FHA_1	73	79	PF00498	0.438
LIG_FHA_2	508	514	PF00498	0.391
LIG_FHA_2	533	539	PF00498	0.454
LIG_FHA_2	555	561	PF00498	0.634
LIG_FHA_2	87	93	PF00498	0.605
LIG_Integrin_RGD_1	595	597	PF01839	0.590
LIG_LIR_Apic_2	337	342	PF02991	0.492
LIG_LIR_Apic_2	617	621	PF02991	0.629
LIG_LIR_Gen_1	167	176	PF02991	0.437
LIG_LIR_Gen_1	318	327	PF02991	0.386
LIG_LIR_Gen_1	416	425	PF02991	0.413
LIG_LIR_Gen_1	535	544	PF02991	0.465
LIG_LIR_Gen_1	613	622	PF02991	0.601
LIG_LIR_Gen_1	754	762	PF02991	0.635
LIG_LIR_Gen_1	843	854	PF02991	0.549
LIG_LIR_Nem_3	167	172	PF02991	0.445
LIG_LIR_Nem_3	318	323	PF02991	0.364
LIG_LIR_Nem_3	344	350	PF02991	0.425
LIG_LIR_Nem_3	416	420	PF02991	0.354
LIG_LIR_Nem_3	505	511	PF02991	0.389
LIG_LIR_Nem_3	535	539	PF02991	0.468
LIG_LIR_Nem_3	613	618	PF02991	0.605
LIG_LIR_Nem_3	754	758	PF02991	0.635
LIG_LIR_Nem_3	843	849	PF02991	0.557
LIG_LIR_Nem_3	9	15	PF02991	0.429
LIG_OCRL_FandH_1	469	481	PF00620	0.375
LIG_Pex14_1	2	6	PF04695	0.332
LIG_Pex14_1	346	350	PF04695	0.380
LIG_PTB_Apo_2	746	753	PF02174	0.516
LIG_REV1ctd_RIR_1	468	477	PF16727	0.389
LIG_SH2_CRK	287	291	PF00017	0.432
LIG_SH2_CRK	508	512	PF00017	0.344
LIG_SH2_CRK	653	657	PF00017	0.566
LIG_SH2_NCK_1	287	291	PF00017	0.367
LIG_SH2_NCK_1	653	657	PF00017	0.566
LIG_SH2_SRC	339	342	PF00017	0.441
LIG_SH2_SRC	425	428	PF00017	0.341
LIG_SH2_SRC	431	434	PF00017	0.376
LIG_SH2_STAP1	425	429	PF00017	0.327
LIG_SH2_STAT5	175	178	PF00017	0.324
LIG_SH2_STAT5	339	342	PF00017	0.441
LIG_SH2_STAT5	401	404	PF00017	0.381
LIG_SH2_STAT5	431	434	PF00017	0.368
LIG_SH3_1	326	332	PF00018	0.418
LIG_SH3_1	519	525	PF00018	0.468
LIG_SH3_1	653	659	PF00018	0.568
LIG_SH3_3	326	332	PF00018	0.418
LIG_SH3_3	483	489	PF00018	0.503
LIG_SH3_3	519	525	PF00018	0.560
LIG_SH3_3	527	533	PF00018	0.505
LIG_SH3_3	547	553	PF00018	0.374
LIG_SH3_3	577	583	PF00018	0.598
LIG_SH3_3	653	659	PF00018	0.568
LIG_SH3_3	692	698	PF00018	0.567
LIG_SUMO_SIM_anti_2	645	650	PF11976	0.613
LIG_SUMO_SIM_anti_2	807	817	PF11976	0.526
LIG_SUMO_SIM_par_1	63	72	PF11976	0.375
LIG_SUMO_SIM_par_1	697	704	PF11976	0.620
LIG_SUMO_SIM_par_1	807	817	PF11976	0.585
LIG_TRAF2_1	535	538	PF00917	0.458
LIG_TRAF2_1	557	560	PF00917	0.676
LIG_TRAF2_1	561	564	PF00917	0.665
LIG_TRAF2_1	569	572	PF00917	0.523
LIG_TRFH_1	653	657	PF08558	0.566
LIG_TYR_ITIM	506	511	PF00017	0.347
LIG_WRC_WIRS_1	467	472	PF05994	0.364
LIG_WRC_WIRS_1	752	757	PF05994	0.532
MOD_CDK_SPxxK_3	784	791	PF00069	0.632
MOD_CK1_1	139	145	PF00069	0.598
MOD_CK1_1	220	226	PF00069	0.553
MOD_CK1_1	244	250	PF00069	0.507
MOD_CK1_1	373	379	PF00069	0.551
MOD_CK1_1	413	419	PF00069	0.421
MOD_CK1_1	456	462	PF00069	0.630
MOD_CK1_1	502	508	PF00069	0.525
MOD_CK1_1	665	671	PF00069	0.583
MOD_CK1_1	714	720	PF00069	0.672
MOD_CK2_1	224	230	PF00069	0.654
MOD_CK2_1	354	360	PF00069	0.553
MOD_CK2_1	507	513	PF00069	0.349
MOD_CK2_1	532	538	PF00069	0.464
MOD_CK2_1	554	560	PF00069	0.628
MOD_CK2_1	566	572	PF00069	0.567
MOD_Cter_Amidation	572	575	PF01082	0.622
MOD_GlcNHglycan	138	141	PF01048	0.715
MOD_GlcNHglycan	142	145	PF01048	0.767
MOD_GlcNHglycan	189	193	PF01048	0.368
MOD_GlcNHglycan	219	222	PF01048	0.534
MOD_GlcNHglycan	226	229	PF01048	0.615
MOD_GlcNHglycan	233	236	PF01048	0.597
MOD_GlcNHglycan	242	246	PF01048	0.412
MOD_GlcNHglycan	251	254	PF01048	0.547
MOD_GlcNHglycan	258	261	PF01048	0.587
MOD_GlcNHglycan	356	359	PF01048	0.618
MOD_GlcNHglycan	388	391	PF01048	0.516
MOD_GlcNHglycan	412	415	PF01048	0.455
MOD_GlcNHglycan	449	452	PF01048	0.479
MOD_GlcNHglycan	639	642	PF01048	0.627
MOD_GlcNHglycan	662	667	PF01048	0.690
MOD_GlcNHglycan	670	674	PF01048	0.605
MOD_GlcNHglycan	780	783	PF01048	0.621
MOD_GlcNHglycan	835	839	PF01048	0.600
MOD_GlcNHglycan	842	845	PF01048	0.512
MOD_GSK3_1	136	143	PF00069	0.649
MOD_GSK3_1	215	222	PF00069	0.469
MOD_GSK3_1	224	231	PF00069	0.565
MOD_GSK3_1	254	261	PF00069	0.688
MOD_GSK3_1	288	295	PF00069	0.347
MOD_GSK3_1	33	40	PF00069	0.400
MOD_GSK3_1	354	361	PF00069	0.647
MOD_GSK3_1	366	373	PF00069	0.542
MOD_GSK3_1	376	383	PF00069	0.611
MOD_GSK3_1	453	460	PF00069	0.540
MOD_GSK3_1	544	551	PF00069	0.543
MOD_GSK3_1	63	70	PF00069	0.425
MOD_GSK3_1	665	672	PF00069	0.563
MOD_GSK3_1	819	826	PF00069	0.653
MOD_GSK3_1	836	843	PF00069	0.484
MOD_GSK3_1	86	93	PF00069	0.632
MOD_N-GLC_1	481	486	PF02516	0.469
MOD_N-GLC_1	637	642	PF02516	0.623
MOD_NEK2_1	152	157	PF00069	0.363
MOD_NEK2_1	188	193	PF00069	0.414
MOD_NEK2_1	246	251	PF00069	0.503
MOD_NEK2_1	292	297	PF00069	0.388
MOD_NEK2_1	378	383	PF00069	0.512
MOD_NEK2_1	42	47	PF00069	0.377
MOD_NEK2_1	432	437	PF00069	0.361
MOD_NEK2_1	453	458	PF00069	0.673
MOD_NEK2_1	48	53	PF00069	0.499
MOD_NEK2_1	598	603	PF00069	0.616
MOD_NEK2_1	67	72	PF00069	0.369
MOD_NEK2_1	711	716	PF00069	0.613
MOD_NEK2_2	466	471	PF00069	0.363
MOD_NEK2_2	514	519	PF00069	0.432
MOD_PIKK_1	220	226	PF00454	0.618
MOD_PIKK_1	228	234	PF00454	0.587
MOD_PIKK_1	246	252	PF00454	0.482
MOD_PIKK_1	563	569	PF00454	0.719
MOD_PKA_1	766	772	PF00069	0.619
MOD_PKA_2	165	171	PF00069	0.465
MOD_PKA_2	354	360	PF00069	0.520
MOD_PKA_2	573	579	PF00069	0.615
MOD_PKA_2	598	604	PF00069	0.635
MOD_PKA_2	766	772	PF00069	0.619
MOD_PKB_1	134	142	PF00069	0.637
MOD_PKB_1	765	773	PF00069	0.564
MOD_Plk_1	188	194	PF00069	0.350
MOD_Plk_1	33	39	PF00069	0.400
MOD_Plk_1	366	372	PF00069	0.586
MOD_Plk_1	68	74	PF00069	0.381
MOD_Plk_2-3	427	433	PF00069	0.447
MOD_Plk_2-3	507	513	PF00069	0.393
MOD_Plk_2-3	86	92	PF00069	0.604
MOD_Plk_4	262	268	PF00069	0.528
MOD_Plk_4	288	294	PF00069	0.320
MOD_Plk_4	342	348	PF00069	0.471
MOD_Plk_4	427	433	PF00069	0.363
MOD_Plk_4	466	472	PF00069	0.368
MOD_Plk_4	507	513	PF00069	0.528
MOD_Plk_4	711	717	PF00069	0.613
MOD_ProDKin_1	107	113	PF00069	0.495
MOD_ProDKin_1	254	260	PF00069	0.591
MOD_ProDKin_1	313	319	PF00069	0.333
MOD_ProDKin_1	325	331	PF00069	0.415
MOD_ProDKin_1	549	555	PF00069	0.477
MOD_ProDKin_1	6	12	PF00069	0.454
MOD_ProDKin_1	784	790	PF00069	0.593
MOD_ProDKin_1	90	96	PF00069	0.662
MOD_SUMO_rev_2	632	637	PF00179	0.633
TRG_DiLeu_BaEn_1	507	512	PF01217	0.346
TRG_DiLeu_LyEn_5	483	488	PF01217	0.502
TRG_ENDOCYTIC_2	287	290	PF00928	0.373
TRG_ENDOCYTIC_2	425	428	PF00928	0.346
TRG_ENDOCYTIC_2	508	511	PF00928	0.394
TRG_ENDOCYTIC_2	658	661	PF00928	0.570
TRG_ER_diArg_1	238	241	PF00400	0.544
TRG_ER_diArg_1	605	608	PF00400	0.618
TRG_ER_diArg_1	706	709	PF00400	0.629
TRG_ER_diArg_1	765	767	PF00400	0.654
TRG_ER_diArg_1	803	805	PF00400	0.600
TRG_NES_CRM1_1	410	421	PF08389	0.338
TRG_NLS_MonoExtC_3	133	138	PF00514	0.659
TRG_NLS_MonoExtN_4	134	139	PF00514	0.655

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6V8	Leptomonas seymouri	46%	95%
A4H4J4	Leishmania braziliensis	73%	98%
A4HSR9	Leishmania infantum	100%	100%
E9AKQ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QJ51	Leishmania major	92%	100%