Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5P1_LEIDO

TriTrypDb:

LdBPK_060270.1 , LdCL_060007800 , LDHU3_06.0330

Length:

312

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H5P1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5P1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.622
CLV_C14_Caspase3-7	56	60	PF00656	0.557
CLV_C14_Caspase3-7	62	66	PF00656	0.466
CLV_NRD_NRD_1	129	131	PF00675	0.653
CLV_NRD_NRD_1	280	282	PF00675	0.651
CLV_NRD_NRD_1	29	31	PF00675	0.516
CLV_PCSK_KEX2_1	129	131	PF00082	0.679
CLV_PCSK_KEX2_1	143	145	PF00082	0.662
CLV_PCSK_KEX2_1	280	282	PF00082	0.629
CLV_PCSK_KEX2_1	29	31	PF00082	0.619
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.475
CLV_PCSK_SKI1_1	259	263	PF00082	0.645
DEG_Nend_UBRbox_2	1	3	PF02207	0.719
DOC_MAPK_MEF2A_6	76	85	PF00069	0.574
DOC_PP1_RVXF_1	82	88	PF00149	0.441
DOC_PP2B_LxvP_1	20	23	PF13499	0.427
DOC_PP4_FxxP_1	55	58	PF00568	0.572
DOC_USP7_MATH_1	273	277	PF00917	0.651
DOC_WW_Pin1_4	110	115	PF00397	0.591
DOC_WW_Pin1_4	176	181	PF00397	0.538
DOC_WW_Pin1_4	263	268	PF00397	0.628
LIG_14-3-3_CanoR_1	129	137	PF00244	0.569
LIG_14-3-3_CanoR_1	212	217	PF00244	0.613
LIG_14-3-3_CanoR_1	84	92	PF00244	0.461
LIG_FHA_1	120	126	PF00498	0.675
LIG_FHA_1	183	189	PF00498	0.617
LIG_FHA_1	44	50	PF00498	0.510
LIG_FHA_1	52	58	PF00498	0.449
LIG_FHA_2	2	8	PF00498	0.656
LIG_FHA_2	250	256	PF00498	0.666
LIG_FHA_2	60	66	PF00498	0.500
LIG_LIR_Apic_2	2	8	PF02991	0.656
LIG_LIR_Apic_2	215	219	PF02991	0.708
LIG_LIR_Apic_2	54	58	PF02991	0.575
LIG_LIR_Gen_1	15	23	PF02991	0.439
LIG_LIR_Gen_1	182	190	PF02991	0.680
LIG_LIR_Gen_1	89	100	PF02991	0.498
LIG_LIR_Nem_3	15	20	PF02991	0.444
LIG_LIR_Nem_3	177	181	PF02991	0.569
LIG_LIR_Nem_3	182	186	PF02991	0.570
LIG_LIR_Nem_3	264	268	PF02991	0.689
LIG_LIR_Nem_3	51	55	PF02991	0.582
LIG_LIR_Nem_3	89	95	PF02991	0.508
LIG_MYND_1	135	139	PF01753	0.594
LIG_PDZ_Class_3	307	312	PF00595	0.780
LIG_SH2_CRK	17	21	PF00017	0.453
LIG_SH2_CRK	265	269	PF00017	0.717
LIG_SH2_NCK_1	265	269	PF00017	0.721
LIG_SH2_STAT5	216	219	PF00017	0.585
LIG_SH3_2	77	82	PF14604	0.589
LIG_SH3_3	187	193	PF00018	0.654
LIG_SH3_3	74	80	PF00018	0.596
LIG_SUMO_SIM_par_1	121	127	PF11976	0.696
LIG_SUMO_SIM_par_1	18	24	PF11976	0.484
LIG_TRAF2_1	158	161	PF00917	0.667
LIG_TRAF2_1	307	310	PF00917	0.743
LIG_TRFH_1	186	190	PF08558	0.585
LIG_WRC_WIRS_1	183	188	PF05994	0.674
MOD_CK1_1	105	111	PF00069	0.581
MOD_CK1_1	124	130	PF00069	0.615
MOD_CK1_1	182	188	PF00069	0.585
MOD_CK1_1	21	27	PF00069	0.572
MOD_CK1_1	226	232	PF00069	0.609
MOD_CK1_1	271	277	PF00069	0.594
MOD_CK2_1	1	7	PF00069	0.700
MOD_Cter_Amidation	278	281	PF01082	0.629
MOD_GlcNHglycan	67	70	PF01048	0.489
MOD_GlcNHglycan	9	12	PF01048	0.659
MOD_GSK3_1	106	113	PF00069	0.514
MOD_GSK3_1	119	126	PF00069	0.527
MOD_GSK3_1	222	229	PF00069	0.703
MOD_GSK3_1	263	270	PF00069	0.571
MOD_GSK3_1	65	72	PF00069	0.596
MOD_GSK3_1	98	105	PF00069	0.552
MOD_N-GLC_1	85	90	PF02516	0.521
MOD_NEK2_1	1	6	PF00069	0.650
MOD_NEK2_1	106	111	PF00069	0.545
MOD_NEK2_1	123	128	PF00069	0.518
MOD_NEK2_1	204	209	PF00069	0.707
MOD_NEK2_1	288	293	PF00069	0.707
MOD_PIKK_1	128	134	PF00454	0.638
MOD_PKA_2	128	134	PF00069	0.583
MOD_Plk_1	1	7	PF00069	0.700
MOD_Plk_1	241	247	PF00069	0.603
MOD_Plk_2-3	250	256	PF00069	0.582
MOD_Plk_2-3	59	65	PF00069	0.606
MOD_Plk_4	182	188	PF00069	0.648
MOD_Plk_4	273	279	PF00069	0.619
MOD_Plk_4	98	104	PF00069	0.616
MOD_ProDKin_1	110	116	PF00069	0.598
MOD_ProDKin_1	176	182	PF00069	0.538
MOD_ProDKin_1	263	269	PF00069	0.630
MOD_SUMO_for_1	118	121	PF00179	0.668
TRG_ENDOCYTIC_2	17	20	PF00928	0.424
TRG_ENDOCYTIC_2	183	186	PF00928	0.684
TRG_ENDOCYTIC_2	265	268	PF00928	0.714
TRG_ENDOCYTIC_2	92	95	PF00928	0.482
TRG_ER_diArg_1	128	130	PF00400	0.605
TRG_ER_diArg_1	135	138	PF00400	0.574
TRG_ER_diArg_1	211	214	PF00400	0.584
TRG_ER_diArg_1	257	260	PF00400	0.668
TRG_ER_diArg_1	28	30	PF00400	0.590
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILE7	Leptomonas seymouri	71%	98%
A0A0S4J5W3	Bodo saltans	32%	100%
A0A1X0NK79	Trypanosomatidae	44%	81%
A0A3R7NJS2	Trypanosoma rangeli	52%	89%
A4H4J3	Leishmania braziliensis	88%	100%
A4HSR8	Leishmania infantum	100%	100%
C9ZTC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	85%
E9AKQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QJ52	Leishmania major	96%	100%
V5AQD0	Trypanosoma cruzi	53%	90%