Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 34

Species:

Leishmania donovani

UniProt:

A0A3S5H5N9_LEIDO

TriTrypDb:

LdBPK_060240.1 , LdCL_060007500 , LDHU3_06.0300

Length:

847

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	1
GO:0016020	membrane	2	3
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A0A3S5H5N9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5N9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	378	382	PF00656	0.645
CLV_C14_Caspase3-7	647	651	PF00656	0.537
CLV_NRD_NRD_1	270	272	PF00675	0.439
CLV_NRD_NRD_1	592	594	PF00675	0.603
CLV_NRD_NRD_1	753	755	PF00675	0.641
CLV_PCSK_KEX2_1	270	272	PF00082	0.439
CLV_PCSK_KEX2_1	4	6	PF00082	0.516
CLV_PCSK_KEX2_1	592	594	PF00082	0.602
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.516
CLV_PCSK_SKI1_1	195	199	PF00082	0.662
CLV_PCSK_SKI1_1	598	602	PF00082	0.493
CLV_PCSK_SKI1_1	696	700	PF00082	0.620
DEG_SCF_FBW7_1	731	738	PF00400	0.624
DOC_CKS1_1	153	158	PF01111	0.522
DOC_CKS1_1	577	582	PF01111	0.798
DOC_CKS1_1	732	737	PF01111	0.764
DOC_CYCLIN_RxL_1	146	157	PF00134	0.510
DOC_CYCLIN_RxL_1	318	329	PF00134	0.536
DOC_CYCLIN_yClb3_PxF_3	23	31	PF00134	0.341
DOC_CYCLIN_yCln2_LP_2	355	361	PF00134	0.527
DOC_CYCLIN_yCln2_LP_2	521	527	PF00134	0.572
DOC_CYCLIN_yCln2_LP_2	798	804	PF00134	0.587
DOC_MAPK_gen_1	318	327	PF00069	0.488
DOC_MAPK_MEF2A_6	318	327	PF00069	0.523
DOC_MAPK_MEF2A_6	35	44	PF00069	0.432
DOC_MAPK_MEF2A_6	536	543	PF00069	0.523
DOC_PP1_RVXF_1	147	154	PF00149	0.430
DOC_PP1_RVXF_1	634	640	PF00149	0.454
DOC_PP2B_LxvP_1	506	509	PF13499	0.552
DOC_PP4_FxxP_1	153	156	PF00568	0.481
DOC_PP4_FxxP_1	340	343	PF00568	0.582
DOC_PP4_FxxP_1	444	447	PF00568	0.467
DOC_PP4_FxxP_1	714	717	PF00568	0.693
DOC_PP4_FxxP_1	783	786	PF00568	0.631
DOC_USP7_MATH_1	158	162	PF00917	0.513
DOC_USP7_MATH_1	281	285	PF00917	0.584
DOC_USP7_MATH_1	410	414	PF00917	0.517
DOC_USP7_MATH_1	420	424	PF00917	0.453
DOC_USP7_MATH_1	451	455	PF00917	0.414
DOC_USP7_MATH_1	578	582	PF00917	0.609
DOC_USP7_MATH_1	666	670	PF00917	0.731
DOC_USP7_MATH_1	735	739	PF00917	0.671
DOC_USP7_MATH_1	764	768	PF00917	0.691
DOC_USP7_MATH_1	770	774	PF00917	0.651
DOC_USP7_MATH_1	819	823	PF00917	0.640
DOC_USP7_MATH_2	553	559	PF00917	0.618
DOC_WW_Pin1_4	152	157	PF00397	0.454
DOC_WW_Pin1_4	22	27	PF00397	0.406
DOC_WW_Pin1_4	549	554	PF00397	0.597
DOC_WW_Pin1_4	576	581	PF00397	0.778
DOC_WW_Pin1_4	731	736	PF00397	0.773
DOC_WW_Pin1_4	743	748	PF00397	0.660
LIG_14-3-3_CanoR_1	123	129	PF00244	0.387
LIG_14-3-3_CanoR_1	135	140	PF00244	0.503
LIG_14-3-3_CanoR_1	351	355	PF00244	0.483
LIG_14-3-3_CanoR_1	422	432	PF00244	0.720
LIG_14-3-3_CanoR_1	463	472	PF00244	0.424
LIG_14-3-3_CanoR_1	505	509	PF00244	0.535
LIG_14-3-3_CanoR_1	626	630	PF00244	0.468
LIG_APCC_ABBA_1	389	394	PF00400	0.485
LIG_BRCT_BRCA1_1	24	28	PF00533	0.481
LIG_BRCT_BRCA1_1	453	457	PF00533	0.372
LIG_BRCT_BRCA1_1	465	469	PF00533	0.431
LIG_BRCT_BRCA1_1	779	783	PF00533	0.644
LIG_EH_1	707	711	PF12763	0.569
LIG_EVH1_1	714	718	PF00568	0.657
LIG_FHA_1	285	291	PF00498	0.609
LIG_FHA_1	351	357	PF00498	0.499
LIG_FHA_1	448	454	PF00498	0.447
LIG_FHA_1	465	471	PF00498	0.450
LIG_FHA_1	529	535	PF00498	0.553
LIG_FHA_1	538	544	PF00498	0.455
LIG_FHA_1	549	555	PF00498	0.438
LIG_FHA_1	87	93	PF00498	0.467
LIG_FHA_2	308	314	PF00498	0.509
LIG_FHA_2	373	379	PF00498	0.614
LIG_FHA_2	44	50	PF00498	0.542
LIG_FHA_2	463	469	PF00498	0.359
LIG_FHA_2	513	519	PF00498	0.575
LIG_FHA_2	55	61	PF00498	0.412
LIG_FHA_2	669	675	PF00498	0.665
LIG_FHA_2	772	778	PF00498	0.671
LIG_Integrin_RGD_1	775	777	PF01839	0.607
LIG_Integrin_RGD_1	787	789	PF01839	0.657
LIG_LIR_Apic_2	127	133	PF02991	0.462
LIG_LIR_Apic_2	254	260	PF02991	0.600
LIG_LIR_Apic_2	442	447	PF02991	0.453
LIG_LIR_Apic_2	780	786	PF02991	0.685
LIG_LIR_Gen_1	101	110	PF02991	0.397
LIG_LIR_Gen_1	142	153	PF02991	0.392
LIG_LIR_Gen_1	159	170	PF02991	0.399
LIG_LIR_Gen_1	387	397	PF02991	0.474
LIG_LIR_Gen_1	401	411	PF02991	0.474
LIG_LIR_Gen_1	454	462	PF02991	0.471
LIG_LIR_Gen_1	466	477	PF02991	0.382
LIG_LIR_Gen_1	491	502	PF02991	0.573
LIG_LIR_Nem_3	101	105	PF02991	0.436
LIG_LIR_Nem_3	142	148	PF02991	0.367
LIG_LIR_Nem_3	159	165	PF02991	0.473
LIG_LIR_Nem_3	241	245	PF02991	0.669
LIG_LIR_Nem_3	387	392	PF02991	0.466
LIG_LIR_Nem_3	401	406	PF02991	0.432
LIG_LIR_Nem_3	43	47	PF02991	0.353
LIG_LIR_Nem_3	442	448	PF02991	0.373
LIG_LIR_Nem_3	454	458	PF02991	0.468
LIG_LIR_Nem_3	466	472	PF02991	0.392
LIG_LIR_Nem_3	491	497	PF02991	0.573
LIG_LIR_Nem_3	599	604	PF02991	0.513
LIG_PAM2_1	705	717	PF00658	0.685
LIG_PCNA_yPIPBox_3	4	14	PF02747	0.530
LIG_Pex14_1	257	261	PF04695	0.577
LIG_Pex14_1	441	445	PF04695	0.469
LIG_Pex14_2	24	28	PF04695	0.481
LIG_Pex14_2	639	643	PF04695	0.537
LIG_Pex14_2	710	714	PF04695	0.602
LIG_PTB_Apo_2	109	116	PF02174	0.297
LIG_SH2_CRK	145	149	PF00017	0.551
LIG_SH2_CRK	174	178	PF00017	0.531
LIG_SH2_CRK	237	241	PF00017	0.642
LIG_SH2_CRK	494	498	PF00017	0.579
LIG_SH2_NCK_1	278	282	PF00017	0.569
LIG_SH2_PTP2	130	133	PF00017	0.438
LIG_SH2_PTP2	445	448	PF00017	0.481
LIG_SH2_SRC	145	148	PF00017	0.436
LIG_SH2_SRC	278	281	PF00017	0.498
LIG_SH2_SRC	445	448	PF00017	0.481
LIG_SH2_STAP1	14	18	PF00017	0.615
LIG_SH2_STAP1	261	265	PF00017	0.538
LIG_SH2_STAT3	14	17	PF00017	0.461
LIG_SH2_STAT3	306	309	PF00017	0.607
LIG_SH2_STAT3	311	314	PF00017	0.514
LIG_SH2_STAT3	611	614	PF00017	0.448
LIG_SH2_STAT3	62	65	PF00017	0.540
LIG_SH2_STAT5	102	105	PF00017	0.374
LIG_SH2_STAT5	130	133	PF00017	0.382
LIG_SH2_STAT5	162	165	PF00017	0.468
LIG_SH2_STAT5	222	225	PF00017	0.611
LIG_SH2_STAT5	237	240	PF00017	0.557
LIG_SH2_STAT5	244	247	PF00017	0.531
LIG_SH2_STAT5	311	314	PF00017	0.527
LIG_SH2_STAT5	403	406	PF00017	0.530
LIG_SH2_STAT5	445	448	PF00017	0.420
LIG_SH2_STAT5	494	497	PF00017	0.479
LIG_SH2_STAT5	611	614	PF00017	0.424
LIG_SH2_STAT5	713	716	PF00017	0.672
LIG_SH2_STAT5	723	726	PF00017	0.632
LIG_SH2_STAT5	824	827	PF00017	0.566
LIG_SH2_STAT5	839	842	PF00017	0.560
LIG_SH3_1	582	588	PF00018	0.700
LIG_SH3_1	713	719	PF00018	0.658
LIG_SH3_2	577	582	PF14604	0.740
LIG_SH3_3	162	168	PF00018	0.602
LIG_SH3_3	20	26	PF00018	0.447
LIG_SH3_3	44	50	PF00018	0.506
LIG_SH3_3	513	519	PF00018	0.510
LIG_SH3_3	574	580	PF00018	0.723
LIG_SH3_3	582	588	PF00018	0.735
LIG_SH3_3	662	668	PF00018	0.502
LIG_SH3_3	712	718	PF00018	0.643
LIG_SUMO_SIM_anti_2	381	387	PF11976	0.398
LIG_SUMO_SIM_anti_2	489	494	PF11976	0.555
LIG_SUMO_SIM_par_1	352	357	PF11976	0.539
LIG_SUMO_SIM_par_1	37	43	PF11976	0.623
LIG_TRAF2_1	375	378	PF00917	0.565
LIG_TRAF2_1	515	518	PF00917	0.578
LIG_TRAF2_1	57	60	PF00917	0.466
LIG_TRAF2_1	794	797	PF00917	0.590
LIG_TYR_ITIM	492	497	PF00017	0.574
LIG_WRC_WIRS_1	209	214	PF05994	0.509
LIG_WRC_WIRS_1	41	46	PF05994	0.464
LIG_WRC_WIRS_1	469	474	PF05994	0.373
LIG_WW_3	584	588	PF00397	0.734
MOD_CDK_SPxK_1	576	582	PF00069	0.729
MOD_CK1_1	199	205	PF00069	0.675
MOD_CK1_1	210	216	PF00069	0.745
MOD_CK1_1	284	290	PF00069	0.607
MOD_CK1_1	350	356	PF00069	0.612
MOD_CK1_1	423	429	PF00069	0.498
MOD_CK1_1	549	555	PF00069	0.649
MOD_CK1_1	669	675	PF00069	0.722
MOD_CK1_1	686	692	PF00069	0.474
MOD_CK1_1	737	743	PF00069	0.705
MOD_CK1_1	791	797	PF00069	0.638
MOD_CK1_1	822	828	PF00069	0.551
MOD_CK2_1	307	313	PF00069	0.520
MOD_CK2_1	372	378	PF00069	0.586
MOD_CK2_1	43	49	PF00069	0.532
MOD_CK2_1	462	468	PF00069	0.404
MOD_CK2_1	512	518	PF00069	0.598
MOD_CK2_1	54	60	PF00069	0.403
MOD_CK2_1	549	555	PF00069	0.601
MOD_CK2_1	669	675	PF00069	0.590
MOD_CK2_1	791	797	PF00069	0.617
MOD_CK2_1	817	823	PF00069	0.532
MOD_Cter_Amidation	268	271	PF01082	0.582
MOD_DYRK1A_RPxSP_1	576	580	PF00069	0.689
MOD_GlcNHglycan	212	215	PF01048	0.615
MOD_GlcNHglycan	301	304	PF01048	0.722
MOD_GlcNHglycan	369	372	PF01048	0.669
MOD_GlcNHglycan	400	403	PF01048	0.636
MOD_GlcNHglycan	412	415	PF01048	0.529
MOD_GlcNHglycan	441	444	PF01048	0.345
MOD_GlcNHglycan	459	462	PF01048	0.444
MOD_GlcNHglycan	558	561	PF01048	0.694
MOD_GlcNHglycan	659	662	PF01048	0.753
MOD_GlcNHglycan	737	740	PF01048	0.745
MOD_GlcNHglycan	766	769	PF01048	0.664
MOD_GlcNHglycan	819	822	PF01048	0.536
MOD_GSK3_1	131	138	PF00069	0.508
MOD_GSK3_1	152	159	PF00069	0.452
MOD_GSK3_1	195	202	PF00069	0.599
MOD_GSK3_1	282	289	PF00069	0.670
MOD_GSK3_1	398	405	PF00069	0.482
MOD_GSK3_1	420	427	PF00069	0.624
MOD_GSK3_1	447	454	PF00069	0.492
MOD_GSK3_1	464	471	PF00069	0.436
MOD_GSK3_1	472	479	PF00069	0.531
MOD_GSK3_1	504	511	PF00069	0.528
MOD_GSK3_1	545	552	PF00069	0.594
MOD_GSK3_1	592	599	PF00069	0.630
MOD_GSK3_1	620	627	PF00069	0.479
MOD_GSK3_1	682	689	PF00069	0.622
MOD_GSK3_1	731	738	PF00069	0.691
MOD_GSK3_1	742	749	PF00069	0.652
MOD_GSK3_1	822	829	PF00069	0.521
MOD_N-GLC_1	367	372	PF02516	0.683
MOD_NEK2_1	124	129	PF00069	0.362
MOD_NEK2_1	196	201	PF00069	0.701
MOD_NEK2_1	208	213	PF00069	0.649
MOD_NEK2_1	457	462	PF00069	0.382
MOD_NEK2_1	472	477	PF00069	0.463
MOD_NEK2_1	504	509	PF00069	0.538
MOD_NEK2_1	546	551	PF00069	0.569
MOD_NEK2_1	817	822	PF00069	0.464
MOD_NEK2_1	826	831	PF00069	0.454
MOD_NEK2_2	113	118	PF00069	0.378
MOD_NEK2_2	451	456	PF00069	0.447
MOD_PIKK_1	620	626	PF00454	0.582
MOD_PIKK_1	683	689	PF00454	0.687
MOD_PIKK_1	777	783	PF00454	0.780
MOD_PIKK_1	788	794	PF00454	0.697
MOD_PK_1	135	141	PF00069	0.498
MOD_PK_1	596	602	PF00069	0.504
MOD_PKA_1	592	598	PF00069	0.608
MOD_PKA_2	223	229	PF00069	0.683
MOD_PKA_2	238	244	PF00069	0.637
MOD_PKA_2	350	356	PF00069	0.526
MOD_PKA_2	423	429	PF00069	0.734
MOD_PKA_2	462	468	PF00069	0.403
MOD_PKA_2	504	510	PF00069	0.541
MOD_PKA_2	592	598	PF00069	0.624
MOD_PKA_2	625	631	PF00069	0.565
MOD_PKB_1	422	430	PF00069	0.560
MOD_Plk_1	624	630	PF00069	0.554
MOD_Plk_1	71	77	PF00069	0.439
MOD_Plk_1	822	828	PF00069	0.474
MOD_Plk_4	158	164	PF00069	0.464
MOD_Plk_4	238	244	PF00069	0.541
MOD_Plk_4	307	313	PF00069	0.520
MOD_Plk_4	350	356	PF00069	0.509
MOD_Plk_4	402	408	PF00069	0.537
MOD_Plk_4	472	478	PF00069	0.455
MOD_Plk_4	488	494	PF00069	0.427
MOD_Plk_4	719	725	PF00069	0.663
MOD_ProDKin_1	152	158	PF00069	0.465
MOD_ProDKin_1	22	28	PF00069	0.407
MOD_ProDKin_1	549	555	PF00069	0.601
MOD_ProDKin_1	576	582	PF00069	0.782
MOD_ProDKin_1	731	737	PF00069	0.776
MOD_ProDKin_1	743	749	PF00069	0.654
MOD_SUMO_for_1	30	33	PF00179	0.527
TRG_DiLeu_BaEn_2	810	816	PF01217	0.411
TRG_DiLeu_BaEn_4	702	708	PF01217	0.580
TRG_DiLeu_BaLyEn_6	35	40	PF01217	0.497
TRG_ENDOCYTIC_2	102	105	PF00928	0.374
TRG_ENDOCYTIC_2	145	148	PF00928	0.553
TRG_ENDOCYTIC_2	162	165	PF00928	0.429
TRG_ENDOCYTIC_2	242	245	PF00928	0.585
TRG_ENDOCYTIC_2	403	406	PF00928	0.530
TRG_ENDOCYTIC_2	445	448	PF00928	0.420
TRG_ENDOCYTIC_2	494	497	PF00928	0.575
TRG_ER_diArg_1	270	272	PF00400	0.440
TRG_Pf-PMV_PEXEL_1	587	591	PF00026	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6D8	Leptomonas seymouri	59%	84%
A0A422MY92	Trypanosoma rangeli	30%	100%
A4H4J0	Leishmania braziliensis	81%	100%
A4HSR5	Leishmania infantum	100%	100%
C9ZTB5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	99%
E9AKQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	94%
Q4QJ55	Leishmania major	93%	100%
V5BEV7	Trypanosoma cruzi	30%	100%