Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5N8_LEIDO

TriTrypDb:

LdBPK_060230.1 , LdCL_060007400 , LDHU3_06.0290

Length:

213

Annotations

LeishMANIAdb annotations

Although obviously looks like a transporter, only very weak homologies exist outside KInetoplastids

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A0A3S5H5N8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5N8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	93	97	PF00656	0.557
CLV_NRD_NRD_1	29	31	PF00675	0.388
CLV_PCSK_KEX2_1	29	31	PF00082	0.378
CLV_PCSK_SKI1_1	152	156	PF00082	0.314
CLV_PCSK_SKI1_1	30	34	PF00082	0.297
CLV_PCSK_SKI1_1	84	88	PF00082	0.304
DOC_ANK_TNKS_1	201	208	PF00023	0.486
DOC_MAPK_gen_1	29	36	PF00069	0.519
DOC_MAPK_HePTP_8	26	38	PF00069	0.477
DOC_MAPK_MEF2A_6	29	38	PF00069	0.516
DOC_MAPK_RevD_3	15	30	PF00069	0.454
DOC_PP4_FxxP_1	201	204	PF00568	0.493
LIG_14-3-3_CanoR_1	152	160	PF00244	0.531
LIG_BRCT_BRCA1_1	125	129	PF00533	0.373
LIG_FHA_1	47	53	PF00498	0.489
LIG_LIR_Apic_2	199	204	PF02991	0.484
LIG_LIR_Gen_1	139	149	PF02991	0.324
LIG_LIR_Gen_1	72	83	PF02991	0.381
LIG_LIR_Nem_3	112	118	PF02991	0.364
LIG_LIR_Nem_3	139	144	PF02991	0.265
LIG_LIR_Nem_3	72	78	PF02991	0.378
LIG_Pex14_1	107	111	PF04695	0.331
LIG_Pex14_1	117	121	PF04695	0.402
LIG_SH2_CRK	111	115	PF00017	0.331
LIG_SH2_STAP1	111	115	PF00017	0.331
LIG_SH2_STAT5	111	114	PF00017	0.398
LIG_SH2_STAT5	141	144	PF00017	0.331
LIG_TYR_ITIM	109	114	PF00017	0.331
LIG_UBA3_1	13	22	PF00899	0.333
MOD_CK1_1	123	129	PF00069	0.366
MOD_CK1_1	153	159	PF00069	0.544
MOD_CK1_1	46	52	PF00069	0.469
MOD_CMANNOS	117	120	PF00535	0.398
MOD_GlcNHglycan	178	181	PF01048	0.343
MOD_GlcNHglycan	196	199	PF01048	0.403
MOD_GSK3_1	152	159	PF00069	0.578
MOD_GSK3_1	183	190	PF00069	0.342
MOD_N-GLC_1	24	29	PF02516	0.411
MOD_N-GLC_1	5	10	PF02516	0.310
MOD_NEK2_1	109	114	PF00069	0.417
MOD_NEK2_1	150	155	PF00069	0.558
MOD_NEK2_1	183	188	PF00069	0.261
MOD_NEK2_1	43	48	PF00069	0.350
MOD_NEK2_1	5	10	PF00069	0.294
MOD_NEK2_2	196	201	PF00069	0.223
MOD_NMyristoyl	1	7	PF02799	0.272
MOD_Plk_1	24	30	PF00069	0.613
MOD_Plk_1	5	11	PF00069	0.310
MOD_Plk_4	102	108	PF00069	0.324
MOD_Plk_4	109	115	PF00069	0.324
MOD_Plk_4	140	146	PF00069	0.307
MOD_Plk_4	183	189	PF00069	0.325
MOD_Plk_4	196	202	PF00069	0.360
MOD_Plk_4	32	38	PF00069	0.318
TRG_ENDOCYTIC_2	111	114	PF00928	0.416
TRG_ENDOCYTIC_2	121	124	PF00928	0.322
TRG_ENDOCYTIC_2	141	144	PF00928	0.331
TRG_ER_diArg_1	28	30	PF00400	0.595

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZR4	Leptomonas seymouri	62%	100%
A0A1X0NL26	Trypanosomatidae	35%	85%
A0A3R7N0V5	Trypanosoma rangeli	32%	97%
A4H4I9	Leishmania braziliensis	78%	100%
A4HSR4	Leishmania infantum	100%	100%
C9ZTB3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	94%