ULP_PROTEASE domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5N7_LEIDO

TriTrypDb:

LdBPK_060200.1 , LdCL_060006900 , LDHU3_06.0240

Length:

496

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H5N7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5N7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.628
CLV_C14_Caspase3-7	277	281	PF00656	0.724
CLV_NRD_NRD_1	139	141	PF00675	0.794
CLV_NRD_NRD_1	159	161	PF00675	0.771
CLV_NRD_NRD_1	193	195	PF00675	0.698
CLV_NRD_NRD_1	202	204	PF00675	0.606
CLV_NRD_NRD_1	217	219	PF00675	0.716
CLV_NRD_NRD_1	251	253	PF00675	0.707
CLV_NRD_NRD_1	267	269	PF00675	0.721
CLV_NRD_NRD_1	50	52	PF00675	0.774
CLV_NRD_NRD_1	55	57	PF00675	0.686
CLV_NRD_NRD_1	77	79	PF00675	0.778
CLV_PCSK_KEX2_1	139	141	PF00082	0.794
CLV_PCSK_KEX2_1	159	161	PF00082	0.772
CLV_PCSK_KEX2_1	192	194	PF00082	0.719
CLV_PCSK_KEX2_1	202	204	PF00082	0.604
CLV_PCSK_KEX2_1	217	219	PF00082	0.716
CLV_PCSK_KEX2_1	251	253	PF00082	0.707
CLV_PCSK_KEX2_1	267	269	PF00082	0.721
CLV_PCSK_KEX2_1	291	293	PF00082	0.705
CLV_PCSK_KEX2_1	494	496	PF00082	0.577
CLV_PCSK_KEX2_1	50	52	PF00082	0.774
CLV_PCSK_KEX2_1	55	57	PF00082	0.686
CLV_PCSK_KEX2_1	77	79	PF00082	0.778
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.705
CLV_PCSK_PC1ET2_1	494	496	PF00082	0.577
CLV_PCSK_PC7_1	46	52	PF00082	0.760
CLV_PCSK_PC7_1	490	496	PF00082	0.532
CLV_PCSK_SKI1_1	202	206	PF00082	0.633
CLV_PCSK_SKI1_1	231	235	PF00082	0.829
CLV_PCSK_SKI1_1	490	494	PF00082	0.508
CLV_PCSK_SKI1_1	78	82	PF00082	0.693
DEG_APCC_DBOX_1	77	85	PF00400	0.714
DEG_SPOP_SBC_1	467	471	PF00917	0.492
DOC_CKS1_1	310	315	PF01111	0.581
DOC_MAPK_DCC_7	252	262	PF00069	0.762
DOC_MAPK_DCC_7	294	304	PF00069	0.580
DOC_MAPK_gen_1	430	440	PF00069	0.548
DOC_MAPK_MEF2A_6	4	11	PF00069	0.704
DOC_MAPK_MEF2A_6	433	440	PF00069	0.534
DOC_PP2B_LxvP_1	254	257	PF13499	0.797
DOC_PP2B_LxvP_1	333	336	PF13499	0.691
DOC_USP7_MATH_1	121	125	PF00917	0.637
DOC_USP7_MATH_1	138	142	PF00917	0.770
DOC_USP7_MATH_1	178	182	PF00917	0.773
DOC_USP7_MATH_1	232	236	PF00917	0.716
DOC_USP7_MATH_1	261	265	PF00917	0.685
DOC_USP7_MATH_1	31	35	PF00917	0.706
DOC_USP7_MATH_1	325	329	PF00917	0.756
DOC_USP7_MATH_1	439	443	PF00917	0.585
DOC_USP7_MATH_1	467	471	PF00917	0.527
DOC_USP7_MATH_1	73	77	PF00917	0.777
DOC_USP7_UBL2_3	433	437	PF12436	0.555
DOC_WW_Pin1_4	10	15	PF00397	0.716
DOC_WW_Pin1_4	104	109	PF00397	0.626
DOC_WW_Pin1_4	309	314	PF00397	0.627
DOC_WW_Pin1_4	35	40	PF00397	0.699
LIG_14-3-3_CanoR_1	139	143	PF00244	0.704
LIG_14-3-3_CanoR_1	23	28	PF00244	0.686
LIG_14-3-3_CanoR_1	267	276	PF00244	0.817
LIG_14-3-3_CanoR_1	292	297	PF00244	0.678
LIG_14-3-3_CanoR_1	332	336	PF00244	0.703
LIG_14-3-3_CanoR_1	396	402	PF00244	0.443
LIG_14-3-3_CanoR_1	423	429	PF00244	0.523
LIG_14-3-3_CanoR_1	461	466	PF00244	0.549
LIG_14-3-3_CanoR_1	468	476	PF00244	0.466
LIG_14-3-3_CanoR_1	77	84	PF00244	0.715
LIG_Actin_WH2_2	408	425	PF00022	0.492
LIG_BIR_II_1	1	5	PF00653	0.701
LIG_BIR_III_2	135	139	PF00653	0.709
LIG_Clathr_ClatBox_1	412	416	PF01394	0.429
LIG_FHA_1	203	209	PF00498	0.733
LIG_FHA_1	232	238	PF00498	0.759
LIG_FHA_1	239	245	PF00498	0.692
LIG_FHA_1	257	263	PF00498	0.797
LIG_FHA_1	365	371	PF00498	0.751
LIG_FHA_1	412	418	PF00498	0.495
LIG_FHA_1	433	439	PF00498	0.583
LIG_FHA_1	446	452	PF00498	0.405
LIG_FHA_2	480	486	PF00498	0.496
LIG_FHA_2	86	92	PF00498	0.655
LIG_LIR_Apic_2	295	299	PF02991	0.735
LIG_LIR_Gen_1	460	467	PF02991	0.525
LIG_LIR_Nem_3	271	276	PF02991	0.734
LIG_LIR_Nem_3	460	466	PF02991	0.533
LIG_NRP_CendR_1	494	496	PF00754	0.577
LIG_SH2_CRK	463	467	PF00017	0.465
LIG_SH2_NCK_1	463	467	PF00017	0.511
LIG_SH2_STAP1	463	467	PF00017	0.465
LIG_SH2_STAT3	320	323	PF00017	0.807
LIG_SH2_STAT5	320	323	PF00017	0.687
LIG_SH2_STAT5	393	396	PF00017	0.480
LIG_SH2_STAT5	463	466	PF00017	0.469
LIG_SH3_3	16	22	PF00018	0.705
LIG_SH3_3	243	249	PF00018	0.711
LIG_SH3_3	255	261	PF00018	0.757
LIG_SH3_3	297	303	PF00018	0.702
LIG_SH3_3	318	324	PF00018	0.747
LIG_SH3_3	8	14	PF00018	0.716
LIG_SUMO_SIM_par_1	410	416	PF11976	0.447
LIG_SUMO_SIM_par_1	442	449	PF11976	0.574
LIG_WRC_WIRS_1	402	407	PF05994	0.494
LIG_WW_2	300	303	PF00397	0.574
MOD_CDK_SPxxK_3	309	316	PF00069	0.587
MOD_CK1_1	13	19	PF00069	0.708
MOD_CK1_1	152	158	PF00069	0.797
MOD_CK1_1	171	177	PF00069	0.753
MOD_CK1_1	26	32	PF00069	0.715
MOD_CK1_1	271	277	PF00069	0.811
MOD_CK1_1	282	288	PF00069	0.598
MOD_CK1_1	315	321	PF00069	0.690
MOD_CK1_1	76	82	PF00069	0.812
MOD_CK2_1	152	158	PF00069	0.820
MOD_CK2_1	292	298	PF00069	0.724
MOD_CK2_1	479	485	PF00069	0.498
MOD_CK2_1	85	91	PF00069	0.656
MOD_GlcNHglycan	123	126	PF01048	0.685
MOD_GlcNHglycan	127	130	PF01048	0.730
MOD_GlcNHglycan	154	157	PF01048	0.711
MOD_GlcNHglycan	180	183	PF01048	0.810
MOD_GlcNHglycan	220	223	PF01048	0.732
MOD_GlcNHglycan	234	237	PF01048	0.831
MOD_GlcNHglycan	275	279	PF01048	0.773
MOD_GlcNHglycan	29	32	PF01048	0.789
MOD_GlcNHglycan	327	330	PF01048	0.667
MOD_GlcNHglycan	33	36	PF01048	0.821
MOD_GlcNHglycan	346	349	PF01048	0.683
MOD_GlcNHglycan	381	384	PF01048	0.720
MOD_GlcNHglycan	409	412	PF01048	0.479
MOD_GlcNHglycan	98	101	PF01048	0.783
MOD_GSK3_1	104	111	PF00069	0.712
MOD_GSK3_1	112	119	PF00069	0.719
MOD_GSK3_1	121	128	PF00069	0.725
MOD_GSK3_1	13	20	PF00069	0.708
MOD_GSK3_1	164	171	PF00069	0.744
MOD_GSK3_1	23	30	PF00069	0.714
MOD_GSK3_1	256	263	PF00069	0.776
MOD_GSK3_1	274	281	PF00069	0.571
MOD_GSK3_1	282	289	PF00069	0.665
MOD_GSK3_1	305	312	PF00069	0.740
MOD_GSK3_1	31	38	PF00069	0.732
MOD_GSK3_1	397	404	PF00069	0.473
MOD_GSK3_1	407	414	PF00069	0.484
MOD_GSK3_1	467	474	PF00069	0.504
MOD_GSK3_1	85	92	PF00069	0.764
MOD_N-GLC_1	152	157	PF02516	0.818
MOD_N-GLC_1	178	183	PF02516	0.629
MOD_N-GLC_1	239	244	PF02516	0.775
MOD_N-GLC_1	278	283	PF02516	0.798
MOD_N-GLC_1	364	369	PF02516	0.632
MOD_NEK2_1	164	169	PF00069	0.766
MOD_NEK2_1	283	288	PF00069	0.797
MOD_NEK2_1	401	406	PF00069	0.495
MOD_NEK2_1	422	427	PF00069	0.602
MOD_NEK2_1	89	94	PF00069	0.759
MOD_NEK2_2	432	437	PF00069	0.633
MOD_NEK2_2	85	90	PF00069	0.578
MOD_PIKK_1	305	311	PF00454	0.798
MOD_PIKK_1	422	428	PF00454	0.605
MOD_PIKK_1	471	477	PF00454	0.501
MOD_PK_1	23	29	PF00069	0.714
MOD_PKA_1	202	208	PF00069	0.729
MOD_PKA_2	113	119	PF00069	0.803
MOD_PKA_2	138	144	PF00069	0.786
MOD_PKA_2	202	208	PF00069	0.729
MOD_PKA_2	315	321	PF00069	0.804
MOD_PKA_2	331	337	PF00069	0.477
MOD_PKA_2	422	428	PF00069	0.507
MOD_PKA_2	467	473	PF00069	0.501
MOD_PKA_2	76	82	PF00069	0.712
MOD_Plk_1	178	184	PF00069	0.777
MOD_Plk_1	239	245	PF00069	0.768
MOD_Plk_1	278	284	PF00069	0.715
MOD_Plk_4	315	321	PF00069	0.804
MOD_Plk_4	40	46	PF00069	0.778
MOD_Plk_4	439	445	PF00069	0.591
MOD_Plk_4	461	467	PF00069	0.489
MOD_ProDKin_1	10	16	PF00069	0.714
MOD_ProDKin_1	104	110	PF00069	0.629
MOD_ProDKin_1	309	315	PF00069	0.628
MOD_ProDKin_1	35	41	PF00069	0.699
MOD_SUMO_for_1	417	420	PF00179	0.498
TRG_ENDOCYTIC_2	463	466	PF00928	0.469
TRG_ER_diArg_1	138	140	PF00400	0.759
TRG_ER_diArg_1	192	194	PF00400	0.714
TRG_ER_diArg_1	201	203	PF00400	0.605
TRG_ER_diArg_1	216	218	PF00400	0.713
TRG_ER_diArg_1	267	270	PF00400	0.749
TRG_ER_diArg_1	49	51	PF00400	0.781
TRG_ER_diArg_1	54	56	PF00400	0.661

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6H1	Leptomonas seymouri	40%	87%
A4H4I6	Leishmania braziliensis	69%	98%
A4HSR1	Leishmania infantum	99%	100%
E9AKP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
Q4QJ59	Leishmania major	90%	100%