Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinesin-like protein

Species:

Leishmania donovani

UniProt:

A0A3S5H5N6_LEIDO

TriTrypDb:

LdBPK_060180.1 , LdCL_060006700 , LDHU3_06.0220

Length:

662

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005871	kinesin complex	3	1
GO:0005874	microtubule	6	9
GO:0005875	microtubule associated complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0099080	supramolecular complex	2	9
GO:0099081	supramolecular polymer	3	9
GO:0099512	supramolecular fiber	4	9
GO:0099513	polymeric cytoskeletal fiber	5	9
GO:0110165	cellular anatomical entity	1	9

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Expansion

Sequence features

A0A3S5H5N6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5N6

Function

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Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0009987	cellular process	1	11

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003774	cytoskeletal motor activity	1	11
GO:0003777	microtubule motor activity	2	11
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0005524	ATP binding	5	11
GO:0008017	microtubule binding	5	11
GO:0008092	cytoskeletal protein binding	3	11
GO:0015631	tubulin binding	4	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	262	266	PF00656	0.457
CLV_C14_Caspase3-7	340	344	PF00656	0.379
CLV_NRD_NRD_1	191	193	PF00675	0.392
CLV_NRD_NRD_1	197	199	PF00675	0.380
CLV_NRD_NRD_1	200	202	PF00675	0.337
CLV_NRD_NRD_1	207	209	PF00675	0.247
CLV_NRD_NRD_1	506	508	PF00675	0.525
CLV_NRD_NRD_1	514	516	PF00675	0.567
CLV_NRD_NRD_1	568	570	PF00675	0.786
CLV_NRD_NRD_1	577	579	PF00675	0.693

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVM1	Leptomonas seymouri	26%	71%
A0A0N1HY56	Leptomonas seymouri	52%	97%
A0A0S4ILK1	Bodo saltans	29%	77%
A0A0S4IP49	Bodo saltans	28%	82%
A0A0S4JN49	Bodo saltans	24%	91%
A0A0S4JQF7	Bodo saltans	28%	72%
A0A0S4KL43	Bodo saltans	30%	100%
A0A1X0NPH9	Trypanosomatidae	25%	72%
A0A1X0NQ03	Trypanosomatidae	26%	80%
A0A1X0P2B6	Trypanosomatidae	27%	100%

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