Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5N4_LEIDO

TriTrypDb:

LdBPK_060150.1 , LdCL_060006400 , LDHU3_06.0190

Length:

109

Annotations

LeishMANIAdb annotations

A single TM segment protein, possibly with a basic mitochondrial transit signal. Unique to kinetoplastids.. Localization: Mitochondrial (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A0A3S5H5N4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5N4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.438
CLV_NRD_NRD_1	16	18	PF00675	0.587
CLV_NRD_NRD_1	3	5	PF00675	0.667
CLV_NRD_NRD_1	82	84	PF00675	0.398
CLV_PCSK_KEX2_1	16	18	PF00082	0.587
CLV_PCSK_KEX2_1	3	5	PF00082	0.667
CLV_PCSK_KEX2_1	84	86	PF00082	0.375
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.391
DEG_Nend_Nbox_1	1	3	PF02207	0.458
DOC_MAPK_gen_1	3	12	PF00069	0.428
DOC_MAPK_MEF2A_6	3	12	PF00069	0.419
LIG_14-3-3_CanoR_1	3	10	PF00244	0.397
LIG_14-3-3_CanoR_1	98	102	PF00244	0.651
LIG_deltaCOP1_diTrp_1	20	26	PF00928	0.394
LIG_FHA_1	44	50	PF00498	0.411
LIG_Integrin_RGD_1	68	70	PF01839	0.350
LIG_LIR_Gen_1	20	31	PF02991	0.378
LIG_LIR_Gen_1	57	66	PF02991	0.443
LIG_LIR_Nem_3	20	26	PF02991	0.380
LIG_LIR_Nem_3	57	62	PF02991	0.433
LIG_SH2_CRK	59	63	PF00017	0.599
LIG_SH2_STAP1	99	103	PF00017	0.604
LIG_SH3_3	7	13	PF00018	0.425
LIG_UBA3_1	8	14	PF00899	0.504
MOD_CK2_1	70	76	PF00069	0.518
MOD_GlcNHglycan	72	75	PF01048	0.540
MOD_GSK3_1	90	97	PF00069	0.500
MOD_NEK2_1	2	7	PF00069	0.456
MOD_PIKK_1	34	40	PF00454	0.437
MOD_PKA_1	3	9	PF00069	0.501
MOD_PKA_2	2	8	PF00069	0.483
MOD_PKA_2	90	96	PF00069	0.514
MOD_PKA_2	97	103	PF00069	0.526
MOD_Plk_4	49	55	PF00069	0.349
TRG_DiLeu_BaLyEn_6	4	9	PF01217	0.564
TRG_ENDOCYTIC_2	59	62	PF00928	0.420
TRG_ER_diArg_1	16	19	PF00400	0.496
TRG_ER_diArg_1	2	4	PF00400	0.567
TRG_ER_diArg_1	82	85	PF00400	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCK1	Leptomonas seymouri	73%	97%
A0A0S4IYD5	Bodo saltans	62%	100%
A0A1X0NJA0	Trypanosomatidae	65%	100%
A0A422NCA7	Trypanosoma rangeli	62%	100%
A4H4I1	Leishmania braziliensis	88%	100%
A4HSQ6	Leishmania infantum	100%	100%
C9ZTA2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9AKP3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QJ64	Leishmania major	96%	100%