Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5N1_LEIDO

TriTrypDb:

LdBPK_060110.1 , LdCL_060006000 , LDHU3_06.0150

Length:

601

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005635	nuclear envelope	4	1
GO:0005794	Golgi apparatus	5	1
GO:0031090	organelle membrane	3	1
GO:0031965	nuclear membrane	4	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S5H5N1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5N1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	155	157	PF00675	0.541
CLV_NRD_NRD_1	213	215	PF00675	0.491
CLV_NRD_NRD_1	318	320	PF00675	0.353
CLV_NRD_NRD_1	590	592	PF00675	0.483
CLV_PCSK_KEX2_1	154	156	PF00082	0.540
CLV_PCSK_KEX2_1	213	215	PF00082	0.472
CLV_PCSK_KEX2_1	318	320	PF00082	0.407
CLV_PCSK_KEX2_1	590	592	PF00082	0.483
CLV_PCSK_SKI1_1	184	188	PF00082	0.498
CLV_PCSK_SKI1_1	496	500	PF00082	0.388
CLV_PCSK_SKI1_1	584	588	PF00082	0.460
CLV_PCSK_SKI1_1	7	11	PF00082	0.400
CLV_PCSK_SKI1_1	91	95	PF00082	0.403
DEG_APCC_DBOX_1	90	98	PF00400	0.462
DEG_Nend_UBRbox_1	1	4	PF02207	0.585
DEG_SPOP_SBC_1	280	284	PF00917	0.685
DEG_SPOP_SBC_1	285	289	PF00917	0.633
DOC_CYCLIN_RxL_1	2	13	PF00134	0.592
DOC_MAPK_gen_1	496	504	PF00069	0.500
DOC_MAPK_gen_1	50	60	PF00069	0.373
DOC_PP1_RVXF_1	195	202	PF00149	0.620
DOC_PP2B_LxvP_1	290	293	PF13499	0.552
DOC_USP7_MATH_1	100	104	PF00917	0.738
DOC_USP7_MATH_1	280	284	PF00917	0.758
DOC_USP7_MATH_1	285	289	PF00917	0.711
DOC_USP7_MATH_1	360	364	PF00917	0.676
DOC_USP7_MATH_1	374	378	PF00917	0.756
DOC_USP7_MATH_1	431	435	PF00917	0.632
DOC_USP7_MATH_1	593	597	PF00917	0.694
DOC_WW_Pin1_4	281	286	PF00397	0.750
LIG_14-3-3_CanoR_1	154	162	PF00244	0.687
LIG_14-3-3_CanoR_1	191	201	PF00244	0.663
LIG_14-3-3_CanoR_1	2	10	PF00244	0.565
LIG_14-3-3_CanoR_1	213	220	PF00244	0.656
LIG_14-3-3_CanoR_1	399	405	PF00244	0.668
LIG_14-3-3_CanoR_1	417	421	PF00244	0.512
LIG_14-3-3_CanoR_1	453	458	PF00244	0.489
LIG_14-3-3_CanoR_1	461	467	PF00244	0.551
LIG_14-3-3_CanoR_1	492	496	PF00244	0.584
LIG_14-3-3_CanoR_1	572	576	PF00244	0.558
LIG_Actin_WH2_2	568	586	PF00022	0.590
LIG_BRCT_BRCA1_1	426	430	PF00533	0.591
LIG_Clathr_ClatBox_1	9	13	PF01394	0.575
LIG_deltaCOP1_diTrp_1	474	480	PF00928	0.592
LIG_deltaCOP1_diTrp_1	69	79	PF00928	0.364
LIG_FHA_1	144	150	PF00498	0.710
LIG_FHA_1	384	390	PF00498	0.578
LIG_FHA_1	43	49	PF00498	0.369
LIG_FHA_1	510	516	PF00498	0.591
LIG_FHA_1	572	578	PF00498	0.520
LIG_FHA_2	113	119	PF00498	0.672
LIG_FHA_2	193	199	PF00498	0.705
LIG_FHA_2	595	601	PF00498	0.669
LIG_FHA_2	6	12	PF00498	0.653
LIG_LIR_Apic_2	366	372	PF02991	0.741
LIG_LIR_Gen_1	291	302	PF02991	0.570
LIG_LIR_Gen_1	31	40	PF02991	0.379
LIG_LIR_Gen_1	500	506	PF02991	0.595
LIG_LIR_Nem_3	291	297	PF02991	0.518
LIG_LIR_Nem_3	31	35	PF02991	0.379
LIG_LIR_Nem_3	39	43	PF02991	0.379
LIG_LIR_Nem_3	500	504	PF02991	0.507
LIG_LIR_Nem_3	524	529	PF02991	0.508
LIG_LIR_Nem_3	566	571	PF02991	0.597
LIG_NRBOX	387	393	PF00104	0.556
LIG_NRBOX	89	95	PF00104	0.344
LIG_Pex14_1	476	480	PF04695	0.571
LIG_Pex14_2	527	531	PF04695	0.557
LIG_SH2_CRK	568	572	PF00017	0.566
LIG_SH2_CRK	82	86	PF00017	0.252
LIG_SH2_GRB2like	259	262	PF00017	0.611
LIG_SH2_SRC	462	465	PF00017	0.576
LIG_SH2_STAP1	414	418	PF00017	0.564
LIG_SH2_STAT3	449	452	PF00017	0.487
LIG_SH2_STAT5	41	44	PF00017	0.266
LIG_SH2_STAT5	449	452	PF00017	0.525
LIG_SH2_STAT5	462	465	PF00017	0.547
LIG_SH2_STAT5	501	504	PF00017	0.531
LIG_SH2_STAT5	518	521	PF00017	0.572
LIG_SH2_STAT5	526	529	PF00017	0.480
LIG_SH3_1	368	374	PF00018	0.626
LIG_SH3_2	189	194	PF14604	0.647
LIG_SH3_3	186	192	PF00018	0.680
LIG_SH3_3	347	353	PF00018	0.635
LIG_SH3_3	368	374	PF00018	0.732
LIG_SH3_3	94	100	PF00018	0.598
LIG_SH3_4	262	269	PF00018	0.656
LIG_SUMO_SIM_anti_2	253	260	PF11976	0.649
LIG_SUMO_SIM_anti_2	31	37	PF11976	0.280
LIG_SUMO_SIM_par_1	573	579	PF11976	0.584
LIG_SUMO_SIM_par_1	61	71	PF11976	0.361
LIG_SUMO_SIM_par_1	8	13	PF11976	0.601
LIG_TRAF2_1	344	347	PF00917	0.562
LIG_TYR_ITIM	562	567	PF00017	0.532
LIG_TYR_ITIM	80	85	PF00017	0.358
LIG_UBA3_1	487	496	PF00899	0.563
LIG_WRC_WIRS_1	37	42	PF05994	0.338
LIG_WRC_WIRS_1	454	459	PF05994	0.482
MOD_CK1_1	136	142	PF00069	0.743
MOD_CK1_1	283	289	PF00069	0.695
MOD_CK1_1	363	369	PF00069	0.790
MOD_CK1_1	433	439	PF00069	0.613
MOD_CK1_1	465	471	PF00069	0.592
MOD_CK1_1	535	541	PF00069	0.633
MOD_CK2_1	112	118	PF00069	0.672
MOD_CK2_1	341	347	PF00069	0.578
MOD_CK2_1	436	442	PF00069	0.559
MOD_CK2_1	545	551	PF00069	0.500
MOD_CK2_1	594	600	PF00069	0.666
MOD_Cter_Amidation	588	591	PF01082	0.455
MOD_GlcNHglycan	102	105	PF01048	0.460
MOD_GlcNHglycan	214	217	PF01048	0.458
MOD_GlcNHglycan	220	223	PF01048	0.412
MOD_GlcNHglycan	243	246	PF01048	0.498
MOD_GlcNHglycan	269	272	PF01048	0.530
MOD_GlcNHglycan	362	365	PF01048	0.532
MOD_GlcNHglycan	425	429	PF01048	0.350
MOD_GlcNHglycan	433	436	PF01048	0.401
MOD_GlcNHglycan	468	471	PF01048	0.456
MOD_GlcNHglycan	477	480	PF01048	0.460
MOD_GSK3_1	1	8	PF00069	0.668
MOD_GSK3_1	122	129	PF00069	0.769
MOD_GSK3_1	279	286	PF00069	0.807
MOD_GSK3_1	302	309	PF00069	0.559
MOD_GSK3_1	359	366	PF00069	0.722
MOD_GSK3_1	383	390	PF00069	0.618
MOD_GSK3_1	426	433	PF00069	0.615
MOD_GSK3_1	462	469	PF00069	0.582
MOD_GSK3_1	505	512	PF00069	0.597
MOD_GSK3_1	535	542	PF00069	0.616
MOD_GSK3_1	594	601	PF00069	0.778
MOD_LATS_1	265	271	PF00433	0.660
MOD_N-GLC_1	133	138	PF02516	0.483
MOD_N-GLC_1	466	471	PF02516	0.419
MOD_N-GLC_1	535	540	PF02516	0.336
MOD_NEK2_1	1	6	PF00069	0.566
MOD_NEK2_1	302	307	PF00069	0.539
MOD_NEK2_1	424	429	PF00069	0.581
MOD_NEK2_1	491	496	PF00069	0.591
MOD_NEK2_1	539	544	PF00069	0.625
MOD_NEK2_1	81	86	PF00069	0.299
MOD_PIKK_1	133	139	PF00454	0.654
MOD_PIKK_1	398	404	PF00454	0.568
MOD_PIKK_1	509	515	PF00454	0.590
MOD_PK_1	182	188	PF00069	0.576
MOD_PKA_1	154	160	PF00069	0.687
MOD_PKA_2	1	7	PF00069	0.575
MOD_PKA_2	154	160	PF00069	0.802
MOD_PKA_2	162	168	PF00069	0.608
MOD_PKA_2	212	218	PF00069	0.699
MOD_PKA_2	398	404	PF00069	0.568
MOD_PKA_2	416	422	PF00069	0.519
MOD_PKA_2	436	442	PF00069	0.617
MOD_PKA_2	491	497	PF00069	0.576
MOD_PKA_2	571	577	PF00069	0.596
MOD_PKB_1	124	132	PF00069	0.702
MOD_PKB_1	267	275	PF00069	0.667
MOD_PKB_1	530	538	PF00069	0.617
MOD_Plk_1	142	148	PF00069	0.714
MOD_Plk_1	302	308	PF00069	0.499
MOD_Plk_1	535	541	PF00069	0.546
MOD_Plk_4	136	142	PF00069	0.676
MOD_Plk_4	182	188	PF00069	0.576
MOD_Plk_4	28	34	PF00069	0.471
MOD_Plk_4	36	42	PF00069	0.274
MOD_Plk_4	387	393	PF00069	0.612
MOD_Plk_4	535	541	PF00069	0.573
MOD_Plk_4	545	551	PF00069	0.484
MOD_Plk_4	59	65	PF00069	0.420
MOD_ProDKin_1	281	287	PF00069	0.745
MOD_SUMO_rev_2	256	264	PF00179	0.648
TRG_ENDOCYTIC_2	501	504	PF00928	0.481
TRG_ENDOCYTIC_2	526	529	PF00928	0.487
TRG_ENDOCYTIC_2	564	567	PF00928	0.503
TRG_ENDOCYTIC_2	568	571	PF00928	0.509
TRG_ENDOCYTIC_2	82	85	PF00928	0.399
TRG_ER_diArg_1	154	156	PF00400	0.740
TRG_ER_diArg_1	318	320	PF00400	0.623
TRG_ER_diArg_1	75	78	PF00400	0.324
TRG_NES_CRM1_1	551	566	PF08389	0.569
TRG_NES_CRM1_1	576	588	PF08389	0.585
TRG_Pf-PMV_PEXEL_1	318	323	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	496	500	PF00026	0.388
TRG_Pf-PMV_PEXEL_1	7	11	PF00026	0.387

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZR5	Leptomonas seymouri	57%	99%
A0A0S4J1D5	Bodo saltans	30%	94%
A0A1X0NL56	Trypanosomatidae	37%	100%
A0A3R7NA89	Trypanosoma rangeli	36%	100%
A4H4H7	Leishmania braziliensis	82%	100%
A4HSQ2	Leishmania infantum	100%	100%
E9AKN9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QJ68	Leishmania major	95%	100%
V5AP94	Trypanosoma cruzi	34%	100%