Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5M8_LEIDO

TriTrypDb:

LdBPK_060060.1 , LdCL_060005500 , LDHU3_06.0090

Length:

322

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H5M8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5M8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	168	170	PF00675	0.465
CLV_NRD_NRD_1	197	199	PF00675	0.563
CLV_NRD_NRD_1	240	242	PF00675	0.620
CLV_NRD_NRD_1	73	75	PF00675	0.741
CLV_NRD_NRD_1	88	90	PF00675	0.406
CLV_PCSK_KEX2_1	155	157	PF00082	0.562
CLV_PCSK_KEX2_1	168	170	PF00082	0.392
CLV_PCSK_KEX2_1	197	199	PF00082	0.563
CLV_PCSK_KEX2_1	87	89	PF00082	0.463
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.501
CLV_PCSK_SKI1_1	88	92	PF00082	0.414
DEG_APCC_DBOX_1	217	225	PF00400	0.498
DEG_Nend_UBRbox_3	1	3	PF02207	0.691
DOC_PP2B_LxvP_1	297	300	PF13499	0.626
DOC_USP7_MATH_1	109	113	PF00917	0.420
DOC_USP7_MATH_1	226	230	PF00917	0.575
DOC_USP7_MATH_1	291	295	PF00917	0.648
DOC_USP7_MATH_1	311	315	PF00917	0.558
DOC_USP7_UBL2_3	129	133	PF12436	0.455
DOC_WW_Pin1_4	233	238	PF00397	0.636
DOC_WW_Pin1_4	309	314	PF00397	0.617
LIG_14-3-3_CanoR_1	182	192	PF00244	0.496
LIG_14-3-3_CanoR_1	278	285	PF00244	0.665
LIG_14-3-3_CanoR_1	88	94	PF00244	0.474
LIG_Actin_WH2_2	14	29	PF00022	0.450
LIG_Actin_WH2_2	204	222	PF00022	0.482
LIG_FHA_1	144	150	PF00498	0.594
LIG_FHA_2	123	129	PF00498	0.477
LIG_FHA_2	234	240	PF00498	0.621
LIG_FHA_2	26	32	PF00498	0.444
LIG_FHA_2	43	49	PF00498	0.513
LIG_FHA_2	90	96	PF00498	0.468
LIG_PCNA_yPIPBox_3	91	104	PF02747	0.468
LIG_SH2_NCK_1	176	180	PF00017	0.446
LIG_SH2_STAP1	119	123	PF00017	0.454
LIG_SH2_STAT3	119	122	PF00017	0.430
LIG_SH2_STAT5	80	83	PF00017	0.484
LIG_SH3_3	282	288	PF00018	0.668
LIG_TRAF2_1	206	209	PF00917	0.517
LIG_TRAF2_1	236	239	PF00917	0.566
LIG_UBA3_1	160	166	PF00899	0.416
LIG_UBA3_1	34	40	PF00899	0.433
MOD_CK1_1	112	118	PF00069	0.479
MOD_CK1_1	143	149	PF00069	0.531
MOD_CK1_1	183	189	PF00069	0.450
MOD_CK1_1	231	237	PF00069	0.588
MOD_CK1_1	267	273	PF00069	0.516
MOD_CK1_1	7	13	PF00069	0.679
MOD_CK1_1	79	85	PF00069	0.492
MOD_CK2_1	122	128	PF00069	0.549
MOD_CK2_1	171	177	PF00069	0.516
MOD_CK2_1	203	209	PF00069	0.443
MOD_CK2_1	233	239	PF00069	0.689
MOD_CK2_1	25	31	PF00069	0.532
MOD_CK2_1	42	48	PF00069	0.366
MOD_Cter_Amidation	72	75	PF01082	0.529
MOD_GlcNHglycan	114	117	PF01048	0.446
MOD_GlcNHglycan	172	176	PF01048	0.457
MOD_GlcNHglycan	226	229	PF01048	0.647
MOD_GlcNHglycan	246	249	PF01048	0.591
MOD_GlcNHglycan	7	10	PF01048	0.642
MOD_GSK3_1	1	8	PF00069	0.584
MOD_GSK3_1	180	187	PF00069	0.425
MOD_GSK3_1	224	231	PF00069	0.563
MOD_GSK3_1	233	240	PF00069	0.597
MOD_GSK3_1	289	296	PF00069	0.690
MOD_LATS_1	276	282	PF00433	0.530
MOD_N-GLC_1	1	6	PF02516	0.576
MOD_NEK2_1	1	6	PF00069	0.601
MOD_NEK2_1	184	189	PF00069	0.434
MOD_NEK2_1	272	277	PF00069	0.642
MOD_NEK2_1	42	47	PF00069	0.553
MOD_PIKK_1	122	128	PF00454	0.456
MOD_PIKK_1	267	273	PF00454	0.544
MOD_PIKK_1	278	284	PF00454	0.553
MOD_PKA_1	74	80	PF00069	0.502
MOD_PKA_1	98	104	PF00069	0.466
MOD_PKB_1	87	95	PF00069	0.499
MOD_Plk_1	1	7	PF00069	0.577
MOD_Plk_1	109	115	PF00069	0.422
MOD_Plk_1	171	177	PF00069	0.511
MOD_Plk_4	76	82	PF00069	0.519
MOD_ProDKin_1	233	239	PF00069	0.636
MOD_ProDKin_1	309	315	PF00069	0.620
MOD_SUMO_rev_2	94	100	PF00179	0.484
TRG_ER_diArg_1	167	169	PF00400	0.460
TRG_ER_diArg_1	197	199	PF00400	0.545
TRG_ER_diArg_1	218	221	PF00400	0.510
TRG_ER_diArg_1	86	89	PF00400	0.465
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.371
TRG_Pf-PMV_PEXEL_1	278	282	PF00026	0.590

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D4	Leptomonas seymouri	39%	80%
A4H4H4	Leishmania braziliensis	68%	100%
A4HSP9	Leishmania infantum	99%	100%
E9AKN4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QJ73	Leishmania major	86%	100%