Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H5M7_LEIDO

TriTrypDb:

LdBPK_060030.1 , LdCL_060005200 , LDHU3_06.0050

Length:

675

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	17
GO:0032991	protein-containing complex	1	17
GO:0043226	organelle	2	17
GO:0043228	non-membrane-bounded organelle	3	17
GO:0043229	intracellular organelle	3	17
GO:0043232	intracellular non-membrane-bounded organelle	4	17
GO:0110165	cellular anatomical entity	1	17
GO:1990904	ribonucleoprotein complex	2	17
GO:0000974	Prp19 complex	2	1
GO:0005654	nucleoplasm	2	1
GO:0005681	spliceosomal complex	3	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:0097361	CIA complex	3	1
GO:0140535	intracellular protein-containing complex	2	1
GO:0005730	nucleolus	5	1

Expansion

Sequence features

A0A3S5H5M7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5M7

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	3
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	3
GO:0000398	mRNA splicing, via spliceosome	8	3
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006396	RNA processing	6	3
GO:0006397	mRNA processing	7	3
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	4
GO:0008380	RNA splicing	7	3
GO:0009987	cellular process	1	4
GO:0016070	RNA metabolic process	5	3
GO:0016071	mRNA metabolic process	6	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	3
GO:0046483	heterocycle metabolic process	3	3
GO:0071704	organic substance metabolic process	2	3
GO:0090304	nucleic acid metabolic process	4	3
GO:1901360	organic cyclic compound metabolic process	3	3
GO:0006790	sulfur compound metabolic process	3	1
GO:0016043	cellular component organization	3	1
GO:0016226	iron-sulfur cluster assembly	4	1
GO:0022607	cellular component assembly	4	1
GO:0031163	metallo-sulfur cluster assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.686
CLV_C14_Caspase3-7	48	52	PF00656	0.547
CLV_C14_Caspase3-7	526	530	PF00656	0.530
CLV_NRD_NRD_1	172	174	PF00675	0.569
CLV_NRD_NRD_1	175	177	PF00675	0.581
CLV_NRD_NRD_1	23	25	PF00675	0.559
CLV_NRD_NRD_1	298	300	PF00675	0.571
CLV_PCSK_KEX2_1	126	128	PF00082	0.638
CLV_PCSK_KEX2_1	23	25	PF00082	0.614
CLV_PCSK_KEX2_1	242	244	PF00082	0.750
CLV_PCSK_KEX2_1	673	675	PF00082	0.553
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.638
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.836
CLV_PCSK_PC7_1	238	244	PF00082	0.632
CLV_PCSK_SKI1_1	107	111	PF00082	0.512
CLV_PCSK_SKI1_1	300	304	PF00082	0.539
CLV_PCSK_SKI1_1	455	459	PF00082	0.317
CLV_PCSK_SKI1_1	467	471	PF00082	0.438
CLV_PCSK_SKI1_1	509	513	PF00082	0.317
CLV_PCSK_SKI1_1	541	545	PF00082	0.323
CLV_PCSK_SKI1_1	574	578	PF00082	0.324
CLV_PCSK_SKI1_1	657	661	PF00082	0.436
DEG_SCF_FBW7_1	278	285	PF00400	0.474
DEG_SPOP_SBC_1	448	452	PF00917	0.573
DOC_ANK_TNKS_1	356	363	PF00023	0.581
DOC_CKS1_1	279	284	PF01111	0.484
DOC_MAPK_gen_1	113	122	PF00069	0.543
DOC_MAPK_gen_1	126	133	PF00069	0.634
DOC_MAPK_gen_1	23	33	PF00069	0.448
DOC_MAPK_gen_1	295	305	PF00069	0.574
DOC_MAPK_HePTP_8	255	267	PF00069	0.690
DOC_MAPK_HePTP_8	293	305	PF00069	0.629
DOC_MAPK_MEF2A_6	24	33	PF00069	0.477
DOC_MAPK_MEF2A_6	258	267	PF00069	0.696
DOC_MAPK_MEF2A_6	296	305	PF00069	0.638
DOC_PP1_RVXF_1	3	9	PF00149	0.473
DOC_USP7_MATH_1	154	158	PF00917	0.546
DOC_USP7_MATH_1	185	189	PF00917	0.639
DOC_USP7_MATH_1	193	197	PF00917	0.751
DOC_USP7_MATH_1	198	202	PF00917	0.711
DOC_USP7_MATH_1	203	207	PF00917	0.691
DOC_USP7_MATH_1	257	261	PF00917	0.765
DOC_USP7_MATH_1	282	286	PF00917	0.674
DOC_USP7_MATH_1	449	453	PF00917	0.534
DOC_USP7_MATH_1	84	88	PF00917	0.883
DOC_USP7_UBL2_3	177	181	PF12436	0.629
DOC_USP7_UBL2_3	291	295	PF12436	0.451
DOC_USP7_UBL2_3	296	300	PF12436	0.457
DOC_USP7_UBL2_3	5	9	PF12436	0.508
DOC_USP7_UBL2_3	75	79	PF12436	0.609
DOC_WW_Pin1_4	278	283	PF00397	0.502
DOC_WW_Pin1_4	397	402	PF00397	0.530
DOC_WW_Pin1_4	439	444	PF00397	0.540
LIG_14-3-3_CanoR_1	447	457	PF00244	0.540
LIG_14-3-3_CanoR_1	514	519	PF00244	0.505
LIG_14-3-3_CanoR_1	595	600	PF00244	0.587
LIG_14-3-3_CanoR_1	631	638	PF00244	0.384
LIG_APCC_ABBA_1	320	325	PF00400	0.563
LIG_APCC_ABBA_1	62	67	PF00400	0.624
LIG_BIR_II_1	1	5	PF00653	0.521
LIG_BIR_III_4	184	188	PF00653	0.600
LIG_BRCT_BRCA1_1	521	525	PF00533	0.517
LIG_deltaCOP1_diTrp_1	624	630	PF00928	0.507
LIG_FHA_1	139	145	PF00498	0.666
LIG_FHA_1	273	279	PF00498	0.626
LIG_FHA_1	367	373	PF00498	0.660
LIG_FHA_1	38	44	PF00498	0.667
LIG_FHA_1	412	418	PF00498	0.642
LIG_FHA_1	454	460	PF00498	0.512
LIG_FHA_1	484	490	PF00498	0.615
LIG_FHA_1	496	502	PF00498	0.518
LIG_FHA_1	506	512	PF00498	0.378
LIG_FHA_1	658	664	PF00498	0.403
LIG_FHA_2	157	163	PF00498	0.550
LIG_FHA_2	43	49	PF00498	0.536
LIG_FHA_2	96	102	PF00498	0.631
LIG_GBD_Chelix_1	320	328	PF00786	0.504
LIG_LIR_Gen_1	161	170	PF02991	0.508
LIG_LIR_Gen_1	285	293	PF02991	0.501
LIG_LIR_Gen_1	563	569	PF02991	0.641
LIG_LIR_Gen_1	580	591	PF02991	0.502
LIG_LIR_Gen_1	624	629	PF02991	0.494
LIG_LIR_Nem_3	118	122	PF02991	0.503
LIG_LIR_Nem_3	16	20	PF02991	0.615
LIG_LIR_Nem_3	161	167	PF02991	0.510
LIG_LIR_Nem_3	285	289	PF02991	0.512
LIG_LIR_Nem_3	563	568	PF02991	0.652
LIG_LIR_Nem_3	580	586	PF02991	0.446
LIG_NRP_CendR_1	673	675	PF00754	0.444
LIG_Pex14_1	565	569	PF04695	0.507
LIG_Pex14_2	521	525	PF04695	0.507
LIG_SH2_CRK	279	283	PF00017	0.517
LIG_SH2_GRB2like	374	377	PF00017	0.580
LIG_SH2_PTP2	119	122	PF00017	0.441
LIG_SH2_STAP1	583	587	PF00017	0.612
LIG_SH2_STAT5	119	122	PF00017	0.660
LIG_SH2_STAT5	266	269	PF00017	0.515
LIG_SH2_STAT5	395	398	PF00017	0.511
LIG_SH2_STAT5	479	482	PF00017	0.554
LIG_SH2_STAT5	575	578	PF00017	0.612
LIG_SH2_STAT5	617	620	PF00017	0.507
LIG_SH3_1	238	244	PF00018	0.594
LIG_SH3_2	342	347	PF14604	0.600
LIG_SH3_3	117	123	PF00018	0.430
LIG_SH3_3	238	244	PF00018	0.697
LIG_SH3_3	339	345	PF00018	0.587
LIG_SUMO_SIM_par_1	38	45	PF11976	0.399
LIG_TRAF2_1	135	138	PF00917	0.490
LIG_TRAF2_1	158	161	PF00917	0.584
LIG_TYR_ITIM	117	122	PF00017	0.633
LIG_UBA3_1	28	34	PF00899	0.445
LIG_WRC_WIRS_1	146	151	PF05994	0.531
LIG_WRC_WIRS_1	43	48	PF05994	0.607
MOD_CDK_SPK_2	397	402	PF00069	0.573
MOD_CDK_SPK_2	439	444	PF00069	0.517
MOD_CK1_1	388	394	PF00069	0.558
MOD_CK1_1	461	467	PF00069	0.570
MOD_CK1_1	494	500	PF00069	0.515
MOD_CK2_1	132	138	PF00069	0.618
MOD_CK2_1	154	160	PF00069	0.546
MOD_CK2_1	208	214	PF00069	0.581
MOD_CK2_1	337	343	PF00069	0.657
MOD_CK2_1	372	378	PF00069	0.576
MOD_CK2_1	42	48	PF00069	0.548
MOD_CK2_1	482	488	PF00069	0.464
MOD_CK2_1	630	636	PF00069	0.482
MOD_CK2_1	67	73	PF00069	0.640
MOD_CK2_1	95	101	PF00069	0.788
MOD_Cter_Amidation	124	127	PF01082	0.515
MOD_Cter_Amidation	297	300	PF01082	0.527
MOD_GlcNHglycan	123	126	PF01048	0.556
MOD_GlcNHglycan	201	204	PF01048	0.691
MOD_GlcNHglycan	259	262	PF01048	0.705
MOD_GlcNHglycan	272	275	PF01048	0.631
MOD_GlcNHglycan	387	390	PF01048	0.299
MOD_GlcNHglycan	491	494	PF01048	0.336
MOD_GlcNHglycan	535	538	PF01048	0.347
MOD_GlcNHglycan	577	580	PF01048	0.363
MOD_GlcNHglycan	69	72	PF01048	0.675
MOD_GlcNHglycan	85	89	PF01048	0.767
MOD_GSK3_1	199	206	PF00069	0.766
MOD_GSK3_1	253	260	PF00069	0.649
MOD_GSK3_1	278	285	PF00069	0.588
MOD_GSK3_1	37	44	PF00069	0.405
MOD_GSK3_1	379	386	PF00069	0.492
MOD_GSK3_1	407	414	PF00069	0.504
MOD_GSK3_1	419	426	PF00069	0.455
MOD_GSK3_1	435	442	PF00069	0.632
MOD_GSK3_1	449	456	PF00069	0.535
MOD_GSK3_1	459	466	PF00069	0.588
MOD_GSK3_1	491	498	PF00069	0.532
MOD_GSK3_1	505	512	PF00069	0.452
MOD_GSK3_1	519	526	PF00069	0.526
MOD_GSK3_1	563	570	PF00069	0.501
MOD_GSK3_1	587	594	PF00069	0.635
MOD_N-GLC_1	13	18	PF02516	0.670
MOD_N-GLC_1	177	182	PF02516	0.594
MOD_N-GLC_1	270	275	PF02516	0.569
MOD_N-GLC_1	379	384	PF02516	0.419
MOD_N-GLC_1	483	488	PF02516	0.314
MOD_NEK2_1	253	258	PF00069	0.666
MOD_NEK2_1	301	306	PF00069	0.538
MOD_NEK2_1	324	329	PF00069	0.570
MOD_NEK2_1	337	342	PF00069	0.597
MOD_NEK2_1	353	358	PF00069	0.818
MOD_NEK2_1	364	369	PF00069	0.785
MOD_NEK2_1	372	377	PF00069	0.638
MOD_NEK2_1	405	410	PF00069	0.560
MOD_NEK2_1	459	464	PF00069	0.660
MOD_NEK2_1	489	494	PF00069	0.540
MOD_NEK2_1	533	538	PF00069	0.598
MOD_NEK2_1	587	592	PF00069	0.638
MOD_NEK2_1	658	663	PF00069	0.363
MOD_NEK2_2	145	150	PF00069	0.580
MOD_NEK2_2	495	500	PF00069	0.505
MOD_PIKK_1	503	509	PF00454	0.561
MOD_PIKK_1	56	62	PF00454	0.629
MOD_PK_1	623	629	PF00069	0.573
MOD_PKA_2	172	178	PF00069	0.708
MOD_PKA_2	257	263	PF00069	0.675
MOD_PKA_2	351	357	PF00069	0.781
MOD_PKA_2	630	636	PF00069	0.384
MOD_Plk_1	13	19	PF00069	0.480
MOD_Plk_1	324	330	PF00069	0.558
MOD_Plk_1	37	43	PF00069	0.514
MOD_Plk_1	411	417	PF00069	0.507
MOD_Plk_1	453	459	PF00069	0.546
MOD_Plk_1	495	501	PF00069	0.547
MOD_Plk_1	623	629	PF00069	0.526
MOD_Plk_2-3	156	162	PF00069	0.659
MOD_Plk_4	115	121	PF00069	0.459
MOD_Plk_4	301	307	PF00069	0.529
MOD_Plk_4	37	43	PF00069	0.408
MOD_Plk_4	423	429	PF00069	0.443
MOD_Plk_4	553	559	PF00069	0.523
MOD_Plk_4	560	566	PF00069	0.486
MOD_Plk_4	637	643	PF00069	0.481
MOD_Plk_4	644	650	PF00069	0.327
MOD_ProDKin_1	278	284	PF00069	0.498
MOD_ProDKin_1	397	403	PF00069	0.530
MOD_ProDKin_1	439	445	PF00069	0.540
MOD_SUMO_rev_2	239	244	PF00179	0.596
MOD_SUMO_rev_2	288	297	PF00179	0.500
MOD_SUMO_rev_2	325	335	PF00179	0.580
MOD_SUMO_rev_2	652	659	PF00179	0.528
MOD_SUMO_rev_2	661	667	PF00179	0.449
MOD_SUMO_rev_2	67	76	PF00179	0.563
TRG_DiLeu_BaEn_1	161	166	PF01217	0.522
TRG_DiLeu_BaEn_1	553	558	PF01217	0.598
TRG_DiLeu_BaLyEn_6	333	338	PF01217	0.645
TRG_ENDOCYTIC_2	119	122	PF00928	0.486
TRG_ENDOCYTIC_2	583	586	PF00928	0.612
TRG_ER_diArg_1	23	25	PF00400	0.491
TRG_ER_diArg_1	672	675	PF00400	0.519
TRG_NES_CRM1_1	27	39	PF08389	0.485
TRG_NES_CRM1_1	318	331	PF08389	0.561
TRG_NLS_MonoExtN_4	332	337	PF00514	0.644

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBF5	Leptomonas seymouri	67%	98%
A0A0S4JTE0	Bodo saltans	42%	89%
A0A0S4KJ87	Bodo saltans	25%	100%
A0A1X0NK47	Trypanosomatidae	50%	96%
A0A3R7K7N9	Trypanosoma rangeli	49%	97%
A0A3S7XBP3	Leishmania donovani	26%	100%
A4H4H1	Leishmania braziliensis	67%	99%
A4HPZ9	Leishmania braziliensis	25%	100%
A4HSP6	Leishmania infantum	99%	100%
A4IDR0	Leishmania infantum	26%	100%
C9ZT89	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	97%
D4AM37	Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)	24%	100%
D4D8P3	Trichophyton verrucosum (strain HKI 0517)	24%	100%
E9AKN1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q0T1	Leishmania major	26%	100%
Q4QJ76	Leishmania major	89%	100%
V5BDR9	Trypanosoma cruzi	51%	98%