Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5M6_LEIDO

TriTrypDb:

LdBPK_060020.1 , LdCL_060005100 , LDHU3_06.0030

Length:

535

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 26
NetGPI	no	yes: 0, no: 26

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	27
GO:0042995	cell projection	2	27
GO:0043226	organelle	2	27
GO:0043227	membrane-bounded organelle	3	27
GO:0110165	cellular anatomical entity	1	27
GO:0120025	plasma membrane bounded cell projection	3	27
GO:0005743	mitochondrial inner membrane	5	1
GO:0016020	membrane	2	1
GO:0019866	organelle inner membrane	4	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0000151	ubiquitin ligase complex	3	1
GO:0019005	SCF ubiquitin ligase complex	5	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A0A3S5H5M6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5M6

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	3
GO:0006796	phosphate-containing compound metabolic process	4	3
GO:0008152	metabolic process	1	4
GO:0009987	cellular process	1	4
GO:0016310	phosphorylation	5	3
GO:0044237	cellular metabolic process	2	4
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	7	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0003824	catalytic activity	1	3
GO:0016301	kinase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	267	271	PF00656	0.320
CLV_NRD_NRD_1	187	189	PF00675	0.507
CLV_NRD_NRD_1	190	192	PF00675	0.467
CLV_PCSK_SKI1_1	427	431	PF00082	0.473
DEG_ODPH_VHL_1	487	499	PF01847	0.258
DEG_SCF_FBW7_1	56	62	PF00400	0.491
DOC_CDC14_PxL_1	206	214	PF14671	0.319
DOC_CKS1_1	344	349	PF01111	0.261
DOC_CKS1_1	56	61	PF01111	0.490
DOC_CYCLIN_RxL_1	199	208	PF00134	0.331
DOC_MAPK_gen_1	188	195	PF00069	0.296
DOC_MAPK_gen_1	521	531	PF00069	0.587
DOC_MAPK_MEF2A_6	279	286	PF00069	0.308
DOC_MAPK_MEF2A_6	374	383	PF00069	0.262
DOC_PP1_RVXF_1	102	109	PF00149	0.543
DOC_PP4_FxxP_1	17	20	PF00568	0.446
DOC_PP4_FxxP_1	43	46	PF00568	0.472
DOC_USP7_MATH_1	102	106	PF00917	0.561
DOC_USP7_MATH_1	229	233	PF00917	0.301
DOC_USP7_MATH_1	26	30	PF00917	0.645
DOC_USP7_MATH_1	288	292	PF00917	0.435
DOC_USP7_MATH_1	422	426	PF00917	0.285
DOC_USP7_MATH_1	491	495	PF00917	0.417
DOC_WW_Pin1_4	28	33	PF00397	0.703
DOC_WW_Pin1_4	296	301	PF00397	0.477
DOC_WW_Pin1_4	343	348	PF00397	0.508
DOC_WW_Pin1_4	390	395	PF00397	0.417
DOC_WW_Pin1_4	406	411	PF00397	0.393
DOC_WW_Pin1_4	438	443	PF00397	0.440
DOC_WW_Pin1_4	52	57	PF00397	0.502
LIG_14-3-3_CanoR_1	235	240	PF00244	0.422
LIG_14-3-3_CanoR_1	258	264	PF00244	0.517
LIG_14-3-3_CanoR_1	294	301	PF00244	0.285
LIG_14-3-3_CanoR_1	316	325	PF00244	0.468
LIG_14-3-3_CanoR_1	380	389	PF00244	0.446
LIG_14-3-3_CanoR_1	397	401	PF00244	0.470
LIG_14-3-3_CanoR_1	435	443	PF00244	0.469
LIG_14-3-3_CanoR_1	524	531	PF00244	0.586
LIG_Actin_WH2_2	67	83	PF00022	0.618
LIG_BIR_II_1	1	5	PF00653	0.496
LIG_BRCT_BRCA1_1	104	108	PF00533	0.555
LIG_FHA_1	164	170	PF00498	0.579
LIG_FHA_1	178	184	PF00498	0.508
LIG_FHA_1	221	227	PF00498	0.435
LIG_FHA_1	236	242	PF00498	0.438
LIG_FHA_1	270	276	PF00498	0.410
LIG_FHA_1	56	62	PF00498	0.634
LIG_FHA_1	75	81	PF00498	0.685
LIG_FHA_2	265	271	PF00498	0.426
LIG_FHA_2	360	366	PF00498	0.417
LIG_LIR_Apic_2	16	20	PF02991	0.427
LIG_LIR_Apic_2	96	102	PF02991	0.423
LIG_LIR_Gen_1	306	317	PF02991	0.285
LIG_LIR_Nem_3	105	110	PF02991	0.499
LIG_LIR_Nem_3	197	201	PF02991	0.501
LIG_LIR_Nem_3	248	253	PF02991	0.454
LIG_LIR_Nem_3	296	301	PF02991	0.285
LIG_LIR_Nem_3	306	312	PF02991	0.234
LIG_LIR_Nem_3	343	348	PF02991	0.521
LIG_LIR_Nem_3	390	395	PF02991	0.456
LIG_LIR_Nem_3	438	443	PF02991	0.344
LIG_LIR_Nem_3	84	88	PF02991	0.576
LIG_MLH1_MIPbox_1	104	108	PF16413	0.351
LIG_MYND_3	209	213	PF01753	0.311
LIG_PDZ_Class_1	530	535	PF00595	0.618
LIG_SH2_SRC	309	312	PF00017	0.272
LIG_SH2_STAT5	107	110	PF00017	0.531
LIG_SH2_STAT5	199	202	PF00017	0.482
LIG_SH2_STAT5	309	312	PF00017	0.272
LIG_SH2_STAT5	498	501	PF00017	0.332
LIG_SH3_3	53	59	PF00018	0.497
LIG_SUMO_SIM_anti_2	117	122	PF11976	0.471
LIG_SUMO_SIM_anti_2	299	306	PF11976	0.291
LIG_SUMO_SIM_anti_2	69	77	PF11976	0.443
LIG_SUMO_SIM_par_1	237	242	PF11976	0.492
LIG_SUMO_SIM_par_1	299	306	PF11976	0.274
LIG_SUMO_SIM_par_1	340	346	PF11976	0.472
LIG_SUMO_SIM_par_1	355	362	PF11976	0.350
LIG_TRAF2_1	448	451	PF00917	0.287
LIG_TRAF2_1	517	520	PF00917	0.368
LIG_TYR_ITIM	307	312	PF00017	0.270
LIG_TYR_ITIM	496	501	PF00017	0.414
LIG_WRC_WIRS_1	247	252	PF05994	0.467
MOD_CDK_SPxxK_3	28	35	PF00069	0.618
MOD_CDK_SPxxK_3	390	397	PF00069	0.471
MOD_CK1_1	129	135	PF00069	0.495
MOD_CK1_1	2	8	PF00069	0.642
MOD_CK1_1	409	415	PF00069	0.417
MOD_CK1_1	438	444	PF00069	0.450
MOD_CK1_1	508	514	PF00069	0.467
MOD_CK1_1	55	61	PF00069	0.727
MOD_CK2_1	109	115	PF00069	0.494
MOD_CK2_1	317	323	PF00069	0.335
MOD_CK2_1	396	402	PF00069	0.340
MOD_CK2_1	445	451	PF00069	0.462
MOD_CK2_1	508	514	PF00069	0.567
MOD_CK2_1	63	69	PF00069	0.654
MOD_GlcNHglycan	111	114	PF01048	0.651
MOD_GlcNHglycan	216	220	PF01048	0.448
MOD_GlcNHglycan	241	244	PF01048	0.442
MOD_GlcNHglycan	383	386	PF01048	0.341
MOD_GSK3_1	164	171	PF00069	0.568
MOD_GSK3_1	235	242	PF00069	0.387
MOD_GSK3_1	411	418	PF00069	0.333
MOD_GSK3_1	479	486	PF00069	0.487
MOD_GSK3_1	501	508	PF00069	0.476
MOD_GSK3_1	55	62	PF00069	0.723
MOD_N-GLC_1	164	169	PF02516	0.479
MOD_N-GLC_1	381	386	PF02516	0.447
MOD_N-GLC_1	404	409	PF02516	0.411
MOD_N-GLC_1	508	513	PF02516	0.534
MOD_N-GLC_2	290	292	PF02516	0.451
MOD_N-GLC_2	432	434	PF02516	0.380
MOD_NEK2_1	1	6	PF00069	0.617
MOD_NEK2_1	108	113	PF00069	0.558
MOD_NEK2_1	126	131	PF00069	0.419
MOD_NEK2_1	163	168	PF00069	0.501
MOD_NEK2_1	169	174	PF00069	0.608
MOD_NEK2_1	217	222	PF00069	0.382
MOD_NEK2_1	239	244	PF00069	0.345
MOD_NEK2_1	25	30	PF00069	0.658
MOD_NEK2_1	262	267	PF00069	0.383
MOD_NEK2_1	277	282	PF00069	0.348
MOD_NEK2_1	381	386	PF00069	0.324
MOD_NEK2_1	404	409	PF00069	0.386
MOD_NEK2_1	87	92	PF00069	0.592
MOD_NEK2_2	102	107	PF00069	0.494
MOD_NEK2_2	229	234	PF00069	0.330
MOD_NEK2_2	422	427	PF00069	0.467
MOD_OFUCOSY	408	415	PF10250	0.299
MOD_PIKK_1	177	183	PF00454	0.567
MOD_PIKK_1	257	263	PF00454	0.556
MOD_PIKK_1	74	80	PF00454	0.695
MOD_PKA_2	257	263	PF00069	0.483
MOD_PKA_2	293	299	PF00069	0.518
MOD_PKA_2	317	323	PF00069	0.458
MOD_PKA_2	359	365	PF00069	0.450
MOD_PKA_2	396	402	PF00069	0.427
MOD_PKA_2	504	510	PF00069	0.482
MOD_PKA_2	523	529	PF00069	0.568
MOD_Plk_1	114	120	PF00069	0.548
MOD_Plk_1	164	170	PF00069	0.549
MOD_Plk_1	305	311	PF00069	0.474
MOD_Plk_2-3	514	520	PF00069	0.548
MOD_Plk_4	164	170	PF00069	0.446
MOD_Plk_4	305	311	PF00069	0.299
MOD_Plk_4	359	365	PF00069	0.401
MOD_Plk_4	396	402	PF00069	0.408
MOD_Plk_4	63	69	PF00069	0.673
MOD_ProDKin_1	28	34	PF00069	0.698
MOD_ProDKin_1	296	302	PF00069	0.481
MOD_ProDKin_1	343	349	PF00069	0.505
MOD_ProDKin_1	390	396	PF00069	0.417
MOD_ProDKin_1	406	412	PF00069	0.397
MOD_ProDKin_1	438	444	PF00069	0.441
MOD_ProDKin_1	52	58	PF00069	0.496
TRG_ENDOCYTIC_2	107	110	PF00928	0.511
TRG_ENDOCYTIC_2	309	312	PF00928	0.272
TRG_ENDOCYTIC_2	498	501	PF00928	0.407
TRG_ER_diArg_1	314	317	PF00400	0.375
TRG_ER_diArg_1	88	91	PF00400	0.588
TRG_NES_CRM1_1	350	361	PF08389	0.457
TRG_NLS_MonoExtC_3	187	192	PF00514	0.306

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8N9	Leptomonas seymouri	26%	81%
A0A0N1IHY9	Leptomonas seymouri	58%	100%
A0A0S4IRN7	Bodo saltans	27%	100%
A0A0S4ITQ8	Bodo saltans	24%	100%
A0A0S4J578	Bodo saltans	27%	71%
A0A1X0P4M6	Trypanosomatidae	24%	92%
A0A3S7X2V4	Leishmania donovani	28%	69%
A0A3S7X7D2	Leishmania donovani	25%	100%
A4H4H0	Leishmania braziliensis	87%	100%
A4H7G0	Leishmania braziliensis	23%	100%
A4HCY0	Leishmania braziliensis	26%	100%
A4HSP5	Leishmania infantum	100%	100%
A4I9H0	Leishmania infantum	25%	100%
C9ZRQ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
C9ZS86	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	99%
C9ZUA8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	72%
C9ZZI9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	88%
D0A0X4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	79%
E9AEF0	Leishmania major	26%	69%
E9AHJ6	Leishmania infantum	28%	69%
E9AKN0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9APJ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
Q4QFY4	Leishmania major	24%	100%
Q4QJ77	Leishmania major	97%	100%
V5BMQ2	Trypanosoma cruzi	24%	95%