Nodulation_protein_S_(NodS)/Methyltransferase_dom ain_containing_protein_putative/Pfam:PF05401/Pfam:PF13847/P fam:PF12847/Pfam:PF08241

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methyltransferase domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H5M0_LEIDO

TriTrypDb:

LdBPK_051100.1 , LdCL_050016300 , LDHU3_05.1230

Length:

245

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H5M0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5M0

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	5
GO:0032259	methylation	2	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0008168	methyltransferase activity	4	5
GO:0016740	transferase activity	2	5
GO:0016741	transferase activity, transferring one-carbon groups	3	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	173	175	PF00675	0.505
CLV_NRD_NRD_1	84	86	PF00675	0.264
CLV_PCSK_KEX2_1	152	154	PF00082	0.334
CLV_PCSK_KEX2_1	173	175	PF00082	0.502
CLV_PCSK_KEX2_1	84	86	PF00082	0.264
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.323
CLV_PCSK_SKI1_1	106	110	PF00082	0.288
CLV_PCSK_SKI1_1	149	153	PF00082	0.225
CLV_PCSK_SKI1_1	188	192	PF00082	0.523
CLV_PCSK_SKI1_1	236	240	PF00082	0.521
CLV_PCSK_SKI1_1	35	39	PF00082	0.467
CLV_PCSK_SKI1_1	67	71	PF00082	0.313
DOC_CKS1_1	100	105	PF01111	0.293
DOC_CYCLIN_RxL_1	171	182	PF00134	0.500
DOC_CYCLIN_RxL_1	32	42	PF00134	0.540
DOC_CYCLIN_yClb5_NLxxxL_5	25	34	PF00134	0.483
DOC_MAPK_gen_1	152	160	PF00069	0.264
DOC_MAPK_gen_1	173	179	PF00069	0.538
DOC_MAPK_gen_1	67	74	PF00069	0.264
DOC_MAPK_MEF2A_6	213	220	PF00069	0.474
DOC_PP1_RVXF_1	173	180	PF00149	0.495
DOC_SPAK_OSR1_1	156	160	PF12202	0.378
DOC_USP7_UBL2_3	184	188	PF12436	0.567
DOC_USP7_UBL2_3	209	213	PF12436	0.525
DOC_WW_Pin1_4	161	166	PF00397	0.288
DOC_WW_Pin1_4	194	199	PF00397	0.577
DOC_WW_Pin1_4	72	77	PF00397	0.283
DOC_WW_Pin1_4	99	104	PF00397	0.260
LIG_14-3-3_CanoR_1	55	61	PF00244	0.288
LIG_14-3-3_CanoR_1	84	92	PF00244	0.400
LIG_AP2alpha_1	233	237	PF02296	0.518
LIG_BIR_II_1	1	5	PF00653	0.482
LIG_BRCT_BRCA1_1	133	137	PF00533	0.378
LIG_FHA_1	99	105	PF00498	0.404
LIG_FHA_2	100	106	PF00498	0.267
LIG_FHA_2	165	171	PF00498	0.254
LIG_FHA_2	17	23	PF00498	0.466
LIG_FHA_2	68	74	PF00498	0.264
LIG_LIR_Apic_2	161	165	PF02991	0.250
LIG_LIR_Apic_2	2	7	PF02991	0.473
LIG_LIR_Gen_1	115	126	PF02991	0.245
LIG_LIR_Gen_1	134	143	PF02991	0.300
LIG_LIR_Gen_1	18	27	PF02991	0.446
LIG_LIR_Gen_1	231	238	PF02991	0.514
LIG_LIR_Nem_3	115	121	PF02991	0.245
LIG_LIR_Nem_3	134	140	PF02991	0.300
LIG_LIR_Nem_3	18	24	PF02991	0.433
LIG_LIR_Nem_3	199	205	PF02991	0.491
LIG_LIR_Nem_3	231	237	PF02991	0.518
LIG_LIR_Nem_3	26	30	PF02991	0.429
LIG_MYND_1	36	40	PF01753	0.517
LIG_PCNA_yPIPBox_3	144	156	PF02747	0.323
LIG_Pex14_1	10	14	PF04695	0.409
LIG_Pex14_1	23	27	PF04695	0.454
LIG_Pex14_2	233	237	PF04695	0.518
LIG_PTB_Apo_2	3	10	PF02174	0.522
LIG_PTB_Phospho_1	3	9	PF10480	0.525
LIG_SH2_CRK	118	122	PF00017	0.323
LIG_SH2_CRK	27	31	PF00017	0.554
LIG_SH2_GRB2like	27	30	PF00017	0.556
LIG_SH2_GRB2like	4	7	PF00017	0.531
LIG_SH2_NCK_1	4	8	PF00017	0.471
LIG_SH2_PTP2	205	208	PF00017	0.634
LIG_SH2_SRC	4	7	PF00017	0.471
LIG_SH2_STAP1	118	122	PF00017	0.323
LIG_SH2_STAP1	234	238	PF00017	0.530
LIG_SH2_STAT5	116	119	PF00017	0.378
LIG_SH2_STAT5	141	144	PF00017	0.264
LIG_SH2_STAT5	205	208	PF00017	0.501
LIG_TYR_ITIM	25	30	PF00017	0.572
LIG_WRC_WIRS_1	140	145	PF05994	0.255
MOD_CDK_SPxxK_3	161	168	PF00069	0.288
MOD_CDK_SPxxK_3	99	106	PF00069	0.293
MOD_CK1_1	16	22	PF00069	0.418
MOD_CK1_1	161	167	PF00069	0.288
MOD_CK1_1	192	198	PF00069	0.638
MOD_CK1_1	54	60	PF00069	0.245
MOD_CK2_1	99	105	PF00069	0.310
MOD_GlcNHglycan	241	244	PF01048	0.713
MOD_GlcNHglycan	56	59	PF01048	0.318
MOD_GSK3_1	13	20	PF00069	0.412
MOD_GSK3_1	190	197	PF00069	0.545
MOD_N-GLC_1	145	150	PF02516	0.264
MOD_N-GLC_1	16	21	PF02516	0.439
MOD_NEK2_1	126	131	PF00069	0.341
MOD_NEK2_1	190	195	PF00069	0.559
MOD_NEK2_2	133	138	PF00069	0.245
MOD_PIKK_1	77	83	PF00454	0.379
MOD_PKA_1	67	73	PF00069	0.264
MOD_PKA_1	84	90	PF00069	0.378
MOD_PKA_2	54	60	PF00069	0.309
MOD_PKA_2	84	90	PF00069	0.399
MOD_Plk_1	145	151	PF00069	0.288
MOD_Plk_1	16	22	PF00069	0.419
MOD_Plk_2-3	224	230	PF00069	0.594
MOD_Plk_4	126	132	PF00069	0.323
MOD_Plk_4	29	35	PF00069	0.591
MOD_Plk_4	74	80	PF00069	0.362
MOD_ProDKin_1	161	167	PF00069	0.288
MOD_ProDKin_1	194	200	PF00069	0.574
MOD_ProDKin_1	72	78	PF00069	0.283
MOD_ProDKin_1	99	105	PF00069	0.260
MOD_SUMO_rev_2	180	186	PF00179	0.562
TRG_DiLeu_BaLyEn_6	146	151	PF01217	0.265
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.538
TRG_ENDOCYTIC_2	118	121	PF00928	0.323
TRG_ENDOCYTIC_2	205	208	PF00928	0.634
TRG_ENDOCYTIC_2	234	237	PF00928	0.520
TRG_ENDOCYTIC_2	27	30	PF00928	0.449
TRG_ENDOCYTIC_2	61	64	PF00928	0.260
TRG_ENDOCYTIC_2	86	89	PF00928	0.264
TRG_ER_diArg_1	172	174	PF00400	0.245
TRG_ER_diArg_1	84	86	PF00400	0.272
TRG_NES_CRM1_1	98	110	PF08389	0.348
TRG_NLS_MonoExtN_4	173	178	PF00514	0.570
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIY0	Leptomonas seymouri	88%	100%
A0A0S4IH71	Bodo saltans	26%	93%
A0A0S4IJP7	Bodo saltans	50%	100%
A0A1X0NKH4	Trypanosomatidae	71%	94%
A0A422MSW3	Trypanosoma rangeli	66%	93%
A0A422NN81	Trypanosoma rangeli	25%	100%
A4H4F5	Leishmania braziliensis	93%	100%
A4HSN2	Leishmania infantum	100%	100%
A8MUP2	Homo sapiens	26%	100%
C9ZU62	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	96%
C9ZY01	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AKL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
P0DPD7	Homo sapiens	28%	96%
P0DPE0	Mus musculus	29%	96%
P0DPE1	Bos taurus	26%	96%
Q4QJ92	Leishmania major	97%	100%
Q5RCI5	Pongo abelii	26%	100%
V5BI94	Trypanosoma cruzi	23%	100%