Phosphatidylinositol 4-phosphate 5-kinase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Phosphatidylinositol 4-phosphate 5-kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H5L8_LEIDO

TriTrypDb:

LdBPK_051080.1 , LdCL_050016100 , LDHU3_05.1200

Length:

726

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H5L8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5L8

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016310	phosphorylation	5	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	205	209	PF00656	0.705
CLV_C14_Caspase3-7	40	44	PF00656	0.635
CLV_C14_Caspase3-7	580	584	PF00656	0.715
CLV_NRD_NRD_1	679	681	PF00675	0.626
CLV_NRD_NRD_1	718	720	PF00675	0.648
CLV_PCSK_FUR_1	114	118	PF00082	0.516
CLV_PCSK_KEX2_1	113	115	PF00082	0.481
CLV_PCSK_KEX2_1	116	118	PF00082	0.504
CLV_PCSK_KEX2_1	161	163	PF00082	0.628
CLV_PCSK_KEX2_1	215	217	PF00082	0.673
CLV_PCSK_KEX2_1	302	304	PF00082	0.413
CLV_PCSK_KEX2_1	515	517	PF00082	0.510
CLV_PCSK_KEX2_1	679	681	PF00082	0.654
CLV_PCSK_KEX2_1	718	720	PF00082	0.567
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.481
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.504
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.619
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.673
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.449
CLV_PCSK_PC1ET2_1	515	517	PF00082	0.515
CLV_PCSK_SKI1_1	113	117	PF00082	0.538
DEG_APCC_DBOX_1	705	713	PF00400	0.580
DEG_APCC_KENBOX_2	251	255	PF00400	0.449
DEG_SIAH_1	685	693	PF03145	0.789
DOC_CKS1_1	695	700	PF01111	0.643
DOC_CYCLIN_yCln2_LP_2	602	605	PF00134	0.720
DOC_MAPK_gen_1	215	222	PF00069	0.650
DOC_MAPK_gen_1	48	58	PF00069	0.695
DOC_MAPK_MEF2A_6	215	224	PF00069	0.600
DOC_MAPK_MEF2A_6	412	421	PF00069	0.531
DOC_PP1_RVXF_1	257	264	PF00149	0.449
DOC_PP2B_LxvP_1	419	422	PF13499	0.648
DOC_PP2B_LxvP_1	537	540	PF13499	0.680
DOC_PP2B_LxvP_1	601	604	PF13499	0.686
DOC_USP7_MATH_1	136	140	PF00917	0.672
DOC_USP7_MATH_1	26	30	PF00917	0.622
DOC_USP7_MATH_1	289	293	PF00917	0.344
DOC_USP7_MATH_1	312	316	PF00917	0.344
DOC_USP7_MATH_1	423	427	PF00917	0.649
DOC_USP7_MATH_1	615	619	PF00917	0.683
DOC_USP7_MATH_1	646	650	PF00917	0.690
DOC_USP7_UBL2_3	302	306	PF12436	0.475
DOC_WW_Pin1_4	553	558	PF00397	0.713
DOC_WW_Pin1_4	694	699	PF00397	0.669
LIG_14-3-3_CanoR_1	117	123	PF00244	0.664
LIG_14-3-3_CanoR_1	458	464	PF00244	0.488
LIG_14-3-3_CanoR_1	570	577	PF00244	0.766
LIG_14-3-3_CanoR_1	680	686	PF00244	0.632
LIG_14-3-3_CanoR_1	687	691	PF00244	0.676
LIG_14-3-3_CanoR_1	92	96	PF00244	0.556
LIG_Actin_WH2_2	443	460	PF00022	0.565
LIG_Actin_WH2_2	468	485	PF00022	0.598
LIG_APCC_ABBA_1	413	418	PF00400	0.596
LIG_BIR_II_1	1	5	PF00653	0.676
LIG_BIR_III_4	583	587	PF00653	0.756
LIG_CaM_NSCaTE_8	459	466	PF13499	0.603
LIG_CtBP_PxDLS_1	191	195	PF00389	0.643
LIG_FHA_1	329	335	PF00498	0.475
LIG_FHA_1	540	546	PF00498	0.575
LIG_FHA_1	648	654	PF00498	0.649
LIG_FHA_2	142	148	PF00498	0.631
LIG_FHA_2	196	202	PF00498	0.713
LIG_FHA_2	40	46	PF00498	0.689
LIG_FHA_2	441	447	PF00498	0.505
LIG_GBD_Chelix_1	107	115	PF00786	0.534
LIG_HP1_1	544	548	PF01393	0.554
LIG_LIR_Gen_1	133	143	PF02991	0.586
LIG_LIR_Gen_1	193	202	PF02991	0.593
LIG_LIR_Gen_1	329	340	PF02991	0.448
LIG_LIR_Gen_1	54	63	PF02991	0.710
LIG_LIR_Gen_1	649	660	PF02991	0.576
LIG_LIR_LC3C_4	418	421	PF02991	0.621
LIG_LIR_LC3C_4	469	472	PF02991	0.434
LIG_LIR_Nem_3	193	199	PF02991	0.602
LIG_LIR_Nem_3	329	335	PF02991	0.448
LIG_LIR_Nem_3	54	58	PF02991	0.743
LIG_LIR_Nem_3	649	655	PF02991	0.587
LIG_MYND_1	701	705	PF01753	0.666
LIG_MYND_1	707	711	PF01753	0.549
LIG_NRBOX	532	538	PF00104	0.642
LIG_Pex14_2	340	344	PF04695	0.386
LIG_Rb_pABgroove_1	707	715	PF01858	0.578
LIG_SH2_CRK	453	457	PF00017	0.592
LIG_SH2_NCK_1	492	496	PF00017	0.614
LIG_SH2_PTP2	18	21	PF00017	0.578
LIG_SH2_PTP2	223	226	PF00017	0.610
LIG_SH2_PTP2	55	58	PF00017	0.739
LIG_SH2_PTP2	652	655	PF00017	0.613
LIG_SH2_SRC	18	21	PF00017	0.578
LIG_SH2_SRC	309	312	PF00017	0.365
LIG_SH2_STAP1	132	136	PF00017	0.662
LIG_SH2_STAP1	622	626	PF00017	0.720
LIG_SH2_STAP1	713	717	PF00017	0.559
LIG_SH2_STAT5	110	113	PF00017	0.475
LIG_SH2_STAT5	18	21	PF00017	0.593
LIG_SH2_STAT5	223	226	PF00017	0.520
LIG_SH2_STAT5	247	250	PF00017	0.333
LIG_SH2_STAT5	271	274	PF00017	0.385
LIG_SH2_STAT5	294	297	PF00017	0.358
LIG_SH2_STAT5	309	312	PF00017	0.303
LIG_SH2_STAT5	363	366	PF00017	0.363
LIG_SH2_STAT5	378	381	PF00017	0.616
LIG_SH2_STAT5	55	58	PF00017	0.724
LIG_SH2_STAT5	652	655	PF00017	0.582
LIG_SH3_1	223	229	PF00018	0.591
LIG_SH3_3	223	229	PF00018	0.591
LIG_SH3_3	417	423	PF00018	0.525
LIG_SH3_3	514	520	PF00018	0.645
LIG_SH3_3	650	656	PF00018	0.618
LIG_SH3_3	689	695	PF00018	0.680
LIG_SUMO_SIM_anti_2	125	131	PF11976	0.694
LIG_SUMO_SIM_anti_2	501	507	PF11976	0.546
LIG_SUMO_SIM_anti_2	531	538	PF11976	0.544
LIG_SUMO_SIM_anti_2	542	549	PF11976	0.587
LIG_SUMO_SIM_par_1	506	511	PF11976	0.558
LIG_SUMO_SIM_par_1	533	538	PF11976	0.593
LIG_SUMO_SIM_par_1	542	549	PF11976	0.542
LIG_TRAF2_1	181	184	PF00917	0.775
LIG_TRAF2_1	33	36	PF00917	0.782
LIG_TYR_ITIM	194	199	PF00017	0.595
LIG_TYR_ITSM	648	655	PF00017	0.666
LIG_WRC_WIRS_1	341	346	PF05994	0.508
MOD_CK1_1	25	31	PF00069	0.724
MOD_CK1_1	426	432	PF00069	0.686
MOD_CK1_1	462	468	PF00069	0.501
MOD_CK1_1	551	557	PF00069	0.755
MOD_CK1_1	572	578	PF00069	0.762
MOD_CK1_1	595	601	PF00069	0.645
MOD_CK1_1	658	664	PF00069	0.649
MOD_CK2_1	141	147	PF00069	0.655
MOD_CK2_1	178	184	PF00069	0.810
MOD_CK2_1	26	32	PF00069	0.796
MOD_CK2_1	553	559	PF00069	0.733
MOD_Cter_Amidation	300	303	PF01082	0.449
MOD_Cter_Amidation	513	516	PF01082	0.535
MOD_DYRK1A_RPxSP_1	694	698	PF00069	0.670
MOD_GlcNHglycan	170	173	PF01048	0.675
MOD_GlcNHglycan	24	27	PF01048	0.740
MOD_GlcNHglycan	242	245	PF01048	0.594
MOD_GlcNHglycan	303	306	PF01048	0.407
MOD_GlcNHglycan	328	331	PF01048	0.421
MOD_GlcNHglycan	350	353	PF01048	0.421
MOD_GlcNHglycan	357	360	PF01048	0.471
MOD_GlcNHglycan	395	398	PF01048	0.664
MOD_GlcNHglycan	425	428	PF01048	0.703
MOD_GlcNHglycan	464	467	PF01048	0.602
MOD_GlcNHglycan	553	556	PF01048	0.725
MOD_GlcNHglycan	60	63	PF01048	0.664
MOD_GlcNHglycan	641	644	PF01048	0.712
MOD_GSK3_1	22	29	PF00069	0.735
MOD_GSK3_1	236	243	PF00069	0.570
MOD_GSK3_1	336	343	PF00069	0.424
MOD_GSK3_1	398	405	PF00069	0.669
MOD_GSK3_1	518	525	PF00069	0.594
MOD_GSK3_1	569	576	PF00069	0.692
MOD_GSK3_1	655	662	PF00069	0.604
MOD_LATS_1	346	352	PF00433	0.481
MOD_NEK2_1	236	241	PF00069	0.500
MOD_NEK2_1	335	340	PF00069	0.348
MOD_NEK2_1	407	412	PF00069	0.512
MOD_NEK2_1	548	553	PF00069	0.586
MOD_NEK2_1	58	63	PF00069	0.684
MOD_NEK2_1	593	598	PF00069	0.597
MOD_NEK2_2	357	362	PF00069	0.595
MOD_PIKK_1	136	142	PF00454	0.718
MOD_PKA_2	569	575	PF00069	0.766
MOD_PKA_2	627	633	PF00069	0.699
MOD_PKA_2	686	692	PF00069	0.759
MOD_PKA_2	91	97	PF00069	0.562
MOD_PKB_1	516	524	PF00069	0.594
MOD_Plk_1	501	507	PF00069	0.521
MOD_Plk_1	548	554	PF00069	0.631
MOD_Plk_1	572	578	PF00069	0.735
MOD_Plk_1	615	621	PF00069	0.732
MOD_Plk_1	658	664	PF00069	0.544
MOD_Plk_2-3	123	129	PF00069	0.666
MOD_Plk_2-3	178	184	PF00069	0.806
MOD_Plk_2-3	313	319	PF00069	0.344
MOD_Plk_4	236	242	PF00069	0.507
MOD_Plk_4	336	342	PF00069	0.450
MOD_Plk_4	398	404	PF00069	0.610
MOD_Plk_4	501	507	PF00069	0.499
MOD_Plk_4	615	621	PF00069	0.732
MOD_Plk_4	648	654	PF00069	0.627
MOD_Plk_4	91	97	PF00069	0.493
MOD_ProDKin_1	553	559	PF00069	0.715
MOD_ProDKin_1	694	700	PF00069	0.669
MOD_SUMO_for_1	322	325	PF00179	0.449
MOD_SUMO_rev_2	392	401	PF00179	0.556
MOD_SUMO_rev_2	474	480	PF00179	0.574
MOD_SUMO_rev_2	629	638	PF00179	0.659
MOD_SUMO_rev_2	708	717	PF00179	0.660
TRG_DiLeu_BaEn_1	543	548	PF01217	0.595
TRG_DiLeu_BaLyEn_6	452	457	PF01217	0.570
TRG_ENDOCYTIC_2	196	199	PF00928	0.589
TRG_ENDOCYTIC_2	283	286	PF00928	0.437
TRG_ENDOCYTIC_2	332	335	PF00928	0.482
TRG_ENDOCYTIC_2	453	456	PF00928	0.580
TRG_ENDOCYTIC_2	55	58	PF00928	0.739
TRG_ENDOCYTIC_2	652	655	PF00928	0.603
TRG_ER_diArg_1	516	519	PF00400	0.588
TRG_NES_CRM1_1	498	511	PF08389	0.587
TRG_NLS_MonoExtC_3	112	117	PF00514	0.497
TRG_NLS_MonoExtC_3	514	519	PF00514	0.583
TRG_Pf-PMV_PEXEL_1	161	165	PF00026	0.669
TRG_Pf-PMV_PEXEL_1	70	74	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3V4	Leptomonas seymouri	72%	100%
A0A0S4IJQ0	Bodo saltans	37%	100%
A0A1X0NLQ2	Trypanosomatidae	43%	86%
A0A422NBM9	Trypanosoma rangeli	48%	93%
A4H4F3	Leishmania braziliensis	87%	100%
A4HSN0	Leishmania infantum	100%	100%
C9ZU66	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	88%
E9AKL5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QJ94	Leishmania major	96%	100%
V5BBF6	Trypanosoma cruzi	50%	100%