Legume-like lectin family, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Legume-like lectin family, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H5L7_LEIDO

TriTrypDb:

LdBPK_051070.1 , LdCL_050016000 , LDHU3_05.1190

Length:

604

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 5, no: 6
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0000139	Golgi membrane	5	1
GO:0005737	cytoplasm	2	1
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	5	1
GO:0030134	COPII-coated ER to Golgi transport vesicle	8	1
GO:0030135	coated vesicle	7	1
GO:0031090	organelle membrane	3	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

A0A3S5H5L7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5L7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	1
GO:0006996	organelle organization	4	1
GO:0007029	endoplasmic reticulum organization	5	1
GO:0007030	Golgi organization	5	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016192	vesicle-mediated transport	4	1
GO:0046907	intracellular transport	3	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	3
GO:0030246	carbohydrate binding	2	3
GO:0005537	mannose binding	4	1
GO:0036094	small molecule binding	2	1
GO:0048029	monosaccharide binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	258	262	PF00656	0.496
CLV_NRD_NRD_1	304	306	PF00675	0.613
CLV_NRD_NRD_1	309	311	PF00675	0.601
CLV_NRD_NRD_1	33	35	PF00675	0.327
CLV_NRD_NRD_1	466	468	PF00675	0.499
CLV_NRD_NRD_1	527	529	PF00675	0.624
CLV_NRD_NRD_1	530	532	PF00675	0.643
CLV_NRD_NRD_1	585	587	PF00675	0.602
CLV_NRD_NRD_1	84	86	PF00675	0.400
CLV_PCSK_FUR_1	528	532	PF00082	0.648
CLV_PCSK_KEX2_1	304	306	PF00082	0.605
CLV_PCSK_KEX2_1	309	311	PF00082	0.594
CLV_PCSK_KEX2_1	317	319	PF00082	0.623
CLV_PCSK_KEX2_1	321	323	PF00082	0.543
CLV_PCSK_KEX2_1	33	35	PF00082	0.362
CLV_PCSK_KEX2_1	466	468	PF00082	0.501
CLV_PCSK_KEX2_1	472	474	PF00082	0.545
CLV_PCSK_KEX2_1	529	531	PF00082	0.659
CLV_PCSK_KEX2_1	585	587	PF00082	0.599
CLV_PCSK_KEX2_1	84	86	PF00082	0.400
CLV_PCSK_PC1ET2_1	309	311	PF00082	0.610
CLV_PCSK_PC1ET2_1	317	319	PF00082	0.618
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.557
CLV_PCSK_PC1ET2_1	472	474	PF00082	0.587
CLV_PCSK_PC1ET2_1	529	531	PF00082	0.676
CLV_PCSK_PC7_1	305	311	PF00082	0.631
CLV_PCSK_SKI1_1	304	308	PF00082	0.618
CLV_PCSK_SKI1_1	312	316	PF00082	0.542
CLV_PCSK_SKI1_1	317	321	PF00082	0.546
CLV_PCSK_SKI1_1	34	38	PF00082	0.175
CLV_PCSK_SKI1_1	441	445	PF00082	0.642
CLV_PCSK_SKI1_1	523	527	PF00082	0.712
CLV_PCSK_SKI1_1	534	538	PF00082	0.685
CLV_PCSK_SKI1_1	543	547	PF00082	0.605
CLV_PCSK_SKI1_1	58	62	PF00082	0.164
CLV_Separin_Metazoa	490	494	PF03568	0.388
DEG_APCC_DBOX_1	529	537	PF00400	0.519
DEG_Nend_Nbox_1	1	3	PF02207	0.540
DOC_CYCLIN_RxL_1	311	324	PF00134	0.460
DOC_MAPK_gen_1	331	340	PF00069	0.386
DOC_MAPK_gen_1	4	13	PF00069	0.529
DOC_MAPK_gen_1	455	465	PF00069	0.293
DOC_MAPK_gen_1	542	550	PF00069	0.484
DOC_MAPK_gen_1	585	591	PF00069	0.492
DOC_MAPK_MEF2A_6	331	340	PF00069	0.386
DOC_MAPK_MEF2A_6	458	465	PF00069	0.289
DOC_PP1_RVXF_1	200	206	PF00149	0.231
DOC_PP1_RVXF_1	471	478	PF00149	0.363
DOC_PP1_RVXF_1	586	592	PF00149	0.443
DOC_PP2B_LxvP_1	384	387	PF13499	0.360
DOC_PP4_FxxP_1	146	149	PF00568	0.244
DOC_SPAK_OSR1_1	204	208	PF12202	0.244
DOC_USP7_MATH_1	117	121	PF00917	0.434
DOC_USP7_MATH_1	149	153	PF00917	0.398
DOC_USP7_MATH_1	28	32	PF00917	0.534
DOC_USP7_MATH_1	532	536	PF00917	0.539
DOC_USP7_UBL2_3	317	321	PF12436	0.536
DOC_WW_Pin1_4	249	254	PF00397	0.511
DOC_WW_Pin1_4	408	413	PF00397	0.322
LIG_14-3-3_CanoR_1	103	109	PF00244	0.466
LIG_14-3-3_CanoR_1	176	182	PF00244	0.257
LIG_14-3-3_CanoR_1	322	327	PF00244	0.396
LIG_14-3-3_CanoR_1	416	420	PF00244	0.435
LIG_14-3-3_CanoR_1	531	537	PF00244	0.472
LIG_14-3-3_CanoR_1	76	82	PF00244	0.612
LIG_14-3-3_CanoR_1	93	99	PF00244	0.700
LIG_BRCT_BRCA1_1	56	60	PF00533	0.164
LIG_CtBP_PxDLS_1	47	51	PF00389	0.161
LIG_deltaCOP1_diTrp_1	197	205	PF00928	0.338
LIG_deltaCOP1_diTrp_1	263	271	PF00928	0.468
LIG_FHA_1	108	114	PF00498	0.290
LIG_FHA_1	177	183	PF00498	0.275
LIG_FHA_1	189	195	PF00498	0.275
LIG_FHA_1	27	33	PF00498	0.536
LIG_FHA_1	375	381	PF00498	0.395
LIG_FHA_1	460	466	PF00498	0.337
LIG_FHA_1	484	490	PF00498	0.413
LIG_FHA_1	571	577	PF00498	0.500
LIG_FHA_1	99	105	PF00498	0.604
LIG_FHA_2	176	182	PF00498	0.345
LIG_FHA_2	289	295	PF00498	0.516
LIG_FHA_2	322	328	PF00498	0.388
LIG_FHA_2	442	448	PF00498	0.341
LIG_FHA_2	492	498	PF00498	0.381
LIG_FHA_2	544	550	PF00498	0.355
LIG_LIR_Apic_2	143	149	PF02991	0.244
LIG_LIR_Gen_1	172	182	PF02991	0.269
LIG_LIR_Gen_1	378	387	PF02991	0.411
LIG_LIR_Gen_1	544	553	PF02991	0.397
LIG_LIR_Gen_1	57	67	PF02991	0.164
LIG_LIR_Nem_3	172	177	PF02991	0.269
LIG_LIR_Nem_3	313	319	PF02991	0.361
LIG_LIR_Nem_3	378	384	PF02991	0.401
LIG_LIR_Nem_3	544	548	PF02991	0.396
LIG_LIR_Nem_3	57	63	PF02991	0.164
LIG_NRBOX	12	18	PF00104	0.534
LIG_PDZ_Class_3	599	604	PF00595	0.492
LIG_Pex14_2	316	320	PF04695	0.463
LIG_Pex14_2	343	347	PF04695	0.339
LIG_Pex14_2	60	64	PF04695	0.164
LIG_PTB_Apo_2	168	175	PF02174	0.257
LIG_REV1ctd_RIR_1	70	80	PF16727	0.559
LIG_SH2_SRC	45	48	PF00017	0.404
LIG_SH2_STAP1	247	251	PF00017	0.487
LIG_SH2_STAP1	495	499	PF00017	0.407
LIG_SH2_STAP1	570	574	PF00017	0.408
LIG_SH2_STAT3	232	235	PF00017	0.257
LIG_SH2_STAT3	456	459	PF00017	0.284
LIG_SH2_STAT5	232	235	PF00017	0.244
LIG_SH2_STAT5	381	384	PF00017	0.400
LIG_SH2_STAT5	45	48	PF00017	0.424
LIG_SH2_STAT5	495	498	PF00017	0.346
LIG_SH3_1	593	599	PF00018	0.435
LIG_SH3_3	22	28	PF00018	0.547
LIG_SH3_3	41	47	PF00018	0.164
LIG_SH3_3	425	431	PF00018	0.472
LIG_SH3_3	593	599	PF00018	0.437
LIG_SUMO_SIM_anti_2	447	454	PF11976	0.288
LIG_SUMO_SIM_anti_2	486	494	PF11976	0.390
LIG_SxIP_EBH_1	90	103	PF03271	0.558
LIG_TRAF2_1	145	148	PF00917	0.400
LIG_TRAF2_1	291	294	PF00917	0.450
LIG_TRAF2_1	445	448	PF00917	0.369
LIG_UBA3_1	315	321	PF00899	0.586
MOD_CDK_SPxxK_3	249	256	PF00069	0.650
MOD_CK1_1	107	113	PF00069	0.336
MOD_CK1_1	23	29	PF00069	0.419
MOD_CK1_1	393	399	PF00069	0.564
MOD_CK1_1	517	523	PF00069	0.399
MOD_CK1_1	77	83	PF00069	0.469
MOD_CK2_1	142	148	PF00069	0.412
MOD_CK2_1	288	294	PF00069	0.636
MOD_CK2_1	322	328	PF00069	0.470
MOD_CK2_1	441	447	PF00069	0.485
MOD_CK2_1	491	497	PF00069	0.474
MOD_Cter_Amidation	5	8	PF01082	0.401
MOD_GlcNHglycan	166	169	PF01048	0.300
MOD_GlcNHglycan	392	395	PF01048	0.650
MOD_GlcNHglycan	516	519	PF01048	0.362
MOD_GSK3_1	19	26	PF00069	0.405
MOD_GSK3_1	245	252	PF00069	0.654
MOD_GSK3_1	322	329	PF00069	0.466
MOD_GSK3_1	389	396	PF00069	0.575
MOD_GSK3_1	437	444	PF00069	0.576
MOD_GSK3_1	491	498	PF00069	0.411
MOD_GSK3_1	72	79	PF00069	0.475
MOD_GSK3_1	83	90	PF00069	0.621
MOD_LATS_1	74	80	PF00433	0.445
MOD_N-GLC_1	216	221	PF02516	0.395
MOD_N-GLC_1	387	392	PF02516	0.549
MOD_NEK2_1	175	180	PF00069	0.425
MOD_NEK2_1	20	25	PF00069	0.464
MOD_NEK2_1	216	221	PF00069	0.369
MOD_NEK2_1	514	519	PF00069	0.344
MOD_NEK2_1	568	573	PF00069	0.480
MOD_NEK2_1	589	594	PF00069	0.637
MOD_NEK2_1	72	77	PF00069	0.466
MOD_NEK2_1	99	104	PF00069	0.578
MOD_NEK2_2	28	33	PF00069	0.408
MOD_NEK2_2	532	537	PF00069	0.572
MOD_PK_1	322	328	PF00069	0.506
MOD_PKA_1	304	310	PF00069	0.621
MOD_PKA_1	321	327	PF00069	0.410
MOD_PKA_2	175	181	PF00069	0.298
MOD_PKA_2	203	209	PF00069	0.279
MOD_PKA_2	304	310	PF00069	0.597
MOD_PKA_2	321	327	PF00069	0.370
MOD_PKA_2	415	421	PF00069	0.479
MOD_PKA_2	83	89	PF00069	0.653
MOD_PKA_2	92	98	PF00069	0.485
MOD_Plk_1	142	148	PF00069	0.298
MOD_Plk_1	473	479	PF00069	0.498
MOD_Plk_2-3	288	294	PF00069	0.646
MOD_Plk_4	104	110	PF00069	0.350
MOD_Plk_4	376	382	PF00069	0.466
MOD_Plk_4	393	399	PF00069	0.540
MOD_Plk_4	459	465	PF00069	0.354
MOD_Plk_4	473	479	PF00069	0.427
MOD_Plk_4	77	83	PF00069	0.604
MOD_ProDKin_1	249	255	PF00069	0.650
MOD_ProDKin_1	408	414	PF00069	0.390
MOD_SUMO_for_1	471	474	PF00179	0.476
MOD_SUMO_rev_2	535	545	PF00179	0.526
MOD_SUMO_rev_2	560	568	PF00179	0.398
TRG_DiLeu_BaEn_1	448	453	PF01217	0.419
TRG_DiLeu_BaLyEn_6	136	141	PF01217	0.429
TRG_ENDOCYTIC_2	381	384	PF00928	0.498
TRG_ENDOCYTIC_2	45	48	PF00928	0.424
TRG_ER_diArg_1	202	205	PF00400	0.282
TRG_ER_diArg_1	32	34	PF00400	0.362
TRG_ER_diArg_1	465	467	PF00400	0.362
TRG_ER_diArg_1	528	531	PF00400	0.616
TRG_NES_CRM1_1	552	564	PF08389	0.543
TRG_NLS_MonoCore_2	307	312	PF00514	0.593
TRG_NLS_MonoCore_2	527	532	PF00514	0.564
TRG_NLS_MonoExtC_3	307	312	PF00514	0.593
TRG_NLS_MonoExtC_3	527	532	PF00514	0.564
TRG_NLS_MonoExtN_4	305	312	PF00514	0.600
TRG_NLS_MonoExtN_4	526	533	PF00514	0.568
TRG_Pf-PMV_PEXEL_1	559	564	PF00026	0.327

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIA0	Leptomonas seymouri	78%	100%
A0A1X0NKB0	Trypanosomatidae	42%	93%
A0A3R7LT82	Trypanosoma rangeli	47%	100%
A4H4F2	Leishmania braziliensis	87%	100%
A4HSM9	Leishmania infantum	100%	100%
C9ZU67	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	97%
E8NHN5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9AKL4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QJ95	Leishmania major	96%	100%
V5ARI9	Trypanosoma cruzi	44%	100%