ATPase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

ATPase, putative

Gene product:

ATPase, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H5L6_LEIDO

TriTrypDb:

LdBPK_051060.1 , LdCL_050015900 , LDHU3_05.1180

Length:

478

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S5H5L6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5L6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0005488	binding	1	13
GO:0005524	ATP binding	5	13
GO:0016462	pyrophosphatase activity	5	13
GO:0016787	hydrolase activity	2	13
GO:0016817	hydrolase activity, acting on acid anhydrides	3	13
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	13
GO:0016887	ATP hydrolysis activity	7	13
GO:0017076	purine nucleotide binding	4	13
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	13
GO:0030554	adenyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032559	adenyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	133	135	PF00675	0.348
CLV_NRD_NRD_1	136	138	PF00675	0.341
CLV_NRD_NRD_1	181	183	PF00675	0.287
CLV_NRD_NRD_1	3	5	PF00675	0.520
CLV_NRD_NRD_1	315	317	PF00675	0.346
CLV_NRD_NRD_1	80	82	PF00675	0.506
CLV_PCSK_FUR_1	134	138	PF00082	0.389
CLV_PCSK_KEX2_1	135	137	PF00082	0.345
CLV_PCSK_KEX2_1	180	182	PF00082	0.270
CLV_PCSK_KEX2_1	222	224	PF00082	0.290
CLV_PCSK_KEX2_1	3	5	PF00082	0.531
CLV_PCSK_KEX2_1	54	56	PF00082	0.537
CLV_PCSK_KEX2_1	60	62	PF00082	0.456
CLV_PCSK_KEX2_1	80	82	PF00082	0.349
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.345
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.379
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.568
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.606
CLV_PCSK_SKI1_1	118	122	PF00082	0.258
CLV_PCSK_SKI1_1	222	226	PF00082	0.253
CLV_PCSK_SKI1_1	302	306	PF00082	0.376
CLV_PCSK_SKI1_1	380	384	PF00082	0.286
DEG_Nend_Nbox_1	1	3	PF02207	0.544
DEG_SCF_FBW7_1	289	294	PF00400	0.286
DOC_CDC14_PxL_1	71	79	PF14671	0.485
DOC_CKS1_1	288	293	PF01111	0.330
DOC_CYCLIN_RxL_1	12	25	PF00134	0.365
DOC_CYCLIN_RxL_1	217	227	PF00134	0.351
DOC_CYCLIN_RxL_1	377	387	PF00134	0.268
DOC_MAPK_DCC_7	253	262	PF00069	0.253
DOC_MAPK_DCC_7	70	79	PF00069	0.603
DOC_MAPK_gen_1	134	140	PF00069	0.243
DOC_MAPK_gen_1	3	11	PF00069	0.542
DOC_MAPK_gen_1	378	385	PF00069	0.268
DOC_MAPK_gen_1	459	466	PF00069	0.559
DOC_MAPK_gen_1	48	58	PF00069	0.540
DOC_MAPK_MEF2A_6	230	237	PF00069	0.268
DOC_MAPK_MEF2A_6	253	262	PF00069	0.253
DOC_MAPK_MEF2A_6	299	307	PF00069	0.269
DOC_MAPK_MEF2A_6	3	11	PF00069	0.469
DOC_MAPK_MEF2A_6	70	79	PF00069	0.488
DOC_PP1_RVXF_1	134	141	PF00149	0.246
DOC_PP2B_LxvP_1	406	409	PF13499	0.395
DOC_PP2B_LxvP_1	464	467	PF13499	0.557
DOC_PP2B_LxvP_1	65	68	PF13499	0.502
DOC_USP7_MATH_1	291	295	PF00917	0.380
DOC_USP7_MATH_1	441	445	PF00917	0.573
DOC_WW_Pin1_4	180	185	PF00397	0.287
DOC_WW_Pin1_4	287	292	PF00397	0.346
LIG_14-3-3_CanoR_1	197	205	PF00244	0.346
LIG_14-3-3_CanoR_1	223	229	PF00244	0.379
LIG_14-3-3_CanoR_1	3	8	PF00244	0.500
LIG_APCC_ABBA_1	188	193	PF00400	0.281
LIG_APCC_ABBA_1	256	261	PF00400	0.268
LIG_Clathr_ClatBox_1	204	208	PF01394	0.253
LIG_Clathr_ClatBox_1	382	386	PF01394	0.287
LIG_FHA_1	167	173	PF00498	0.289
LIG_FHA_1	359	365	PF00498	0.253
LIG_Integrin_RGD_1	23	25	PF01839	0.471
LIG_LIR_Apic_2	286	291	PF02991	0.272
LIG_LIR_Gen_1	298	307	PF02991	0.255
LIG_LIR_Gen_1	351	359	PF02991	0.255
LIG_LIR_Gen_1	379	389	PF02991	0.327
LIG_LIR_Gen_1	40	49	PF02991	0.293
LIG_LIR_Gen_1	460	470	PF02991	0.581
LIG_LIR_Nem_3	14	20	PF02991	0.329
LIG_LIR_Nem_3	227	231	PF02991	0.382
LIG_LIR_Nem_3	298	303	PF02991	0.248
LIG_LIR_Nem_3	351	355	PF02991	0.247
LIG_LIR_Nem_3	358	362	PF02991	0.243
LIG_LIR_Nem_3	379	384	PF02991	0.327
LIG_LIR_Nem_3	40	46	PF02991	0.303
LIG_LIR_Nem_3	460	466	PF02991	0.567
LIG_NRBOX	120	126	PF00104	0.258
LIG_PCNA_yPIPBox_3	240	253	PF02747	0.330
LIG_Pex14_2	300	304	PF04695	0.229
LIG_Pex14_2	359	363	PF04695	0.253
LIG_Rb_pABgroove_1	120	128	PF01858	0.389
LIG_SH2_CRK	17	21	PF00017	0.371
LIG_SH2_CRK	99	103	PF00017	0.346
LIG_SH2_GRB2like	126	129	PF00017	0.303
LIG_SH2_GRB2like	372	375	PF00017	0.330
LIG_SH2_NCK_1	126	130	PF00017	0.303
LIG_SH2_NCK_1	352	356	PF00017	0.268
LIG_SH2_SRC	126	129	PF00017	0.360
LIG_SH2_SRC	372	375	PF00017	0.330
LIG_SH2_SRC	463	466	PF00017	0.438
LIG_SH2_STAP1	352	356	PF00017	0.255
LIG_SH2_STAP1	43	47	PF00017	0.334
LIG_SH2_STAT5	109	112	PF00017	0.243
LIG_SH2_STAT5	288	291	PF00017	0.253
LIG_SH2_STAT5	336	339	PF00017	0.395
LIG_SH2_STAT5	463	466	PF00017	0.387
LIG_SH2_STAT5	49	52	PF00017	0.349
LIG_SH3_3	322	328	PF00018	0.287
LIG_SH3_3	365	371	PF00018	0.346
LIG_SH3_3	398	404	PF00018	0.411
LIG_SH3_3	464	470	PF00018	0.458
LIG_SH3_3	95	101	PF00018	0.520
LIG_SUMO_SIM_anti_2	200	206	PF11976	0.269
LIG_SUMO_SIM_par_1	232	239	PF11976	0.268
LIG_SUMO_SIM_par_1	381	387	PF11976	0.312
LIG_TRAF2_1	158	161	PF00917	0.395
LIG_TRAF2_1	409	412	PF00917	0.467
LIG_UBA3_1	144	149	PF00899	0.308
LIG_UBA3_1	303	309	PF00899	0.312
LIG_WRC_WIRS_1	225	230	PF05994	0.395
MOD_CK2_1	155	161	PF00069	0.351
MOD_CK2_1	197	203	PF00069	0.267
MOD_CK2_1	24	30	PF00069	0.491
MOD_CK2_1	425	431	PF00069	0.529
MOD_GlcNHglycan	33	36	PF01048	0.385
MOD_GlcNHglycan	346	350	PF01048	0.271
MOD_GlcNHglycan	433	436	PF01048	0.541
MOD_GlcNHglycan	442	446	PF01048	0.458
MOD_GSK3_1	287	294	PF00069	0.319
MOD_GSK3_1	3	10	PF00069	0.574
MOD_GSK3_1	372	379	PF00069	0.281
MOD_N-GLC_1	166	171	PF02516	0.367
MOD_N-GLC_1	174	179	PF02516	0.405
MOD_N-GLC_1	295	300	PF02516	0.395
MOD_NEK2_1	147	152	PF00069	0.308
MOD_NEK2_1	224	229	PF00069	0.395
MOD_NEK2_1	384	389	PF00069	0.346
MOD_PK_1	3	9	PF00069	0.650
MOD_PKA_1	3	9	PF00069	0.509
MOD_PKA_2	11	17	PF00069	0.340
MOD_PKA_2	3	9	PF00069	0.530
MOD_PKA_2	431	437	PF00069	0.509
MOD_Plk_1	441	447	PF00069	0.496
MOD_Plk_2-3	25	31	PF00069	0.296
MOD_Plk_2-3	425	431	PF00069	0.576
MOD_Plk_4	116	122	PF00069	0.278
MOD_Plk_4	224	230	PF00069	0.418
MOD_Plk_4	284	290	PF00069	0.295
MOD_Plk_4	3	9	PF00069	0.604
MOD_Plk_4	358	364	PF00069	0.284
MOD_Plk_4	384	390	PF00069	0.370
MOD_Plk_4	73	79	PF00069	0.516
MOD_ProDKin_1	180	186	PF00069	0.287
MOD_ProDKin_1	287	293	PF00069	0.346
MOD_SUMO_for_1	409	412	PF00179	0.606
MOD_SUMO_rev_2	373	379	PF00179	0.336
MOD_SUMO_rev_2	82	87	PF00179	0.502
MOD_SUMO_rev_2	88	98	PF00179	0.517
TRG_DiLeu_BaLyEn_6	276	281	PF01217	0.390
TRG_ENDOCYTIC_2	17	20	PF00928	0.335
TRG_ENDOCYTIC_2	336	339	PF00928	0.346
TRG_ENDOCYTIC_2	352	355	PF00928	0.164
TRG_ENDOCYTIC_2	43	46	PF00928	0.290
TRG_ENDOCYTIC_2	463	466	PF00928	0.513
TRG_ENDOCYTIC_2	99	102	PF00928	0.354
TRG_ER_diArg_1	133	136	PF00400	0.341
TRG_ER_diArg_1	180	182	PF00400	0.346
TRG_ER_diArg_1	2	4	PF00400	0.531
TRG_ER_diArg_1	79	81	PF00400	0.500
TRG_NES_CRM1_1	203	214	PF08389	0.253
TRG_NLS_MonoCore_2	133	138	PF00514	0.303
TRG_NLS_MonoExtN_4	131	138	PF00514	0.285
TRG_Pf-PMV_PEXEL_1	197	201	PF00026	0.312
TRG_Pf-PMV_PEXEL_1	241	245	PF00026	0.286
TRG_Pf-PMV_PEXEL_1	279	284	PF00026	0.390

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P494	Leptomonas seymouri	80%	100%
A0A0N1I0J7	Leptomonas seymouri	28%	93%
A0A0S4J9H9	Bodo saltans	48%	100%
A0A0S4JPV5	Bodo saltans	29%	94%
A0A1X0NK74	Trypanosomatidae	60%	100%
A0A1X0NN10	Trypanosomatidae	28%	100%
A0A3R7K771	Trypanosoma rangeli	57%	100%
A0A3R7L848	Trypanosoma rangeli	27%	100%
A0A3S7XCB8	Leishmania donovani	28%	90%
A4H4F1	Leishmania braziliensis	89%	100%
A4HSM8	Leishmania infantum	99%	100%
A4ICB9	Leishmania infantum	29%	100%
C9ZU69	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	98%
D0A3Q2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	97%
E9AIY4	Leishmania braziliensis	28%	100%
E9AKL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9AKL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9AUB4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	90%
O42895	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
P32317	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	94%
P46441	Haematobia irritans	32%	100%
P64612	Escherichia coli (strain K12)	27%	100%
P64613	Escherichia coli O157:H7	27%	100%
Q32PX9	Rattus norvegicus	31%	100%
Q3V384	Mus musculus	30%	100%
Q4Q076	Leishmania major	29%	100%
Q4QJ96	Leishmania major	97%	100%
Q5TYS0	Danio rerio	33%	95%
Q8WV93	Homo sapiens	31%	99%
V5BD25	Trypanosoma cruzi	29%	100%
V5D7E6	Trypanosoma cruzi	59%	90%