Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S5H5L5_LEIDO

TriTrypDb:

LdBPK_051050.1 , LdCL_050015800

Length:

443

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H5L5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5L5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	250	254	PF00656	0.686
CLV_C14_Caspase3-7	94	98	PF00656	0.674
CLV_NRD_NRD_1	139	141	PF00675	0.540
CLV_NRD_NRD_1	155	157	PF00675	0.564
CLV_NRD_NRD_1	291	293	PF00675	0.505
CLV_NRD_NRD_1	355	357	PF00675	0.584
CLV_NRD_NRD_1	362	364	PF00675	0.611
CLV_NRD_NRD_1	426	428	PF00675	0.616
CLV_PCSK_KEX2_1	138	140	PF00082	0.545
CLV_PCSK_KEX2_1	155	157	PF00082	0.564
CLV_PCSK_KEX2_1	290	292	PF00082	0.503
CLV_PCSK_KEX2_1	355	357	PF00082	0.584
CLV_PCSK_KEX2_1	362	364	PF00082	0.611
CLV_PCSK_KEX2_1	426	428	PF00082	0.616
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.545
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.529
CLV_PCSK_SKI1_1	11	15	PF00082	0.767
CLV_PCSK_SKI1_1	347	351	PF00082	0.570
CLV_PCSK_SKI1_1	372	376	PF00082	0.636
CLV_PCSK_SKI1_1	418	422	PF00082	0.632
CLV_PCSK_SKI1_1	74	78	PF00082	0.658
DEG_Nend_Nbox_1	1	3	PF02207	0.746
DOC_ANK_TNKS_1	328	335	PF00023	0.609
DOC_CYCLIN_RxL_1	74	84	PF00134	0.711
DOC_MAPK_MEF2A_6	96	105	PF00069	0.595
DOC_PP2B_LxvP_1	55	58	PF13499	0.735
DOC_PP2B_LxvP_1	7	10	PF13499	0.801
DOC_USP7_MATH_1	108	112	PF00917	0.724
DOC_USP7_MATH_1	214	218	PF00917	0.542
DOC_USP7_MATH_1	26	30	PF00917	0.662
DOC_USP7_MATH_1	332	336	PF00917	0.612
DOC_WW_Pin1_4	223	228	PF00397	0.691
LIG_14-3-3_CanoR_1	291	296	PF00244	0.591
LIG_14-3-3_CanoR_1	322	326	PF00244	0.504
LIG_14-3-3_CanoR_1	329	337	PF00244	0.506
LIG_14-3-3_CanoR_1	363	369	PF00244	0.580
LIG_14-3-3_CanoR_1	50	54	PF00244	0.821
LIG_Actin_WH2_2	409	425	PF00022	0.627
LIG_APCC_ABBA_1	371	376	PF00400	0.691
LIG_BIR_III_4	253	257	PF00653	0.693
LIG_deltaCOP1_diTrp_1	333	341	PF00928	0.518
LIG_FHA_1	100	106	PF00498	0.769
LIG_FHA_1	14	20	PF00498	0.634
LIG_FHA_1	2	8	PF00498	0.750
LIG_FHA_1	415	421	PF00498	0.632
LIG_FHA_1	50	56	PF00498	0.752
LIG_FHA_1	66	72	PF00498	0.565
LIG_FHA_2	116	122	PF00498	0.617
LIG_FHA_2	188	194	PF00498	0.528
LIG_FHA_2	245	251	PF00498	0.742
LIG_FHA_2	401	407	PF00498	0.727
LIG_LIR_Gen_1	111	120	PF02991	0.593
LIG_LIR_Gen_1	274	285	PF02991	0.605
LIG_LIR_Gen_1	294	304	PF02991	0.612
LIG_LIR_Nem_3	111	116	PF02991	0.553
LIG_LIR_Nem_3	274	280	PF02991	0.607
LIG_LIR_Nem_3	294	299	PF02991	0.609
LIG_LIR_Nem_3	431	435	PF02991	0.746
LIG_NRBOX	75	81	PF00104	0.713
LIG_PCNA_yPIPBox_3	123	136	PF02747	0.553
LIG_PCNA_yPIPBox_3	67	80	PF02747	0.650
LIG_SH2_GRB2like	203	206	PF00017	0.545
LIG_SH2_STAP1	192	196	PF00017	0.534
LIG_SH2_STAP1	277	281	PF00017	0.496
LIG_SH2_STAP1	296	300	PF00017	0.275
LIG_SH2_STAP1	326	330	PF00017	0.504
LIG_SH2_STAP1	353	357	PF00017	0.591
LIG_SH2_STAT3	269	272	PF00017	0.523
LIG_SH2_STAT5	269	272	PF00017	0.523
LIG_SH3_3	27	33	PF00018	0.752
LIG_SH3_3	51	57	PF00018	0.710
MOD_CDK_SPxK_1	223	229	PF00069	0.691
MOD_CK1_1	115	121	PF00069	0.563
MOD_CK1_1	391	397	PF00069	0.738
MOD_CK1_1	42	48	PF00069	0.742
MOD_CK2_1	108	114	PF00069	0.619
MOD_CK2_1	115	121	PF00069	0.589
MOD_CK2_1	187	193	PF00069	0.526
MOD_CK2_1	291	297	PF00069	0.535
MOD_CK2_1	433	439	PF00069	0.674
MOD_CK2_1	59	65	PF00069	0.701
MOD_GlcNHglycan	16	19	PF01048	0.761
MOD_GlcNHglycan	44	47	PF01048	0.746
MOD_GlcNHglycan	83	86	PF01048	0.700
MOD_GSK3_1	108	115	PF00069	0.592
MOD_GSK3_1	14	21	PF00069	0.816
MOD_GSK3_1	317	324	PF00069	0.561
MOD_GSK3_1	328	335	PF00069	0.476
MOD_GSK3_1	36	43	PF00069	0.754
MOD_GSK3_1	45	52	PF00069	0.768
MOD_N-GLC_1	40	45	PF02516	0.627
MOD_N-GLC_2	346	348	PF02516	0.560
MOD_NEK2_1	1	6	PF00069	0.749
MOD_NEK2_1	106	111	PF00069	0.732
MOD_NEK2_1	112	117	PF00069	0.594
MOD_NEK2_1	244	249	PF00069	0.634
MOD_NEK2_1	349	354	PF00069	0.684
MOD_NEK2_1	79	84	PF00069	0.717
MOD_NEK2_2	108	113	PF00069	0.619
MOD_PIKK_1	317	323	PF00454	0.533
MOD_PKA_1	291	297	PF00069	0.613
MOD_PKA_2	106	112	PF00069	0.642
MOD_PKA_2	187	193	PF00069	0.526
MOD_PKA_2	291	297	PF00069	0.601
MOD_PKA_2	321	327	PF00069	0.495
MOD_PKA_2	328	334	PF00069	0.522
MOD_PKA_2	49	55	PF00069	0.819
MOD_Plk_1	244	250	PF00069	0.662
MOD_Plk_1	26	32	PF00069	0.780
MOD_Plk_1	388	394	PF00069	0.745
MOD_Plk_1	39	45	PF00069	0.601
MOD_Plk_4	108	114	PF00069	0.619
MOD_Plk_4	291	297	PF00069	0.613
MOD_Plk_4	321	327	PF00069	0.499
MOD_Plk_4	332	338	PF00069	0.542
MOD_Plk_4	400	406	PF00069	0.655
MOD_ProDKin_1	223	229	PF00069	0.691
MOD_SUMO_rev_2	152	161	PF00179	0.554
TRG_DiLeu_BaEn_2	130	136	PF01217	0.637
TRG_ENDOCYTIC_2	277	280	PF00928	0.602
TRG_ENDOCYTIC_2	296	299	PF00928	0.277
TRG_ER_diArg_1	139	141	PF00400	0.522
TRG_ER_diArg_1	154	156	PF00400	0.590
TRG_ER_diArg_1	210	213	PF00400	0.685
TRG_ER_diArg_1	362	364	PF00400	0.611
TRG_ER_diArg_1	426	428	PF00400	0.616
TRG_NLS_MonoCore_2	289	294	PF00514	0.616
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.575
TRG_Pf-PMV_PEXEL_1	74	78	PF00026	0.721

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3V2	Leptomonas seymouri	65%	100%
A4H4F0	Leishmania braziliensis	86%	100%
A4HSM7	Leishmania infantum	99%	100%
E9AKL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4QJ97	Leishmania major	97%	100%