Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5K7_LEIDO

TriTrypDb:

LdBPK_050880.1 , LdCL_050013900 , LDHU3_05.0970

Length:

205

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3S5H5K7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5K7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.550
CLV_NRD_NRD_1	118	120	PF00675	0.350
CLV_NRD_NRD_1	158	160	PF00675	0.604
CLV_NRD_NRD_1	34	36	PF00675	0.424
CLV_NRD_NRD_1	52	54	PF00675	0.366
CLV_PCSK_KEX2_1	118	120	PF00082	0.350
CLV_PCSK_KEX2_1	160	162	PF00082	0.629
CLV_PCSK_KEX2_1	196	198	PF00082	0.613
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.629
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.613
CLV_PCSK_SKI1_1	161	165	PF00082	0.655
CLV_PCSK_SKI1_1	36	40	PF00082	0.402
DEG_Nend_UBRbox_3	1	3	PF02207	0.679
DOC_CKS1_1	150	155	PF01111	0.433
DOC_CYCLIN_RxL_1	32	40	PF00134	0.601
DOC_CYCLIN_yCln2_LP_2	6	12	PF00134	0.635
DOC_MAPK_gen_1	118	126	PF00069	0.449
DOC_MAPK_MEF2A_6	119	128	PF00069	0.449
DOC_PP2B_LxvP_1	179	182	PF13499	0.445
DOC_PP2B_LxvP_1	27	30	PF13499	0.578
DOC_PP2B_LxvP_1	6	9	PF13499	0.623
DOC_PP4_FxxP_1	39	42	PF00568	0.595
DOC_USP7_MATH_1	12	16	PF00917	0.749
DOC_USP7_MATH_1	20	24	PF00917	0.641
DOC_USP7_UBL2_3	160	164	PF12436	0.493
DOC_USP7_UBL2_3	66	70	PF12436	0.603
DOC_WW_Pin1_4	149	154	PF00397	0.438
DOC_WW_Pin1_4	16	21	PF00397	0.684
LIG_14-3-3_CanoR_1	197	202	PF00244	0.450
LIG_Actin_WH2_2	31	48	PF00022	0.688
LIG_Actin_WH2_2	79	97	PF00022	0.613
LIG_APCC_ABBAyCdc20_2	110	116	PF00400	0.569
LIG_BRCT_BRCA1_1	30	34	PF00533	0.639
LIG_BRCT_BRCA1_2	30	36	PF00533	0.636
LIG_FHA_1	137	143	PF00498	0.402
LIG_FHA_1	145	151	PF00498	0.382
LIG_FHA_1	66	72	PF00498	0.666
LIG_FHA_2	181	187	PF00498	0.476
LIG_FHA_2	95	101	PF00498	0.619
LIG_LIR_Apic_2	146	151	PF02991	0.370
LIG_LIR_Apic_2	37	42	PF02991	0.595
LIG_LIR_Nem_3	117	123	PF02991	0.436
LIG_SH2_GRB2like	120	123	PF00017	0.271
LIG_SH2_PTP2	123	126	PF00017	0.289
LIG_SH2_STAP1	120	124	PF00017	0.287
LIG_SH2_STAP1	138	142	PF00017	0.322
LIG_SH2_STAT5	123	126	PF00017	0.271
LIG_SH2_STAT5	138	141	PF00017	0.390
LIG_SUMO_SIM_par_1	177	184	PF11976	0.414
MOD_CK1_1	15	21	PF00069	0.689
MOD_CK2_1	180	186	PF00069	0.481
MOD_CK2_1	94	100	PF00069	0.626
MOD_GlcNHglycan	168	172	PF01048	0.721
MOD_GlcNHglycan	22	25	PF01048	0.524
MOD_GSK3_1	12	19	PF00069	0.750
MOD_GSK3_1	197	204	PF00069	0.485
MOD_GSK3_1	99	106	PF00069	0.598
MOD_NEK2_1	103	108	PF00069	0.589
MOD_NEK2_1	131	136	PF00069	0.284
MOD_NEK2_1	71	76	PF00069	0.592
MOD_NEK2_1	94	99	PF00069	0.627
MOD_PIKK_1	154	160	PF00454	0.393
MOD_PIKK_1	94	100	PF00454	0.626
MOD_PKA_1	196	202	PF00069	0.485
MOD_PKA_2	196	202	PF00069	0.485
MOD_PKA_2	94	100	PF00069	0.626
MOD_ProDKin_1	149	155	PF00069	0.435
MOD_ProDKin_1	16	22	PF00069	0.683
MOD_SUMO_rev_2	40	47	PF00179	0.613
TRG_ENDOCYTIC_2	123	126	PF00928	0.271
TRG_ER_diArg_1	118	120	PF00400	0.550
TRG_ER_diArg_1	159	162	PF00400	0.491
TRG_ER_diArg_1	3	6	PF00400	0.698
TRG_ER_diArg_1	92	95	PF00400	0.631
TRG_Pf-PMV_PEXEL_1	36	40	PF00026	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSV2	Leptomonas seymouri	89%	98%
A0A0S4J1S7	Bodo saltans	67%	100%
A0A1X0NK70	Trypanosomatidae	65%	71%
A0A3R7RHS1	Trypanosoma rangeli	68%	87%
A4H4D0	Leishmania braziliensis	91%	100%
A4HSL0	Leishmania infantum	100%	100%
C9ZU79	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	68%
E9AKJ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q4QJB4	Leishmania major	98%	100%