Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5K6_LEIDO

TriTrypDb:

LdBPK_050860.1 , LdCL_050013700 , LDHU3_05.0950

Length:

155

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H5K6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5K6

PDB structure(s): 7aih_Af , 7am2_Af , 7ane_Af

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	61	67	PF00089	0.563
CLV_NRD_NRD_1	26	28	PF00675	0.292
CLV_NRD_NRD_1	3	5	PF00675	0.595
CLV_NRD_NRD_1	9	11	PF00675	0.497
CLV_NRD_NRD_1	91	93	PF00675	0.509
CLV_PCSK_KEX2_1	3	5	PF00082	0.595
CLV_PCSK_KEX2_1	33	35	PF00082	0.408
CLV_PCSK_KEX2_1	9	11	PF00082	0.504
CLV_PCSK_KEX2_1	91	93	PF00082	0.449
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.410
CLV_PCSK_SKI1_1	16	20	PF00082	0.417
DEG_APCC_DBOX_1	102	110	PF00400	0.543
DEG_APCC_DBOX_1	15	23	PF00400	0.392
DEG_Nend_Nbox_1	1	3	PF02207	0.587
DEG_SIAH_1	56	64	PF03145	0.503
DOC_CYCLIN_yCln2_LP_2	18	24	PF00134	0.385
DOC_MAPK_DCC_7	16	24	PF00069	0.389
DOC_PP4_FxxP_1	54	57	PF00568	0.417
DOC_PP4_FxxP_1	60	63	PF00568	0.519
DOC_USP7_MATH_1	150	154	PF00917	0.551
DOC_USP7_MATH_1	63	67	PF00917	0.587
DOC_WW_Pin1_4	2	7	PF00397	0.572
DOC_WW_Pin1_4	59	64	PF00397	0.549
DOC_WW_Pin1_4	92	97	PF00397	0.473
LIG_14-3-3_CanoR_1	137	143	PF00244	0.483
LIG_14-3-3_CanoR_1	50	55	PF00244	0.460
LIG_14-3-3_CanoR_1	9	19	PF00244	0.483
LIG_LIR_Apic_2	53	57	PF02991	0.407
LIG_LIR_Gen_1	141	150	PF02991	0.504
LIG_LIR_Nem_3	13	18	PF02991	0.441
LIG_LIR_Nem_3	141	145	PF02991	0.492
LIG_LIR_Nem_3	46	51	PF02991	0.482
LIG_PDZ_Class_1	150	155	PF00595	0.564
LIG_SH3_1	133	139	PF00018	0.458
LIG_SH3_2	147	152	PF14604	0.480
LIG_SH3_3	111	117	PF00018	0.517
LIG_SH3_3	133	139	PF00018	0.470
LIG_SH3_3	144	150	PF00018	0.496
LIG_WRC_WIRS_1	51	56	PF05994	0.425
MOD_CDC14_SPxK_1	95	98	PF00782	0.493
MOD_CDK_SPK_2	59	64	PF00069	0.501
MOD_CDK_SPxK_1	92	98	PF00069	0.505
MOD_CDK_SPxxK_3	2	9	PF00069	0.561
MOD_CK1_1	141	147	PF00069	0.457
MOD_CK2_1	148	154	PF00069	0.545
MOD_DYRK1A_RPxSP_1	92	96	PF00069	0.503
MOD_GlcNHglycan	67	70	PF01048	0.679
MOD_GSK3_1	59	66	PF00069	0.598
MOD_GSK3_1	72	79	PF00069	0.611
MOD_NEK2_1	108	113	PF00069	0.561
MOD_PIKK_1	72	78	PF00454	0.617
MOD_PKA_1	33	39	PF00069	0.526
MOD_PKA_2	33	39	PF00069	0.526
MOD_PKA_2	63	69	PF00069	0.651
MOD_ProDKin_1	2	8	PF00069	0.566
MOD_ProDKin_1	59	65	PF00069	0.557
MOD_ProDKin_1	92	98	PF00069	0.471
TRG_DiLeu_BaEn_2	103	109	PF01217	0.434
TRG_ENDOCYTIC_2	48	51	PF00928	0.411
TRG_ER_diArg_1	133	136	PF00400	0.434
TRG_ER_diArg_1	2	4	PF00400	0.595
TRG_ER_diArg_1	8	10	PF00400	0.477
TRG_ER_diArg_1	90	92	PF00400	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBF6	Leptomonas seymouri	72%	100%
A0A0S4J4H9	Bodo saltans	36%	100%
A0A1X0NJY4	Trypanosomatidae	52%	100%
A0A3R7M1F1	Trypanosoma rangeli	53%	97%
A4H4C8	Leishmania braziliensis	92%	100%
A4HSK8	Leishmania infantum	99%	100%
C9ZU82	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	79%
E9AKJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4QJB6	Leishmania major	98%	100%