Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5K4_LEIDO

TriTrypDb:

LdBPK_050820.1 , LdCL_050013300 , LDHU3_05.0910

Length:

941

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H5K4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5K4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.762
CLV_C14_Caspase3-7	405	409	PF00656	0.310
CLV_C14_Caspase3-7	916	920	PF00656	0.414
CLV_MEL_PAP_1	426	432	PF00089	0.578
CLV_MEL_PAP_1	760	766	PF00089	0.251
CLV_NRD_NRD_1	199	201	PF00675	0.354
CLV_NRD_NRD_1	245	247	PF00675	0.459
CLV_NRD_NRD_1	336	338	PF00675	0.274
CLV_NRD_NRD_1	732	734	PF00675	0.311
CLV_NRD_NRD_1	8	10	PF00675	0.565
CLV_NRD_NRD_1	839	841	PF00675	0.325
CLV_NRD_NRD_1	899	901	PF00675	0.500
CLV_PCSK_KEX2_1	198	200	PF00082	0.356
CLV_PCSK_KEX2_1	244	246	PF00082	0.506
CLV_PCSK_KEX2_1	335	337	PF00082	0.279
CLV_PCSK_KEX2_1	7	9	PF00082	0.544
CLV_PCSK_KEX2_1	839	841	PF00082	0.324
CLV_PCSK_KEX2_1	890	892	PF00082	0.508
CLV_PCSK_KEX2_1	898	900	PF00082	0.486
CLV_PCSK_KEX2_1	908	910	PF00082	0.522
CLV_PCSK_PC1ET2_1	335	337	PF00082	0.292
CLV_PCSK_PC1ET2_1	890	892	PF00082	0.508
CLV_PCSK_PC1ET2_1	898	900	PF00082	0.486
CLV_PCSK_PC1ET2_1	908	910	PF00082	0.522
CLV_PCSK_PC7_1	241	247	PF00082	0.366
CLV_PCSK_PC7_1	332	338	PF00082	0.290
CLV_PCSK_SKI1_1	137	141	PF00082	0.398
CLV_PCSK_SKI1_1	332	336	PF00082	0.292
CLV_PCSK_SKI1_1	585	589	PF00082	0.481
CLV_PCSK_SKI1_1	673	677	PF00082	0.304
CLV_PCSK_SKI1_1	800	804	PF00082	0.280
CLV_PCSK_SKI1_1	818	822	PF00082	0.301
DEG_APCC_DBOX_1	672	680	PF00400	0.482
DEG_APCC_DBOX_1	799	807	PF00400	0.478
DEG_APCC_DBOX_1	839	847	PF00400	0.482
DEG_ODPH_VHL_1	471	484	PF01847	0.401
DEG_SPOP_SBC_1	299	303	PF00917	0.555
DEG_SPOP_SBC_1	379	383	PF00917	0.542
DOC_CYCLIN_RxL_1	477	488	PF00134	0.506
DOC_CYCLIN_RxL_1	815	822	PF00134	0.522
DOC_CYCLIN_yClb5_NLxxxL_5	252	258	PF00134	0.428
DOC_MAPK_gen_1	890	897	PF00069	0.298
DOC_MAPK_MEF2A_6	419	426	PF00069	0.404
DOC_MAPK_MEF2A_6	890	897	PF00069	0.393
DOC_PP1_RVXF_1	250	257	PF00149	0.574
DOC_PP1_RVXF_1	583	590	PF00149	0.460
DOC_PP1_RVXF_1	761	767	PF00149	0.478
DOC_PP2B_LxvP_1	658	661	PF13499	0.349
DOC_PP4_FxxP_1	98	101	PF00568	0.667
DOC_USP7_MATH_1	165	169	PF00917	0.610
DOC_USP7_MATH_1	236	240	PF00917	0.692
DOC_USP7_MATH_1	267	271	PF00917	0.575
DOC_USP7_MATH_1	322	326	PF00917	0.605
DOC_USP7_MATH_1	379	383	PF00917	0.535
DOC_USP7_MATH_1	388	392	PF00917	0.516
DOC_USP7_MATH_1	627	631	PF00917	0.363
DOC_USP7_MATH_1	661	665	PF00917	0.404
DOC_USP7_MATH_1	768	772	PF00917	0.579
DOC_USP7_MATH_1	812	816	PF00917	0.558
DOC_USP7_UBL2_3	11	15	PF12436	0.815
DOC_USP7_UBL2_3	937	941	PF12436	0.413
DOC_WW_Pin1_4	111	116	PF00397	0.677
DOC_WW_Pin1_4	354	359	PF00397	0.474
DOC_WW_Pin1_4	389	394	PF00397	0.542
DOC_WW_Pin1_4	44	49	PF00397	0.686
DOC_WW_Pin1_4	588	593	PF00397	0.424
DOC_WW_Pin1_4	829	834	PF00397	0.673
DOC_WW_Pin1_4	914	919	PF00397	0.429
DOC_WW_Pin1_4	96	101	PF00397	0.623
LIG_14-3-3_CanoR_1	297	307	PF00244	0.567
LIG_14-3-3_CanoR_1	429	436	PF00244	0.366
LIG_14-3-3_CanoR_1	459	463	PF00244	0.407
LIG_14-3-3_CanoR_1	528	538	PF00244	0.569
LIG_14-3-3_CanoR_1	763	767	PF00244	0.558
LIG_14-3-3_CanoR_1	775	782	PF00244	0.532
LIG_14-3-3_CanoR_1	9	18	PF00244	0.810
LIG_Actin_WH2_2	70	87	PF00022	0.523
LIG_APCC_ABBA_1	864	869	PF00400	0.288
LIG_APCC_ABBAyCdc20_2	682	688	PF00400	0.593
LIG_BIR_III_2	112	116	PF00653	0.687
LIG_BRCT_BRCA1_1	381	385	PF00533	0.436
LIG_Clathr_ClatBox_1	290	294	PF01394	0.506
LIG_eIF4E_1	578	584	PF01652	0.289
LIG_EVH1_2	42	46	PF00568	0.623
LIG_FHA_1	112	118	PF00498	0.789
LIG_FHA_1	150	156	PF00498	0.538
LIG_FHA_1	249	255	PF00498	0.551
LIG_FHA_1	284	290	PF00498	0.573
LIG_FHA_1	347	353	PF00498	0.422
LIG_FHA_1	398	404	PF00498	0.329
LIG_FHA_1	459	465	PF00498	0.404
LIG_FHA_1	524	530	PF00498	0.563
LIG_FHA_1	610	616	PF00498	0.459
LIG_FHA_1	653	659	PF00498	0.267
LIG_FHA_1	711	717	PF00498	0.550
LIG_FHA_1	905	911	PF00498	0.353
LIG_FHA_2	107	113	PF00498	0.689
LIG_FHA_2	125	131	PF00498	0.607
LIG_FHA_2	23	29	PF00498	0.670
LIG_FHA_2	300	306	PF00498	0.519
LIG_FHA_2	403	409	PF00498	0.378
LIG_FHA_2	752	758	PF00498	0.533
LIG_FHA_2	860	866	PF00498	0.385
LIG_GBD_Chelix_1	474	482	PF00786	0.504
LIG_GBD_Chelix_1	652	660	PF00786	0.531
LIG_LIR_Apic_2	586	592	PF02991	0.348
LIG_LIR_Apic_2	99	105	PF02991	0.701
LIG_LIR_Gen_1	301	312	PF02991	0.624
LIG_LIR_Gen_1	57	66	PF02991	0.575
LIG_LIR_Gen_1	822	829	PF02991	0.522
LIG_LIR_Gen_1	921	930	PF02991	0.353
LIG_LIR_LC3C_4	152	155	PF02991	0.493
LIG_LIR_Nem_3	204	209	PF02991	0.674
LIG_LIR_Nem_3	301	307	PF02991	0.565
LIG_LIR_Nem_3	45	49	PF02991	0.681
LIG_LIR_Nem_3	57	63	PF02991	0.596
LIG_LIR_Nem_3	671	675	PF02991	0.502
LIG_LIR_Nem_3	69	75	PF02991	0.583
LIG_LIR_Nem_3	822	827	PF02991	0.520
LIG_LIR_Nem_3	921	926	PF02991	0.321
LIG_LIR_Nem_3	931	936	PF02991	0.264
LIG_NRBOX	288	294	PF00104	0.490
LIG_NRBOX	351	357	PF00104	0.335
LIG_NRBOX	453	459	PF00104	0.355
LIG_NRBOX	91	97	PF00104	0.533
LIG_RPA_C_Fungi	523	535	PF08784	0.353
LIG_SH2_CRK	824	828	PF00017	0.389
LIG_SH2_NCK_1	102	106	PF00017	0.550
LIG_SH2_SRC	102	105	PF00017	0.486
LIG_SH2_STAP1	315	319	PF00017	0.486
LIG_SH2_STAP1	824	828	PF00017	0.367
LIG_SH2_STAT5	255	258	PF00017	0.432
LIG_SH2_STAT5	72	75	PF00017	0.383
LIG_SH2_STAT5	896	899	PF00017	0.470
LIG_SH3_3	114	120	PF00018	0.698
LIG_SH3_3	33	39	PF00018	0.699
LIG_SH3_3	600	606	PF00018	0.587
LIG_SH3_3	830	836	PF00018	0.487
LIG_SH3_3	873	879	PF00018	0.313
LIG_SH3_3	98	104	PF00018	0.576
LIG_SH3_5	310	314	PF00018	0.368
LIG_SUMO_SIM_anti_2	284	294	PF11976	0.475
LIG_SUMO_SIM_anti_2	351	357	PF11976	0.470
LIG_SUMO_SIM_anti_2	654	660	PF11976	0.317
LIG_SUMO_SIM_anti_2	757	762	PF11976	0.344
LIG_SUMO_SIM_par_1	151	158	PF11976	0.364
LIG_SUMO_SIM_par_1	263	270	PF11976	0.426
LIG_SUMO_SIM_par_1	284	294	PF11976	0.355
LIG_SUMO_SIM_par_1	351	357	PF11976	0.475
LIG_SUMO_SIM_par_1	639	646	PF11976	0.349
LIG_TRAF2_1	128	131	PF00917	0.804
LIG_TYR_ITIM	70	75	PF00017	0.294
LIG_UBA3_1	727	734	PF00899	0.327
LIG_WRC_WIRS_1	435	440	PF05994	0.488
MOD_CK1_1	248	254	PF00069	0.531
MOD_CK1_1	284	290	PF00069	0.367
MOD_CK1_1	381	387	PF00069	0.706
MOD_CK1_1	431	437	PF00069	0.436
MOD_CK1_1	591	597	PF00069	0.553
MOD_CK1_1	710	716	PF00069	0.469
MOD_CK1_1	736	742	PF00069	0.462
MOD_CK1_1	769	775	PF00069	0.469
MOD_CK1_1	914	920	PF00069	0.537
MOD_CK2_1	124	130	PF00069	0.790
MOD_CK2_1	22	28	PF00069	0.597
MOD_CK2_1	299	305	PF00069	0.482
MOD_CK2_1	692	698	PF00069	0.557
MOD_Cter_Amidation	816	819	PF01082	0.372
MOD_GlcNHglycan	12	15	PF01048	0.800
MOD_GlcNHglycan	122	125	PF01048	0.742
MOD_GlcNHglycan	167	170	PF01048	0.663
MOD_GlcNHglycan	174	177	PF01048	0.585
MOD_GlcNHglycan	219	222	PF01048	0.789
MOD_GlcNHglycan	237	241	PF01048	0.653
MOD_GlcNHglycan	247	250	PF01048	0.526
MOD_GlcNHglycan	286	289	PF01048	0.384
MOD_GlcNHglycan	310	313	PF01048	0.547
MOD_GlcNHglycan	386	389	PF01048	0.742
MOD_GlcNHglycan	572	575	PF01048	0.335
MOD_GlcNHglycan	595	599	PF01048	0.722
MOD_GlcNHglycan	700	703	PF01048	0.579
MOD_GlcNHglycan	709	712	PF01048	0.420
MOD_GlcNHglycan	738	741	PF01048	0.609
MOD_GlcNHglycan	754	757	PF01048	0.320
MOD_GlcNHglycan	767	771	PF01048	0.470
MOD_GlcNHglycan	930	933	PF01048	0.319
MOD_GSK3_1	116	123	PF00069	0.749
MOD_GSK3_1	279	286	PF00069	0.552
MOD_GSK3_1	299	306	PF00069	0.512
MOD_GSK3_1	341	348	PF00069	0.423
MOD_GSK3_1	380	387	PF00069	0.727
MOD_GSK3_1	389	396	PF00069	0.575
MOD_GSK3_1	739	746	PF00069	0.602
MOD_GSK3_1	762	769	PF00069	0.462
MOD_LATS_1	243	249	PF00433	0.398
MOD_N-GLC_1	359	364	PF02516	0.386
MOD_N-GLC_1	549	554	PF02516	0.507
MOD_N-GLC_1	928	933	PF02516	0.315
MOD_NEK2_1	1	6	PF00069	0.701
MOD_NEK2_1	283	288	PF00069	0.457
MOD_NEK2_1	341	346	PF00069	0.404
MOD_NEK2_1	402	407	PF00069	0.398
MOD_NEK2_1	458	463	PF00069	0.349
MOD_NEK2_1	485	490	PF00069	0.485
MOD_NEK2_1	529	534	PF00069	0.507
MOD_NEK2_1	707	712	PF00069	0.499
MOD_NEK2_1	727	732	PF00069	0.211
MOD_NEK2_1	774	779	PF00069	0.399
MOD_NEK2_1	785	790	PF00069	0.340
MOD_NEK2_2	851	856	PF00069	0.404
MOD_PIKK_1	529	535	PF00454	0.434
MOD_PKA_1	245	251	PF00069	0.390
MOD_PKA_1	733	739	PF00069	0.448
MOD_PKA_2	245	251	PF00069	0.582
MOD_PKA_2	428	434	PF00069	0.544
MOD_PKA_2	458	464	PF00069	0.404
MOD_PKA_2	529	535	PF00069	0.453
MOD_PKA_2	54	60	PF00069	0.410
MOD_PKA_2	762	768	PF00069	0.448
MOD_PKA_2	774	780	PF00069	0.406
MOD_Plk_1	359	365	PF00069	0.393
MOD_Plk_1	397	403	PF00069	0.525
MOD_Plk_1	431	437	PF00069	0.447
MOD_Plk_1	485	491	PF00069	0.477
MOD_Plk_4	303	309	PF00069	0.483
MOD_Plk_4	402	408	PF00069	0.303
MOD_Plk_4	434	440	PF00069	0.444
MOD_Plk_4	652	658	PF00069	0.271
MOD_Plk_4	769	775	PF00069	0.338
MOD_Plk_4	859	865	PF00069	0.479
MOD_ProDKin_1	111	117	PF00069	0.604
MOD_ProDKin_1	354	360	PF00069	0.472
MOD_ProDKin_1	389	395	PF00069	0.680
MOD_ProDKin_1	44	50	PF00069	0.604
MOD_ProDKin_1	588	594	PF00069	0.546
MOD_ProDKin_1	829	835	PF00069	0.607
MOD_ProDKin_1	914	920	PF00069	0.537
MOD_ProDKin_1	96	102	PF00069	0.532
MOD_SUMO_rev_2	904	910	PF00179	0.423
MOD_SUMO_rev_2	931	938	PF00179	0.305
TRG_DiLeu_BaEn_2	397	403	PF01217	0.504
TRG_DiLeu_BaEn_4	263	269	PF01217	0.356
TRG_DiLeu_BaLyEn_6	480	485	PF01217	0.455
TRG_DiLeu_BaLyEn_6	501	506	PF01217	0.337
TRG_DiLeu_BaLyEn_6	534	539	PF01217	0.452
TRG_ENDOCYTIC_2	255	258	PF00928	0.432
TRG_ENDOCYTIC_2	60	63	PF00928	0.511
TRG_ENDOCYTIC_2	72	75	PF00928	0.553
TRG_ENDOCYTIC_2	824	827	PF00928	0.394
TRG_ENDOCYTIC_2	877	880	PF00928	0.342
TRG_ER_diArg_1	198	200	PF00400	0.475
TRG_ER_diArg_1	244	246	PF00400	0.642
TRG_ER_diArg_1	6	9	PF00400	0.713
TRG_ER_diArg_1	839	841	PF00400	0.404
TRG_NES_CRM1_1	639	651	PF08389	0.457
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.296
TRG_Pf-PMV_PEXEL_1	452	456	PF00026	0.382
TRG_Pf-PMV_PEXEL_1	623	628	PF00026	0.543
TRG_Pf-PMV_PEXEL_1	673	677	PF00026	0.409

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF34	Leptomonas seymouri	60%	100%
A0A1X0NLT0	Trypanosomatidae	34%	100%
A0A422NJC1	Trypanosoma rangeli	35%	100%
A4H4C4	Leishmania braziliensis	77%	98%
A4HSK4	Leishmania infantum	100%	100%
C9ZU88	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	98%
E9AKI8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
Q4QJC0	Leishmania major	93%	100%
V5BBH0	Trypanosoma cruzi	34%	96%