MYND zinc finger (ZnF) domain-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MYND zinc finger (ZnF) domain-like protein

Species:

Leishmania donovani

UniProt:

A0A3S5H5K2_LEIDO

TriTrypDb:

LdBPK_050800.1 , LdCL_050013100 , LDHU3_05.0890

Length:

505

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H5K2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5K2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.588
CLV_NRD_NRD_1	155	157	PF00675	0.565
CLV_NRD_NRD_1	322	324	PF00675	0.533
CLV_NRD_NRD_1	477	479	PF00675	0.539
CLV_PCSK_KEX2_1	155	157	PF00082	0.570
CLV_PCSK_KEX2_1	322	324	PF00082	0.533
CLV_PCSK_KEX2_1	387	389	PF00082	0.401
CLV_PCSK_KEX2_1	477	479	PF00082	0.539
CLV_PCSK_PC1ET2_1	387	389	PF00082	0.401
CLV_PCSK_SKI1_1	116	120	PF00082	0.532
CLV_PCSK_SKI1_1	158	162	PF00082	0.630
CLV_PCSK_SKI1_1	277	281	PF00082	0.607
CLV_PCSK_SKI1_1	322	326	PF00082	0.467
CLV_PCSK_SKI1_1	454	458	PF00082	0.698
DEG_APCC_KENBOX_2	215	219	PF00400	0.544
DEG_Nend_UBRbox_4	1	3	PF02207	0.462
DEG_SPOP_SBC_1	127	131	PF00917	0.680
DEG_SPOP_SBC_1	138	142	PF00917	0.574
DEG_SPOP_SBC_1	272	276	PF00917	0.675
DEG_SPOP_SBC_1	391	395	PF00917	0.424
DEG_SPOP_SBC_1	52	56	PF00917	0.677
DOC_CKS1_1	18	23	PF01111	0.468
DOC_CKS1_1	59	64	PF01111	0.557
DOC_CYCLIN_yCln2_LP_2	464	470	PF00134	0.564
DOC_MAPK_gen_1	155	165	PF00069	0.669
DOC_MAPK_gen_1	452	464	PF00069	0.631
DOC_MAPK_MEF2A_6	457	466	PF00069	0.730
DOC_PP1_RVXF_1	159	166	PF00149	0.571
DOC_PP1_RVXF_1	354	361	PF00149	0.623
DOC_PP2B_LxvP_1	464	467	PF13499	0.571
DOC_PP2B_LxvP_1	71	74	PF13499	0.588
DOC_PP4_FxxP_1	120	123	PF00568	0.717
DOC_USP7_MATH_1	126	130	PF00917	0.638
DOC_USP7_MATH_1	271	275	PF00917	0.709
DOC_USP7_MATH_1	363	367	PF00917	0.582
DOC_USP7_MATH_1	390	394	PF00917	0.468
DOC_USP7_MATH_1	52	56	PF00917	0.668
DOC_USP7_UBL2_3	453	457	PF12436	0.703
DOC_WW_Pin1_4	132	137	PF00397	0.753
DOC_WW_Pin1_4	141	146	PF00397	0.524
DOC_WW_Pin1_4	17	22	PF00397	0.467
DOC_WW_Pin1_4	424	429	PF00397	0.484
DOC_WW_Pin1_4	55	60	PF00397	0.567
LIG_14-3-3_CanoR_1	139	145	PF00244	0.755
LIG_14-3-3_CanoR_1	32	41	PF00244	0.531
LIG_14-3-3_CanoR_1	336	344	PF00244	0.655
LIG_14-3-3_CanoR_1	402	411	PF00244	0.394
LIG_Actin_WH2_2	147	163	PF00022	0.639
LIG_APCC_ABBA_1	117	122	PF00400	0.692
LIG_APCC_ABBAyCdc20_2	116	122	PF00400	0.686
LIG_APCC_ABBAyCdc20_2	356	362	PF00400	0.640
LIG_BIR_III_4	246	250	PF00653	0.688
LIG_BRCT_BRCA1_1	470	474	PF00533	0.694
LIG_BRCT_BRCA1_1	493	497	PF00533	0.612
LIG_BRCT_BRCA1_2	493	499	PF00533	0.629
LIG_Clathr_ClatBox_1	117	121	PF01394	0.543
LIG_Clathr_ClatBox_1	358	362	PF01394	0.541
LIG_EVH1_1	71	75	PF00568	0.589
LIG_FHA_1	18	24	PF00498	0.716
LIG_FHA_1	180	186	PF00498	0.537
LIG_FHA_1	199	205	PF00498	0.569
LIG_FHA_1	363	369	PF00498	0.532
LIG_FHA_1	456	462	PF00498	0.649
LIG_FHA_2	240	246	PF00498	0.669
LIG_FHA_2	88	94	PF00498	0.527
LIG_IRF3_LxIS_1	22	29	PF10401	0.533
LIG_LIR_Gen_1	177	186	PF02991	0.566
LIG_LIR_Gen_1	419	428	PF02991	0.444
LIG_LIR_Gen_1	485	496	PF02991	0.565
LIG_LIR_Gen_1	83	94	PF02991	0.518
LIG_LIR_Nem_3	177	183	PF02991	0.573
LIG_LIR_Nem_3	419	424	PF02991	0.427
LIG_LIR_Nem_3	485	491	PF02991	0.550
LIG_LIR_Nem_3	492	496	PF02991	0.504
LIG_LIR_Nem_3	83	89	PF02991	0.525
LIG_MLH1_MIPbox_1	470	474	PF16413	0.694
LIG_MLH1_MIPbox_1	493	497	PF16413	0.612
LIG_PTB_Apo_2	159	166	PF02174	0.557
LIG_REV1ctd_RIR_1	471	482	PF16727	0.687
LIG_SH2_CRK	101	105	PF00017	0.563
LIG_SH2_CRK	48	52	PF00017	0.551
LIG_SH2_STAP1	493	497	PF00017	0.621
LIG_SH2_STAP1	96	100	PF00017	0.651
LIG_SH2_STAT3	221	224	PF00017	0.613
LIG_SH2_STAT5	221	224	PF00017	0.572
LIG_SH2_STAT5	411	414	PF00017	0.344
LIG_SH2_STAT5	479	482	PF00017	0.518
LIG_SH2_STAT5	496	499	PF00017	0.500
LIG_SH2_STAT5	500	503	PF00017	0.552
LIG_SH3_3	464	470	PF00018	0.564
LIG_SH3_3	56	62	PF00018	0.736
LIG_SH3_3	69	75	PF00018	0.633
LIG_SUMO_SIM_anti_2	181	188	PF11976	0.559
LIG_SUMO_SIM_anti_2	458	465	PF11976	0.589
LIG_SUMO_SIM_par_1	102	108	PF11976	0.505
LIG_SUMO_SIM_par_1	309	320	PF11976	0.620
LIG_SUMO_SIM_par_1	458	465	PF11976	0.643
LIG_SUMO_SIM_par_1	78	83	PF11976	0.595
LIG_SxIP_EBH_1	32	46	PF03271	0.553
LIG_TRAF2_1	307	310	PF00917	0.656
LIG_WW_3	73	77	PF00397	0.649
MOD_CDK_SPxK_1	424	430	PF00069	0.444
MOD_CDK_SPxxK_3	132	139	PF00069	0.682
MOD_CK1_1	129	135	PF00069	0.719
MOD_CK1_1	140	146	PF00069	0.602
MOD_CK1_1	16	22	PF00069	0.468
MOD_CK1_1	194	200	PF00069	0.724
MOD_CK1_1	267	273	PF00069	0.723
MOD_CK1_1	275	281	PF00069	0.725
MOD_CK1_1	334	340	PF00069	0.585
MOD_CK1_1	445	451	PF00069	0.645
MOD_CK1_1	55	61	PF00069	0.633
MOD_CK2_1	128	134	PF00069	0.686
MOD_Cter_Amidation	450	453	PF01082	0.686
MOD_GlcNHglycan	193	196	PF01048	0.695
MOD_GlcNHglycan	201	204	PF01048	0.692
MOD_GlcNHglycan	266	270	PF01048	0.683
MOD_GlcNHglycan	277	280	PF01048	0.690
MOD_GlcNHglycan	331	334	PF01048	0.663
MOD_GlcNHglycan	339	342	PF01048	0.562
MOD_GlcNHglycan	346	350	PF01048	0.300
MOD_GlcNHglycan	394	397	PF01048	0.412
MOD_GlcNHglycan	412	415	PF01048	0.452
MOD_GlcNHglycan	449	452	PF01048	0.642
MOD_GSK3_1	126	133	PF00069	0.669
MOD_GSK3_1	13	20	PF00069	0.699
MOD_GSK3_1	137	144	PF00069	0.643
MOD_GSK3_1	194	201	PF00069	0.652
MOD_GSK3_1	22	29	PF00069	0.628
MOD_GSK3_1	267	274	PF00069	0.676
MOD_GSK3_1	331	338	PF00069	0.644
MOD_GSK3_1	416	423	PF00069	0.437
MOD_GSK3_1	443	450	PF00069	0.631
MOD_GSK3_1	498	505	PF00069	0.607
MOD_GSK3_1	51	58	PF00069	0.639
MOD_N-GLC_1	33	38	PF02516	0.547
MOD_N-GLC_1	8	13	PF02516	0.482
MOD_NEK2_1	26	31	PF00069	0.545
MOD_NEK2_1	345	350	PF00069	0.523
MOD_NEK2_1	401	406	PF00069	0.439
MOD_NEK2_1	473	478	PF00069	0.551
MOD_NEK2_1	498	503	PF00069	0.574
MOD_NEK2_2	22	27	PF00069	0.510
MOD_PIKK_1	3	9	PF00454	0.447
MOD_PKA_2	138	144	PF00069	0.770
MOD_PKA_2	290	296	PF00069	0.733
MOD_PKA_2	329	335	PF00069	0.711
MOD_PKA_2	401	407	PF00069	0.401
MOD_Plk_1	249	255	PF00069	0.683
MOD_Plk_1	484	490	PF00069	0.551
MOD_Plk_1	8	14	PF00069	0.653
MOD_Plk_2-3	78	84	PF00069	0.591
MOD_Plk_4	181	187	PF00069	0.630
MOD_Plk_4	231	237	PF00069	0.626
MOD_Plk_4	363	369	PF00069	0.532
MOD_Plk_4	468	474	PF00069	0.564
MOD_ProDKin_1	132	138	PF00069	0.754
MOD_ProDKin_1	141	147	PF00069	0.519
MOD_ProDKin_1	17	23	PF00069	0.469
MOD_ProDKin_1	424	430	PF00069	0.484
MOD_ProDKin_1	55	61	PF00069	0.565
MOD_SUMO_rev_2	202	211	PF00179	0.647
MOD_SUMO_rev_2	93	100	PF00179	0.634
TRG_DiLeu_BaEn_1	181	186	PF01217	0.555
TRG_DiLeu_BaLyEn_6	19	24	PF01217	0.510
TRG_DiLeu_BaLyEn_6	396	401	PF01217	0.408
TRG_ENDOCYTIC_2	101	104	PF00928	0.605
TRG_ER_diArg_1	154	156	PF00400	0.550
TRG_ER_diArg_1	321	323	PF00400	0.547
TRG_ER_diArg_1	43	46	PF00400	0.673
TRG_ER_diArg_1	477	479	PF00400	0.539
TRG_Pf-PMV_PEXEL_1	478	482	PF00026	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6V4	Leptomonas seymouri	60%	100%
A0A422NJC5	Trypanosoma rangeli	46%	100%
A4H4C3	Leishmania braziliensis	81%	100%
A4HSK2	Leishmania infantum	99%	100%
C9ZU91	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AKI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QJC2	Leishmania major	94%	100%
V5BG20	Trypanosoma cruzi	44%	100%