Mitochondrial glycoprotein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial glycoprotein, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H5K1_LEIDO

TriTrypDb:

LdBPK_050790.1 , LdCL_050013000 , LDHU3_05.0880

Length:

387

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	10
GO:0031974	membrane-enclosed lumen	2	10
GO:0043233	organelle lumen	3	10
GO:0070013	intracellular organelle lumen	4	10
GO:0110165	cellular anatomical entity	1	10
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S5H5K1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5K1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.665
CLV_C14_Caspase3-7	211	215	PF00656	0.539
CLV_C14_Caspase3-7	288	292	PF00656	0.430
CLV_C14_Caspase3-7	340	344	PF00656	0.447
CLV_NRD_NRD_1	145	147	PF00675	0.436
CLV_NRD_NRD_1	170	172	PF00675	0.583
CLV_NRD_NRD_1	27	29	PF00675	0.669
CLV_NRD_NRD_1	3	5	PF00675	0.677
CLV_PCSK_FUR_1	25	29	PF00082	0.586
CLV_PCSK_KEX2_1	145	147	PF00082	0.436
CLV_PCSK_KEX2_1	170	172	PF00082	0.583
CLV_PCSK_KEX2_1	27	29	PF00082	0.669
CLV_PCSK_KEX2_1	3	5	PF00082	0.618
CLV_PCSK_SKI1_1	109	113	PF00082	0.550
CLV_PCSK_SKI1_1	192	196	PF00082	0.717
CLV_PCSK_SKI1_1	203	207	PF00082	0.415
CLV_PCSK_SKI1_1	3	7	PF00082	0.469
CLV_PCSK_SKI1_1	88	92	PF00082	0.581
DEG_Nend_Nbox_1	1	3	PF02207	0.524
DEG_SPOP_SBC_1	152	156	PF00917	0.675
DEG_SPOP_SBC_1	311	315	PF00917	0.705
DEG_SPOP_SBC_1	33	37	PF00917	0.607
DOC_MAPK_MEF2A_6	203	210	PF00069	0.368
DOC_PP2B_LxvP_1	147	150	PF13499	0.614
DOC_PP4_MxPP_1	149	152	PF00568	0.552
DOC_USP7_MATH_1	153	157	PF00917	0.642
DOC_USP7_MATH_1	174	178	PF00917	0.640
DOC_USP7_MATH_1	261	265	PF00917	0.710
DOC_USP7_MATH_1	312	316	PF00917	0.677
DOC_USP7_MATH_1	33	37	PF00917	0.726
DOC_USP7_MATH_1	99	103	PF00917	0.450
DOC_USP7_UBL2_3	105	109	PF12436	0.386
DOC_WW_Pin1_4	156	161	PF00397	0.645
DOC_WW_Pin1_4	194	199	PF00397	0.659
DOC_WW_Pin1_4	314	319	PF00397	0.619
DOC_WW_Pin1_4	48	53	PF00397	0.704
LIG_14-3-3_CanoR_1	15	24	PF00244	0.525
LIG_14-3-3_CanoR_1	207	217	PF00244	0.426
LIG_14-3-3_CanoR_1	39	47	PF00244	0.652
LIG_CSL_BTD_1	147	150	PF09270	0.400
LIG_EH_1	323	327	PF12763	0.591
LIG_FHA_1	137	143	PF00498	0.507
LIG_FHA_2	209	215	PF00498	0.413
LIG_Integrin_RGD_1	171	173	PF01839	0.588
LIG_LIR_Gen_1	202	210	PF02991	0.482
LIG_LIR_Nem_3	202	208	PF02991	0.476
LIG_LIR_Nem_3	323	329	PF02991	0.580
LIG_PDZ_Class_2	382	387	PF00595	0.446
LIG_Pex14_2	228	232	PF04695	0.409
LIG_REV1ctd_RIR_1	230	238	PF16727	0.440
LIG_SH2_CRK	301	305	PF00017	0.490
LIG_SH2_CRK	322	326	PF00017	0.495
LIG_SH2_GRB2like	279	282	PF00017	0.464
LIG_SH2_GRB2like	322	325	PF00017	0.580
LIG_SH2_NCK_1	322	326	PF00017	0.495
LIG_SH2_STAP1	365	369	PF00017	0.446
LIG_SH2_STAP1	374	378	PF00017	0.446
LIG_SH2_STAT5	322	325	PF00017	0.662
LIG_SH2_STAT5	384	387	PF00017	0.603
LIG_SH3_1	301	307	PF00018	0.484
LIG_SH3_3	122	128	PF00018	0.476
LIG_SH3_3	147	153	PF00018	0.481
LIG_SH3_3	301	307	PF00018	0.597
LIG_TRAF2_1	178	181	PF00917	0.683
LIG_TRAF2_1	272	275	PF00917	0.492
MOD_CDK_SPxxK_3	314	321	PF00069	0.430
MOD_CK1_1	154	160	PF00069	0.661
MOD_CK1_1	161	167	PF00069	0.687
MOD_CK1_1	314	320	PF00069	0.472
MOD_CK1_1	41	47	PF00069	0.596
MOD_CK2_1	175	181	PF00069	0.682
MOD_CK2_1	251	257	PF00069	0.684
MOD_CK2_1	269	275	PF00069	0.532
MOD_CK2_1	91	97	PF00069	0.656
MOD_Cter_Amidation	143	146	PF01082	0.375
MOD_GlcNHglycan	163	166	PF01048	0.746
MOD_GlcNHglycan	254	257	PF01048	0.663
MOD_GlcNHglycan	314	317	PF01048	0.735
MOD_GlcNHglycan	88	91	PF01048	0.651
MOD_GlcNHglycan	93	96	PF01048	0.626
MOD_GSK3_1	129	136	PF00069	0.516
MOD_GSK3_1	151	158	PF00069	0.670
MOD_GSK3_1	175	182	PF00069	0.778
MOD_GSK3_1	209	216	PF00069	0.457
MOD_GSK3_1	248	255	PF00069	0.697
MOD_GSK3_1	306	313	PF00069	0.654
MOD_GSK3_1	34	41	PF00069	0.670
MOD_NEK2_1	34	39	PF00069	0.678
MOD_PIKK_1	176	182	PF00454	0.681
MOD_PIKK_1	261	267	PF00454	0.623
MOD_PKA_2	252	258	PF00069	0.691
MOD_PKA_2	320	326	PF00069	0.552
MOD_PKA_2	38	44	PF00069	0.643
MOD_Plk_1	213	219	PF00069	0.553
MOD_Plk_1	274	280	PF00069	0.442
MOD_Plk_1	99	105	PF00069	0.460
MOD_Plk_4	137	143	PF00069	0.391
MOD_Plk_4	274	280	PF00069	0.532
MOD_Plk_4	344	350	PF00069	0.529
MOD_Plk_4	363	369	PF00069	0.463
MOD_Plk_4	99	105	PF00069	0.495
MOD_ProDKin_1	156	162	PF00069	0.647
MOD_ProDKin_1	194	200	PF00069	0.639
MOD_ProDKin_1	314	320	PF00069	0.612
MOD_ProDKin_1	48	54	PF00069	0.704
MOD_SUMO_rev_2	108	116	PF00179	0.469
MOD_SUMO_rev_2	191	197	PF00179	0.588
TRG_DiLeu_BaEn_2	136	142	PF01217	0.515
TRG_ER_diArg_1	145	147	PF00400	0.434
TRG_ER_diArg_1	2	4	PF00400	0.622
TRG_ER_diArg_1	24	27	PF00400	0.651
TRG_Pf-PMV_PEXEL_1	236	240	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	376	380	PF00026	0.288

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDY6	Leptomonas seymouri	56%	100%
A0A422NJ89	Trypanosoma rangeli	49%	100%
A4H4C2	Leishmania braziliensis	81%	99%
A4HSK1	Leishmania infantum	98%	100%
C9ZU92	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AKI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QJC3	Leishmania major	91%	100%
V5B710	Trypanosoma cruzi	48%	99%