Nitroreductase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nitroreductase-like protein

Species:

Leishmania donovani

UniProt:

A0A3S5H5J0_LEIDO

TriTrypDb:

LdBPK_050660.1 , LdCL_050011700 , LDHU3_05.0740

Length:

323

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H5J0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5J0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016491	oxidoreductase activity	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	34	38	PF00656	0.703
CLV_NRD_NRD_1	3	5	PF00675	0.660
CLV_NRD_NRD_1	6	8	PF00675	0.643
CLV_PCSK_FUR_1	4	8	PF00082	0.534
CLV_PCSK_KEX2_1	114	116	PF00082	0.473
CLV_PCSK_KEX2_1	276	278	PF00082	0.375
CLV_PCSK_KEX2_1	3	5	PF00082	0.660
CLV_PCSK_KEX2_1	304	306	PF00082	0.642
CLV_PCSK_KEX2_1	6	8	PF00082	0.643
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.450
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.434
CLV_PCSK_PC1ET2_1	304	306	PF00082	0.642
CLV_PCSK_SKI1_1	114	118	PF00082	0.441
CLV_PCSK_SKI1_1	148	152	PF00082	0.349
CLV_PCSK_SKI1_1	276	280	PF00082	0.447
CLV_PCSK_SKI1_1	311	315	PF00082	0.605
CLV_PCSK_SKI1_1	6	10	PF00082	0.672
DEG_Nend_Nbox_1	1	3	PF02207	0.693
DEG_SPOP_SBC_1	65	69	PF00917	0.690
DOC_CKS1_1	312	317	PF01111	0.528
DOC_CYCLIN_yCln2_LP_2	157	163	PF00134	0.447
DOC_MAPK_gen_1	3	10	PF00069	0.634
DOC_MAPK_MEF2A_6	285	294	PF00069	0.355
DOC_PP2B_LxvP_1	157	160	PF13499	0.447
DOC_PP2B_LxvP_1	279	282	PF13499	0.447
DOC_PP4_FxxP_1	312	315	PF00568	0.533
DOC_USP7_MATH_1	208	212	PF00917	0.360
DOC_USP7_MATH_1	214	218	PF00917	0.322
DOC_USP7_MATH_1	64	68	PF00917	0.620
DOC_USP7_MATH_1	78	82	PF00917	0.625
DOC_WW_Pin1_4	18	23	PF00397	0.734
DOC_WW_Pin1_4	186	191	PF00397	0.473
DOC_WW_Pin1_4	226	231	PF00397	0.378
DOC_WW_Pin1_4	311	316	PF00397	0.480
DOC_WW_Pin1_4	73	78	PF00397	0.658
LIG_14-3-3_CanoR_1	285	289	PF00244	0.378
LIG_14-3-3_CanoR_1	94	102	PF00244	0.333
LIG_BRCT_BRCA1_1	308	312	PF00533	0.495
LIG_FHA_1	19	25	PF00498	0.479
LIG_FHA_1	227	233	PF00498	0.378
LIG_FHA_1	249	255	PF00498	0.355
LIG_FHA_1	285	291	PF00498	0.335
LIG_FHA_2	167	173	PF00498	0.434
LIG_FHA_2	296	302	PF00498	0.554
LIG_LIR_Apic_2	184	190	PF02991	0.398
LIG_LIR_Apic_2	284	289	PF02991	0.411
LIG_LIR_Apic_2	309	315	PF02991	0.544
LIG_LIR_Gen_1	251	260	PF02991	0.336
LIG_LIR_Gen_1	317	323	PF02991	0.575
LIG_LIR_Nem_3	185	191	PF02991	0.356
LIG_LIR_Nem_3	251	256	PF02991	0.336
LIG_LIR_Nem_3	317	323	PF02991	0.575
LIG_PTB_Apo_2	196	203	PF02174	0.408
LIG_PTB_Phospho_1	196	202	PF10480	0.408
LIG_RPA_C_Fungi	54	66	PF08784	0.614
LIG_SH2_CRK	188	192	PF00017	0.359
LIG_SH2_CRK	286	290	PF00017	0.408
LIG_SH2_NCK_1	223	227	PF00017	0.378
LIG_SH2_NCK_1	296	300	PF00017	0.555
LIG_SH2_STAP1	223	227	PF00017	0.447
LIG_SH2_STAP1	296	300	PF00017	0.458
LIG_SH2_STAT5	196	199	PF00017	0.364
LIG_SH2_STAT5	202	205	PF00017	0.369
LIG_SH2_STAT5	286	289	PF00017	0.408
LIG_SUMO_SIM_par_1	106	112	PF11976	0.411
LIG_SUMO_SIM_par_1	287	293	PF11976	0.355
LIG_SxIP_EBH_1	244	254	PF03271	0.408
MOD_CDK_SPK_2	18	23	PF00069	0.648
MOD_CDK_SPxxK_3	18	25	PF00069	0.554
MOD_CK1_1	217	223	PF00069	0.346
MOD_CK1_1	38	44	PF00069	0.715
MOD_CK1_1	67	73	PF00069	0.639
MOD_CK2_1	166	172	PF00069	0.434
MOD_CK2_1	295	301	PF00069	0.543
MOD_CK2_1	69	75	PF00069	0.642
MOD_GlcNHglycan	219	222	PF01048	0.341
MOD_GlcNHglycan	41	44	PF01048	0.716
MOD_GlcNHglycan	69	72	PF01048	0.592
MOD_GSK3_1	118	125	PF00069	0.378
MOD_GSK3_1	182	189	PF00069	0.424
MOD_GSK3_1	217	224	PF00069	0.354
MOD_GSK3_1	226	233	PF00069	0.337
MOD_GSK3_1	307	314	PF00069	0.525
MOD_GSK3_1	35	42	PF00069	0.738
MOD_GSK3_1	65	72	PF00069	0.645
MOD_N-GLC_1	38	43	PF02516	0.736
MOD_N-GLC_1	57	62	PF02516	0.369
MOD_N-GLC_2	255	257	PF02516	0.363
MOD_NEK2_1	117	122	PF00069	0.353
MOD_NEK2_1	2	7	PF00069	0.568
MOD_NEK2_1	47	52	PF00069	0.549
MOD_NEK2_2	95	100	PF00069	0.266
MOD_PIKK_1	221	227	PF00454	0.266
MOD_PKA_2	2	8	PF00069	0.532
MOD_PKA_2	284	290	PF00069	0.359
MOD_PKA_2	35	41	PF00069	0.747
MOD_PKA_2	95	101	PF00069	0.329
MOD_Plk_4	159	165	PF00069	0.335
MOD_Plk_4	214	220	PF00069	0.385
MOD_Plk_4	243	249	PF00069	0.373
MOD_ProDKin_1	18	24	PF00069	0.735
MOD_ProDKin_1	186	192	PF00069	0.473
MOD_ProDKin_1	226	232	PF00069	0.378
MOD_ProDKin_1	311	317	PF00069	0.479
MOD_ProDKin_1	73	79	PF00069	0.656
TRG_DiLeu_BaLyEn_6	227	232	PF01217	0.356
TRG_DiLeu_BaLyEn_6	4	9	PF01217	0.672
TRG_ENDOCYTIC_2	188	191	PF00928	0.351
TRG_ENDOCYTIC_2	201	204	PF00928	0.301
TRG_ER_diArg_1	2	4	PF00400	0.655
TRG_ER_diArg_1	22	25	PF00400	0.603
TRG_ER_diArg_1	6	8	PF00400	0.633
TRG_ER_diArg_1	93	96	PF00400	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5M3	Leptomonas seymouri	66%	100%
A0A1X0NKR5	Trypanosomatidae	54%	100%
A0A3R7M8G7	Trypanosoma rangeli	58%	100%
A4H4B0	Leishmania braziliensis	82%	100%
A4HSI8	Leishmania infantum	100%	100%
C9ZUB5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AKH2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QJD6	Leishmania major	95%	100%
V5BAS5	Trypanosoma cruzi	58%	100%