Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5I9_LEIDO

TriTrypDb:

LdBPK_050650.1 , LdCL_050011600 , LDHU3_05.0730

Length:

867

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7

Expansion

Sequence features

A0A3S5H5I9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5I9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.628
CLV_C14_Caspase3-7	368	372	PF00656	0.523
CLV_C14_Caspase3-7	543	547	PF00656	0.662
CLV_C14_Caspase3-7	807	811	PF00656	0.614
CLV_NRD_NRD_1	381	383	PF00675	0.464
CLV_NRD_NRD_1	471	473	PF00675	0.636
CLV_NRD_NRD_1	510	512	PF00675	0.711
CLV_NRD_NRD_1	567	569	PF00675	0.740
CLV_NRD_NRD_1	762	764	PF00675	0.748
CLV_NRD_NRD_1	791	793	PF00675	0.817
CLV_PCSK_KEX2_1	471	473	PF00082	0.636
CLV_PCSK_KEX2_1	509	511	PF00082	0.706
CLV_PCSK_KEX2_1	566	568	PF00082	0.743
CLV_PCSK_KEX2_1	680	682	PF00082	0.692
CLV_PCSK_KEX2_1	761	763	PF00082	0.736
CLV_PCSK_PC1ET2_1	680	682	PF00082	0.640
CLV_PCSK_SKI1_1	220	224	PF00082	0.466
CLV_PCSK_SKI1_1	349	353	PF00082	0.551
CLV_PCSK_SKI1_1	382	386	PF00082	0.408
CLV_PCSK_SKI1_1	773	777	PF00082	0.641
DEG_APCC_DBOX_1	18	26	PF00400	0.476
DEG_APCC_DBOX_1	219	227	PF00400	0.470
DEG_APCC_DBOX_1	565	573	PF00400	0.665
DEG_Nend_UBRbox_2	1	3	PF02207	0.615
DEG_ODPH_VHL_1	134	146	PF01847	0.391
DEG_SCF_FBW7_1	513	518	PF00400	0.630
DEG_SPOP_SBC_1	59	63	PF00917	0.679
DOC_CDC14_PxL_1	141	149	PF14671	0.383
DOC_CKS1_1	512	517	PF01111	0.635
DOC_CKS1_1	538	543	PF01111	0.614
DOC_CKS1_1	549	554	PF01111	0.529
DOC_CKS1_1	649	654	PF01111	0.550
DOC_CYCLIN_RxL_1	115	125	PF00134	0.527
DOC_CYCLIN_yCln2_LP_2	620	626	PF00134	0.590
DOC_MAPK_DCC_7	566	574	PF00069	0.596
DOC_MAPK_gen_1	115	124	PF00069	0.460
DOC_MAPK_gen_1	382	392	PF00069	0.407
DOC_MAPK_gen_1	499	508	PF00069	0.684
DOC_MAPK_gen_1	566	574	PF00069	0.672
DOC_MAPK_gen_1	707	714	PF00069	0.705
DOC_MAPK_gen_1	761	772	PF00069	0.776
DOC_MAPK_HePTP_8	380	392	PF00069	0.340
DOC_MAPK_MEF2A_6	118	126	PF00069	0.458
DOC_MAPK_MEF2A_6	142	149	PF00069	0.465
DOC_MAPK_MEF2A_6	24	33	PF00069	0.519
DOC_MAPK_MEF2A_6	248	256	PF00069	0.542
DOC_MAPK_MEF2A_6	383	392	PF00069	0.400
DOC_MAPK_MEF2A_6	707	714	PF00069	0.705
DOC_MAPK_NFAT4_5	707	715	PF00069	0.710
DOC_PP1_RVXF_1	798	805	PF00149	0.696
DOC_PP2B_LxvP_1	620	623	PF13499	0.590
DOC_PP2B_LxvP_1	712	715	PF13499	0.657
DOC_PP4_FxxP_1	549	552	PF00568	0.583
DOC_PP4_FxxP_1	851	854	PF00568	0.562
DOC_USP7_MATH_1	244	248	PF00917	0.506
DOC_USP7_MATH_1	418	422	PF00917	0.709
DOC_USP7_MATH_1	462	466	PF00917	0.689
DOC_USP7_MATH_1	515	519	PF00917	0.642
DOC_USP7_MATH_1	55	59	PF00917	0.665
DOC_USP7_MATH_1	582	586	PF00917	0.742
DOC_USP7_MATH_1	701	705	PF00917	0.722
DOC_USP7_MATH_1	715	719	PF00917	0.580
DOC_USP7_MATH_1	788	792	PF00917	0.635
DOC_USP7_MATH_1	806	810	PF00917	0.538
DOC_USP7_MATH_1	854	858	PF00917	0.614
DOC_USP7_UBL2_3	776	780	PF12436	0.669
DOC_WW_Pin1_4	127	132	PF00397	0.396
DOC_WW_Pin1_4	283	288	PF00397	0.495
DOC_WW_Pin1_4	349	354	PF00397	0.523
DOC_WW_Pin1_4	455	460	PF00397	0.735
DOC_WW_Pin1_4	500	505	PF00397	0.693
DOC_WW_Pin1_4	511	516	PF00397	0.577
DOC_WW_Pin1_4	521	526	PF00397	0.574
DOC_WW_Pin1_4	537	542	PF00397	0.618
DOC_WW_Pin1_4	548	553	PF00397	0.698
DOC_WW_Pin1_4	648	653	PF00397	0.563
DOC_WW_Pin1_4	685	690	PF00397	0.712
DOC_WW_Pin1_4	843	848	PF00397	0.502
DOC_WW_Pin1_4	97	102	PF00397	0.539
LIG_14-3-3_CanoR_1	230	235	PF00244	0.507
LIG_14-3-3_CanoR_1	292	298	PF00244	0.604
LIG_14-3-3_CanoR_1	401	409	PF00244	0.605
LIG_14-3-3_CanoR_1	471	475	PF00244	0.580
LIG_14-3-3_CanoR_1	499	504	PF00244	0.662
LIG_14-3-3_CanoR_1	653	657	PF00244	0.637
LIG_14-3-3_CanoR_1	765	771	PF00244	0.706
LIG_14-3-3_CanoR_1	828	833	PF00244	0.634
LIG_14-3-3_CanoR_1	9	18	PF00244	0.581
LIG_Actin_WH2_2	137	153	PF00022	0.375
LIG_Actin_WH2_2	812	830	PF00022	0.647
LIG_APCC_ABBA_1	80	85	PF00400	0.537
LIG_BIR_III_4	54	58	PF00653	0.641
LIG_EH1_1	216	224	PF00400	0.410
LIG_FHA_1	10	16	PF00498	0.489
LIG_FHA_1	128	134	PF00498	0.388
LIG_FHA_1	175	181	PF00498	0.558
LIG_FHA_1	234	240	PF00498	0.398
LIG_FHA_1	43	49	PF00498	0.664
LIG_FHA_1	512	518	PF00498	0.706
LIG_FHA_1	597	603	PF00498	0.601
LIG_FHA_1	741	747	PF00498	0.574
LIG_FHA_1	767	773	PF00498	0.618
LIG_FHA_2	262	268	PF00498	0.386
LIG_FHA_2	538	544	PF00498	0.586
LIG_FHA_2	805	811	PF00498	0.666
LIG_FHA_2	861	867	PF00498	0.658
LIG_LIR_Apic_2	546	552	PF02991	0.693
LIG_LIR_Apic_2	849	854	PF02991	0.603
LIG_LIR_Gen_1	108	113	PF02991	0.482
LIG_LIR_Gen_1	123	134	PF02991	0.293
LIG_LIR_Gen_1	630	640	PF02991	0.606
LIG_LIR_Nem_3	108	112	PF02991	0.487
LIG_LIR_Nem_3	123	129	PF02991	0.290
LIG_LIR_Nem_3	473	477	PF02991	0.605
LIG_LIR_Nem_3	630	635	PF02991	0.620
LIG_LIR_Nem_3	659	665	PF02991	0.531
LIG_MAD2	618	626	PF02301	0.590
LIG_MYND_1	711	715	PF01753	0.648
LIG_MYND_1	723	727	PF01753	0.577
LIG_SH2_CRK	662	666	PF00017	0.534
LIG_SH2_CRK	668	672	PF00017	0.503
LIG_SH2_CRK	845	849	PF00017	0.567
LIG_SH2_GRB2like	359	362	PF00017	0.518
LIG_SH2_NCK_1	845	849	PF00017	0.567
LIG_SH2_STAT5	197	200	PF00017	0.523
LIG_SH2_STAT5	359	362	PF00017	0.445
LIG_SH2_STAT5	365	368	PF00017	0.577
LIG_SH2_STAT5	737	740	PF00017	0.472
LIG_SH3_3	130	136	PF00018	0.471
LIG_SH3_3	372	378	PF00018	0.473
LIG_SH3_3	390	396	PF00018	0.571
LIG_SH3_3	453	459	PF00018	0.585
LIG_SH3_3	485	491	PF00018	0.692
LIG_SH3_3	519	525	PF00018	0.664
LIG_SH3_3	535	541	PF00018	0.639
LIG_SH3_3	607	613	PF00018	0.618
LIG_SH3_3	620	626	PF00018	0.590
LIG_SH3_3	641	647	PF00018	0.574
LIG_SH3_3	697	703	PF00018	0.688
LIG_SH3_3	98	104	PF00018	0.478
LIG_SUMO_SIM_anti_2	108	114	PF11976	0.437
LIG_SUMO_SIM_par_1	120	125	PF11976	0.361
LIG_SUMO_SIM_par_1	176	183	PF11976	0.521
LIG_SUMO_SIM_par_1	330	335	PF11976	0.639
LIG_TRAF2_1	38	41	PF00917	0.629
LIG_TRAF2_1	540	543	PF00917	0.591
LIG_TRAF2_1	82	85	PF00917	0.518
LIG_TRAF2_2	491	496	PF00917	0.658
LIG_TRFH_1	609	613	PF08558	0.570
LIG_TYR_ITIM	666	671	PF00017	0.502
LIG_TYR_ITIM	843	848	PF00017	0.571
LIG_UBA3_1	146	151	PF00899	0.442
LIG_WRC_WIRS_1	106	111	PF05994	0.492
LIG_WW_3	392	396	PF00397	0.511
MOD_CDK_SPK_2	648	653	PF00069	0.612
MOD_CDK_SPxK_1	548	554	PF00069	0.658
MOD_CK1_1	108	114	PF00069	0.425
MOD_CK1_1	159	165	PF00069	0.563
MOD_CK1_1	176	182	PF00069	0.460
MOD_CK1_1	293	299	PF00069	0.575
MOD_CK1_1	478	484	PF00069	0.587
MOD_CK1_1	518	524	PF00069	0.832
MOD_CK1_1	58	64	PF00069	0.671
MOD_CK1_1	656	662	PF00069	0.603
MOD_CK1_1	781	787	PF00069	0.643
MOD_CK1_1	791	797	PF00069	0.599
MOD_CK1_1	846	852	PF00069	0.559
MOD_CK1_1	857	863	PF00069	0.601
MOD_CK2_1	165	171	PF00069	0.574
MOD_CK2_1	176	182	PF00069	0.515
MOD_CK2_1	261	267	PF00069	0.395
MOD_CK2_1	537	543	PF00069	0.594
MOD_CK2_1	729	735	PF00069	0.630
MOD_CK2_1	860	866	PF00069	0.660
MOD_Cter_Amidation	759	762	PF01082	0.585
MOD_GlcNHglycan	152	155	PF01048	0.367
MOD_GlcNHglycan	158	161	PF01048	0.482
MOD_GlcNHglycan	223	226	PF01048	0.474
MOD_GlcNHglycan	248	251	PF01048	0.573
MOD_GlcNHglycan	292	295	PF01048	0.566
MOD_GlcNHglycan	300	303	PF01048	0.661
MOD_GlcNHglycan	313	318	PF01048	0.579
MOD_GlcNHglycan	324	327	PF01048	0.567
MOD_GlcNHglycan	418	421	PF01048	0.625
MOD_GlcNHglycan	431	435	PF01048	0.538
MOD_GlcNHglycan	438	441	PF01048	0.604
MOD_GlcNHglycan	451	454	PF01048	0.550
MOD_GlcNHglycan	465	468	PF01048	0.532
MOD_GlcNHglycan	477	480	PF01048	0.632
MOD_GlcNHglycan	526	529	PF01048	0.712
MOD_GlcNHglycan	57	60	PF01048	0.686
MOD_GlcNHglycan	588	591	PF01048	0.710
MOD_GlcNHglycan	592	595	PF01048	0.677
MOD_GlcNHglycan	63	66	PF01048	0.651
MOD_GlcNHglycan	702	706	PF01048	0.732
MOD_GlcNHglycan	748	751	PF01048	0.707
MOD_GlcNHglycan	780	783	PF01048	0.627
MOD_GlcNHglycan	788	791	PF01048	0.627
MOD_GlcNHglycan	851	854	PF01048	0.686
MOD_GlcNHglycan	859	862	PF01048	0.568
MOD_GlcNHglycan	88	91	PF01048	0.425
MOD_GSK3_1	229	236	PF00069	0.469
MOD_GSK3_1	318	325	PF00069	0.688
MOD_GSK3_1	414	421	PF00069	0.697
MOD_GSK3_1	426	433	PF00069	0.566
MOD_GSK3_1	445	452	PF00069	0.695
MOD_GSK3_1	511	518	PF00069	0.751
MOD_GSK3_1	55	62	PF00069	0.676
MOD_GSK3_1	582	589	PF00069	0.624
MOD_GSK3_1	590	597	PF00069	0.612
MOD_GSK3_1	648	655	PF00069	0.621
MOD_GSK3_1	685	692	PF00069	0.711
MOD_GSK3_1	701	708	PF00069	0.522
MOD_GSK3_1	802	809	PF00069	0.703
MOD_GSK3_1	811	818	PF00069	0.587
MOD_GSK3_1	827	834	PF00069	0.614
MOD_LATS_1	228	234	PF00433	0.525
MOD_N-GLC_1	127	132	PF02516	0.339
MOD_N-GLC_1	165	170	PF02516	0.604
MOD_N-GLC_1	230	235	PF02516	0.507
MOD_N-GLC_1	261	266	PF02516	0.422
MOD_N-GLC_1	463	468	PF02516	0.642
MOD_N-GLC_1	843	848	PF02516	0.502
MOD_N-GLC_2	361	363	PF02516	0.590
MOD_NEK2_1	122	127	PF00069	0.364
MOD_NEK2_1	150	155	PF00069	0.364
MOD_NEK2_1	156	161	PF00069	0.453
MOD_NEK2_1	237	242	PF00069	0.596
MOD_NEK2_1	260	265	PF00069	0.580
MOD_NEK2_1	370	375	PF00069	0.538
MOD_NEK2_1	436	441	PF00069	0.601
MOD_NEK2_1	746	751	PF00069	0.521
MOD_NEK2_1	766	771	PF00069	0.650
MOD_NEK2_1	778	783	PF00069	0.611
MOD_NEK2_1	802	807	PF00069	0.654
MOD_NEK2_1	815	820	PF00069	0.567
MOD_NEK2_1	827	832	PF00069	0.618
MOD_NEK2_1	86	91	PF00069	0.468
MOD_NEK2_2	386	391	PF00069	0.426
MOD_PIKK_1	274	280	PF00454	0.634
MOD_PIKK_1	42	48	PF00454	0.574
MOD_PIKK_1	426	432	PF00454	0.609
MOD_PIKK_1	715	721	PF00454	0.656
MOD_PKA_2	114	120	PF00069	0.397
MOD_PKA_2	229	235	PF00069	0.579
MOD_PKA_2	414	420	PF00069	0.590
MOD_PKA_2	470	476	PF00069	0.577
MOD_PKA_2	652	658	PF00069	0.635
MOD_PKA_2	766	772	PF00069	0.739
MOD_PKA_2	791	797	PF00069	0.620
MOD_PKA_2	8	14	PF00069	0.608
MOD_PKA_2	827	833	PF00069	0.710
MOD_PKB_1	763	771	PF00069	0.621
MOD_Plk_1	122	128	PF00069	0.355
MOD_Plk_1	173	179	PF00069	0.489
MOD_Plk_1	230	236	PF00069	0.428
MOD_Plk_1	261	267	PF00069	0.428
MOD_Plk_1	582	588	PF00069	0.689
MOD_Plk_2-3	330	336	PF00069	0.588
MOD_Plk_4	105	111	PF00069	0.531
MOD_Plk_4	293	299	PF00069	0.718
MOD_Plk_4	318	324	PF00069	0.551
MOD_Plk_4	811	817	PF00069	0.662
MOD_ProDKin_1	127	133	PF00069	0.389
MOD_ProDKin_1	283	289	PF00069	0.495
MOD_ProDKin_1	349	355	PF00069	0.522
MOD_ProDKin_1	455	461	PF00069	0.737
MOD_ProDKin_1	500	506	PF00069	0.692
MOD_ProDKin_1	511	517	PF00069	0.577
MOD_ProDKin_1	521	527	PF00069	0.576
MOD_ProDKin_1	537	543	PF00069	0.615
MOD_ProDKin_1	548	554	PF00069	0.696
MOD_ProDKin_1	648	654	PF00069	0.569
MOD_ProDKin_1	685	691	PF00069	0.712
MOD_ProDKin_1	843	849	PF00069	0.501
MOD_ProDKin_1	97	103	PF00069	0.547
MOD_SUMO_rev_2	51	58	PF00179	0.626
TRG_DiLeu_BaEn_1	21	26	PF01217	0.449
TRG_DiLeu_BaEn_1	74	79	PF01217	0.605
TRG_DiLeu_BaLyEn_6	133	138	PF01217	0.411
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.437
TRG_DiLeu_BaLyEn_6	708	713	PF01217	0.709
TRG_ENDOCYTIC_2	662	665	PF00928	0.533
TRG_ENDOCYTIC_2	668	671	PF00928	0.495
TRG_ENDOCYTIC_2	845	848	PF00928	0.568
TRG_ER_diArg_1	118	121	PF00400	0.444
TRG_ER_diArg_1	362	365	PF00400	0.595
TRG_ER_diArg_1	394	397	PF00400	0.538
TRG_ER_diArg_1	498	501	PF00400	0.736
TRG_ER_diArg_1	508	511	PF00400	0.627
TRG_ER_diArg_1	565	568	PF00400	0.737
TRG_ER_diArg_1	761	763	PF00400	0.755
TRG_NES_CRM1_1	21	34	PF08389	0.427
TRG_Pf-PMV_PEXEL_1	364	368	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE62	Leptomonas seymouri	36%	100%
A4HD44	Leishmania braziliensis	69%	100%
A4HSI7	Leishmania infantum	99%	100%
E9AKH1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%
Q4QJD7	Leishmania major	89%	100%