Ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5I7_LEIDO

TriTrypDb:

LdBPK_050620.1 , LdCL_050011300 , LDHU3_05.0700

Length:

892

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H5I7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5I7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	227	231	PF00656	0.581
CLV_C14_Caspase3-7	483	487	PF00656	0.626
CLV_C14_Caspase3-7	563	567	PF00656	0.540
CLV_C14_Caspase3-7	806	810	PF00656	0.570
CLV_MEL_PAP_1	341	347	PF00089	0.660
CLV_NRD_NRD_1	104	106	PF00675	0.706
CLV_NRD_NRD_1	120	122	PF00675	0.557
CLV_NRD_NRD_1	174	176	PF00675	0.576
CLV_NRD_NRD_1	219	221	PF00675	0.630
CLV_NRD_NRD_1	279	281	PF00675	0.651
CLV_NRD_NRD_1	311	313	PF00675	0.671
CLV_NRD_NRD_1	363	365	PF00675	0.585
CLV_NRD_NRD_1	599	601	PF00675	0.822
CLV_NRD_NRD_1	659	661	PF00675	0.693
CLV_NRD_NRD_1	712	714	PF00675	0.549
CLV_NRD_NRD_1	821	823	PF00675	0.580
CLV_PCSK_FUR_1	102	106	PF00082	0.663
CLV_PCSK_FUR_1	118	122	PF00082	0.554
CLV_PCSK_FUR_1	309	313	PF00082	0.669
CLV_PCSK_FUR_1	710	714	PF00082	0.544
CLV_PCSK_KEX2_1	104	106	PF00082	0.706
CLV_PCSK_KEX2_1	118	120	PF00082	0.592
CLV_PCSK_KEX2_1	174	176	PF00082	0.599
CLV_PCSK_KEX2_1	219	221	PF00082	0.630
CLV_PCSK_KEX2_1	279	281	PF00082	0.651
CLV_PCSK_KEX2_1	311	313	PF00082	0.671
CLV_PCSK_KEX2_1	334	336	PF00082	0.591
CLV_PCSK_KEX2_1	363	365	PF00082	0.585
CLV_PCSK_KEX2_1	599	601	PF00082	0.736
CLV_PCSK_KEX2_1	659	661	PF00082	0.693
CLV_PCSK_KEX2_1	712	714	PF00082	0.549
CLV_PCSK_KEX2_1	821	823	PF00082	0.580
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.591
CLV_PCSK_SKI1_1	175	179	PF00082	0.635
CLV_PCSK_SKI1_1	762	766	PF00082	0.600
CLV_PCSK_SKI1_1	822	826	PF00082	0.581
CLV_PCSK_SKI1_1	90	94	PF00082	0.648
CLV_Separin_Metazoa	50	54	PF03568	0.601
DEG_SPOP_SBC_1	32	36	PF00917	0.623
DEG_SPOP_SBC_1	429	433	PF00917	0.516
DOC_ANK_TNKS_1	140	147	PF00023	0.661
DOC_ANK_TNKS_1	343	350	PF00023	0.673
DOC_CKS1_1	368	373	PF01111	0.572
DOC_CKS1_1	73	78	PF01111	0.583
DOC_CYCLIN_RxL_1	707	720	PF00134	0.592
DOC_CYCLIN_yCln2_LP_2	333	339	PF00134	0.536
DOC_CYCLIN_yCln2_LP_2	765	771	PF00134	0.558
DOC_CYCLIN_yCln2_LP_2	820	826	PF00134	0.520
DOC_MAPK_gen_1	334	341	PF00069	0.598
DOC_MAPK_gen_1	659	666	PF00069	0.692
DOC_MAPK_MEF2A_6	334	341	PF00069	0.598
DOC_PP2B_LxvP_1	183	186	PF13499	0.679
DOC_PP2B_LxvP_1	192	195	PF13499	0.644
DOC_PP2B_LxvP_1	288	291	PF13499	0.694
DOC_PP2B_LxvP_1	815	818	PF13499	0.601
DOC_USP7_MATH_1	164	168	PF00917	0.639
DOC_USP7_MATH_1	184	188	PF00917	0.536
DOC_USP7_MATH_1	226	230	PF00917	0.656
DOC_USP7_MATH_1	258	262	PF00917	0.655
DOC_USP7_MATH_1	33	37	PF00917	0.600
DOC_USP7_MATH_1	394	398	PF00917	0.653
DOC_USP7_MATH_1	409	413	PF00917	0.579
DOC_USP7_MATH_1	430	434	PF00917	0.612
DOC_USP7_MATH_1	447	451	PF00917	0.482
DOC_USP7_MATH_1	584	588	PF00917	0.622
DOC_USP7_MATH_1	687	691	PF00917	0.611
DOC_USP7_MATH_1	719	723	PF00917	0.598
DOC_USP7_MATH_1	744	748	PF00917	0.625
DOC_USP7_MATH_1	77	81	PF00917	0.623
DOC_USP7_MATH_1	792	796	PF00917	0.609
DOC_USP7_MATH_1	827	831	PF00917	0.601
DOC_USP7_MATH_1	853	857	PF00917	0.602
DOC_USP7_MATH_1	859	863	PF00917	0.565
DOC_USP7_MATH_1	96	100	PF00917	0.534
DOC_WW_Pin1_4	152	157	PF00397	0.701
DOC_WW_Pin1_4	200	205	PF00397	0.573
DOC_WW_Pin1_4	244	249	PF00397	0.668
DOC_WW_Pin1_4	251	256	PF00397	0.654
DOC_WW_Pin1_4	291	296	PF00397	0.694
DOC_WW_Pin1_4	318	323	PF00397	0.564
DOC_WW_Pin1_4	355	360	PF00397	0.685
DOC_WW_Pin1_4	367	372	PF00397	0.579
DOC_WW_Pin1_4	375	380	PF00397	0.491
DOC_WW_Pin1_4	407	412	PF00397	0.678
DOC_WW_Pin1_4	53	58	PF00397	0.644
DOC_WW_Pin1_4	600	605	PF00397	0.741
DOC_WW_Pin1_4	607	612	PF00397	0.671
DOC_WW_Pin1_4	63	68	PF00397	0.616
DOC_WW_Pin1_4	635	640	PF00397	0.615
DOC_WW_Pin1_4	653	658	PF00397	0.573
DOC_WW_Pin1_4	72	77	PF00397	0.533
DOC_WW_Pin1_4	764	769	PF00397	0.637
DOC_WW_Pin1_4	798	803	PF00397	0.557
DOC_WW_Pin1_4	90	95	PF00397	0.546
LIG_14-3-3_CanoR_1	16	24	PF00244	0.594
LIG_14-3-3_CanoR_1	222	226	PF00244	0.634
LIG_14-3-3_CanoR_1	253	263	PF00244	0.572
LIG_14-3-3_CanoR_1	490	496	PF00244	0.545
LIG_14-3-3_CanoR_1	696	704	PF00244	0.519
LIG_14-3-3_CanoR_1	783	793	PF00244	0.574
LIG_14-3-3_CanoR_1	821	827	PF00244	0.578
LIG_Actin_WH2_2	512	528	PF00022	0.498
LIG_APCC_ABBA_1	457	462	PF00400	0.453
LIG_BIR_II_1	1	5	PF00653	0.666
LIG_BIR_III_2	616	620	PF00653	0.534
LIG_BIR_III_4	860	864	PF00653	0.589
LIG_BRCT_BRCA1_1	878	882	PF00533	0.545
LIG_EVH1_1	815	819	PF00568	0.631
LIG_FHA_1	33	39	PF00498	0.655
LIG_FHA_1	375	381	PF00498	0.657
LIG_FHA_1	396	402	PF00498	0.648
LIG_FHA_1	57	63	PF00498	0.657
LIG_FHA_1	596	602	PF00498	0.685
LIG_FHA_1	698	704	PF00498	0.622
LIG_FHA_1	9	15	PF00498	0.661
LIG_FHA_2	171	177	PF00498	0.571
LIG_FHA_2	311	317	PF00498	0.658
LIG_FHA_2	490	496	PF00498	0.613
LIG_FHA_2	513	519	PF00498	0.690
LIG_Integrin_RGD_1	127	129	PF01839	0.671
LIG_IRF3_LxIS_1	631	638	PF10401	0.527
LIG_LIR_Gen_1	825	834	PF02991	0.582
LIG_LIR_Nem_3	388	392	PF02991	0.535
LIG_LIR_Nem_3	576	581	PF02991	0.545
LIG_LIR_Nem_3	825	831	PF02991	0.583
LIG_MYND_1	291	295	PF01753	0.694
LIG_NRBOX	630	636	PF00104	0.582
LIG_SH2_CRK	538	542	PF00017	0.556
LIG_SH2_NCK_1	828	832	PF00017	0.511
LIG_SH2_SRC	392	395	PF00017	0.556
LIG_SH2_SRC	620	623	PF00017	0.579
LIG_SH2_STAP1	460	464	PF00017	0.678
LIG_SH2_STAP1	538	542	PF00017	0.556
LIG_SH2_STAT3	384	387	PF00017	0.599
LIG_SH2_STAT5	384	387	PF00017	0.647
LIG_SH2_STAT5	392	395	PF00017	0.573
LIG_SH2_STAT5	491	494	PF00017	0.608
LIG_SH2_STAT5	715	718	PF00017	0.631
LIG_SH2_STAT5	86	89	PF00017	0.634
LIG_SH3_2	816	821	PF14604	0.555
LIG_SH3_3	107	113	PF00018	0.620
LIG_SH3_3	153	159	PF00018	0.667
LIG_SH3_3	297	303	PF00018	0.633
LIG_SH3_3	319	325	PF00018	0.552
LIG_SH3_3	336	342	PF00018	0.577
LIG_SH3_3	34	40	PF00018	0.642
LIG_SH3_3	412	418	PF00018	0.606
LIG_SH3_3	446	452	PF00018	0.580
LIG_SH3_3	578	584	PF00018	0.592
LIG_SH3_3	636	642	PF00018	0.652
LIG_SH3_3	64	70	PF00018	0.697
LIG_SH3_3	813	819	PF00018	0.541
LIG_SH3_3	821	827	PF00018	0.587
LIG_SH3_3	842	848	PF00018	0.597
LIG_SUMO_SIM_anti_2	440	446	PF11976	0.636
LIG_SUMO_SIM_par_1	633	638	PF11976	0.613
LIG_TRAF2_1	213	216	PF00917	0.615
LIG_TRAF2_2	186	191	PF00917	0.597
LIG_TYR_ITIM	536	541	PF00017	0.541
LIG_TYR_ITIM	826	831	PF00017	0.574
LIG_WRC_WIRS_1	386	391	PF05994	0.594
LIG_WW_1	83	86	PF00397	0.631
LIG_WW_3	248	252	PF00397	0.602
LIG_WW_3	603	607	PF00397	0.641
LIG_WW_3	82	86	PF00397	0.627
MOD_CDC14_SPxK_1	603	606	PF00782	0.689
MOD_CDC14_SPxK_1	638	641	PF00782	0.617
MOD_CDC14_SPxK_1	656	659	PF00782	0.565
MOD_CDC14_SPxK_1	767	770	PF00782	0.616
MOD_CDC14_SPxK_1	801	804	PF00782	0.507
MOD_CDK_SPxK_1	600	606	PF00069	0.689
MOD_CDK_SPxK_1	635	641	PF00069	0.617
MOD_CDK_SPxK_1	653	659	PF00069	0.574
MOD_CDK_SPxK_1	764	770	PF00069	0.619
MOD_CDK_SPxK_1	798	804	PF00069	0.515
MOD_CDK_SPxxK_3	244	251	PF00069	0.656
MOD_CDK_SPxxK_3	375	382	PF00069	0.657
MOD_CDK_SPxxK_3	53	60	PF00069	0.647
MOD_CDK_SPxxK_3	653	660	PF00069	0.695
MOD_CK1_1	10	16	PF00069	0.590
MOD_CK1_1	133	139	PF00069	0.682
MOD_CK1_1	166	172	PF00069	0.631
MOD_CK1_1	187	193	PF00069	0.640
MOD_CK1_1	19	25	PF00069	0.564
MOD_CK1_1	2	8	PF00069	0.640
MOD_CK1_1	244	250	PF00069	0.642
MOD_CK1_1	254	260	PF00069	0.658
MOD_CK1_1	388	394	PF00069	0.641
MOD_CK1_1	410	416	PF00069	0.654
MOD_CK1_1	56	62	PF00069	0.686
MOD_CK1_1	586	592	PF00069	0.778
MOD_CK1_1	633	639	PF00069	0.589
MOD_CK1_1	669	675	PF00069	0.657
MOD_CK1_1	690	696	PF00069	0.568
MOD_CK1_1	722	728	PF00069	0.517
MOD_CK1_1	795	801	PF00069	0.610
MOD_CK1_1	830	836	PF00069	0.615
MOD_CK1_1	873	879	PF00069	0.638
MOD_CK1_1	881	887	PF00069	0.560
MOD_CK2_1	170	176	PF00069	0.573
MOD_CK2_1	447	453	PF00069	0.586
MOD_CK2_1	714	720	PF00069	0.708
MOD_Cter_Amidation	102	105	PF01082	0.716
MOD_DYRK1A_RPxSP_1	251	255	PF00069	0.656
MOD_GlcNHglycan	1	4	PF01048	0.653
MOD_GlcNHglycan	21	24	PF01048	0.542
MOD_GlcNHglycan	242	246	PF01048	0.603
MOD_GlcNHglycan	256	259	PF01048	0.567
MOD_GlcNHglycan	351	354	PF01048	0.654
MOD_GlcNHglycan	359	362	PF01048	0.629
MOD_GlcNHglycan	412	415	PF01048	0.621
MOD_GlcNHglycan	424	427	PF01048	0.629
MOD_GlcNHglycan	475	478	PF01048	0.767
MOD_GlcNHglycan	571	574	PF01048	0.634
MOD_GlcNHglycan	588	592	PF01048	0.600
MOD_GlcNHglycan	676	679	PF01048	0.617
MOD_GlcNHglycan	689	692	PF01048	0.560
MOD_GlcNHglycan	723	727	PF01048	0.569
MOD_GlcNHglycan	788	791	PF01048	0.570
MOD_GlcNHglycan	794	797	PF01048	0.586
MOD_GlcNHglycan	860	864	PF01048	0.552
MOD_GlcNHglycan	878	881	PF01048	0.513
MOD_GlcNHglycan	883	886	PF01048	0.532
MOD_GlcNHglycan	98	101	PF01048	0.629
MOD_GSK3_1	12	19	PF00069	0.589
MOD_GSK3_1	130	137	PF00069	0.623
MOD_GSK3_1	166	173	PF00069	0.641
MOD_GSK3_1	254	261	PF00069	0.692
MOD_GSK3_1	3	10	PF00069	0.655
MOD_GSK3_1	443	450	PF00069	0.517
MOD_GSK3_1	473	480	PF00069	0.733
MOD_GSK3_1	583	590	PF00069	0.572
MOD_GSK3_1	666	673	PF00069	0.667
MOD_GSK3_1	681	688	PF00069	0.638
MOD_GSK3_1	745	752	PF00069	0.725
MOD_GSK3_1	832	839	PF00069	0.655
MOD_GSK3_1	849	856	PF00069	0.633
MOD_GSK3_1	870	877	PF00069	0.643
MOD_GSK3_1	92	99	PF00069	0.603
MOD_N-GLC_1	266	271	PF02516	0.644
MOD_N-GLC_1	669	674	PF02516	0.711
MOD_N-GLC_2	207	209	PF02516	0.637
MOD_NEK2_1	1	6	PF00069	0.599
MOD_NEK2_1	286	291	PF00069	0.657
MOD_NEK2_1	374	379	PF00069	0.638
MOD_NEK2_1	569	574	PF00069	0.569
MOD_NEK2_1	666	671	PF00069	0.671
MOD_NEK2_1	681	686	PF00069	0.566
MOD_NEK2_1	714	719	PF00069	0.571
MOD_NEK2_1	784	789	PF00069	0.569
MOD_NEK2_1	878	883	PF00069	0.633
MOD_PIKK_1	166	172	PF00454	0.651
MOD_PIKK_1	184	190	PF00454	0.576
MOD_PIKK_1	221	227	PF00454	0.687
MOD_PIKK_1	233	239	PF00454	0.612
MOD_PIKK_1	302	308	PF00454	0.600
MOD_PIKK_1	416	422	PF00454	0.670
MOD_PIKK_1	840	846	PF00454	0.618
MOD_PKA_2	131	137	PF00069	0.687
MOD_PKA_2	221	227	PF00069	0.684
MOD_PKA_2	310	316	PF00069	0.660
MOD_PKA_2	489	495	PF00069	0.560
MOD_PKA_2	595	601	PF00069	0.744
MOD_PKA_2	644	650	PF00069	0.614
MOD_PKB_1	119	127	PF00069	0.660
MOD_PKB_1	130	138	PF00069	0.598
MOD_PKB_1	641	649	PF00069	0.618
MOD_Plk_1	175	181	PF00069	0.588
MOD_Plk_1	395	401	PF00069	0.667
MOD_Plk_1	870	876	PF00069	0.646
MOD_Plk_4	33	39	PF00069	0.630
MOD_Plk_4	388	394	PF00069	0.620
MOD_Plk_4	395	401	PF00069	0.629
MOD_Plk_4	630	636	PF00069	0.522
MOD_Plk_4	676	682	PF00069	0.566
MOD_Plk_4	870	876	PF00069	0.646
MOD_ProDKin_1	152	158	PF00069	0.701
MOD_ProDKin_1	200	206	PF00069	0.572
MOD_ProDKin_1	244	250	PF00069	0.667
MOD_ProDKin_1	251	257	PF00069	0.654
MOD_ProDKin_1	291	297	PF00069	0.695
MOD_ProDKin_1	318	324	PF00069	0.564
MOD_ProDKin_1	355	361	PF00069	0.685
MOD_ProDKin_1	367	373	PF00069	0.579
MOD_ProDKin_1	375	381	PF00069	0.489
MOD_ProDKin_1	407	413	PF00069	0.680
MOD_ProDKin_1	53	59	PF00069	0.644
MOD_ProDKin_1	600	606	PF00069	0.743
MOD_ProDKin_1	607	613	PF00069	0.672
MOD_ProDKin_1	63	69	PF00069	0.615
MOD_ProDKin_1	635	641	PF00069	0.617
MOD_ProDKin_1	653	659	PF00069	0.574
MOD_ProDKin_1	72	78	PF00069	0.532
MOD_ProDKin_1	764	770	PF00069	0.638
MOD_ProDKin_1	798	804	PF00069	0.556
MOD_ProDKin_1	90	96	PF00069	0.551
MOD_SUMO_for_1	519	522	PF00179	0.552
TRG_DiLeu_BaEn_1	396	401	PF01217	0.647
TRG_ENDOCYTIC_2	460	463	PF00928	0.683
TRG_ENDOCYTIC_2	538	541	PF00928	0.604
TRG_ENDOCYTIC_2	828	831	PF00928	0.621
TRG_ER_diArg_1	102	105	PF00400	0.589
TRG_ER_diArg_1	118	121	PF00400	0.568
TRG_ER_diArg_1	250	253	PF00400	0.623
TRG_ER_diArg_1	309	312	PF00400	0.670
TRG_ER_diArg_1	464	467	PF00400	0.472
TRG_ER_diArg_1	599	601	PF00400	0.806
TRG_ER_diArg_1	640	643	PF00400	0.602
TRG_ER_diArg_1	659	661	PF00400	0.686
TRG_ER_diArg_1	710	713	PF00400	0.602
TRG_ER_diArg_1	780	783	PF00400	0.592
TRG_ER_diArg_1	820	822	PF00400	0.577
TRG_ER_diArg_1	87	90	PF00400	0.637
TRG_NES_CRM1_1	494	507	PF08389	0.507
TRG_NES_CRM1_1	706	720	PF08389	0.631

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HD47	Leishmania braziliensis	50%	98%
E9AKG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	99%
Q4QJE0	Leishmania major	82%	98%