Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5I5_LEIDO

TriTrypDb:

LdBPK_050560.1 , LdCL_050010700 , LDHU3_05.0640

Length:

419

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A0A3S5H5I5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5I5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.654
CLV_NRD_NRD_1	265	267	PF00675	0.527
CLV_NRD_NRD_1	283	285	PF00675	0.544
CLV_NRD_NRD_1	382	384	PF00675	0.656
CLV_NRD_NRD_1	417	419	PF00675	0.684
CLV_PCSK_KEX2_1	265	267	PF00082	0.509
CLV_PCSK_KEX2_1	283	285	PF00082	0.443
CLV_PCSK_KEX2_1	382	384	PF00082	0.656
CLV_PCSK_SKI1_1	238	242	PF00082	0.527
CLV_PCSK_SKI1_1	383	387	PF00082	0.737
DEG_SPOP_SBC_1	103	107	PF00917	0.742
DOC_MAPK_gen_1	14	23	PF00069	0.563
DOC_MAPK_gen_1	358	364	PF00069	0.586
DOC_MAPK_MEF2A_6	358	366	PF00069	0.598
DOC_MAPK_NFAT4_5	363	371	PF00069	0.453
DOC_PP1_RVXF_1	20	26	PF00149	0.568
DOC_PP2B_LxvP_1	215	218	PF13499	0.644
DOC_SPAK_OSR1_1	125	129	PF12202	0.557
DOC_USP7_MATH_1	196	200	PF00917	0.655
DOC_USP7_MATH_1	218	222	PF00917	0.724
DOC_USP7_MATH_1	234	238	PF00917	0.709
DOC_USP7_MATH_1	293	297	PF00917	0.721
DOC_USP7_MATH_1	330	334	PF00917	0.737
DOC_USP7_MATH_1	34	38	PF00917	0.534
DOC_USP7_MATH_1	68	72	PF00917	0.644
DOC_USP7_UBL2_3	359	363	PF12436	0.663
DOC_WW_Pin1_4	113	118	PF00397	0.707
DOC_WW_Pin1_4	241	246	PF00397	0.793
DOC_WW_Pin1_4	285	290	PF00397	0.722
DOC_WW_Pin1_4	299	304	PF00397	0.752
DOC_WW_Pin1_4	66	71	PF00397	0.684
DOC_WW_Pin1_4	91	96	PF00397	0.783
LIG_14-3-3_CanoR_1	100	104	PF00244	0.732
LIG_14-3-3_CanoR_1	111	120	PF00244	0.653
LIG_14-3-3_CanoR_1	223	229	PF00244	0.742
LIG_14-3-3_CanoR_1	298	303	PF00244	0.739
LIG_14-3-3_CanoR_1	382	391	PF00244	0.491
LIG_APCC_ABBA_1	182	187	PF00400	0.551
LIG_BIR_III_4	63	67	PF00653	0.586
LIG_BRCT_BRCA1_1	260	264	PF00533	0.707
LIG_BRCT_BRCA1_1	36	40	PF00533	0.525
LIG_EH1_1	364	372	PF00400	0.422
LIG_eIF4E_1	365	371	PF01652	0.490
LIG_FHA_1	152	158	PF00498	0.607
LIG_FHA_1	203	209	PF00498	0.641
LIG_FHA_1	258	264	PF00498	0.806
LIG_FHA_1	34	40	PF00498	0.566
LIG_FHA_1	73	79	PF00498	0.563
LIG_FHA_2	217	223	PF00498	0.577
LIG_FHA_2	384	390	PF00498	0.487
LIG_LIR_Gen_1	129	138	PF02991	0.545
LIG_LIR_Gen_1	333	342	PF02991	0.717
LIG_LIR_Gen_1	372	381	PF02991	0.373
LIG_LIR_Nem_3	129	133	PF02991	0.518
LIG_LIR_Nem_3	333	338	PF02991	0.719
LIG_LIR_Nem_3	372	378	PF02991	0.375
LIG_MYND_1	239	243	PF01753	0.737
LIG_SH2_CRK	365	369	PF00017	0.365
LIG_SH2_CRK	56	60	PF00017	0.500
LIG_SH2_PTP2	130	133	PF00017	0.570
LIG_SH2_PTP2	375	378	PF00017	0.498
LIG_SH2_STAP1	335	339	PF00017	0.714
LIG_SH2_STAP1	406	410	PF00017	0.492
LIG_SH2_STAT3	406	409	PF00017	0.492
LIG_SH2_STAT5	11	14	PF00017	0.523
LIG_SH2_STAT5	130	133	PF00017	0.493
LIG_SH2_STAT5	375	378	PF00017	0.341
LIG_SH3_3	10	16	PF00018	0.542
LIG_SH3_3	114	120	PF00018	0.723
LIG_SH3_3	187	193	PF00018	0.585
LIG_SH3_3	204	210	PF00018	0.566
LIG_SH3_3	228	234	PF00018	0.800
LIG_SH3_3	28	34	PF00018	0.637
LIG_Sin3_3	213	220	PF02671	0.625
LIG_SUMO_SIM_par_1	366	372	PF11976	0.292
LIG_TRAF2_1	121	124	PF00917	0.598
LIG_TYR_ITIM	128	133	PF00017	0.540
MOD_CDK_SPK_2	241	246	PF00069	0.791
MOD_CDK_SPK_2	285	290	PF00069	0.661
MOD_CDK_SPxxK_3	304	311	PF00069	0.758
MOD_CK1_1	110	116	PF00069	0.626
MOD_CK1_1	259	265	PF00069	0.701
MOD_CK1_1	301	307	PF00069	0.788
MOD_CK1_1	72	78	PF00069	0.668
MOD_CK1_1	99	105	PF00069	0.750
MOD_CK2_1	216	222	PF00069	0.631
MOD_CK2_1	330	336	PF00069	0.683
MOD_CK2_1	383	389	PF00069	0.481
MOD_CK2_1	408	414	PF00069	0.491
MOD_CK2_1	78	84	PF00069	0.638
MOD_GlcNHglycan	113	116	PF01048	0.513
MOD_GlcNHglycan	165	168	PF01048	0.438
MOD_GlcNHglycan	198	201	PF01048	0.485
MOD_GlcNHglycan	285	288	PF01048	0.597
MOD_GlcNHglycan	290	293	PF01048	0.556
MOD_GlcNHglycan	371	374	PF01048	0.260
MOD_GlcNHglycan	394	397	PF01048	0.765
MOD_GSK3_1	107	114	PF00069	0.696
MOD_GSK3_1	159	166	PF00069	0.619
MOD_GSK3_1	293	300	PF00069	0.713
MOD_GSK3_1	62	69	PF00069	0.640
MOD_GSK3_1	72	79	PF00069	0.548
MOD_GSK3_1	99	106	PF00069	0.775
MOD_N-GLC_1	298	303	PF02516	0.590
MOD_N-GLC_1	34	39	PF02516	0.392
MOD_N-GLC_1	392	397	PF02516	0.708
MOD_N-GLC_1	72	77	PF02516	0.431
MOD_NEK2_1	163	168	PF00069	0.602
MOD_NEK2_1	257	262	PF00069	0.775
MOD_NEK2_1	3	8	PF00069	0.555
MOD_NEK2_1	369	374	PF00069	0.345
MOD_NEK2_1	82	87	PF00069	0.678
MOD_NEK2_2	293	298	PF00069	0.671
MOD_PKA_1	283	289	PF00069	0.715
MOD_PKA_2	107	113	PF00069	0.687
MOD_PKA_2	283	289	PF00069	0.728
MOD_PKA_2	297	303	PF00069	0.781
MOD_PKA_2	82	88	PF00069	0.684
MOD_PKA_2	99	105	PF00069	0.790
MOD_Plk_1	34	40	PF00069	0.592
MOD_Plk_4	259	265	PF00069	0.753
MOD_Plk_4	34	40	PF00069	0.533
MOD_ProDKin_1	113	119	PF00069	0.700
MOD_ProDKin_1	241	247	PF00069	0.793
MOD_ProDKin_1	285	291	PF00069	0.726
MOD_ProDKin_1	299	305	PF00069	0.752
MOD_ProDKin_1	66	72	PF00069	0.686
MOD_ProDKin_1	91	97	PF00069	0.785
MOD_SUMO_for_1	133	136	PF00179	0.587
TRG_ENDOCYTIC_2	130	133	PF00928	0.501
TRG_ENDOCYTIC_2	335	338	PF00928	0.717
TRG_ENDOCYTIC_2	365	368	PF00928	0.425
TRG_ENDOCYTIC_2	375	378	PF00928	0.425
TRG_ENDOCYTIC_2	56	59	PF00928	0.499
TRG_ER_diArg_1	236	239	PF00400	0.784
TRG_ER_diArg_1	264	266	PF00400	0.788
TRG_ER_diArg_1	282	284	PF00400	0.675
TRG_ER_diArg_1	381	383	PF00400	0.448
TRG_Pf-PMV_PEXEL_1	273	277	PF00026	0.486

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2J2	Leptomonas seymouri	52%	100%
A0A1X0NKC1	Trypanosomatidae	33%	100%
A0A422ND80	Trypanosoma rangeli	31%	100%
A4H4A2	Leishmania braziliensis	71%	99%
A4HSH8	Leishmania infantum	100%	100%
E9AKG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QJE6	Leishmania major	92%	100%
V5BAR1	Trypanosoma cruzi	29%	100%