LeishMANIAdb
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Zinc-binding dehydrogenase family protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Zinc-binding dehydrogenase family protein
Gene product:
nuclear receptor binding factor-like protein
Species:
Leishmania donovani
UniProt:
A0A3S5H5I3_LEIDO
TriTrypDb:
LdBPK_050520.1 , LdCL_050010300 , LDHU3_05.0600
Length:
340

Annotations

Annotations by Jardim et al.

Receptors, Nuclear receptor binding factor-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 27
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 14
NetGPI no yes: 0, no: 14
Cellular components
Term Name Level Count
GO:0005739 mitochondrion 5 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

A0A3S5H5I3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5I3

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 2
GO:0006629 lipid metabolic process 3 2
GO:0006631 fatty acid metabolic process 4 2
GO:0008152 metabolic process 1 2
GO:0009987 cellular process 1 2
GO:0019752 carboxylic acid metabolic process 5 2
GO:0032787 monocarboxylic acid metabolic process 6 2
GO:0043436 oxoacid metabolic process 4 2
GO:0044237 cellular metabolic process 2 2
GO:0044238 primary metabolic process 2 2
GO:0044255 cellular lipid metabolic process 3 2
GO:0044281 small molecule metabolic process 2 2
GO:0071704 organic substance metabolic process 2 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0016491 oxidoreductase activity 2 3
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 3 2
GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 4 2
GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity 5 2
GO:0003960 NADPH:quinone reductase activity 5 1
GO:0016651 oxidoreductase activity, acting on NAD(P)H 3 1
GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 331 333 PF00675 0.401
CLV_NRD_NRD_1 58 60 PF00675 0.454
CLV_PCSK_KEX2_1 220 222 PF00082 0.366
CLV_PCSK_KEX2_1 60 62 PF00082 0.431
CLV_PCSK_PC1ET2_1 220 222 PF00082 0.267
CLV_PCSK_PC1ET2_1 60 62 PF00082 0.453
CLV_PCSK_SKI1_1 178 182 PF00082 0.242
CLV_PCSK_SKI1_1 195 199 PF00082 0.239
CLV_PCSK_SKI1_1 290 294 PF00082 0.450
DEG_SCF_FBW7_2 28 33 PF00400 0.292
DEG_SCF_SKP2-CKS1_1 25 32 PF00560 0.441
DOC_CDC14_PxL_1 310 318 PF14671 0.469
DOC_MAPK_gen_1 148 156 PF00069 0.339
DOC_MAPK_gen_1 220 227 PF00069 0.334
DOC_PP1_RVXF_1 291 297 PF00149 0.406
DOC_PP2B_LxvP_1 276 279 PF13499 0.263
DOC_USP7_MATH_1 131 135 PF00917 0.400
DOC_USP7_MATH_1 183 187 PF00917 0.160
DOC_USP7_UBL2_3 333 337 PF12436 0.250
DOC_WW_Pin1_4 181 186 PF00397 0.239
DOC_WW_Pin1_4 26 31 PF00397 0.404
DOC_WW_Pin1_4 86 91 PF00397 0.556
LIG_BIR_II_1 1 5 PF00653 0.328
LIG_BRCT_BRCA1_1 185 189 PF00533 0.313
LIG_BRCT_BRCA1_1 200 204 PF00533 0.200
LIG_FHA_1 39 45 PF00498 0.525
LIG_FHA_1 96 102 PF00498 0.297
LIG_IRF3_LxIS_1 257 262 PF10401 0.263
LIG_LIR_Apic_2 97 103 PF02991 0.281
LIG_LIR_Gen_1 144 154 PF02991 0.390
LIG_LIR_Gen_1 265 276 PF02991 0.327
LIG_LIR_Gen_1 321 328 PF02991 0.430
LIG_LIR_Nem_3 144 149 PF02991 0.385
LIG_LIR_Nem_3 265 271 PF02991 0.344
LIG_LIR_Nem_3 321 326 PF02991 0.403
LIG_LIR_Nem_3 66 70 PF02991 0.421
LIG_Pex14_1 323 327 PF04695 0.290
LIG_Pex14_2 277 281 PF04695 0.303
LIG_SH2_CRK 146 150 PF00017 0.488
LIG_SH2_GRB2like 226 229 PF00017 0.263
LIG_SH2_GRB2like 327 330 PF00017 0.284
LIG_SH2_NCK_1 268 272 PF00017 0.263
LIG_SH2_SRC 226 229 PF00017 0.288
LIG_SH2_SRC 327 330 PF00017 0.284
LIG_SH2_STAT3 251 254 PF00017 0.237
LIG_SH2_STAT5 226 229 PF00017 0.288
LIG_SH2_STAT5 234 237 PF00017 0.228
LIG_SH2_STAT5 327 330 PF00017 0.441
LIG_SH3_3 77 83 PF00018 0.438
LIG_TRAF2_1 300 303 PF00917 0.486
LIG_TYR_ITIM 266 271 PF00017 0.263
LIG_UBA3_1 25 32 PF00899 0.273
MOD_CDC14_SPxK_1 91 94 PF00782 0.469
MOD_CDK_SPxK_1 26 32 PF00069 0.413
MOD_CDK_SPxK_1 88 94 PF00069 0.509
MOD_CDK_SPxxK_3 181 188 PF00069 0.239
MOD_CK1_1 161 167 PF00069 0.251
MOD_CK1_1 262 268 PF00069 0.327
MOD_CK1_1 283 289 PF00069 0.239
MOD_CK2_1 283 289 PF00069 0.298
MOD_Cter_Amidation 218 221 PF01082 0.334
MOD_Cter_Amidation 330 333 PF01082 0.328
MOD_Cter_Amidation 57 60 PF01082 0.430
MOD_GlcNHglycan 168 171 PF01048 0.309
MOD_GlcNHglycan 185 188 PF01048 0.408
MOD_GlcNHglycan 261 264 PF01048 0.246
MOD_GlcNHglycan 5 8 PF01048 0.447
MOD_GSK3_1 158 165 PF00069 0.290
MOD_GSK3_1 277 284 PF00069 0.364
MOD_LATS_1 196 202 PF00433 0.263
MOD_N-GLC_1 52 57 PF02516 0.333
MOD_NEK2_1 104 109 PF00069 0.313
MOD_NEK2_1 129 134 PF00069 0.385
MOD_NEK2_1 166 171 PF00069 0.289
MOD_NEK2_1 259 264 PF00069 0.258
MOD_NEK2_1 281 286 PF00069 0.426
MOD_PIKK_1 114 120 PF00454 0.480
MOD_PIKK_1 15 21 PF00454 0.231
MOD_Plk_1 269 275 PF00069 0.234
MOD_Plk_4 234 240 PF00069 0.226
MOD_Plk_4 262 268 PF00069 0.299
MOD_Plk_4 277 283 PF00069 0.243
MOD_Plk_4 95 101 PF00069 0.305
MOD_ProDKin_1 181 187 PF00069 0.239
MOD_ProDKin_1 26 32 PF00069 0.413
MOD_ProDKin_1 86 92 PF00069 0.545
MOD_SUMO_for_1 292 295 PF00179 0.246
TRG_ENDOCYTIC_2 146 149 PF00928 0.423
TRG_ENDOCYTIC_2 23 26 PF00928 0.401
TRG_ENDOCYTIC_2 268 271 PF00928 0.227
TRG_ER_diArg_1 59 62 PF00400 0.440

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2X4 Leptomonas seymouri 31% 76%
A0A0N1PA01 Leptomonas seymouri 78% 100%
A0A0S4ILA6 Bodo saltans 51% 100%
A0A0S4J2L6 Bodo saltans 30% 78%
A0A1X0NK33 Trypanosomatidae 61% 100%
A0A1X0NL46 Trypanosomatidae 27% 74%
A0A3R7KI38 Trypanosoma rangeli 26% 85%
A0A3S5H593 Leishmania donovani 30% 100%
A4H3U9 Leishmania braziliensis 28% 100%
A4H498 Leishmania braziliensis 90% 100%
A4HS24 Leishmania infantum 29% 100%
A4HSH5 Leishmania infantum 100% 100%
C9ZUD7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 54% 100%
C9ZY17 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 76%
E9AK11 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9AKF8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
O45903 Caenorhabditis elegans 26% 99%
Q28GQ2 Xenopus tropicalis 24% 97%
Q4QJF0 Leishmania major 95% 100%
Q54YT4 Dictyostelium discoideum 27% 97%
Q6BLV6 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 25% 90%
Q6GQN8 Danio rerio 25% 90%
Q757U3 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 25% 90%
Q7YS70 Bos taurus 28% 91%
Q8LCU7 Arabidopsis thaliana 28% 91%
Q8NJJ9 Kluyveromyces marxianus 26% 89%
Q9BV79 Homo sapiens 26% 91%
Q9DCS3 Mus musculus 26% 91%
Q9V6U9 Drosophila melanogaster 23% 95%
Q9XXC8 Caenorhabditis elegans 30% 98%
Q9XZY9 Leishmania major 30% 100%
Q9Z311 Rattus norvegicus 25% 91%
V5D9R3 Trypanosoma cruzi 30% 75%
V5DBG0 Trypanosoma cruzi 62% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS