ATP_synthase_F1_alpha_subunit_putative/GeneDB:Lmj F.05.0500/GeneDB:LmjF.05.0510

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP synthase F1, alpha subunit, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H5I2_LEIDO

TriTrypDb:

LdBPK_050510.1 , LdCL_050010000 , LdCL_050010100 , LdCL_050010200 , LDHU3_05.0580

Length:

574

Annotations

Annotations by Jardim et al.

ATP metabolism, ATP synthase subunit alpha

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 6
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 18

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 15

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 15

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 11
NetGPI	no	yes: 0, no: 12

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Cellular components
Term	Name	Level	Count
GO:0000275	mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)	4	1
GO:0032991	protein-containing complex	1	13
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain	3	13
GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)	4	13
GO:0098796	membrane protein complex	2	13
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1

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Expansion

Sequence features

A0A3S5H5I2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5I2

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006163	purine nucleotide metabolic process	5	1
GO:0006164	purine nucleotide biosynthetic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006754	ATP biosynthetic process	8	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0005215	transporter activity	1	13
GO:0005216	monoatomic ion channel activity	4	13
GO:0005261	monoatomic cation channel activity	5	13
GO:0005488	binding	1	13
GO:0005524	ATP binding	5	13
GO:0008324	monoatomic cation transmembrane transporter activity	4	13
GO:0015075	monoatomic ion transmembrane transporter activity	3	13
GO:0015078	proton transmembrane transporter activity	5	13

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	371	375	PF00656	0.362
CLV_NRD_NRD_1	2	4	PF00675	0.645
CLV_NRD_NRD_1	313	315	PF00675	0.362
CLV_NRD_NRD_1	424	426	PF00675	0.362
CLV_PCSK_KEX2_1	2	4	PF00082	0.644
CLV_PCSK_KEX2_1	313	315	PF00082	0.362
CLV_PCSK_KEX2_1	571	573	PF00082	0.453
CLV_PCSK_PC1ET2_1	571	573	PF00082	0.453
CLV_PCSK_SKI1_1	144	148	PF00082	0.539
CLV_PCSK_SKI1_1	31	35	PF00082	0.543

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P244	Leptomonas seymouri	24%	100%
A0A0N1PBM9	Leptomonas seymouri	97%	100%
A0A0S4JQS7	Bodo saltans	89%	99%
A0A1X0NJW9	Trypanosomatidae	93%	98%
A0A1X0NM27	Trypanosomatidae	25%	100%
A0A381MM20	Leishmania infantum	25%	100%
A0A3Q8IE37	Leishmania donovani	27%	100%
A0A3Q8IFA8	Leishmania donovani	25%	100%
A0A3R7P2I7	Trypanosoma rangeli	25%	100%
A0A422N2S4	Trypanosoma rangeli	89%	98%

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