Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S5H5I0_LEIDO

TriTrypDb:

LdBPK_050470.1 , LdCL_050009700 , LDHU3_05.0540

Length:

242

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H5I0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5I0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	199	203	PF00656	0.453
CLV_NRD_NRD_1	188	190	PF00675	0.497
CLV_NRD_NRD_1	191	193	PF00675	0.475
CLV_NRD_NRD_1	210	212	PF00675	0.600
CLV_NRD_NRD_1	223	225	PF00675	0.495
CLV_NRD_NRD_1	229	231	PF00675	0.506
CLV_NRD_NRD_1	92	94	PF00675	0.531
CLV_PCSK_FUR_1	189	193	PF00082	0.485
CLV_PCSK_FUR_1	227	231	PF00082	0.502
CLV_PCSK_KEX2_1	142	144	PF00082	0.734
CLV_PCSK_KEX2_1	188	190	PF00082	0.497
CLV_PCSK_KEX2_1	191	193	PF00082	0.475
CLV_PCSK_KEX2_1	210	212	PF00082	0.600
CLV_PCSK_KEX2_1	229	231	PF00082	0.506
CLV_PCSK_KEX2_1	92	94	PF00082	0.531
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.734
CLV_PCSK_SKI1_1	150	154	PF00082	0.673
CLV_PCSK_SKI1_1	191	195	PF00082	0.494
CLV_Separin_Metazoa	214	218	PF03568	0.529
DEG_APCC_DBOX_1	190	198	PF00400	0.487
DOC_CKS1_1	151	156	PF01111	0.611
DOC_CYCLIN_RxL_1	188	200	PF00134	0.507
DOC_CYCLIN_yCln2_LP_2	102	108	PF00134	0.542
DOC_CYCLIN_yCln2_LP_2	124	130	PF00134	0.599
DOC_MAPK_gen_1	188	196	PF00069	0.558
DOC_PP1_RVXF_1	190	197	PF00149	0.509
DOC_PP2B_LxvP_1	102	105	PF13499	0.631
DOC_USP7_MATH_1	112	116	PF00917	0.570
DOC_USP7_MATH_1	129	133	PF00917	0.599
DOC_USP7_MATH_1	141	145	PF00917	0.628
DOC_WW_Pin1_4	119	124	PF00397	0.600
DOC_WW_Pin1_4	135	140	PF00397	0.509
DOC_WW_Pin1_4	150	155	PF00397	0.795
LIG_14-3-3_CanoR_1	107	114	PF00244	0.528
LIG_14-3-3_CanoR_1	143	152	PF00244	0.735
LIG_14-3-3_CanoR_1	92	101	PF00244	0.561
LIG_BRCT_BRCA1_1	40	44	PF00533	0.556
LIG_FHA_1	76	82	PF00498	0.617
LIG_FHA_2	159	165	PF00498	0.637
LIG_FHA_2	180	186	PF00498	0.476
LIG_GBD_Chelix_1	13	21	PF00786	0.474
LIG_MYND_1	123	127	PF01753	0.556
LIG_MYND_1	135	139	PF01753	0.551
LIG_SH2_CRK	31	35	PF00017	0.507
LIG_SH2_GRB2like	204	207	PF00017	0.446
LIG_SH2_STAP1	31	35	PF00017	0.507
LIG_SH2_STAT5	204	207	PF00017	0.446
LIG_SH3_3	130	136	PF00018	0.650
LIG_SH3_3	148	154	PF00018	0.511
LIG_SH3_3	173	179	PF00018	0.642
LIG_SH3_3	66	72	PF00018	0.579
LIG_SH3_3	84	90	PF00018	0.539
LIG_SH3_3	98	104	PF00018	0.600
MOD_CDK_SPxxK_3	135	142	PF00069	0.550
MOD_CK1_1	115	121	PF00069	0.557
MOD_CK1_1	144	150	PF00069	0.639
MOD_CK1_1	3	9	PF00069	0.590
MOD_CK2_1	179	185	PF00069	0.486
MOD_CK2_1	52	58	PF00069	0.538
MOD_GlcNHglycan	108	111	PF01048	0.582
MOD_GlcNHglycan	143	146	PF01048	0.703
MOD_GlcNHglycan	54	57	PF01048	0.599
MOD_GlcNHglycan	84	87	PF01048	0.560
MOD_GSK3_1	112	119	PF00069	0.552
MOD_N-GLC_1	3	8	PF02516	0.590
MOD_NEK2_1	106	111	PF00069	0.595
MOD_NEK2_1	128	133	PF00069	0.621
MOD_NEK2_1	234	239	PF00069	0.489
MOD_NEK2_2	158	163	PF00069	0.562
MOD_PKA_1	92	98	PF00069	0.528
MOD_PKA_2	106	112	PF00069	0.549
MOD_PKA_2	92	98	PF00069	0.551
MOD_Plk_1	3	9	PF00069	0.590
MOD_Plk_4	49	55	PF00069	0.575
MOD_ProDKin_1	119	125	PF00069	0.604
MOD_ProDKin_1	135	141	PF00069	0.510
MOD_ProDKin_1	150	156	PF00069	0.793
MOD_SUMO_for_1	70	73	PF00179	0.580
TRG_DiLeu_BaLyEn_6	120	125	PF01217	0.527
TRG_ENDOCYTIC_2	31	34	PF00928	0.510
TRG_ER_diArg_1	188	191	PF00400	0.513
TRG_ER_diArg_1	227	230	PF00400	0.511
TRG_ER_diArg_1	91	93	PF00400	0.651
TRG_NLS_Bipartite_1	210	228	PF00514	0.497
TRG_Pf-PMV_PEXEL_1	195	199	PF00026	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZW8	Leptomonas seymouri	34%	100%
A4H493	Leishmania braziliensis	60%	82%
A4HSG9	Leishmania infantum	100%	100%
E9AKF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QJF5	Leishmania major	90%	100%