Hypothetical_protein_conserved

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5H8_LEIDO

TriTrypDb:

LdBPK_050450.1 , LdCL_050009500 , LDHU3_05.0520

Length:

196

Annotations

Annotations by Jardim et al.

Protein modification, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S5H5H8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5H8

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006511	ubiquitin-dependent protein catabolic process	7	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0019941	modification-dependent protein catabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043632	modification-dependent macromolecule catabolic process	5	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044265	obsolete cellular macromolecule catabolic process	4	12
GO:0051603	proteolysis involved in protein catabolic process	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901575	organic substance catabolic process	3	12
GO:0010498	proteasomal protein catabolic process	5	1
GO:0030163	protein catabolic process	4	1
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	7	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:1901565	organonitrogen compound catabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0097602	cullin family protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	10	14	PF00082	0.650
DOC_MAPK_FxFP_2	61	64	PF00069	0.521
DOC_MAPK_gen_1	21	30	PF00069	0.620
DOC_MAPK_MEF2A_6	21	30	PF00069	0.647
DOC_PP4_FxxP_1	61	64	PF00568	0.521
DOC_USP7_UBL2_3	149	153	PF12436	0.636
DOC_USP7_UBL2_3	191	195	PF12436	0.677
DOC_USP7_UBL2_3	42	46	PF12436	0.563
DOC_WW_Pin1_4	113	118	PF00397	0.644
LIG_APCC_ABBA_1	28	33	PF00400	0.629
LIG_APCC_ABBAyCdc20_2	90	96	PF00400	0.641
LIG_BIR_II_1	1	5	PF00653	0.585
LIG_deltaCOP1_diTrp_1	103	110	PF00928	0.563
LIG_EH1_1	132	140	PF00400	0.609
LIG_FHA_2	126	132	PF00498	0.624
LIG_FHA_2	170	176	PF00498	0.600
LIG_LIR_Apic_2	60	64	PF02991	0.525
LIG_LIR_Gen_1	140	146	PF02991	0.520
LIG_LIR_Gen_1	25	34	PF02991	0.553
LIG_LIR_Gen_1	96	101	PF02991	0.638
LIG_LIR_Nem_3	140	144	PF02991	0.519
LIG_LIR_Nem_3	180	186	PF02991	0.511
LIG_LIR_Nem_3	25	30	PF02991	0.552
LIG_LIR_Nem_3	34	40	PF02991	0.462
LIG_LIR_Nem_3	96	100	PF02991	0.639
LIG_LRP6_Inhibitor_1	40	46	PF00058	0.522
LIG_PCNA_yPIPBox_3	149	163	PF02747	0.591
LIG_Pex14_1	105	109	PF04695	0.500
LIG_Pex14_1	74	78	PF04695	0.491
LIG_REV1ctd_RIR_1	107	116	PF16727	0.548
LIG_SH2_PTP2	27	30	PF00017	0.594
LIG_SH2_PTP2	37	40	PF00017	0.508
LIG_SH2_SRC	27	30	PF00017	0.581
LIG_SH2_SRC	37	40	PF00017	0.469
LIG_SH2_STAT3	44	47	PF00017	0.649
LIG_SH2_STAT5	123	126	PF00017	0.518
LIG_SH2_STAT5	27	30	PF00017	0.594
LIG_SH2_STAT5	37	40	PF00017	0.496
LIG_SH2_STAT5	44	47	PF00017	0.367
LIG_SH2_STAT5	99	102	PF00017	0.606
MOD_CK1_1	86	92	PF00069	0.605
MOD_CK2_1	125	131	PF00069	0.626
MOD_GSK3_1	166	173	PF00069	0.629
MOD_GSK3_1	95	102	PF00069	0.619
MOD_NEK2_1	125	130	PF00069	0.556
MOD_PIKK_1	83	89	PF00454	0.585
MOD_Plk_1	95	101	PF00069	0.623
MOD_Plk_2-3	170	176	PF00069	0.657
MOD_ProDKin_1	113	119	PF00069	0.645
MOD_SUMO_rev_2	33	38	PF00179	0.514
TRG_ENDOCYTIC_2	183	186	PF00928	0.499
TRG_ENDOCYTIC_2	27	30	PF00928	0.545
TRG_ENDOCYTIC_2	37	40	PF00928	0.448
TRG_ENDOCYTIC_2	94	97	PF00928	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2L3	Leptomonas seymouri	74%	99%
A0A0S4JVJ4	Bodo saltans	28%	90%
A0A1X0NKB1	Trypanosomatidae	47%	100%
A0A422N2V0	Trypanosoma rangeli	46%	100%
A4H491	Leishmania braziliensis	91%	100%
A4HSG7	Leishmania infantum	100%	100%
C9ZUE2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AKF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4QJF7	Leishmania major	98%	100%
V5AVE3	Trypanosoma cruzi	51%	100%