DNA replication licensing factor MCM8, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA replication licensing factor, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H5H2_LEIDO

TriTrypDb:

LdBPK_050330.1 , LdCL_050008300 , LDHU3_05.0380

Length:

994

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0032991	protein-containing complex	1	1
GO:0042555	MCM complex	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H5H2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5H2

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	7
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	7
GO:0032392	DNA geometric change	7	7
GO:0032508	DNA duplex unwinding	8	7
GO:0051276	chromosome organization	5	7
GO:0071103	DNA conformation change	6	7
GO:0071840	cellular component organization or biogenesis	2	7

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003676	nucleic acid binding	3	7
GO:0003677	DNA binding	4	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003697	single-stranded DNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.548
CLV_C14_Caspase3-7	268	272	PF00656	0.433
CLV_C14_Caspase3-7	928	932	PF00656	0.337
CLV_NRD_NRD_1	167	169	PF00675	0.510
CLV_NRD_NRD_1	181	183	PF00675	0.555
CLV_NRD_NRD_1	207	209	PF00675	0.466
CLV_NRD_NRD_1	386	388	PF00675	0.475
CLV_NRD_NRD_1	429	431	PF00675	0.586
CLV_NRD_NRD_1	707	709	PF00675	0.283
CLV_NRD_NRD_1	754	756	PF00675	0.635
CLV_NRD_NRD_1	922	924	PF00675	0.630
CLV_PCSK_KEX2_1	180	182	PF00082	0.595
CLV_PCSK_KEX2_1	207	209	PF00082	0.466
CLV_PCSK_KEX2_1	386	388	PF00082	0.475
CLV_PCSK_KEX2_1	429	431	PF00082	0.586
CLV_PCSK_KEX2_1	754	756	PF00082	0.635
CLV_PCSK_KEX2_1	922	924	PF00082	0.630
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.573
CLV_PCSK_SKI1_1	140	144	PF00082	0.448
CLV_PCSK_SKI1_1	218	222	PF00082	0.622
CLV_PCSK_SKI1_1	233	237	PF00082	0.224
CLV_PCSK_SKI1_1	563	567	PF00082	0.333
CLV_PCSK_SKI1_1	611	615	PF00082	0.270
CLV_PCSK_SKI1_1	666	670	PF00082	0.276
CLV_PCSK_SKI1_1	787	791	PF00082	0.378
CLV_PCSK_SKI1_1	923	927	PF00082	0.536
DEG_APCC_DBOX_1	935	943	PF00400	0.510
DEG_SCF_TRCP1_1	844	849	PF00400	0.613
DEG_SPOP_SBC_1	617	621	PF00917	0.533
DOC_ANK_TNKS_1	180	187	PF00023	0.595
DOC_ANK_TNKS_1	3	10	PF00023	0.650
DOC_ANK_TNKS_1	472	479	PF00023	0.668
DOC_CKS1_1	105	110	PF01111	0.630
DOC_CYCLIN_RxL_1	784	794	PF00134	0.374
DOC_CYCLIN_yCln2_LP_2	102	108	PF00134	0.523
DOC_CYCLIN_yCln2_LP_2	144	150	PF00134	0.360
DOC_MAPK_MEF2A_6	563	570	PF00069	0.476
DOC_MAPK_MEF2A_6	583	590	PF00069	0.383
DOC_MAPK_NFAT4_5	563	571	PF00069	0.533
DOC_PP1_RVXF_1	515	521	PF00149	0.609
DOC_PP1_RVXF_1	785	792	PF00149	0.368
DOC_PP2B_LxvP_1	363	366	PF13499	0.386
DOC_PP2B_LxvP_1	780	783	PF13499	0.504
DOC_PP4_FxxP_1	686	689	PF00568	0.476
DOC_SPAK_OSR1_1	724	728	PF12202	0.454
DOC_USP7_MATH_1	211	215	PF00917	0.424
DOC_USP7_MATH_1	22	26	PF00917	0.545
DOC_USP7_MATH_1	279	283	PF00917	0.533
DOC_USP7_MATH_1	321	325	PF00917	0.583
DOC_USP7_MATH_1	342	346	PF00917	0.605
DOC_USP7_MATH_1	405	409	PF00917	0.478
DOC_USP7_MATH_1	504	508	PF00917	0.611
DOC_USP7_MATH_1	511	515	PF00917	0.615
DOC_USP7_MATH_1	516	520	PF00917	0.566
DOC_USP7_MATH_1	617	621	PF00917	0.527
DOC_USP7_MATH_1	707	711	PF00917	0.491
DOC_USP7_MATH_1	734	738	PF00917	0.500
DOC_USP7_MATH_1	830	834	PF00917	0.626
DOC_USP7_MATH_1	911	915	PF00917	0.702
DOC_USP7_UBL2_3	984	988	PF12436	0.489
DOC_WW_Pin1_4	104	109	PF00397	0.612
DOC_WW_Pin1_4	190	195	PF00397	0.664
DOC_WW_Pin1_4	218	223	PF00397	0.609
DOC_WW_Pin1_4	242	247	PF00397	0.476
DOC_WW_Pin1_4	288	293	PF00397	0.509
DOC_WW_Pin1_4	316	321	PF00397	0.474
DOC_WW_Pin1_4	39	44	PF00397	0.553
DOC_WW_Pin1_4	415	420	PF00397	0.620
DOC_WW_Pin1_4	715	720	PF00397	0.503
DOC_WW_Pin1_4	861	866	PF00397	0.470
LIG_14-3-3_CanoR_1	168	177	PF00244	0.523
LIG_14-3-3_CanoR_1	248	256	PF00244	0.559
LIG_14-3-3_CanoR_1	404	410	PF00244	0.522
LIG_14-3-3_CanoR_1	49	55	PF00244	0.511
LIG_14-3-3_CanoR_1	517	527	PF00244	0.614
LIG_14-3-3_CanoR_1	547	553	PF00244	0.476
LIG_14-3-3_CanoR_1	708	712	PF00244	0.483
LIG_BRCT_BRCA1_1	520	524	PF00533	0.548
LIG_CtBP_PxDLS_1	558	563	PF00389	0.476
LIG_deltaCOP1_diTrp_1	29	36	PF00928	0.512
LIG_EH1_1	147	155	PF00400	0.329
LIG_EH1_1	96	104	PF00400	0.501
LIG_eIF4E_1	148	154	PF01652	0.333
LIG_FHA_1	139	145	PF00498	0.592
LIG_FHA_1	49	55	PF00498	0.511
LIG_FHA_1	547	553	PF00498	0.476
LIG_FHA_1	624	630	PF00498	0.476
LIG_FHA_1	674	680	PF00498	0.570
LIG_FHA_1	690	696	PF00498	0.410
LIG_FHA_1	744	750	PF00498	0.476
LIG_FHA_1	93	99	PF00498	0.528
LIG_FHA_2	219	225	PF00498	0.435
LIG_FHA_2	266	272	PF00498	0.466
LIG_FHA_2	310	316	PF00498	0.533
LIG_FHA_2	370	376	PF00498	0.391
LIG_FHA_2	55	61	PF00498	0.630
LIG_FHA_2	636	642	PF00498	0.476
LIG_FHA_2	651	657	PF00498	0.476
LIG_FHA_2	721	727	PF00498	0.433
LIG_FHA_2	886	892	PF00498	0.476
LIG_Integrin_RGD_1	473	475	PF01839	0.676
LIG_LIR_Apic_2	275	279	PF02991	0.533
LIG_LIR_Gen_1	145	156	PF02991	0.425
LIG_LIR_Gen_1	221	231	PF02991	0.308
LIG_LIR_Gen_1	57	66	PF02991	0.461
LIG_LIR_Gen_1	723	731	PF02991	0.476
LIG_LIR_Gen_1	91	102	PF02991	0.531
LIG_LIR_Nem_3	145	151	PF02991	0.436
LIG_LIR_Nem_3	155	160	PF02991	0.377
LIG_LIR_Nem_3	221	226	PF02991	0.429
LIG_LIR_Nem_3	57	62	PF02991	0.459
LIG_LIR_Nem_3	723	728	PF02991	0.476
LIG_LIR_Nem_3	905	909	PF02991	0.504
LIG_LIR_Nem_3	91	97	PF02991	0.549
LIG_PALB2_WD40_1	540	548	PF16756	0.476
LIG_Pex14_1	161	165	PF04695	0.411
LIG_Pex14_2	157	161	PF04695	0.398
LIG_Pex14_2	520	524	PF04695	0.548
LIG_SH2_CRK	210	214	PF00017	0.442
LIG_SH2_NCK_1	210	214	PF00017	0.442
LIG_SH2_PTP2	148	151	PF00017	0.340
LIG_SH2_STAP1	50	54	PF00017	0.590
LIG_SH2_STAP1	894	898	PF00017	0.476
LIG_SH2_STAT3	812	815	PF00017	0.413
LIG_SH2_STAT3	894	897	PF00017	0.476
LIG_SH2_STAT5	148	151	PF00017	0.340
LIG_SH2_STAT5	50	53	PF00017	0.519
LIG_SH2_STAT5	812	815	PF00017	0.413
LIG_SH2_STAT5	867	870	PF00017	0.476
LIG_SH2_STAT5	989	992	PF00017	0.381
LIG_SH3_2	105	110	PF14604	0.677
LIG_SH3_3	102	108	PF00018	0.633
LIG_SH3_3	317	323	PF00018	0.483
LIG_SH3_3	588	594	PF00018	0.470
LIG_SH3_3	845	851	PF00018	0.610
LIG_SUMO_SIM_par_1	149	155	PF11976	0.389
LIG_SUMO_SIM_par_1	357	362	PF11976	0.413
LIG_SUMO_SIM_par_1	587	593	PF11976	0.476
LIG_SUMO_SIM_par_1	667	673	PF11976	0.476
LIG_SUMO_SIM_par_1	72	78	PF11976	0.725
LIG_SUMO_SIM_par_1	955	962	PF11976	0.468
LIG_TRAF2_1	528	531	PF00917	0.455
LIG_UBA3_1	556	563	PF00899	0.476
LIG_WRC_WIRS_1	903	908	PF05994	0.468
MOD_CDC14_SPxK_1	245	248	PF00782	0.476
MOD_CDK_SPK_2	861	866	PF00069	0.476
MOD_CDK_SPxK_1	104	110	PF00069	0.621
MOD_CDK_SPxK_1	242	248	PF00069	0.476
MOD_CK1_1	198	204	PF00069	0.673
MOD_CK1_1	319	325	PF00069	0.744
MOD_CK1_1	327	333	PF00069	0.807
MOD_CK1_1	408	414	PF00069	0.548
MOD_CK1_1	415	421	PF00069	0.558
MOD_CK1_1	507	513	PF00069	0.616
MOD_CK1_1	519	525	PF00069	0.516
MOD_CK1_1	635	641	PF00069	0.476
MOD_CK1_1	64	70	PF00069	0.514
MOD_CK2_1	149	155	PF00069	0.328
MOD_CK2_1	525	531	PF00069	0.466
MOD_CK2_1	54	60	PF00069	0.630
MOD_CK2_1	635	641	PF00069	0.476
MOD_Cter_Amidation	178	181	PF01082	0.563
MOD_Cter_Amidation	920	923	PF01082	0.681
MOD_DYRK1A_RPxSP_1	190	194	PF00069	0.644
MOD_GlcNHglycan	14	17	PF01048	0.585
MOD_GlcNHglycan	197	200	PF01048	0.724
MOD_GlcNHglycan	213	216	PF01048	0.361
MOD_GlcNHglycan	24	27	PF01048	0.511
MOD_GlcNHglycan	281	284	PF01048	0.337
MOD_GlcNHglycan	323	326	PF01048	0.671
MOD_GlcNHglycan	351	354	PF01048	0.564
MOD_GlcNHglycan	413	417	PF01048	0.582
MOD_GlcNHglycan	437	440	PF01048	0.614
MOD_GlcNHglycan	506	509	PF01048	0.731
MOD_GlcNHglycan	513	516	PF01048	0.607
MOD_GlcNHglycan	521	524	PF01048	0.453
MOD_GlcNHglycan	527	530	PF01048	0.387
MOD_GlcNHglycan	611	614	PF01048	0.270
MOD_GlcNHglycan	634	637	PF01048	0.276
MOD_GlcNHglycan	737	740	PF01048	0.254
MOD_GlcNHglycan	844	847	PF01048	0.705
MOD_GlcNHglycan	848	851	PF01048	0.585
MOD_GlcNHglycan	911	914	PF01048	0.580
MOD_GlcNHglycan	943	948	PF01048	0.494
MOD_GlcNHglycan	966	969	PF01048	0.424
MOD_GSK3_1	233	240	PF00069	0.476
MOD_GSK3_1	315	322	PF00069	0.531
MOD_GSK3_1	408	415	PF00069	0.600
MOD_GSK3_1	507	514	PF00069	0.589
MOD_GSK3_1	519	526	PF00069	0.707
MOD_GSK3_1	548	555	PF00069	0.476
MOD_GSK3_1	619	626	PF00069	0.494
MOD_GSK3_1	632	639	PF00069	0.552
MOD_GSK3_1	8	15	PF00069	0.633
MOD_GSK3_1	80	87	PF00069	0.577
MOD_GSK3_1	840	847	PF00069	0.598
MOD_GSK3_1	88	95	PF00069	0.581
MOD_GSK3_1	898	905	PF00069	0.476
MOD_N-GLC_1	715	720	PF02516	0.276
MOD_NEK2_1	170	175	PF00069	0.661
MOD_NEK2_1	314	319	PF00069	0.533
MOD_NEK2_1	437	442	PF00069	0.682
MOD_NEK2_1	548	553	PF00069	0.476
MOD_NEK2_1	566	571	PF00069	0.477
MOD_NEK2_1	596	601	PF00069	0.476
MOD_NEK2_1	625	630	PF00069	0.526
MOD_NEK2_1	684	689	PF00069	0.476
MOD_NEK2_1	791	796	PF00069	0.373
MOD_NEK2_1	842	847	PF00069	0.636
MOD_NEK2_1	859	864	PF00069	0.314
MOD_NEK2_1	898	903	PF00069	0.476
MOD_NEK2_1	909	914	PF00069	0.568
MOD_NEK2_2	405	410	PF00069	0.485
MOD_NMyristoyl	1	7	PF02799	0.644
MOD_OFUCOSY	616	623	PF10250	0.276
MOD_PIKK_1	170	176	PF00454	0.559
MOD_PIKK_1	266	272	PF00454	0.449
MOD_PIKK_1	327	333	PF00454	0.716
MOD_PIKK_1	344	350	PF00454	0.528
MOD_PIKK_1	408	414	PF00454	0.599
MOD_PIKK_1	596	602	PF00454	0.476
MOD_PIKK_1	791	797	PF00454	0.373
MOD_PIKK_1	925	931	PF00454	0.386
MOD_PKA_1	168	174	PF00069	0.549
MOD_PKA_1	265	271	PF00069	0.433
MOD_PKA_2	247	253	PF00069	0.466
MOD_PKA_2	48	54	PF00069	0.518
MOD_PKA_2	516	522	PF00069	0.649
MOD_PKA_2	546	552	PF00069	0.476
MOD_PKA_2	582	588	PF00069	0.476
MOD_PKA_2	690	696	PF00069	0.559
MOD_PKA_2	707	713	PF00069	0.405
MOD_PKB_1	190	198	PF00069	0.552
MOD_Plk_1	308	314	PF00069	0.476
MOD_Plk_1	636	642	PF00069	0.476
MOD_Plk_1	859	865	PF00069	0.393
MOD_Plk_2-3	309	315	PF00069	0.533
MOD_Plk_2-3	369	375	PF00069	0.400
MOD_Plk_4	149	155	PF00069	0.324
MOD_Plk_4	237	243	PF00069	0.476
MOD_Plk_4	309	315	PF00069	0.533
MOD_Plk_4	54	60	PF00069	0.538
MOD_Plk_4	552	558	PF00069	0.476
MOD_Plk_4	566	572	PF00069	0.476
MOD_Plk_4	61	67	PF00069	0.476
MOD_Plk_4	690	696	PF00069	0.476
MOD_ProDKin_1	104	110	PF00069	0.621
MOD_ProDKin_1	190	196	PF00069	0.664
MOD_ProDKin_1	218	224	PF00069	0.614
MOD_ProDKin_1	242	248	PF00069	0.476
MOD_ProDKin_1	288	294	PF00069	0.509
MOD_ProDKin_1	316	322	PF00069	0.474
MOD_ProDKin_1	39	45	PF00069	0.562
MOD_ProDKin_1	415	421	PF00069	0.623
MOD_ProDKin_1	715	721	PF00069	0.503
MOD_ProDKin_1	861	867	PF00069	0.470
MOD_SUMO_for_1	879	882	PF00179	0.476
MOD_SUMO_rev_2	659	668	PF00179	0.476
TRG_DiLeu_BaEn_1	300	305	PF01217	0.533
TRG_DiLeu_BaEn_1	664	669	PF01217	0.476
TRG_DiLeu_BaEn_1	977	982	PF01217	0.411
TRG_DiLeu_BaEn_4	300	306	PF01217	0.533
TRG_DiLeu_BaLyEn_6	98	103	PF01217	0.553
TRG_ENDOCYTIC_2	148	151	PF00928	0.340
TRG_ENDOCYTIC_2	210	213	PF00928	0.436
TRG_ER_diArg_1	206	208	PF00400	0.489
TRG_ER_diArg_1	401	404	PF00400	0.405
TRG_ER_diArg_1	429	432	PF00400	0.593
TRG_ER_diArg_1	922	924	PF00400	0.630
TRG_NLS_Bipartite_1	168	184	PF00514	0.516
TRG_NLS_MonoExtC_3	179	185	PF00514	0.570
TRG_NLS_MonoExtN_4	177	184	PF00514	0.565
TRG_Pf-PMV_PEXEL_1	407	412	PF00026	0.576
TRG_Pf-PMV_PEXEL_1	666	670	PF00026	0.276
TRG_Pf-PMV_PEXEL_1	973	977	PF00026	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAM6	Leptomonas seymouri	63%	99%
A4H477	Leishmania braziliensis	80%	99%
A4HSF2	Leishmania infantum	99%	100%
E9AKD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QJG9	Leishmania major	92%	99%