Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3S5H5G9_LEIDO

TriTrypDb:

LdCL_050007600 , LDHU3_05.0320

Length:

320

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H5G9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5G9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.544
CLV_NRD_NRD_1	264	266	PF00675	0.575
CLV_NRD_NRD_1	317	319	PF00675	0.671
CLV_PCSK_FUR_1	270	274	PF00082	0.578
CLV_PCSK_KEX2_1	11	13	PF00082	0.484
CLV_PCSK_KEX2_1	264	266	PF00082	0.593
CLV_PCSK_KEX2_1	272	274	PF00082	0.631
CLV_PCSK_KEX2_1	315	317	PF00082	0.624
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.626
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.641
CLV_PCSK_PC7_1	268	274	PF00082	0.610
CLV_PCSK_SKI1_1	286	290	PF00082	0.597
DEG_Kelch_Keap1_1	87	92	PF01344	0.621
DEG_SPOP_SBC_1	215	219	PF00917	0.616
DEG_SPOP_SBC_1	228	232	PF00917	0.666
DOC_ANK_TNKS_1	22	29	PF00023	0.554
DOC_CKS1_1	75	80	PF01111	0.584
DOC_USP7_MATH_1	171	175	PF00917	0.655
DOC_USP7_MATH_1	216	220	PF00917	0.728
DOC_USP7_UBL2_3	82	86	PF12436	0.604
DOC_WW_Pin1_4	108	113	PF00397	0.633
DOC_WW_Pin1_4	222	227	PF00397	0.722
DOC_WW_Pin1_4	74	79	PF00397	0.507
DOC_WW_Pin1_4	84	89	PF00397	0.570
LIG_14-3-3_CanoR_1	18	23	PF00244	0.561
LIG_14-3-3_CanoR_1	201	205	PF00244	0.454
LIG_14-3-3_CanoR_1	254	263	PF00244	0.586
LIG_BIR_II_1	1	5	PF00653	0.686
LIG_BIR_III_4	37	41	PF00653	0.704
LIG_DLG_GKlike_1	18	25	PF00625	0.544
LIG_EH1_1	154	162	PF00400	0.430
LIG_FHA_1	132	138	PF00498	0.401
LIG_FHA_1	173	179	PF00498	0.604
LIG_FHA_1	205	211	PF00498	0.425
LIG_FHA_1	230	236	PF00498	0.512
LIG_FHA_1	71	77	PF00498	0.438
LIG_FHA_1	88	94	PF00498	0.455
LIG_FHA_2	2	8	PF00498	0.607
LIG_FHA_2	201	207	PF00498	0.573
LIG_FHA_2	255	261	PF00498	0.544
LIG_GBD_Chelix_1	25	33	PF00786	0.571
LIG_LIR_Apic_2	96	102	PF02991	0.553
LIG_LIR_Gen_1	292	302	PF02991	0.494
LIG_LIR_Nem_3	127	132	PF02991	0.415
LIG_LIR_Nem_3	21	25	PF02991	0.433
LIG_LIR_Nem_3	292	297	PF02991	0.478
LIG_LYPXL_yS_3	129	132	PF13949	0.482
LIG_MYND_1	112	116	PF01753	0.540
LIG_NRBOX	63	69	PF00104	0.519
LIG_PCNA_yPIPBox_3	289	302	PF02747	0.615
LIG_RPA_C_Plants	275	286	PF08784	0.617
LIG_SH2_CRK	248	252	PF00017	0.542
LIG_SH2_SRC	194	197	PF00017	0.538
LIG_SH2_STAP1	119	123	PF00017	0.379
LIG_SH2_STAP1	162	166	PF00017	0.479
LIG_SH2_STAT5	194	197	PF00017	0.538
LIG_SH3_1	99	105	PF00018	0.547
LIG_SH3_3	133	139	PF00018	0.446
LIG_SH3_3	165	171	PF00018	0.435
LIG_SH3_3	183	189	PF00018	0.526
LIG_SH3_3	207	213	PF00018	0.527
LIG_SH3_3	232	238	PF00018	0.535
LIG_SH3_3	99	105	PF00018	0.621
LIG_TRAF2_1	14	17	PF00917	0.489
LIG_TRAF2_1	203	206	PF00917	0.621
LIG_TRAF2_1	257	260	PF00917	0.554
LIG_TRAF2_1	5	8	PF00917	0.705
MOD_CDK_SPxxK_3	108	115	PF00069	0.600
MOD_CK1_1	217	223	PF00069	0.727
MOD_CK1_1	227	233	PF00069	0.616
MOD_CK1_1	87	93	PF00069	0.559
MOD_CK2_1	1	7	PF00069	0.737
MOD_CK2_1	11	17	PF00069	0.508
MOD_CK2_1	18	24	PF00069	0.483
MOD_CK2_1	200	206	PF00069	0.575
MOD_CK2_1	254	260	PF00069	0.553
MOD_Cter_Amidation	310	313	PF01082	0.605
MOD_GlcNHglycan	226	229	PF01048	0.662
MOD_GlcNHglycan	305	308	PF01048	0.675
MOD_GSK3_1	100	107	PF00069	0.674
MOD_GSK3_1	169	176	PF00069	0.635
MOD_GSK3_1	200	207	PF00069	0.434
MOD_GSK3_1	216	223	PF00069	0.674
MOD_GSK3_1	224	231	PF00069	0.662
MOD_GSK3_1	233	240	PF00069	0.494
MOD_GSK3_1	70	77	PF00069	0.486
MOD_NEK2_1	1	6	PF00069	0.741
MOD_NEK2_1	204	209	PF00069	0.445
MOD_NEK2_2	180	185	PF00069	0.545
MOD_PIKK_1	246	252	PF00454	0.609
MOD_PKA_1	11	17	PF00069	0.381
MOD_PKA_2	11	17	PF00069	0.522
MOD_PKA_2	200	206	PF00069	0.446
MOD_PKB_1	252	260	PF00069	0.659
MOD_Plk_1	204	210	PF00069	0.455
MOD_Plk_1	70	76	PF00069	0.620
MOD_Plk_2-3	200	206	PF00069	0.478
MOD_Plk_4	204	210	PF00069	0.436
MOD_Plk_4	93	99	PF00069	0.516
MOD_ProDKin_1	108	114	PF00069	0.618
MOD_ProDKin_1	222	228	PF00069	0.721
MOD_ProDKin_1	74	80	PF00069	0.507
MOD_ProDKin_1	84	90	PF00069	0.570
MOD_SUMO_for_1	255	258	PF00179	0.649
MOD_SUMO_for_1	271	274	PF00179	0.374
TRG_DiLeu_BaEn_1	205	210	PF01217	0.540
TRG_ENDOCYTIC_2	119	122	PF00928	0.433
TRG_ENDOCYTIC_2	129	132	PF00928	0.315
TRG_ENDOCYTIC_2	22	25	PF00928	0.433
TRG_ENDOCYTIC_2	248	251	PF00928	0.477
TRG_ER_diArg_1	10	12	PF00400	0.409
TRG_ER_diArg_1	251	254	PF00400	0.514
TRG_ER_diArg_1	263	265	PF00400	0.541
TRG_ER_diArg_1	268	271	PF00400	0.515
TRG_ER_diArg_1	316	318	PF00400	0.674
TRG_NES_CRM1_1	48	60	PF08389	0.566
TRG_NLS_MonoCore_2	314	319	PF00514	0.670
TRG_NLS_MonoExtC_3	311	316	PF00514	0.639
TRG_NLS_MonoExtN_4	312	319	PF00514	0.658
TRG_Pf-PMV_PEXEL_1	23	27	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	62	66	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3H6	Leptomonas seymouri	67%	100%
A0A0S4J6H5	Bodo saltans	32%	100%
A0A1X0P0L2	Trypanosomatidae	42%	100%
A0A3R7LUJ2	Trypanosoma rangeli	43%	100%
A4H471	Leishmania braziliensis	88%	100%
A4HSE6	Leishmania infantum	98%	100%
D0A4J8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AKD2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
Q4QJH6	Leishmania major	95%	100%
V5BBA9	Trypanosoma cruzi	42%	100%