LeishMANIAdb
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Viscerotropic leishmaniasis antigen, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Viscerotropic leishmaniasis antigen, putative
Gene product:
viscerotropic leishmaniasis antigen, putative
Species:
Leishmania donovani
UniProt:
A0A3S5H5G8_LEIDO
TriTrypDb:
LdBPK_050240.1 * , LdCL_050007300 , LDHU3_05.0280
Length:
956

Annotations

LeishMANIAdb annotations

A family of very long coiled-coil proteins, likely performing cytoskeletal functions.. Two varieties have evolved, one with an N-terminal FYVE domain (Non-TM) and another with a C-terminal PDZ domain (might be TM)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 4
NetGPI no yes: 0, no: 4
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5
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Expansion

Sequence features

A0A3S5H5G8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5G8

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 277 279 PF00675 0.531
CLV_NRD_NRD_1 890 892 PF00675 0.512
CLV_NRD_NRD_1 913 915 PF00675 0.497
CLV_NRD_NRD_1 953 955 PF00675 0.441
CLV_NRD_NRD_1 98 100 PF00675 0.423
CLV_PCSK_KEX2_1 201 203 PF00082 0.475
CLV_PCSK_KEX2_1 890 892 PF00082 0.512
CLV_PCSK_KEX2_1 913 915 PF00082 0.497
CLV_PCSK_KEX2_1 953 955 PF00082 0.441
CLV_PCSK_PC1ET2_1 201 203 PF00082 0.475
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Homologs

ProteinTaxonomySequence identityCoverage
A4HSF6 Leishmania infantum 92% 100%
E9AKC8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 72% 85%
Q4QJH9 Leishmania major 68% 77%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS