LeishMANIAdb
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Dual specificity phosphatase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Dual specificity phosphatase-like protein
Gene product:
dual specificity phosphatase-like protein
Species:
Leishmania donovani
UniProt:
A0A3S5H5G7_LEIDO
TriTrypDb:
LdBPK_050220.1 , LdCL_050007100 , LDHU3_05.0260
Length:
668

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3S5H5G7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5G7

Function

Biological processes
Term Name Level Count
GO:0006470 protein dephosphorylation 5 6
GO:0006793 phosphorus metabolic process 3 6
GO:0006796 phosphate-containing compound metabolic process 4 6
GO:0006807 nitrogen compound metabolic process 2 6
GO:0008152 metabolic process 1 6
GO:0009987 cellular process 1 6
GO:0016311 dephosphorylation 5 6
GO:0019538 protein metabolic process 3 6
GO:0036211 protein modification process 4 6
GO:0043170 macromolecule metabolic process 3 6
GO:0043412 macromolecule modification 4 6
GO:0044237 cellular metabolic process 2 6
GO:0044238 primary metabolic process 2 6
GO:0071704 organic substance metabolic process 2 6
GO:1901564 organonitrogen compound metabolic process 3 6
GO:0009966 regulation of signal transduction 4 1
GO:0009968 negative regulation of signal transduction 5 1
GO:0010646 regulation of cell communication 4 1
GO:0010648 negative regulation of cell communication 5 1
GO:0023051 regulation of signaling 3 1
GO:0023057 negative regulation of signaling 4 1
GO:0043408 regulation of MAPK cascade 6 1
GO:0043409 negative regulation of MAPK cascade 7 1
GO:0048519 negative regulation of biological process 3 1
GO:0048523 negative regulation of cellular process 4 1
GO:0048583 regulation of response to stimulus 3 1
GO:0048585 negative regulation of response to stimulus 4 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
GO:1902531 regulation of intracellular signal transduction 5 1
GO:1902532 negative regulation of intracellular signal transduction 6 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 6
GO:0004721 phosphoprotein phosphatase activity 3 6
GO:0004725 protein tyrosine phosphatase activity 4 6
GO:0008138 protein tyrosine/serine/threonine phosphatase activity 4 6
GO:0016787 hydrolase activity 2 6
GO:0016788 hydrolase activity, acting on ester bonds 3 6
GO:0016791 phosphatase activity 5 6
GO:0042578 phosphoric ester hydrolase activity 4 6
GO:0140096 catalytic activity, acting on a protein 2 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 504 508 PF00656 0.686
CLV_C14_Caspase3-7 86 90 PF00656 0.388
CLV_NRD_NRD_1 167 169 PF00675 0.388
CLV_NRD_NRD_1 199 201 PF00675 0.420
CLV_NRD_NRD_1 368 370 PF00675 0.703
CLV_NRD_NRD_1 437 439 PF00675 0.683
CLV_NRD_NRD_1 457 459 PF00675 0.619
CLV_NRD_NRD_1 572 574 PF00675 0.665
CLV_PCSK_KEX2_1 167 169 PF00082 0.388
CLV_PCSK_KEX2_1 199 201 PF00082 0.420
CLV_PCSK_KEX2_1 368 370 PF00082 0.703
CLV_PCSK_KEX2_1 37 39 PF00082 0.615
CLV_PCSK_KEX2_1 437 439 PF00082 0.683
CLV_PCSK_PC1ET2_1 37 39 PF00082 0.615
CLV_PCSK_SKI1_1 102 106 PF00082 0.388
CLV_PCSK_SKI1_1 194 198 PF00082 0.388
CLV_PCSK_SKI1_1 288 292 PF00082 0.615
CLV_PCSK_SKI1_1 437 441 PF00082 0.646
CLV_PCSK_SKI1_1 573 577 PF00082 0.688
DEG_APCC_DBOX_1 436 444 PF00400 0.682
DEG_SCF_FBW7_2 406 413 PF00400 0.650
DEG_SPOP_SBC_1 2 6 PF00917 0.578
DEG_SPOP_SBC_1 290 294 PF00917 0.672
DEG_SPOP_SBC_1 448 452 PF00917 0.601
DEG_SPOP_SBC_1 471 475 PF00917 0.631
DOC_CYCLIN_yCln2_LP_2 282 285 PF00134 0.589
DOC_MAPK_gen_1 199 207 PF00069 0.388
DOC_MAPK_MEF2A_6 199 207 PF00069 0.388
DOC_PP2B_LxvP_1 281 284 PF13499 0.626
DOC_PP4_FxxP_1 223 226 PF00568 0.554
DOC_USP7_MATH_1 243 247 PF00917 0.630
DOC_USP7_MATH_1 25 29 PF00917 0.611
DOC_USP7_MATH_1 265 269 PF00917 0.792
DOC_USP7_MATH_1 311 315 PF00917 0.654
DOC_USP7_MATH_1 355 359 PF00917 0.620
DOC_USP7_MATH_1 446 450 PF00917 0.717
DOC_USP7_MATH_1 517 521 PF00917 0.644
DOC_USP7_MATH_1 83 87 PF00917 0.366
DOC_USP7_MATH_2 284 290 PF00917 0.599
DOC_WW_Pin1_4 23 28 PF00397 0.611
DOC_WW_Pin1_4 236 241 PF00397 0.655
DOC_WW_Pin1_4 393 398 PF00397 0.611
DOC_WW_Pin1_4 406 411 PF00397 0.619
DOC_WW_Pin1_4 427 432 PF00397 0.645
DOC_WW_Pin1_4 526 531 PF00397 0.792
DOC_WW_Pin1_4 555 560 PF00397 0.748
DOC_WW_Pin1_4 604 609 PF00397 0.675
DOC_WW_Pin1_4 643 648 PF00397 0.699
LIG_14-3-3_CanoR_1 154 163 PF00244 0.475
LIG_14-3-3_CanoR_1 199 207 PF00244 0.375
LIG_14-3-3_CanoR_1 212 218 PF00244 0.233
LIG_14-3-3_CanoR_1 302 309 PF00244 0.672
LIG_14-3-3_CanoR_1 385 391 PF00244 0.631
LIG_14-3-3_CanoR_1 463 472 PF00244 0.647
LIG_14-3-3_CanoR_1 662 667 PF00244 0.631
LIG_Actin_WH2_2 36 53 PF00022 0.593
LIG_BIR_II_1 1 5 PF00653 0.584
LIG_BRCT_BRCA1_1 218 222 PF00533 0.544
LIG_FHA_1 136 142 PF00498 0.391
LIG_FHA_1 381 387 PF00498 0.739
LIG_FHA_1 394 400 PF00498 0.629
LIG_FHA_1 477 483 PF00498 0.683
LIG_FHA_1 77 83 PF00498 0.470
LIG_FHA_2 348 354 PF00498 0.729
LIG_FHA_2 57 63 PF00498 0.545
LIG_LIR_Apic_2 220 226 PF02991 0.534
LIG_LYPXL_L_2 72 81 PF13949 0.360
LIG_MLH1_MIPbox_1 219 223 PF16413 0.498
LIG_MYND_1 280 284 PF01753 0.595
LIG_PCNA_yPIPBox_3 118 131 PF02747 0.388
LIG_RPA_C_Fungi 163 175 PF08784 0.388
LIG_SH2_SRC 189 192 PF00017 0.388
LIG_SH2_STAP1 189 193 PF00017 0.455
LIG_SH2_STAT3 631 634 PF00017 0.658
LIG_SH2_STAT5 103 106 PF00017 0.388
LIG_SH2_STAT5 180 183 PF00017 0.388
LIG_SH3_2 24 29 PF14604 0.587
LIG_SH3_3 12 18 PF00018 0.683
LIG_SH3_3 21 27 PF00018 0.605
LIG_SH3_3 422 428 PF00018 0.776
LIG_SH3_3 527 533 PF00018 0.647
LIG_SH3_3 641 647 PF00018 0.807
LIG_SUMO_SIM_par_1 79 86 PF11976 0.440
LIG_TRAF2_1 113 116 PF00917 0.523
LIG_TRAF2_1 208 211 PF00917 0.334
LIG_TRAF2_1 466 469 PF00917 0.620
LIG_TRAF2_1 501 504 PF00917 0.677
LIG_TRAF2_1 52 55 PF00917 0.552
LIG_TRAF2_2 273 278 PF00917 0.649
MOD_CDC14_SPxK_1 26 29 PF00782 0.584
MOD_CDK_SPK_2 526 531 PF00069 0.709
MOD_CDK_SPxK_1 23 29 PF00069 0.590
MOD_CK1_1 157 163 PF00069 0.334
MOD_CK1_1 201 207 PF00069 0.388
MOD_CK1_1 239 245 PF00069 0.730
MOD_CK1_1 28 34 PF00069 0.603
MOD_CK1_1 289 295 PF00069 0.671
MOD_CK1_1 297 303 PF00069 0.601
MOD_CK1_1 329 335 PF00069 0.706
MOD_CK1_1 343 349 PF00069 0.637
MOD_CK1_1 387 393 PF00069 0.610
MOD_CK1_1 414 420 PF00069 0.738
MOD_CK1_1 449 455 PF00069 0.811
MOD_CK1_1 513 519 PF00069 0.701
MOD_CK1_1 577 583 PF00069 0.691
MOD_CK1_1 661 667 PF00069 0.752
MOD_CK1_1 76 82 PF00069 0.391
MOD_CK2_1 347 353 PF00069 0.653
MOD_CK2_1 463 469 PF00069 0.673
MOD_CK2_1 540 546 PF00069 0.667
MOD_CK2_1 56 62 PF00069 0.525
MOD_CK2_1 583 589 PF00069 0.661
MOD_CK2_1 88 94 PF00069 0.408
MOD_Cter_Amidation 435 438 PF01082 0.684
MOD_GlcNHglycan 172 175 PF01048 0.516
MOD_GlcNHglycan 241 244 PF01048 0.673
MOD_GlcNHglycan 261 264 PF01048 0.834
MOD_GlcNHglycan 304 307 PF01048 0.667
MOD_GlcNHglycan 328 331 PF01048 0.654
MOD_GlcNHglycan 342 345 PF01048 0.619
MOD_GlcNHglycan 370 373 PF01048 0.661
MOD_GlcNHglycan 386 389 PF01048 0.620
MOD_GlcNHglycan 400 403 PF01048 0.671
MOD_GlcNHglycan 451 454 PF01048 0.691
MOD_GlcNHglycan 465 468 PF01048 0.619
MOD_GlcNHglycan 515 518 PF01048 0.749
MOD_GlcNHglycan 537 540 PF01048 0.713
MOD_GlcNHglycan 576 579 PF01048 0.787
MOD_GlcNHglycan 634 637 PF01048 0.759
MOD_GSK3_1 131 138 PF00069 0.410
MOD_GSK3_1 181 188 PF00069 0.388
MOD_GSK3_1 194 201 PF00069 0.265
MOD_GSK3_1 239 246 PF00069 0.668
MOD_GSK3_1 286 293 PF00069 0.688
MOD_GSK3_1 294 301 PF00069 0.622
MOD_GSK3_1 322 329 PF00069 0.636
MOD_GSK3_1 335 342 PF00069 0.624
MOD_GSK3_1 343 350 PF00069 0.617
MOD_GSK3_1 377 384 PF00069 0.577
MOD_GSK3_1 447 454 PF00069 0.642
MOD_GSK3_1 472 479 PF00069 0.667
MOD_GSK3_1 512 519 PF00069 0.683
MOD_GSK3_1 549 556 PF00069 0.655
MOD_GSK3_1 574 581 PF00069 0.640
MOD_GSK3_1 604 611 PF00069 0.698
MOD_GSK3_1 626 633 PF00069 0.685
MOD_GSK3_1 657 664 PF00069 0.718
MOD_GSK3_1 73 80 PF00069 0.471
MOD_N-GLC_1 265 270 PF02516 0.636
MOD_N-GLC_1 517 522 PF02516 0.637
MOD_N-GLC_1 549 554 PF02516 0.684
MOD_N-GLC_1 578 583 PF02516 0.678
MOD_N-GLC_1 590 595 PF02516 0.646
MOD_N-GLC_1 604 609 PF02516 0.566
MOD_N-GLC_2 490 492 PF02516 0.624
MOD_NEK2_1 133 138 PF00069 0.388
MOD_NEK2_1 241 246 PF00069 0.658
MOD_NEK2_1 377 382 PF00069 0.633
MOD_NEK2_1 472 477 PF00069 0.646
MOD_NEK2_1 478 483 PF00069 0.633
MOD_NEK2_1 616 621 PF00069 0.643
MOD_PIKK_1 135 141 PF00454 0.388
MOD_PIKK_1 225 231 PF00454 0.672
MOD_PIKK_1 266 272 PF00454 0.660
MOD_PIKK_1 309 315 PF00454 0.685
MOD_PIKK_1 563 569 PF00454 0.657
MOD_PIKK_1 630 636 PF00454 0.711
MOD_PK_1 322 328 PF00069 0.601
MOD_PKA_1 368 374 PF00069 0.641
MOD_PKA_2 198 204 PF00069 0.388
MOD_PKA_2 211 217 PF00069 0.246
MOD_PKA_2 28 34 PF00069 0.603
MOD_PKA_2 301 307 PF00069 0.699
MOD_PKA_2 339 345 PF00069 0.697
MOD_PKA_2 368 374 PF00069 0.800
MOD_PKA_2 384 390 PF00069 0.523
MOD_PKA_2 441 447 PF00069 0.643
MOD_PKA_2 510 516 PF00069 0.747
MOD_PKA_2 535 541 PF00069 0.704
MOD_PKA_2 661 667 PF00069 0.631
MOD_PKB_1 604 612 PF00069 0.631
MOD_Plk_1 157 163 PF00069 0.334
MOD_Plk_1 62 68 PF00069 0.593
MOD_Plk_1 76 82 PF00069 0.313
MOD_Plk_2-3 185 191 PF00069 0.388
MOD_Plk_4 245 251 PF00069 0.596
MOD_Plk_4 322 328 PF00069 0.617
MOD_Plk_4 482 488 PF00069 0.654
MOD_Plk_4 56 62 PF00069 0.627
MOD_Plk_4 651 657 PF00069 0.617
MOD_Plk_4 77 83 PF00069 0.470
MOD_ProDKin_1 23 29 PF00069 0.612
MOD_ProDKin_1 236 242 PF00069 0.653
MOD_ProDKin_1 393 399 PF00069 0.613
MOD_ProDKin_1 406 412 PF00069 0.614
MOD_ProDKin_1 427 433 PF00069 0.644
MOD_ProDKin_1 526 532 PF00069 0.791
MOD_ProDKin_1 555 561 PF00069 0.747
MOD_ProDKin_1 604 610 PF00069 0.674
MOD_ProDKin_1 643 649 PF00069 0.699
MOD_SUMO_rev_2 110 120 PF00179 0.388
TRG_DiLeu_BaLyEn_6 277 282 PF01217 0.639
TRG_ER_diArg_1 367 369 PF00400 0.544
TRG_ER_diArg_1 570 573 PF00400 0.650

Homologs

Protein Taxonomy Sequence identity Coverage
A4H479 Leishmania braziliensis 59% 100%
A4HSF4 Leishmania infantum 99% 100%
E9AKC6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 99%
Q4QJI1 Leishmania major 90% 99%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS