Fip1 motif/Zinc finger C-x8-C-x5-C-x3-H type (And similar), putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Fip1 motif/Zinc finger C-x8-C-x5-C-x3-H type (and similar), putative

Species:

Leishmania donovani

UniProt:

A0A3S5H5G4_LEIDO

TriTrypDb:

LdBPK_050190.1 , LdCL_050006800 , LDHU3_05.0230

Length:

361

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	8
GO:0110165	cellular anatomical entity	1	9
GO:0005654	nucleoplasm	2	1
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	4	1
GO:0005849	mRNA cleavage factor complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A0A3S5H5G4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5G4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006378	mRNA polyadenylation	7	1
GO:0006379	mRNA cleavage	7	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0031123	RNA 3'-end processing	7	1
GO:0031124	mRNA 3'-end processing	8	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043631	RNA polyadenylation	6	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0090501	RNA phosphodiester bond hydrolysis	6	1
GO:0098787	mRNA cleavage involved in mRNA processing	8	1
GO:0098789	pre-mRNA cleavage required for polyadenylation	9	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.737
CLV_C14_Caspase3-7	333	337	PF00656	0.800
CLV_PCSK_KEX2_1	347	349	PF00082	0.679
CLV_PCSK_KEX2_1	72	74	PF00082	0.357
CLV_PCSK_PC1ET2_1	347	349	PF00082	0.706
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.376
CLV_PCSK_PC7_1	343	349	PF00082	0.702
DEG_Nend_UBRbox_2	1	3	PF02207	0.618
DOC_ANK_TNKS_1	349	356	PF00023	0.595
DOC_CKS1_1	286	291	PF01111	0.801
DOC_CYCLIN_yCln2_LP_2	310	313	PF00134	0.710
DOC_PP2B_LxvP_1	310	313	PF13499	0.710
DOC_PP4_FxxP_1	342	345	PF00568	0.706
DOC_USP7_MATH_1	38	42	PF00917	0.521
DOC_WW_Pin1_4	285	290	PF00397	0.793
LIG_14-3-3_CanoR_1	210	216	PF00244	0.386
LIG_BIR_III_2	24	28	PF00653	0.758
LIG_BRCT_BRCA1_1	59	63	PF00533	0.668
LIG_BRCT_BRCA1_1	82	86	PF00533	0.369
LIG_FHA_1	112	118	PF00498	0.588
LIG_FHA_2	32	38	PF00498	0.701
LIG_Integrin_RGD_1	222	224	PF01839	0.416
LIG_LIR_Apic_2	285	290	PF02991	0.577
LIG_LIR_Apic_2	340	345	PF02991	0.755
LIG_LIR_Nem_3	83	88	PF02991	0.357
LIG_LIR_Nem_3	92	98	PF02991	0.333
LIG_MLH1_MIPbox_1	82	86	PF16413	0.369
LIG_Pex14_2	86	90	PF04695	0.357
LIG_PTB_Apo_2	201	208	PF02174	0.595
LIG_PTB_Apo_2	84	91	PF02174	0.357
LIG_PTB_Phospho_1	201	207	PF10480	0.610
LIG_SH2_CRK	182	186	PF00017	0.795
LIG_SH2_CRK	287	291	PF00017	0.767
LIG_SH2_GRB2like	85	88	PF00017	0.357
LIG_SH2_NCK_1	287	291	PF00017	0.785
LIG_SH2_SRC	65	68	PF00017	0.391
LIG_SH2_STAP1	65	69	PF00017	0.492
LIG_SH2_STAT3	170	173	PF00017	0.724
LIG_SH2_STAT3	357	360	PF00017	0.738
LIG_SH2_STAT5	163	166	PF00017	0.553
LIG_SH2_STAT5	287	290	PF00017	0.758
LIG_SH2_STAT5	309	312	PF00017	0.730
LIG_SH2_STAT5	85	88	PF00017	0.357
LIG_SH2_STAT5	98	101	PF00017	0.357
LIG_SH3_1	182	188	PF00018	0.790
LIG_SH3_1	286	292	PF00018	0.788
LIG_SH3_1	343	349	PF00018	0.804
LIG_SH3_2	301	306	PF14604	0.738
LIG_SH3_3	139	145	PF00018	0.635
LIG_SH3_3	182	188	PF00018	0.790
LIG_SH3_3	240	246	PF00018	0.739
LIG_SH3_3	286	292	PF00018	0.734
LIG_SH3_3	298	304	PF00018	0.657
LIG_SH3_3	324	330	PF00018	0.749
LIG_SH3_3	343	349	PF00018	0.740
LIG_SH3_3	353	359	PF00018	0.658
LIG_SUMO_SIM_anti_2	66	71	PF11976	0.492
LIG_TRAF2_1	100	103	PF00917	0.492
LIG_TRAF2_2	349	354	PF00917	0.593
MOD_CK1_1	285	291	PF00069	0.646
MOD_CK1_1	59	65	PF00069	0.672
MOD_CK2_1	211	217	PF00069	0.386
MOD_CK2_1	31	37	PF00069	0.666
MOD_GlcNHglycan	266	269	PF01048	0.785
MOD_GlcNHglycan	295	298	PF01048	0.633
MOD_GlcNHglycan	333	336	PF01048	0.792
MOD_GlcNHglycan	339	342	PF01048	0.822
MOD_GlcNHglycan	59	62	PF01048	0.632
MOD_N-GLC_1	111	116	PF02516	0.647
MOD_NEK2_1	211	216	PF00069	0.309
MOD_NEK2_2	38	43	PF00069	0.525
MOD_Plk_1	105	111	PF00069	0.570
MOD_Plk_1	91	97	PF00069	0.358
MOD_Plk_4	105	111	PF00069	0.575
MOD_Plk_4	282	288	PF00069	0.712
MOD_ProDKin_1	285	291	PF00069	0.791
TRG_DiLeu_BaEn_1	144	149	PF01217	0.543
TRG_ENDOCYTIC_2	98	101	PF00928	0.351
TRG_NES_CRM1_1	37	51	PF08389	0.669
TRG_NLS_MonoCore_2	346	351	PF00514	0.807
TRG_NLS_MonoExtC_3	346	352	PF00514	0.751
TRG_NLS_MonoExtN_4	345	351	PF00514	0.750

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5N7	Leptomonas seymouri	53%	100%
A0A0S4JNN9	Bodo saltans	33%	100%
A4H465	Leishmania braziliensis	79%	97%
A4HSD3	Leishmania infantum	99%	100%
C9ZPW6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AKC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QJI4	Leishmania major	89%	100%