LeishMANIAdb
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Leucine Rich repeat/Leucine rich repeat/Leucine Rich Repeat, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Leucine Rich repeat/Leucine rich repeat/Leucine Rich Repeat, putative
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S5H5G2_LEIDO
TriTrypDb:
LdBPK_050150.1 * , LdCL_050006400 , LDHU3_05.0190
Length:
441

Annotations

LeishMANIAdb annotations

Leucine-rich repeat proteins with a hydrophobic terminal helix. Unlike its distant animal relatives, this cytoplasmic sensor protein might be anchored to the membrane.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 27
NetGPI no yes: 0, no: 27
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 1
GO:0005929 cilium 4 27
GO:0005930 axoneme 2 1
GO:0016020 membrane 2 1
GO:0042995 cell projection 2 27
GO:0043226 organelle 2 27
GO:0043227 membrane-bounded organelle 3 27
GO:0110165 cellular anatomical entity 1 28
GO:0120025 plasma membrane bounded cell projection 3 27
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Expansion

Sequence features

A0A3S5H5G2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5G2

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 73 77 PF00656 0.399
CLV_NRD_NRD_1 377 379 PF00675 0.392
CLV_NRD_NRD_1 5 7 PF00675 0.668
CLV_PCSK_KEX2_1 377 379 PF00082 0.391
CLV_PCSK_KEX2_1 7 9 PF00082 0.696
CLV_PCSK_PC1ET2_1 7 9 PF00082 0.718
CLV_PCSK_SKI1_1 129 133 PF00082 0.354
CLV_PCSK_SKI1_1 157 161 PF00082 0.399
CLV_PCSK_SKI1_1 264 268 PF00082 0.324
CLV_PCSK_SKI1_1 31 35 PF00082 0.392
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1HUH0 Leptomonas seymouri 27% 94%
A0A0N1I317 Leptomonas seymouri 26% 100%
A0A0N1PD72 Leptomonas seymouri 71% 99%
A0A0S4IK39 Bodo saltans 25% 70%
A0A0S4IT30 Bodo saltans 26% 66%
A0A0S4JGH2 Bodo saltans 23% 100%
A0A0S4JL85 Bodo saltans 48% 100%
A0A0S4JPV3 Bodo saltans 28% 91%
A0A0S4JV86 Bodo saltans 23% 100%
A0A1X0P364 Trypanosomatidae 51% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS