Leucine Rich repeat/Leucine rich repeat/Leucine Rich Repeat, putative

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5G2_LEIDO

TriTrypDb:

LdBPK_050150.1 , LdCL_050006400 , LDHU3_05.0190

Length:

441

Annotations

LeishMANIAdb annotations

Leucine-rich repeat proteins with a hydrophobic terminal helix. Unlike its distant animal relatives, this cytoplasmic sensor protein might be anchored to the membrane.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 27
NetGPI	no	yes: 0, no: 27

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	27
GO:0042995	cell projection	2	27
GO:0043226	organelle	2	27
GO:0043227	membrane-bounded organelle	3	27
GO:0110165	cellular anatomical entity	1	28
GO:0120025	plasma membrane bounded cell projection	3	27
GO:0016020	membrane	2	1
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1

Expansion

Sequence features

A0A3S5H5G2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5G2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	73	77	PF00656	0.399
CLV_NRD_NRD_1	377	379	PF00675	0.392
CLV_NRD_NRD_1	5	7	PF00675	0.668
CLV_PCSK_KEX2_1	377	379	PF00082	0.391
CLV_PCSK_KEX2_1	7	9	PF00082	0.696
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.718
CLV_PCSK_SKI1_1	129	133	PF00082	0.354
CLV_PCSK_SKI1_1	157	161	PF00082	0.399
CLV_PCSK_SKI1_1	264	268	PF00082	0.324
CLV_PCSK_SKI1_1	31	35	PF00082	0.392
CLV_PCSK_SKI1_1	360	364	PF00082	0.399
CLV_PCSK_SKI1_1	378	382	PF00082	0.540
CLV_PCSK_SKI1_1	435	439	PF00082	0.434
CLV_PCSK_SKI1_1	49	53	PF00082	0.417
DOC_MAPK_gen_1	377	384	PF00069	0.523
DOC_MAPK_MEF2A_6	377	384	PF00069	0.523
DOC_USP7_MATH_1	109	113	PF00917	0.284
DOC_USP7_MATH_1	239	243	PF00917	0.339
DOC_USP7_MATH_1	273	277	PF00917	0.399
DOC_USP7_MATH_1	81	85	PF00917	0.399
DOC_USP7_UBL2_3	27	31	PF12436	0.517
DOC_USP7_UBL2_3	435	439	PF12436	0.535
DOC_WW_Pin1_4	116	121	PF00397	0.535
LIG_14-3-3_CanoR_1	129	135	PF00244	0.398
LIG_14-3-3_CanoR_1	223	229	PF00244	0.514
LIG_14-3-3_CanoR_1	264	272	PF00244	0.416
LIG_14-3-3_CanoR_1	360	366	PF00244	0.461
LIG_14-3-3_CanoR_1	377	381	PF00244	0.390
LIG_14-3-3_CanoR_1	87	95	PF00244	0.440
LIG_BIR_III_4	400	404	PF00653	0.659
LIG_BRCT_BRCA1_1	20	24	PF00533	0.392
LIG_FHA_1	172	178	PF00498	0.257
LIG_FHA_1	199	205	PF00498	0.340
LIG_FHA_1	216	222	PF00498	0.432
LIG_FHA_1	229	235	PF00498	0.278
LIG_FHA_1	320	326	PF00498	0.393
LIG_FHA_1	330	336	PF00498	0.415
LIG_FHA_1	357	363	PF00498	0.473
LIG_FHA_1	377	383	PF00498	0.544
LIG_FHA_1	385	391	PF00498	0.574
LIG_FHA_1	405	411	PF00498	0.672
LIG_FHA_1	412	418	PF00498	0.398
LIG_FHA_2	158	164	PF00498	0.310
LIG_FHA_2	35	41	PF00498	0.519
LIG_FHA_2	63	69	PF00498	0.298
LIG_LIR_Gen_1	130	137	PF02991	0.339
LIG_LIR_Nem_3	130	135	PF02991	0.342
LIG_LIR_Nem_3	163	169	PF02991	0.276
LIG_LIR_Nem_3	253	259	PF02991	0.466
LIG_NRP_CendR_1	438	441	PF00754	0.452
LIG_PCNA_yPIPBox_3	128	140	PF02747	0.266
LIG_SH2_STAT5	203	206	PF00017	0.416
LIG_SH2_STAT5	25	28	PF00017	0.487
LIG_SH2_STAT5	63	66	PF00017	0.418
LIG_SH3_3	8	14	PF00018	0.603
LIG_SUMO_SIM_anti_2	133	138	PF11976	0.409
LIG_SUMO_SIM_anti_2	332	338	PF11976	0.466
LIG_SUMO_SIM_par_1	379	388	PF11976	0.532
MOD_CK1_1	215	221	PF00069	0.492
MOD_CK2_1	67	73	PF00069	0.359
MOD_GlcNHglycan	111	114	PF01048	0.388
MOD_GlcNHglycan	120	123	PF01048	0.490
MOD_GlcNHglycan	3	6	PF01048	0.744
MOD_GlcNHglycan	372	375	PF01048	0.533
MOD_GSK3_1	19	26	PF00069	0.435
MOD_GSK3_1	224	231	PF00069	0.410
MOD_GSK3_1	319	326	PF00069	0.373
MOD_GSK3_1	356	363	PF00069	0.421
MOD_GSK3_1	59	66	PF00069	0.338
MOD_LATS_1	376	382	PF00433	0.510
MOD_N-GLC_1	116	121	PF02516	0.471
MOD_N-GLC_1	127	132	PF02516	0.384
MOD_N-GLC_1	171	176	PF02516	0.395
MOD_N-GLC_1	239	244	PF02516	0.454
MOD_N-GLC_1	280	285	PF02516	0.347
MOD_N-GLC_1	95	100	PF02516	0.336
MOD_NEK2_1	147	152	PF00069	0.362
MOD_NEK2_1	238	243	PF00069	0.393
MOD_NEK2_1	280	285	PF00069	0.312
MOD_NEK2_1	329	334	PF00069	0.345
MOD_NEK2_1	34	39	PF00069	0.526
MOD_NEK2_1	59	64	PF00069	0.308
MOD_NEK2_1	67	72	PF00069	0.319
MOD_NEK2_1	95	100	PF00069	0.348
MOD_NEK2_2	127	132	PF00069	0.364
MOD_NEK2_2	273	278	PF00069	0.424
MOD_PIKK_1	212	218	PF00454	0.542
MOD_PIKK_1	67	73	PF00454	0.323
MOD_PIKK_1	87	93	PF00454	0.218
MOD_PK_1	29	35	PF00069	0.342
MOD_PKA_2	222	228	PF00069	0.511
MOD_PKA_2	376	382	PF00069	0.421
MOD_Plk_1	127	133	PF00069	0.356
MOD_Plk_1	142	148	PF00069	0.282
MOD_Plk_1	157	163	PF00069	0.285
MOD_Plk_1	239	245	PF00069	0.401
MOD_Plk_4	142	148	PF00069	0.335
MOD_Plk_4	198	204	PF00069	0.414
MOD_Plk_4	239	245	PF00069	0.477
MOD_Plk_4	29	35	PF00069	0.544
MOD_Plk_4	59	65	PF00069	0.360
MOD_Plk_4	81	87	PF00069	0.457
MOD_ProDKin_1	116	122	PF00069	0.537
MOD_SUMO_for_1	16	19	PF00179	0.680
MOD_SUMO_rev_2	307	317	PF00179	0.418
TRG_DiLeu_BaEn_1	405	410	PF01217	0.621
TRG_DiLeu_BaLyEn_6	233	238	PF01217	0.354
TRG_DiLeu_BaLyEn_6	351	356	PF01217	0.269
TRG_ER_diLys_1	436	441	PF00400	0.578
TRG_NLS_MonoExtC_3	26	31	PF00514	0.548
TRG_NLS_MonoExtC_3	434	439	PF00514	0.506
TRG_NLS_MonoExtN_4	27	32	PF00514	0.418
TRG_Pf-PMV_PEXEL_1	264	268	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	354	358	PF00026	0.464

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUH0	Leptomonas seymouri	27%	94%
A0A0N1I317	Leptomonas seymouri	26%	100%
A0A0N1PD72	Leptomonas seymouri	71%	99%
A0A0S4IK39	Bodo saltans	25%	70%
A0A0S4IT30	Bodo saltans	26%	66%
A0A0S4JGH2	Bodo saltans	23%	100%
A0A0S4JL85	Bodo saltans	48%	100%
A0A0S4JPV3	Bodo saltans	28%	91%
A0A0S4JV86	Bodo saltans	23%	100%
A0A1X0P364	Trypanosomatidae	51%	100%
A0A3Q8IDE6	Leishmania donovani	28%	100%
A0A3R7L7Y9	Trypanosoma rangeli	28%	99%
A0A3R7P015	Trypanosoma rangeli	52%	93%
A0A3S7WZL6	Leishmania donovani	28%	100%
A4H461	Leishmania braziliensis	87%	100%
A4HEQ6	Leishmania braziliensis	26%	100%
A4HFQ6	Leishmania braziliensis	27%	100%
A4HHW0	Leishmania braziliensis	26%	100%
A4HSD0	Leishmania infantum	99%	100%
A4I1Y5	Leishmania infantum	28%	100%
A4I2T1	Leishmania infantum	28%	100%
C9ZPX6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
C9ZS33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	98%
E9ADA9	Leishmania major	27%	100%
E9AKB9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9AY32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AZ34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
P10775	Sus scrofa	24%	97%
P29315	Rattus norvegicus	25%	97%
Q4Q9E1	Leishmania major	27%	100%
Q4QJI8	Leishmania major	97%	100%
Q4V8D9	Rattus norvegicus	21%	100%
Q8IZ02	Homo sapiens	24%	95%
Q9LE82	Arabidopsis thaliana	26%	82%
Q9M651	Arabidopsis thaliana	26%	81%
V5BC66	Trypanosoma cruzi	28%	67%
V5BJF0	Trypanosoma cruzi	52%	89%
V5BPZ7	Trypanosoma cruzi	28%	98%
V5DHF2	Trypanosoma cruzi	24%	100%