Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5F9_LEIDO

TriTrypDb:

LdBPK_050120.1 , LdCL_050006100 , LDHU3_05.0150

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H5F9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5F9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0008173	RNA methyltransferase activity	4	1
GO:0008175	tRNA methyltransferase activity	5	1
GO:0008176	tRNA (guanine-N7-)-methyltransferase activity	7	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016423	tRNA (guanine) methyltransferase activity	6	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140101	catalytic activity, acting on a tRNA	4	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	306	310	PF00656	0.602
CLV_NRD_NRD_1	112	114	PF00675	0.446
CLV_NRD_NRD_1	160	162	PF00675	0.429
CLV_NRD_NRD_1	201	203	PF00675	0.390
CLV_NRD_NRD_1	255	257	PF00675	0.559
CLV_NRD_NRD_1	284	286	PF00675	0.614
CLV_NRD_NRD_1	3	5	PF00675	0.638
CLV_NRD_NRD_1	311	313	PF00675	0.522
CLV_NRD_NRD_1	320	322	PF00675	0.410
CLV_PCSK_FUR_1	282	286	PF00082	0.662
CLV_PCSK_KEX2_1	112	114	PF00082	0.471
CLV_PCSK_KEX2_1	126	128	PF00082	0.347
CLV_PCSK_KEX2_1	160	162	PF00082	0.429
CLV_PCSK_KEX2_1	201	203	PF00082	0.385
CLV_PCSK_KEX2_1	282	284	PF00082	0.676
CLV_PCSK_KEX2_1	3	5	PF00082	0.638
CLV_PCSK_KEX2_1	311	313	PF00082	0.512
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.524
CLV_PCSK_SKI1_1	127	131	PF00082	0.447
CLV_PCSK_SKI1_1	160	164	PF00082	0.447
CLV_PCSK_SKI1_1	311	315	PF00082	0.580
CLV_PCSK_SKI1_1	82	86	PF00082	0.490
DEG_APCC_DBOX_1	28	36	PF00400	0.591
DEG_Nend_Nbox_1	1	3	PF02207	0.623
DEG_ODPH_VHL_1	103	116	PF01847	0.542
DOC_CYCLIN_RxL_1	124	134	PF00134	0.466
DOC_CYCLIN_yCln2_LP_2	102	108	PF00134	0.547
DOC_MAPK_gen_1	289	298	PF00069	0.594
DOC_MAPK_gen_1	7	17	PF00069	0.547
DOC_MAPK_MEF2A_6	10	19	PF00069	0.609
DOC_PP1_RVXF_1	111	118	PF00149	0.447
DOC_PP1_RVXF_1	158	165	PF00149	0.378
DOC_PP1_RVXF_1	200	207	PF00149	0.455
DOC_PP2B_LxvP_1	102	105	PF13499	0.546
DOC_PP2B_LxvP_1	250	253	PF13499	0.509
DOC_USP7_MATH_1	211	215	PF00917	0.484
DOC_USP7_MATH_1	300	304	PF00917	0.467
DOC_USP7_MATH_1	74	78	PF00917	0.528
DOC_WW_Pin1_4	152	157	PF00397	0.544
DOC_WW_Pin1_4	304	309	PF00397	0.535
LIG_14-3-3_CanoR_1	27	33	PF00244	0.542
LIG_14-3-3_CanoR_1	3	11	PF00244	0.695
LIG_14-3-3_CanoR_1	311	319	PF00244	0.596
LIG_APCC_ABBA_1	228	233	PF00400	0.526
LIG_APCC_ABBAyCdc20_2	201	207	PF00400	0.491
LIG_Clathr_ClatBox_1	203	207	PF01394	0.484
LIG_eIF4E_1	124	130	PF01652	0.488
LIG_FHA_1	179	185	PF00498	0.422
LIG_FHA_1	48	54	PF00498	0.600
LIG_FHA_2	230	236	PF00498	0.395
LIG_FHA_2	304	310	PF00498	0.534
LIG_LIR_Gen_1	134	144	PF02991	0.417
LIG_LIR_Gen_1	168	179	PF02991	0.484
LIG_LIR_Gen_1	235	245	PF02991	0.473
LIG_LIR_LC3C_4	247	252	PF02991	0.543
LIG_LIR_Nem_3	134	140	PF02991	0.407
LIG_LIR_Nem_3	168	174	PF02991	0.404
LIG_LIR_Nem_3	235	240	PF02991	0.474
LIG_NRBOX	31	37	PF00104	0.563
LIG_OCRL_FandH_1	192	204	PF00620	0.549
LIG_REV1ctd_RIR_1	161	170	PF16727	0.463
LIG_SH2_STAP1	237	241	PF00017	0.488
LIG_SH2_STAP1	319	323	PF00017	0.540
LIG_SH2_STAT3	64	67	PF00017	0.532
LIG_SH2_STAT5	124	127	PF00017	0.375
LIG_SH2_STAT5	209	212	PF00017	0.501
LIG_SH2_STAT5	254	257	PF00017	0.662
LIG_SH3_1	219	225	PF00018	0.472
LIG_SH3_3	173	179	PF00018	0.433
LIG_SH3_3	184	190	PF00018	0.317
LIG_SH3_3	219	225	PF00018	0.472
LIG_SUMO_SIM_anti_2	183	188	PF11976	0.442
LIG_SUMO_SIM_par_1	49	56	PF11976	0.625
LIG_UBA3_1	241	249	PF00899	0.489
MOD_CDK_SPxxK_3	304	311	PF00069	0.488
MOD_CK1_1	169	175	PF00069	0.428
MOD_CK1_1	303	309	PF00069	0.485
MOD_CK2_1	140	146	PF00069	0.518
MOD_CK2_1	229	235	PF00069	0.482
MOD_GlcNHglycan	302	305	PF01048	0.477
MOD_GlcNHglycan	314	317	PF01048	0.432
MOD_GlcNHglycan	60	63	PF01048	0.524
MOD_GlcNHglycan	76	79	PF01048	0.338
MOD_GlcNHglycan	91	94	PF01048	0.436
MOD_GSK3_1	192	199	PF00069	0.424
MOD_GSK3_1	300	307	PF00069	0.468
MOD_GSK3_1	47	54	PF00069	0.558
MOD_N-GLC_1	317	322	PF02516	0.398
MOD_NEK2_1	130	135	PF00069	0.525
MOD_NEK2_1	2	7	PF00069	0.625
MOD_NEK2_1	89	94	PF00069	0.472
MOD_OFUCOSY	167	173	PF10250	0.421
MOD_PKA_1	3	9	PF00069	0.657
MOD_PKA_2	2	8	PF00069	0.625
MOD_PKA_2	28	34	PF00069	0.523
MOD_Plk_4	133	139	PF00069	0.413
MOD_Plk_4	166	172	PF00069	0.459
MOD_Plk_4	211	217	PF00069	0.461
MOD_ProDKin_1	152	158	PF00069	0.539
MOD_ProDKin_1	304	310	PF00069	0.531
MOD_SUMO_rev_2	243	251	PF00179	0.510
TRG_DiLeu_BaEn_1	246	251	PF01217	0.479
TRG_DiLeu_BaLyEn_6	309	314	PF01217	0.567
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.559
TRG_DiLeu_BaLyEn_6	98	103	PF01217	0.471
TRG_ENDOCYTIC_2	237	240	PF00928	0.492
TRG_ENDOCYTIC_2	324	327	PF00928	0.413
TRG_ER_diArg_1	112	114	PF00400	0.471
TRG_ER_diArg_1	160	162	PF00400	0.433
TRG_ER_diArg_1	2	4	PF00400	0.671
TRG_ER_diArg_1	201	203	PF00400	0.395
TRG_ER_diArg_1	216	219	PF00400	0.425
TRG_ER_diArg_1	282	285	PF00400	0.666
TRG_ER_diArg_1	311	313	PF00400	0.520
TRG_Pf-PMV_PEXEL_1	127	132	PF00026	0.408
TRG_Pf-PMV_PEXEL_1	265	269	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5N8	Leptomonas seymouri	67%	100%
A0A1X0P3K8	Trypanosomatidae	42%	98%
A0A3S5ISB0	Trypanosoma rangeli	48%	100%
A4H458	Leishmania braziliensis	88%	100%
A4HSE1	Leishmania infantum	100%	100%
C9ZPX1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AKB6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QJJ1	Leishmania major	97%	100%
V5AUY0	Trypanosoma cruzi	43%	100%