LeishMANIAdb
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Serine/threonine-protein phosphatase

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Serine/threonine-protein phosphatase
Gene product:
phosphoprotein phosphatase, putative
Species:
Leishmania donovani
UniProt:
A0A3S5H5F8_LEIDO
TriTrypDb:
LdBPK_050100.1 , LdCL_050005900 , LDHU3_05.0130
Length:
637

Annotations

LeishMANIAdb annotations

A large collection of various protein phosphatases. Very highly expanded in kinetoplastids.

Annotations by Jardim et al.

Phosphatase, Serine/threonine- phosphatase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 4
Forrest at al. (procyclic) yes yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 10
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 17
NetGPI no yes: 0, no: 17
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 2
GO:0005737 cytoplasm 2 2
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 2

Phosphorylation

Amastigote: 254
Promastigote: 232
Promastigote/Amastigote: 268, 270, 5, 9

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3S5H5F8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5F8

Function

Biological processes
Term Name Level Count
GO:0000724 double-strand break repair via homologous recombination 7 1
GO:0000725 recombinational repair 6 1
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006259 DNA metabolic process 4 1
GO:0006281 DNA repair 5 1
GO:0006302 double-strand break repair 6 1
GO:0006310 DNA recombination 5 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0006950 response to stress 2 1
GO:0006974 DNA damage response 4 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0033554 cellular response to stress 3 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0046483 heterocycle metabolic process 3 1
GO:0050896 response to stimulus 1 1
GO:0051716 cellular response to stimulus 2 1
GO:0071704 organic substance metabolic process 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 12
GO:0003677 DNA binding 4 12
GO:0003824 catalytic activity 1 18
GO:0004721 phosphoprotein phosphatase activity 3 18
GO:0004722 protein serine/threonine phosphatase activity 4 18
GO:0005488 binding 1 12
GO:0016787 hydrolase activity 2 18
GO:0016788 hydrolase activity, acting on ester bonds 3 18
GO:0016791 phosphatase activity 5 18
GO:0017018 myosin phosphatase activity 5 18
GO:0042578 phosphoric ester hydrolase activity 4 18
GO:0097159 organic cyclic compound binding 2 12
GO:0140096 catalytic activity, acting on a protein 2 18
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 558 562 PF00656 0.460
CLV_C14_Caspase3-7 74 78 PF00656 0.314
CLV_NRD_NRD_1 171 173 PF00675 0.641
CLV_NRD_NRD_1 176 178 PF00675 0.660
CLV_NRD_NRD_1 284 286 PF00675 0.450
CLV_PCSK_KEX2_1 170 172 PF00082 0.630
CLV_PCSK_KEX2_1 175 177 PF00082 0.642
CLV_PCSK_KEX2_1 284 286 PF00082 0.450
CLV_PCSK_KEX2_1 473 475 PF00082 0.328
CLV_PCSK_PC1ET2_1 473 475 PF00082 0.328
CLV_PCSK_PC7_1 171 177 PF00082 0.649
CLV_PCSK_SKI1_1 191 195 PF00082 0.470
CLV_PCSK_SKI1_1 374 378 PF00082 0.361
CLV_PCSK_SKI1_1 455 459 PF00082 0.328
CLV_PCSK_SKI1_1 570 574 PF00082 0.408
CLV_PCSK_SKI1_1 88 92 PF00082 0.320
DEG_APCC_DBOX_1 55 63 PF00400 0.328
DEG_Nend_UBRbox_2 1 3 PF02207 0.674
DOC_CKS1_1 15 20 PF01111 0.698
DOC_CKS1_1 230 235 PF01111 0.650
DOC_CYCLIN_yCln2_LP_2 162 168 PF00134 0.579
DOC_CYCLIN_yCln2_LP_2 326 332 PF00134 0.344
DOC_MAPK_gen_1 427 436 PF00069 0.328
DOC_MAPK_gen_1 88 98 PF00069 0.328
DOC_MAPK_MEF2A_6 319 326 PF00069 0.415
DOC_MAPK_MEF2A_6 430 438 PF00069 0.328
DOC_MAPK_MEF2A_6 91 100 PF00069 0.328
DOC_PP1_RVXF_1 347 354 PF00149 0.328
DOC_PP4_MxPP_1 1 4 PF00568 0.672
DOC_USP7_MATH_1 166 170 PF00917 0.695
DOC_USP7_MATH_1 181 185 PF00917 0.752
DOC_USP7_MATH_1 249 253 PF00917 0.635
DOC_USP7_MATH_1 287 291 PF00917 0.567
DOC_USP7_MATH_1 61 65 PF00917 0.363
DOC_USP7_UBL2_3 54 58 PF12436 0.440
DOC_WW_Pin1_4 133 138 PF00397 0.642
DOC_WW_Pin1_4 14 19 PF00397 0.653
DOC_WW_Pin1_4 229 234 PF00397 0.654
DOC_WW_Pin1_4 265 270 PF00397 0.597
DOC_WW_Pin1_4 325 330 PF00397 0.401
DOC_WW_Pin1_4 402 407 PF00397 0.338
DOC_WW_Pin1_4 6 11 PF00397 0.656
DOC_WW_Pin1_4 615 620 PF00397 0.626
LIG_14-3-3_CanoR_1 374 380 PF00244 0.348
LIG_14-3-3_CanoR_1 564 572 PF00244 0.448
LIG_Actin_WH2_2 343 361 PF00022 0.328
LIG_Actin_WH2_2 375 391 PF00022 0.328
LIG_APCC_ABBA_1 330 335 PF00400 0.344
LIG_APCC_ABBA_1 540 545 PF00400 0.328
LIG_BRCT_BRCA1_1 63 67 PF00533 0.358
LIG_deltaCOP1_diTrp_1 435 444 PF00928 0.328
LIG_EH1_1 359 367 PF00400 0.455
LIG_eIF4E_1 360 366 PF01652 0.328
LIG_FHA_1 101 107 PF00498 0.328
LIG_FHA_1 142 148 PF00498 0.589
LIG_FHA_1 209 215 PF00498 0.509
LIG_FHA_1 275 281 PF00498 0.583
LIG_FHA_2 100 106 PF00498 0.320
LIG_FHA_2 111 117 PF00498 0.328
LIG_FHA_2 211 217 PF00498 0.511
LIG_IRF3_LxIS_1 302 308 PF10401 0.403
LIG_LIR_Apic_2 505 511 PF02991 0.303
LIG_LIR_Gen_1 113 123 PF02991 0.328
LIG_LIR_Gen_1 202 212 PF02991 0.519
LIG_LIR_Gen_1 293 302 PF02991 0.419
LIG_LIR_Gen_1 320 330 PF02991 0.423
LIG_LIR_Gen_1 419 428 PF02991 0.328
LIG_LIR_Gen_1 435 444 PF02991 0.351
LIG_LIR_Nem_3 113 118 PF02991 0.328
LIG_LIR_Nem_3 202 208 PF02991 0.520
LIG_LIR_Nem_3 293 299 PF02991 0.434
LIG_LIR_Nem_3 301 305 PF02991 0.358
LIG_LIR_Nem_3 320 326 PF02991 0.398
LIG_LIR_Nem_3 331 336 PF02991 0.394
LIG_LIR_Nem_3 419 425 PF02991 0.335
LIG_LIR_Nem_3 435 440 PF02991 0.343
LIG_LIR_Nem_3 442 447 PF02991 0.323
LIG_LIR_Nem_3 480 486 PF02991 0.315
LIG_MLH1_MIPbox_1 63 67 PF16413 0.344
LIG_MYND_1 137 141 PF01753 0.549
LIG_OCRL_FandH_1 332 344 PF00620 0.328
LIG_PTB_Apo_2 361 368 PF02174 0.427
LIG_REV1ctd_RIR_1 64 73 PF16727 0.314
LIG_SH2_CRK 115 119 PF00017 0.328
LIG_SH2_CRK 296 300 PF00017 0.451
LIG_SH2_CRK 549 553 PF00017 0.328
LIG_SH2_GRB2like 265 268 PF00017 0.593
LIG_SH2_GRB2like 296 299 PF00017 0.427
LIG_SH2_NCK_1 115 119 PF00017 0.328
LIG_SH2_PTP2 205 208 PF00017 0.644
LIG_SH2_SRC 446 449 PF00017 0.416
LIG_SH2_SRC 549 552 PF00017 0.328
LIG_SH2_STAT3 360 363 PF00017 0.455
LIG_SH2_STAT3 547 550 PF00017 0.322
LIG_SH2_STAT5 192 195 PF00017 0.467
LIG_SH2_STAT5 205 208 PF00017 0.493
LIG_SH2_STAT5 345 348 PF00017 0.348
LIG_SH2_STAT5 360 363 PF00017 0.325
LIG_SH2_STAT5 371 374 PF00017 0.353
LIG_SH2_STAT5 384 387 PF00017 0.344
LIG_SH2_STAT5 446 449 PF00017 0.416
LIG_SH2_STAT5 551 554 PF00017 0.330
LIG_SH3_2 186 191 PF14604 0.669
LIG_SH3_2 273 278 PF14604 0.578
LIG_SH3_3 1 7 PF00018 0.663
LIG_SH3_3 183 189 PF00018 0.706
LIG_SH3_3 203 209 PF00018 0.331
LIG_SH3_3 224 230 PF00018 0.644
LIG_SH3_3 266 272 PF00018 0.591
LIG_SH3_3 387 393 PF00018 0.394
LIG_SH3_3 478 484 PF00018 0.326
LIG_SH3_3 508 514 PF00018 0.311
LIG_SH3_3 524 530 PF00018 0.323
LIG_SH3_3 613 619 PF00018 0.644
LIG_SH3_4 603 610 PF00018 0.627
LIG_SUMO_SIM_anti_2 211 216 PF11976 0.515
LIG_SUMO_SIM_anti_2 394 400 PF11976 0.355
LIG_SUMO_SIM_anti_2 97 105 PF11976 0.328
LIG_SUMO_SIM_par_1 210 216 PF11976 0.516
LIG_SUMO_SIM_par_1 305 311 PF11976 0.426
LIG_SUMO_SIM_par_1 570 579 PF11976 0.407
LIG_TRAF2_1 555 558 PF00917 0.328
LIG_TRAF2_2 514 519 PF00917 0.455
LIG_TYR_ITSM 111 118 PF00017 0.328
LIG_UBA3_1 322 327 PF00899 0.401
LIG_UBA3_1 385 389 PF00899 0.358
LIG_WRC_WIRS_1 417 422 PF05994 0.328
LIG_WRC_WIRS_1 532 537 PF05994 0.328
MOD_CDK_SPK_2 229 234 PF00069 0.650
MOD_CDK_SPK_2 615 620 PF00069 0.630
MOD_CK1_1 252 258 PF00069 0.598
MOD_CK1_1 290 296 PF00069 0.579
MOD_CK1_1 308 314 PF00069 0.380
MOD_CK1_1 31 37 PF00069 0.554
MOD_CK1_1 328 334 PF00069 0.342
MOD_CK1_1 618 624 PF00069 0.644
MOD_CK2_1 121 127 PF00069 0.320
MOD_CK2_1 465 471 PF00069 0.339
MOD_CK2_1 99 105 PF00069 0.325
MOD_GlcNHglycan 123 126 PF01048 0.441
MOD_GlcNHglycan 183 186 PF01048 0.685
MOD_GlcNHglycan 467 470 PF01048 0.383
MOD_GlcNHglycan 624 627 PF01048 0.749
MOD_GlcNHglycan 63 66 PF01048 0.338
MOD_GSK3_1 2 9 PF00069 0.708
MOD_GSK3_1 204 211 PF00069 0.575
MOD_GSK3_1 570 577 PF00069 0.395
MOD_GSK3_1 618 625 PF00069 0.625
MOD_N-GLC_1 110 115 PF02516 0.416
MOD_NEK2_1 305 310 PF00069 0.371
MOD_NEK2_1 358 363 PF00069 0.328
MOD_NEK2_1 622 627 PF00069 0.637
MOD_NEK2_2 416 421 PF00069 0.328
MOD_PIKK_1 192 198 PF00454 0.487
MOD_PIKK_1 267 273 PF00454 0.627
MOD_PKA_2 563 569 PF00069 0.470
MOD_PKA_2 610 616 PF00069 0.780
MOD_Plk_1 29 35 PF00069 0.644
MOD_Plk_1 72 78 PF00069 0.455
MOD_Plk_1 92 98 PF00069 0.158
MOD_Plk_4 127 133 PF00069 0.364
MOD_Plk_4 143 149 PF00069 0.481
MOD_Plk_4 210 216 PF00069 0.532
MOD_Plk_4 252 258 PF00069 0.586
MOD_Plk_4 394 400 PF00069 0.372
MOD_Plk_4 570 576 PF00069 0.395
MOD_ProDKin_1 133 139 PF00069 0.645
MOD_ProDKin_1 14 20 PF00069 0.650
MOD_ProDKin_1 229 235 PF00069 0.656
MOD_ProDKin_1 265 271 PF00069 0.595
MOD_ProDKin_1 325 331 PF00069 0.395
MOD_ProDKin_1 402 408 PF00069 0.338
MOD_ProDKin_1 6 12 PF00069 0.659
MOD_ProDKin_1 615 621 PF00069 0.626
MOD_SUMO_rev_2 452 458 PF00179 0.328
MOD_SUMO_rev_2 468 475 PF00179 0.386
MOD_SUMO_rev_2 608 616 PF00179 0.643
TRG_DiLeu_BaEn_1 301 306 PF01217 0.365
TRG_DiLeu_BaEn_3 151 157 PF01217 0.565
TRG_DiLeu_BaLyEn_6 275 280 PF01217 0.440
TRG_ENDOCYTIC_2 115 118 PF00928 0.328
TRG_ENDOCYTIC_2 205 208 PF00928 0.644
TRG_ENDOCYTIC_2 296 299 PF00928 0.412
TRG_ENDOCYTIC_2 417 420 PF00928 0.336
TRG_ENDOCYTIC_2 422 425 PF00928 0.335
TRG_ENDOCYTIC_2 446 449 PF00928 0.426
TRG_ENDOCYTIC_2 549 552 PF00928 0.328
TRG_ER_diArg_1 170 172 PF00400 0.738
TRG_ER_diArg_1 175 177 PF00400 0.736
TRG_ER_diArg_1 242 245 PF00400 0.714
TRG_ER_diArg_1 283 285 PF00400 0.450
TRG_ER_diArg_1 68 71 PF00400 0.393
TRG_ER_diLys_1 634 637 PF00400 0.721
TRG_NES_CRM1_1 152 164 PF08389 0.595

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I548 Leptomonas seymouri 94% 100%
A0A0S4JP77 Bodo saltans 72% 100%
A0A1X0P2R2 Trypanosomatidae 81% 100%
A0A3Q8I8M6 Leishmania donovani 34% 100%
A0A422NYB5 Trypanosoma rangeli 78% 100%
A4H456 Leishmania braziliensis 98% 100%
A4HSD9 Leishmania infantum 100% 100%
A4HVT0 Leishmania infantum 34% 100%
C9ZPX4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 78% 100%
D0A366 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
E9AKB4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 99% 100%
E9APH5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
Q4QG03 Leishmania major 32% 100%
Q4QJJ3 Leishmania major 100% 100%
V5BAC7 Trypanosoma cruzi 81% 100%
V5BBS3 Trypanosoma cruzi 28% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS