Nudix hydrolase 2, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nudix hydrolase 2, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H5F7_LEIDO

TriTrypDb:

LdBPK_050090.1 , LdCL_050005800 , LDHU3_05.0120

Length:

179

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H5F7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5F7

Function

Biological processes
Term	Name	Level	Count
GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA	8	1
GO:0000956	nuclear-transcribed mRNA catabolic process	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006401	RNA catabolic process	5	1
GO:0006402	mRNA catabolic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010629	negative regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0048519	negative regulation of biological process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0110154	RNA decapping	6	1
GO:0110156	methylguanosine-cap decapping	7	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	16
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	16
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0050072	obsolete m7G(5')pppN diphosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.523
CLV_NRD_NRD_1	88	90	PF00675	0.411
CLV_PCSK_KEX2_1	166	168	PF00082	0.620
CLV_PCSK_KEX2_1	88	90	PF00082	0.432
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.630
CLV_PCSK_SKI1_1	111	115	PF00082	0.427
CLV_PCSK_SKI1_1	161	165	PF00082	0.532
CLV_PCSK_SKI1_1	167	171	PF00082	0.551
CLV_PCSK_SKI1_1	98	102	PF00082	0.415
DEG_Nend_Nbox_1	1	3	PF02207	0.442
DOC_CKS1_1	102	107	PF01111	0.435
DOC_CYCLIN_RxL_1	161	172	PF00134	0.623
DOC_CYCLIN_RxL_1	95	106	PF00134	0.522
DOC_CYCLIN_yCln2_LP_2	114	117	PF00134	0.464
DOC_MAPK_gen_1	127	134	PF00069	0.546
DOC_MAPK_gen_1	96	103	PF00069	0.549
DOC_MAPK_JIP1_4	57	63	PF00069	0.468
DOC_MAPK_MEF2A_6	3	10	PF00069	0.431
DOC_MAPK_MEF2A_6	96	103	PF00069	0.482
DOC_MAPK_NFAT4_5	96	104	PF00069	0.482
DOC_PP1_RVXF_1	12	18	PF00149	0.511
DOC_PP1_RVXF_1	125	132	PF00149	0.478
DOC_PP1_RVXF_1	96	103	PF00149	0.480
DOC_PP2B_LxvP_1	114	117	PF13499	0.464
DOC_PP4_FxxP_1	102	105	PF00568	0.420
DOC_USP7_MATH_2	105	111	PF00917	0.387
DOC_WW_Pin1_4	101	106	PF00397	0.435
LIG_14-3-3_CanoR_1	22	31	PF00244	0.489
LIG_APCC_ABBA_1	8	13	PF00400	0.490
LIG_BRCT_BRCA1_1	122	126	PF00533	0.418
LIG_BRCT_BRCA1_2	122	128	PF00533	0.387
LIG_FHA_2	102	108	PF00498	0.507
LIG_LIR_Gen_1	25	35	PF02991	0.466
LIG_LIR_Nem_3	123	129	PF02991	0.404
LIG_LIR_Nem_3	130	134	PF02991	0.381
LIG_LIR_Nem_3	25	31	PF02991	0.466
LIG_SH2_NCK_1	79	83	PF00017	0.517
LIG_SH2_STAT3	92	95	PF00017	0.442
LIG_SH2_STAT5	79	82	PF00017	0.464
LIG_SH2_STAT5	92	95	PF00017	0.425
LIG_SH3_3	110	116	PF00018	0.467
LIG_SUMO_SIM_anti_2	110	116	PF11976	0.445
LIG_TRAF2_1	122	125	PF00917	0.410
MOD_CK2_1	101	107	PF00069	0.540
MOD_CK2_1	138	144	PF00069	0.417
MOD_GSK3_1	103	110	PF00069	0.515
MOD_N-GLC_1	107	112	PF02516	0.387
MOD_N-GLC_2	5	7	PF02516	0.430
MOD_NEK2_1	77	82	PF00069	0.446
MOD_PIKK_1	120	126	PF00454	0.525
MOD_ProDKin_1	101	107	PF00069	0.435
TRG_DiLeu_BaEn_2	12	18	PF01217	0.441
TRG_DiLeu_BaEn_4	51	57	PF01217	0.466
TRG_ER_diArg_1	87	89	PF00400	0.464
TRG_Pf-PMV_PEXEL_1	140	144	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	167	172	PF00026	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5P0	Leptomonas seymouri	72%	100%
A0A0N0P9K0	Leptomonas seymouri	30%	76%
A0A0S4J332	Bodo saltans	45%	70%
A0A1X0P2U2	Trypanosomatidae	59%	100%
A0A422NYC4	Trypanosoma rangeli	55%	100%
A0A422P4Y4	Trypanosoma rangeli	35%	75%
A4H455	Leishmania braziliensis	88%	100%
A4HKE1	Leishmania braziliensis	30%	100%
A4HSD8	Leishmania infantum	99%	100%
B2FJU2	Stenotrophomonas maltophilia (strain K279a)	28%	87%
C9ZPX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AKB3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QJJ4	Leishmania major	94%	100%
V5BU70	Trypanosoma cruzi	33%	70%
V5DQQ5	Trypanosoma cruzi	33%	70%